Sangeeta Khare

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. pmc Vaccination with attenuated Salmonella enterica Dublin expressing E coli O157:H7 outer membrane protein Intimin induces transient reduction of fecal shedding of E coli O157:H7 in cattle
    Sangeeta Khare
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 USA
    BMC Vet Res 6:35. 2010
  2. pmc Systems biology analysis of gene expression during in vivo Mycobacterium avium paratuberculosis enteric colonization reveals role for immune tolerance
    Sangeeta Khare
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 7:e42127. 2012
  3. pmc Enhancing the role of veterinary vaccines reducing zoonotic diseases of humans: linking systems biology with vaccine development
    L Garry Adams
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
    Vaccine 29:7197-206. 2011
  4. pmc Role of SPI-1 secreted effectors in acute bovine response to Salmonella enterica Serovar Typhimurium: a systems biology analysis approach
    Sara D Lawhon
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 6:e26869. 2011
  5. doi Salmonella enterica Typhimurium SipA induces CXC-chemokine expression through p38MAPK and JUN pathways
    Josely F Figueiredo
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
    Microbes Infect 11:302-10. 2009
  6. pmc Systems biology analysis of Brucella infected Peyer's patch reveals rapid invasion with modest transient perturbations of the host transcriptome
    Carlos A Rossetti
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 8:e81719. 2013
  7. pmc The Salmonella enterica serotype Typhi Vi capsular antigen is expressed after the bacterium enters the ileal mucosa
    Quynh T Tran
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4467, USA
    Infect Immun 78:527-35. 2010
  8. ncbi Mycobacterium bovis DeltaleuD auxotroph-induced protective immunity against tissue colonization, burden and distribution in cattle intranasally challenged with Mycobacterium bovis Ravenel S
    Sangeeta Khare
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Vaccine 25:1743-55. 2007
  9. pmc Rapid and sensitive detection of Mycobacterium avium subsp. paratuberculosis in bovine milk and feces by a combination of immunomagnetic bead separation-conventional PCR and real-time PCR
    Sangeeta Khare
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843 4467, USA
    J Clin Microbiol 42:1075-81. 2004
  10. pmc Multi-comparative systems biology analysis reveals time-course biosignatures of in vivo bovine pathway responses to B.melitensis, S.enterica Typhimurium and M.avium paratuberculosis
    L Garry Adams
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
    BMC Proc 5:S6. 2011

Collaborators

Detail Information

Publications11

  1. pmc Vaccination with attenuated Salmonella enterica Dublin expressing E coli O157:H7 outer membrane protein Intimin induces transient reduction of fecal shedding of E coli O157:H7 in cattle
    Sangeeta Khare
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 USA
    BMC Vet Res 6:35. 2010
    ..The present study was undertaken to test the hypothesis that an adaptive mucosal immune response directed against intimin will reduce or prevent enteric colonization and fecal shedding of E. coli O157:H7 in cattle...
  2. pmc Systems biology analysis of gene expression during in vivo Mycobacterium avium paratuberculosis enteric colonization reveals role for immune tolerance
    Sangeeta Khare
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 7:e42127. 2012
    ..Our study provides evidence that MAP infection resulted in differentially regulated genes, perturbed pathways and specifically modified mechanistic genes contributing to the colonization of Peyer's patch...
  3. pmc Enhancing the role of veterinary vaccines reducing zoonotic diseases of humans: linking systems biology with vaccine development
    L Garry Adams
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
    Vaccine 29:7197-206. 2011
    ..Thus, we propose that such an approach has immediate application to the rational design of brucellosis and salmonellosis vaccines...
  4. pmc Role of SPI-1 secreted effectors in acute bovine response to Salmonella enterica Serovar Typhimurium: a systems biology analysis approach
    Sara D Lawhon
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 6:e26869. 2011
    ....
  5. doi Salmonella enterica Typhimurium SipA induces CXC-chemokine expression through p38MAPK and JUN pathways
    Josely F Figueiredo
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
    Microbes Infect 11:302-10. 2009
    ..These data indicate that S. typhimurium SipA induces expression of CXC chemokines through phosphorylation of IL-8-transcription regulatory proteins, JUN and p38MAK...
  6. pmc Systems biology analysis of Brucella infected Peyer's patch reveals rapid invasion with modest transient perturbations of the host transcriptome
    Carlos A Rossetti
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 8:e81719. 2013
    ..Cumulatively, our results indicate that the in vivo pathogenesis of the early infectious process of Brucella is primarily accomplished by compromising the mucosal immune barrier and subverting critical immune response mechanisms. ..
  7. pmc The Salmonella enterica serotype Typhi Vi capsular antigen is expressed after the bacterium enters the ileal mucosa
    Quynh T Tran
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4467, USA
    Infect Immun 78:527-35. 2010
    ..Together, these results support the concept that expression of the Vi capsular antigen is induced when S. Typhi transits from the intestinal lumen into the ileal mucosa...
  8. ncbi Mycobacterium bovis DeltaleuD auxotroph-induced protective immunity against tissue colonization, burden and distribution in cattle intranasally challenged with Mycobacterium bovis Ravenel S
    Sangeeta Khare
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Vaccine 25:1743-55. 2007
    ..bovis DeltaleuD mutant produced highly significantly protective immunity as measured by a reduction in tissue colonization, burden, bacilli dissemination, and histopathology caused by virulent M. bovis Ravenel S challenge...
  9. pmc Rapid and sensitive detection of Mycobacterium avium subsp. paratuberculosis in bovine milk and feces by a combination of immunomagnetic bead separation-conventional PCR and real-time PCR
    Sangeeta Khare
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843 4467, USA
    J Clin Microbiol 42:1075-81. 2004
    ....
  10. pmc Multi-comparative systems biology analysis reveals time-course biosignatures of in vivo bovine pathway responses to B.melitensis, S.enterica Typhimurium and M.avium paratuberculosis
    L Garry Adams
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
    BMC Proc 5:S6. 2011
    ....
  11. pmc Secreted effector proteins of Salmonella enterica serotype typhimurium elicit host-specific chemokine profiles in animal models of typhoid fever and enterocolitis
    Shuping Zhang
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843 4467, USA
    Infect Immun 71:4795-803. 2003
    ..Thus, different disease outcomes between mice (i.e., no diarrhea) and calves (i.e., diarrhea) may be due to differences in sipA sopABDE2-dependent CXC chemokine gene expression in epithelial cells...