Indira Jutooru

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. pmc Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth
    Indira Jutooru
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843 4466, USA
    Exp Cell Res 316:2174-88. 2010
  2. pmc Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation
    Indira Jutooru
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843, USA
    J Biol Chem 285:25332-44. 2010
  3. pmc Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells
    Sudhakar Chintharlapalli
    Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, TX 77843 4466, USA
    Int J Cancer 125:1965-74. 2009
  4. pmc Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells
    Satya S Pathi
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466, USA
    Nutr Cancer 63:1133-42. 2011
  5. pmc 1,1-Bis(3'-indolyl)-1-(p-bromophenyl)methane and related compounds repress survivin and decrease gamma-radiation-induced survivin in colon and pancreatic cancer cells
    Sandeep Sreevalsan
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843 4466, USA
    Int J Oncol 35:1191-9. 2009
  6. pmc Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a
    Indira Jutooru
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, Vet Res Bldg 410, College Station, TX 77843 4466, USA
    Mol Pharmacol 78:226-36. 2010
  7. pmc Induction of apoptosis and nonsteroidal anti-inflammatory drug-activated gene 1 in pancreatic cancer cells by a glycyrrhetinic acid derivative
    Indira Jutooru
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466, USA
    Mol Carcinog 48:692-702. 2009
  8. pmc Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors
    Vijayalekshmi Nair
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843, USA
    Carcinogenesis 34:2870-9. 2013
  9. pmc 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer
    Kathy Vanderlaag
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843 4466, USA
    BMC Cancer 10:669. 2010
  10. pmc Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells
    Gayathri Chadalapaka
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, Veterinary Research Building 410, College Station, TX 77843 4466, USA
    Mol Cancer Res 8:739-50. 2010

Collaborators

Detail Information

Publications22

  1. pmc Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth
    Indira Jutooru
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843 4466, USA
    Exp Cell Res 316:2174-88. 2010
    ....
  2. pmc Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation
    Indira Jutooru
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843, USA
    J Biol Chem 285:25332-44. 2010
    ....
  3. pmc Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells
    Sudhakar Chintharlapalli
    Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, TX 77843 4466, USA
    Int J Cancer 125:1965-74. 2009
    ..Both CDODA-Me and antisense miR-27a induced comparable responses in RKO and SW480 cells, suggesting that the potent anticarcinogenic activity of CDODA-Me is due to repression of oncogenic miR-27a...
  4. pmc Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells
    Satya S Pathi
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466, USA
    Nutr Cancer 63:1133-42. 2011
    ..This study demonstrates for the first time that the anticancer activities of ascorbic acid are due, in part, to ROS-dependent repression of Sp transcription factors...
  5. pmc 1,1-Bis(3'-indolyl)-1-(p-bromophenyl)methane and related compounds repress survivin and decrease gamma-radiation-induced survivin in colon and pancreatic cancer cells
    Sandeep Sreevalsan
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843 4466, USA
    Int J Oncol 35:1191-9. 2009
    ....
  6. pmc Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a
    Indira Jutooru
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, Vet Res Bldg 410, College Station, TX 77843 4466, USA
    Mol Pharmacol 78:226-36. 2010
    ..This results in decreased expression of Sp-regulated genes, growth inhibition, induction of apoptosis, and antiangiogenic responses...
  7. pmc Induction of apoptosis and nonsteroidal anti-inflammatory drug-activated gene 1 in pancreatic cancer cells by a glycyrrhetinic acid derivative
    Indira Jutooru
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466, USA
    Mol Carcinog 48:692-702. 2009
    ..This is the first report of the induction of the proapoptotic protein NAG-1 in pancreatic cancer cells...
  8. pmc Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors
    Vijayalekshmi Nair
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843, USA
    Carcinogenesis 34:2870-9. 2013
    ..6pL cells were injected directly into the pancreas. The results demonstrate for the first time that the anticancer activities of metformin are also due, in part, to downregulation of Sp transcription factors and Sp-regulated genes. ..
  9. pmc 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer
    Kathy Vanderlaag
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843 4466, USA
    BMC Cancer 10:669. 2010
    ..The main purpose of this study was to investigate the pathways of C-DIM-induced cell death...
  10. pmc Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells
    Gayathri Chadalapaka
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, Veterinary Research Building 410, College Station, TX 77843 4466, USA
    Mol Cancer Res 8:739-50. 2010
    ..Thus, compounds such as curcumin and BA that downregulate Sp transcription factors represent a novel class of anticancer drugs that target EGFR in bladder cancer cells and tumors by inhibiting receptor expression...
  11. pmc Curcumin decreases specificity protein expression in bladder cancer cells
    Gayathri Chadalapaka
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466, USA
    Cancer Res 68:5345-54. 2008
    ..These results show for the first time that one of the underlying mechanisms of action of curcumin as a cancer chemotherapeutic agent is due, in part, to decreased expression of Sp transcription factors in bladder cancer cells...
  12. pmc Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors
    Satya Pathi
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX, USA
    PLoS ONE 7:e48208. 2012
    ....
  13. pmc Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors
    Gayathri Chadalapaka
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843 4466, USA
    Int J Cancer 132:795-806. 2013
    ..These results suggest that NSAIDs such as TA may have potential clinical efficacy in drug combinations for treating RMS patients...
  14. doi request reprint Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer
    Xinyi Liu
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843, USA
    Mol Cancer Ther 11:1421-31. 2012
    ....
  15. pmc GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway
    Satya S Pathi
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, Vet Res Bldg 410, College Station, TX 77843, USA
    Mol Cancer Res 9:195-202. 2011
    ....
  16. pmc Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs
    Stephen H Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, College Station, TX 77843 4466, USA
    Anticancer Agents Med Chem 12:1211-20. 2012
    ....
  17. pmc Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives
    Gayathri Chadalapaka
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843 4466, USA
    Bioorg Med Chem Lett 18:2633-9. 2008
    ..However, differences in growth inhibitory IC(50) values were highly variable and dependent on the 2-substituent (CN vs CF(3)) and cancer cell context...
  18. pmc Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents
    Indira Jutooru
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas, USA
    Mol Cell Biol 34:2382-95. 2014
    ....
  19. pmc Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent
    Sandeep Sreevalsan
    Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A and M University, College Station, TX, USA
    Anticancer Res 31:3799-807. 2011
    ..We hypothesized that the anticancer activity of cannabinoids was linked to induction of phosphatases...
  20. ncbi request reprint Transcription factor Sp1, also known as specificity protein 1 as a therapeutic target
    Stephen Safe
    Texas A and M University, Veterinary Physiology and Pharmacology, 4466 TAMU, College Station, TX 77843 4466, USA
    Expert Opin Ther Targets 18:759-69. 2014
    ....
  21. pmc Celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells
    Gayathri Chadalapaka
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, Vet Res Bldg 410, College Station, TX 77843, USA
    Carcinogenesis 33:886-94. 2012
    ..Thus, the anticancer activity of CSL in 253JB-V cells is due to induction of ROS and ROS-mediated induction of Sp repressors (ZBTB4/ZBTB10) through downregulation of miR-27a and miR-20a/17-5p...
  22. ncbi request reprint Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cells
    Sudhakar Chintharlapalli
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas, TX 77843 4466, USA
    Mol Cancer Ther 6:1588-98. 2007
    ..This shows for the first time that PPARgamma agonists derived from glycyrrhetinic acid induced cell-dependent caveolin-1 and KLF-4 expression through receptor-dependent pathways...