Richard J Johnson

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Thiazide diuretics exacerbate fructose-induced metabolic syndrome
    Sirirat Reungjui
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Florida, USA
    J Am Soc Nephrol 18:2724-31. 2007
  2. ncbi request reprint Hypothesis: dysregulation of immunologic balance resulting from hygiene and socioeconomic factors may influence the epidemiology and cause of glomerulonephritis worldwide
    Richard J Johnson
    Division of Nephrology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Kidney Dis 42:575-81. 2003
  3. ncbi request reprint Subtle acquired renal injury as a mechanism of salt-sensitive hypertension
    Richard J Johnson
    Division of Nephrology, Baylor College of Medicine, Houston 77030, USA
    N Engl J Med 346:913-23. 2002
  4. ncbi request reprint Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2
    John Kanellis
    Division of Nephrology, