G Karsenty

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Reaching a genetic and molecular understanding of skeletal development
    Gerard Karsenty
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Cell 2:389-406. 2002
  2. pmc Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
    Masaki Kato
    Department of Molecular and Cellular Biology and Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 157:303-14. 2002
  3. pmc Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo
    Romain Dacquin
    Department of Molecular and Human Genetics and Bone Disease Program of Texas, Baylor College of Medicine, One Baylor Plaza, Room S921, Houston, TX 77030, USA
    J Cell Biol 164:509-14. 2004
  4. pmc Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins
    Monzur Murshed
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Rm S921, Houston, TX 77030, USA
    J Cell Biol 165:625-30. 2004
  5. ncbi request reprint The central regulation of bone remodeling
    G Karsenty
    Baylor College of Medicine, Department of Molecular and Human Genetics, One Baylor Plaza, Houston, TX 77030, USA
    Trends Endocrinol Metab 11:437-9. 2000
  6. ncbi request reprint The complexities of skeletal biology
    Gerard Karsenty
    Baylor College of Medicine, Bone Disease Program of Texas, One Baylor Plaza, Houston, Texas 77030, USA
    Nature 423:316-8. 2003
  7. ncbi request reprint Transcriptional regulation of osteoblast differentiation during development
    G Karsenty
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Front Biosci 3:d834-7. 1998
  8. ncbi request reprint Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes
    B Kern
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 276:7101-7. 2001
  9. ncbi request reprint [Bone mass regulation by leptin: a hypothalamic control of bone formation]
    F Elefteriou
    Département de génétique moléculaire et humaine, Bone Disease Program of Texas, Baylor College of Medicine, Houston, 77030 Texas, Etats Unis
    Pathol Biol (Paris) 52:148-53. 2004
  10. ncbi request reprint Leptin regulation of bone resorption by the sympathetic nervous system and CART
    Florent Elefteriou
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 434:514-20. 2005

Collaborators

Detail Information

Publications68

  1. ncbi request reprint Reaching a genetic and molecular understanding of skeletal development
    Gerard Karsenty
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Cell 2:389-406. 2002
    ..This review addresses the role of the principal growth factors and transcription factors affecting these different processes and presents, in several cases, the genetic cascade leading to cell differentiation...
  2. pmc Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
    Masaki Kato
    Department of Molecular and Cellular Biology and Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 157:303-14. 2002
    ..Moreover, these features recapitulate human osteoporosis-pseudoglioma syndrome, caused by LRP5 inactivation...
  3. pmc Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo
    Romain Dacquin
    Department of Molecular and Human Genetics and Bone Disease Program of Texas, Baylor College of Medicine, One Baylor Plaza, Room S921, Houston, TX 77030, USA
    J Cell Biol 164:509-14. 2004
    ..Thus, amylin is a physiological regulator of bone resorption that acts through an unidentified receptor...
  4. pmc Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins
    Monzur Murshed
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Rm S921, Houston, TX 77030, USA
    J Cell Biol 165:625-30. 2004
    ..These results indicate that ECMM is regulated locally in animals and uncover a striking disparity of function between proteins sharing identical structural motifs...
  5. ncbi request reprint The central regulation of bone remodeling
    G Karsenty
    Baylor College of Medicine, Department of Molecular and Human Genetics, One Baylor Plaza, Houston, TX 77030, USA
    Trends Endocrinol Metab 11:437-9. 2000
    ..The recent development of molecular endocrinology uncovers a common, central regulation of bone formation, body weight and reproduction mediated by leptin...
  6. ncbi request reprint The complexities of skeletal biology
    Gerard Karsenty
    Baylor College of Medicine, Bone Disease Program of Texas, One Baylor Plaza, Houston, Texas 77030, USA
    Nature 423:316-8. 2003
    ..By so doing this progress has affected our understanding of diseases and suggested in many instances new therapeutic opportunities...
  7. ncbi request reprint Transcriptional regulation of osteoblast differentiation during development
    G Karsenty
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Front Biosci 3:d834-7. 1998
    ..These result demonstrate that Osf2/Cbfa1 is an osteoblast-specific transcriptional activator of osteoblast differentiation whose function is non redundant with the function of other gene products during development...
  8. ncbi request reprint Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes
    B Kern
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 276:7101-7. 2001
    ..Thus, our results suggest that Cbfa1 is one of the positive regulators of the osteoblast-specific expression of both type I collagen genes...
