Richard Kelley


Affiliation: Texas Medical Center
Country: USA


  1. Kelley R, Lee O, Shim Y. Transcription rate of noncoding roX1 RNA controls local spreading of the Drosophila MSL chromatin remodeling complex. Mech Dev. 2008;125:1009-19 pubmed publisher
    ..We propose that assembly of the MSL proteins onto the extreme 3' region of elongating roX1 transcripts determines whether the MSL complex spreads in cis. ..
  2. Prabhakaran M, Kelley R. A new strategy for isolating genes controlling dosage compensation in Drosophila using a simple epigenetic mosaic eye phenotype. BMC Biol. 2010;8:80 pubmed publisher
    ..This strategy is a promising alternative route for identifying previously unknown components of the dosage compensation pathway and novel alleles of known MSL proteins. ..
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    Kelley R, Kuroda M. The role of chromosomal RNAs in marking the X for dosage compensation. Curr Opin Genet Dev. 2000;10:555-61 pubmed
    ..A novel class of noncoding RNAs that paint entire chromosomes are centrally involved in this process. The genes encoding these unusual RNAs are themselves located on the X, and are key sites that target the X for dosage compensation. ..
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    Kelley R, Kuroda M. Noncoding RNA genes in dosage compensation and imprinting. Cell. 2000;103:9-12 pubmed
  5. Kelley R, Kuroda M. The Drosophila roX1 RNA gene can overcome silent chromatin by recruiting the male-specific lethal dosage compensation complex. Genetics. 2003;164:565-74 pubmed
    ..The potency with which an ectopic MSL complex overcomes silent chromatin suggests that its normal action on the X must be under strict regulation. ..