  9. ncbi request reprint [Bone mass regulation by leptin: a hypothalamic control of bone formation]
    F Elefteriou
    Département de génétique moléculaire et humaine, Bone Disease Program of Texas, Baylor College of Medicine, Houston, 77030 Texas, Etats Unis
    Pathol Biol (Paris) 52:148-53. 2004
    ..Conversely, beta-blockers increased bone formation and bone mass and blunt the bone loss induced by ovariectomy...
  10. ncbi request reprint Leptin regulation of bone resorption by the sympathetic nervous system and CART
    Florent Elefteriou
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 434:514-20. 2005
    ..Our study establishes that leptin-regulated neural pathways control both aspects of bone remodelling, and demonstrates that integrity of sympathetic signalling is necessary for the increase in bone resorption caused by gonadal failure...
  11. ncbi request reprint Knock-in of nuclear localised beta-galactosidase reveals that the tyrosine phosphatase Ptprv is specifically expressed in cells of the bone collar
    R Dacquin
    Baylor College of Medicine, Department of Molecular and Human Genetics and Bone Disease Program of Texas, Houston, Texas, USA
    Dev Dyn 229:826-34. 2004
    ..The specificity of Ptprv expression in these cells may be a useful tool to elucidate their role in the transition of skeletal elements from cartilage template to bone...
  12. pmc Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice
    S Takeda
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 15:467-81. 2001
    ..These results identify Cbfa1 as a hypertrophic chondrocyte differentiation factor and provide a genetic argument for a common regulation of osteoblast and chondrocyte differentiation mediated by Cbfa1...
  13. pmc A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development
    P Ducy
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 13:1025-36. 1999
    ....
  14. ncbi request reprint Reversible skeletal abnormalities in gamma-glutamyl transpeptidase-deficient mice
    Regis Levasseur
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Endocrinology 144:2761-4. 2003
    ..These results establish the importance of cysteine metabolism for the regulation of bone remodeling and longitudinal growth...
  15. ncbi request reprint Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass
    P Ducy
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 100:197-207. 2000
    ..This study identifies leptin as a potent inhibitor of bone formation acting through the central nervous system and therefore describes the central nature of bone mass control and its disorders...
  16. ncbi request reprint Leptin regulates bone formation via the sympathetic nervous system
    Shu Takeda
    Department of Molecular and Human Genetics, One Baylor Plaza, Houston, TX 77030, USA
    Cell 111:305-17. 2002
    ..None of these manipulations affects body weight. This study demonstrates a leptin-dependent neuronal regulation of bone formation with potential therapeutic implications for osteoporosis...
  17. ncbi request reprint Monosodium glutamate-sensitive hypothalamic neurons contribute to the control of bone mass
    Florent Elefteriou
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 144:3842-7. 2003
    ..It also indicates that NPY deficiency does not affect bone mass...
  18. ncbi request reprint Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia
    B Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 16:307-10. 1997
    ..Thus, these results together suggest that CCD is produced by haploinsufficiency of OSF2/CBFA1 and provide direct genetic evidence that the phenotype is secondary to an alteration of osteoblast differentiation...
  19. ncbi request reprint CBFA1 mutation analysis and functional correlation with phenotypic variability in cleidocranial dysplasia
    G Zhou
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, BCM225, 630E, Houston, TX 77030, USA
    Hum Mol Genet 8:2311-6. 1999
    ..Together these data show that variable loss of function due to alterations in the runt and PST domains of CBFA1 may give rise to clinical variability, including classic CCD, mild CCD and isolated primary dental anomalies...
  20. ncbi request reprint Leptin controls bone formation through a hypothalamic relay
    G Karsenty
    Baylor College of Medicine, Houston, Texas 77030, USA
    Recent Prog Horm Res 56:401-15. 2001
    ..This result revealed that bone remodeling, like most other homeostatic functions, is under hypothalamic control. The nature of the signal downstream of the hypothalamus is unknown but current experiments are attempting to identify it...
  21. ncbi request reprint Genetic ablation of parathyroid glands reveals another source of parathyroid hormone
    T Gunther
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 406:199-203. 2000
    ..Thus, Gcm2 deletion uncovers an auxiliary mechanism for the regulation of calcium homeostasis in the absence of parathyroid glands. We propose that this backup mechanism may be a general feature of endocrine regulation...
  22. ncbi request reprint Prostate cancer cells induce osteoblast differentiation through a Cbfa1-dependent pathway
    J Yang
    Department of Genitourinary Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 61:5652-9. 2001
    ..Moreover, it allows to screen for therapeutic agents blocking the osteoblast response to prostate cancer...
  23. ncbi request reprint The hypothalamic control of bone mass, implication for the treatment of osteoporosis
    G Karsenty
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Ann Endocrinol (Paris) 67:123. 2006
  24. ncbi request reprint Genetic control of skeletal development
    G Karsenty
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Novartis Found Symp 232:6-17; discussion 17-22. 2001
    ..Our current knowledge in each of these areas of skeleton biology will be presented in broad terms to set the course for other presentations during the symposium...
  25. ncbi request reprint Characterization of Osf1, an osteoblast-specific transcription factor binding to a critical cis-acting element in the mouse Osteocalcin promoters
    T Schinke
    Department of Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 274:30182-9. 1999
    ....
  26. ncbi request reprint Central control of bone formation
    S Takeda
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    J Bone Miner Metab 19:195-8. 2001
    ..This finding also has therapeutic implications...
  27. pmc Deletion of Ku86 causes early onset of senescence in mice
    H Vogel
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 96:10770-5. 1999
    ..These data indicate that Ku86-dependent chromosomal metabolism is important for determining the onset of age-specific changes characteristic of senescence in mice...
  28. ncbi request reprint Minireview: transcriptional control of osteoblast differentiation
    G Karsenty
    Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 142:2731-3. 2001
    ..Although other transcription factors are likely to be involved in osteoblast differentiation, Cbfal, by the multiplicity of the role that it plays, can be viewed as the central regulator of intramembranous and endochondral ossification...
  29. pmc Serum leptin level is a regulator of bone mass
    F Elefteriou
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:3258-63. 2004
    ..Taken together, these results indicate that adipocyte-derived circulating leptin is a determinant of bone formation and suggests that leptin antiosteogenic function is conserved in vertebrates...
  30. pmc Two domains unique to osteoblast-specific transcription factor Osf2/Cbfa1 contribute to its transactivation function and its inability to heterodimerize with Cbfbeta
    K Thirunavukkarasu
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 18:4197-208. 1998
    ..Thus, our results uncover the unique functional organization of Osf2 by identifying functional domains not shared with other Runt-related proteins that largely control its transactivation and heterodimerization abilities...
  31. ncbi request reprint Identification of novel genes expressed during metanephric induction through single-cell library screening
    J M Abidari
    Scott Department of Urology, Department of Molecular and Human Genetics, and Department of Pediatrics, Baylor College of Medicine, and Texas Children s Hospital, Houston, Texas 77030, USA
    Kidney Int 57:2221-8. 2000
    ..These findings suggest that Bmp7 controls the expression of genes important for nephrogenesis, but the identity of these genes has remained largely undetermined...
  32. ncbi request reprint The family of bone morphogenetic proteins
    P Ducy
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77003, USA
    Kidney Int 57:2207-14. 2000
    ..This review presents our current knowledge about the functions of BMPs during skeleton development as well as in many other biologic processes...
  33. ncbi request reprint Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice
    R N D'Souza
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, FIN 00014 University of Helsinki, Finland
    Development 126:2911-20. 1999
    ....
  34. ncbi request reprint BMP 7 is required for nephrogenesis, eye development, and skeletal patterning
    G Karsenty
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Ann N Y Acad Sci 785:98-107. 1996
    ....
  35. ncbi request reprint The matrix Gla protein gene is a marker of the chondrogenesis cell lineage during mouse development
    G Luo
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, USA
    J Bone Miner Res 10:325-34. 1995
    ..This finding raises the intriguing possibility that MGP may play distinct roles during embryogenesis and in the adult organism...
  36. ncbi request reprint [Central control of bone formation]
    G Karsenty
    Department of Molecular and Human Genetic Baylor College of Medicine, One Baylor Plaza Houston, TX 77030, USA
    Ann Endocrinol (Paris) 63:145-53. 2002
  37. ncbi request reprint c-Krox binds to several sites in the promoter of both mouse type I collagen genes. Structure/function study and developmental expression analysis
    P Galera
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 271:21331-9. 1996
    ..Thus, our findings suggest that c-Krox is one transcription factor controlling the coordinated expression of the two type I collagen genes in skin...
  38. ncbi request reprint Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice
    T Katagiri
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, USA
    Dev Genet 22:340-8. 1998
    ..In the limbs, these molecules appear to play a similar role in controlling digit number, possibly through induction of apoptosis in the interdigital and anterior mesenchyme...
  39. ncbi request reprint Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
    Donald A Glass
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Houston, 77030, USA
    Dev Cell 8:751-64. 2005
    ....
  40. ncbi request reprint Transcription factors in bone: developmental and pathological aspects
    Xiangli Yang
    Dept of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, S930, Houston, TX 77030, USA
    Trends Mol Med 8:340-5. 2002
    ..1 and nuclear factor (NF)-kappaB, and chondrocytes, such as Sox proteins. Finally, recent progress in identifying mutations in transcription factors affecting skeletal patterning and development is also described...
  41. ncbi request reprint Canonical Wnt signaling in osteoblasts is required for osteoclast differentiation
    Donald A Glass
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Ann N Y Acad Sci 1068:117-30. 2006
    ....
  42. pmc Bigenic Cre/loxP, puDeltatk conditional genetic ablation
    You Tzung Chen
    Program in Developmental Biology, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Nucleic Acids Res 32:e161. 2004
    ..5 dpc embryos. Crosses between the puDeltatk selector transgenic line and existing cre lines will facilitate numerous temporally regulated tissue-specific ablation experiments...
  43. pmc ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae
    Florent Elefteriou
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Cell Metab 4:441-51. 2006
    ..By showing that ATF4-dependent skeletal dysplasiae are treatable by dietary manipulations, this study reveals a molecular connection between nutrition and skeletal development...
  44. ncbi request reprint ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome
    Xiangli Yang
    Department of Molecular and Human Genetics and Bone Disease Program of Texas, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 117:387-98. 2004
    ..These findings identify ATF4 as a critical regulator of osteoblast differentiation and function, and indicate that lack of ATF4 phosphorylation by RSK2 may contribute to the skeletal phenotype of CLS...
  45. ncbi request reprint Cart overexpression is the only identifiable cause of high bone mass in melanocortin 4 receptor deficiency
    Jong Deok Ahn
    Department of Molecular and Human Genetics, One Baylor Plaza, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 147:3196-202. 2006
    ..As importantly, they also indicate that CART regulates bone resorption independently of the role it may exert in energy metabolism, suggesting that the neural control of appetite and bone remodeling are independent of each other...
  46. ncbi request reprint p53 mutant mice that display early ageing-associated phenotypes
    Stuart D Tyner
    Cell and Molecular Biology Program, Baylor College of Medicine, Houston, TX 77030, USA
    Nature 415:45-53. 2002
    ..A second line of transgenic mice containing a temperature-sensitive mutant allele of p53 also exhibits early ageing phenotypes. These data suggest that p53 has a role in regulating organismal ageing...
  47. ncbi request reprint A twist code determines the onset of osteoblast differentiation
    Peter Bialek
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dev Cell 6:423-35. 2004
    ..In vivo mutagenesis confirms the antiosteogenic function of the Twist box. Thus, relief of inhibition by Twist proteins is a mandatory event precluding osteoblast differentiation...
  48. ncbi request reprint Prostate cancer cells-osteoblast interaction shifts expression of growth/survival-related genes in prostate cancer and reduces expression of osteoprotegerin in osteoblasts
    Karim Fizazi
    Departments of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:2587-97. 2003
    ....
  49. ncbi request reprint In vivo analysis of Wnt signaling in bone
    Donald A Glass
    Medical Scientist Training Prtogram, Baylor College of Medicine, Houston, TX 77030, USA
    Endocrinology 148:2630-4. 2007
    ..These mouse models help establish the canonical Wnt signaling pathway as a major regulator of chondrogenesis, osteoblastogenesis, and osteoclastogenesis. This review will summarize these advances...
  50. ncbi request reprint SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation
    Gergana Dobreva
    Max Planck Institute of Immunobiology, Department of Cellular and Molecular Immunology, 79108 Freiburg, Germany
    Cell 125:971-86. 2006
    ..Thus, SATB2 acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation...
  51. ncbi request reprint Calcineurin/NFAT signaling in osteoblasts regulates bone mass
    Monte M Winslow
    Program in Immunology, Stanford University, Stanford, California 94305, USA
    Dev Cell 10:771-82. 2006
    ..Our results indicate that NFATc1 regulates bone mass by functioning in both osteoblasts and osteoclasts...
  52. pmc Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium
    Eiichi Hinoi
    Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Genes Dev 20:2937-42. 2006
    ..This study identifies a transcriptional basis for the inhibition of chondrocyte maturation by perichondrium and reveals that Runx2 fulfills antagonistic functions during chondrogenesis...
  53. ncbi request reprint Convergence between bone and energy homeostases: leptin regulation of bone mass
    Gerard Karsenty
    Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    Cell Metab 4:341-8. 2006
    ..This review summarizes the genetic and molecular bases of this regulation and discusses its potential clinical implications...
  54. ncbi request reprint Overexpression of gamma-glutamyltransferase in transgenic mice accelerates bone resorption and causes osteoporosis
    Kiyoshi Hiramatsu
    Department of Bone and Joint Disease, Research Institute, National Center for Geriatrics and Gerontology NCGG, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    Endocrinology 148:2708-15. 2007
    ..Thus, GGT is implicated as being involved in diseases characterized by accelerated osteoclast development and bone destruction and provides a new target for therapeutic intervention...
  55. pmc Endocrine regulation of energy metabolism by the skeleton
    Na Kyung Lee
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell 130:456-69. 2007
    ..By revealing that the skeleton exerts an endocrine regulation of sugar homeostasis this study expands the biological importance of this organ and our understanding of energy metabolism...
  56. ncbi request reprint Reciprocal regulation of bone and energy metabolism
    Na Kyung Lee
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Trends Endocrinol Metab 19:161-6. 2008
    ..This review highlights the most important salient features of this novel regulation of energy metabolism...
  57. pmc Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background
    Qisheng Tu
    Center for Bone and Mineral Disorders, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 111:1029-37. 2003
    ..Double Gcm2- and CasR-deficient mice provide an important model for evaluating the extraparathyroid functions of CasR...
  58. pmc p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling
    Xueying Wang
    The Institute of Molecular and Cell Biology, Singapore 138673
    J Cell Biol 172:115-25. 2006
    ..Thus, these results identify p53 as a novel regulator of osteoblast differentiation, osteoblast-dependent osteoclastogenesis, and bone remodeling...
  59. pmc Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZ
    Cai Bin Cui
    Department of Periodontology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mol Cell Biol 23:1004-13. 2003
    ..These data indicate that TAZ is a transcription coactivator for Cbfa1 and may be involved in the regulation of osteoblast differentiation...
  60. pmc Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation
    Sunhwa Kim
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Genes Dev 17:1979-91. 2003
    ..Our study provides a unique example in which a latent transcription factor attenuates the activity of another transcription factor in the cytoplasm, and reveals a new regulatory mechanism in bone remodeling...
  61. ncbi request reprint PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps
    Tatsuya Kobayashi
    Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Development 129:2977-86. 2002
    ..Thus, chondrocyte differentiation is controlled at multiple steps by PTHrP and Ihh through the mutual regulation of their activities...
  62. ncbi request reprint Bone health in children and adolescents: a symposium at the annual meeting of the Pediatric Academic Societies/Lawson Wilkins Pediatric Endocrine Society, May 2003
    Catherine M Gordon
    Division of Endocrinology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Curr Probl Pediatr Adolesc Health Care 34:226-42. 2004
  63. ncbi request reprint Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis
    Rick B Vega
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 119:555-66. 2004
    ..These results establish HDAC4 as a central regulator of chondrocyte hypertrophy and skeletogenesis and suggest general roles for class II HDACs in the control of cellular hypertrophy...
  64. ncbi request reprint Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone
    Kenneth R Chien
    UCSD Institute of Molecular Medicine, UCSD School of Medicine, La Jolla, California 92093, USA
    Cell 120:533-44. 2005
    ..These advances form a foundation for new therapeutic strategies to delay the onset of aging-related disorders...
  65. ncbi request reprint Deficiency of the G-protein alpha-subunit G(s)alpha in osteoblasts leads to differential effects on trabecular and cortical bone
    Akio Sakamoto
    Metabolic Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:21369-75. 2005
    ..Osteoblast-specific G(s)alpha deficiency leads to reduced bone turnover...
  66. ncbi request reprint Unloading induces osteoblastic cell suppression and osteoclastic cell activation to lead to bone loss via sympathetic nervous system
    Hisataka Kondo
    Department of Molecular Pharmacology, Tokyo Medical and Dental University, Japan
    J Biol Chem 280:30192-200. 2005
    ..These observations indicated that sympathetic nervous tone mediates unloading-induced bone loss through suppression of bone formation by osteoblasts and enhancement of resorption by osteoclasts...
  67. ncbi request reprint An in vivo model to study osteogenic gene regulation: targeting an avian retroviral receptor (TVA) to bone with the bone sialoprotein (BSP) promoter
    Ling Li
    Division of Oral Biology, Tufts School of Dental Medicine, Boston, Massachusetts 02111, USA
    J Bone Miner Res 20:1403-13. 2005
    ..The model was validated by showing suppressed BSP expression and delayed bone and tooth formation after infection with a virus expressing a mutated Cbfa1/Runx2 gene...
  68. pmc Proteoglycan desulfation determines the efficiency of chondrocyte autophagy and the extent of FGF signaling during endochondral ossification
    Carmine Settembre
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Genes Dev 22:2645-50. 2008
    ..Conversely, in chondrocytes it favors ECM production and autophagy and promotes proliferation and differentiation by limiting FGF signaling. Thus, proteoglycan desulfation is a critical regulator of chondrogenesis...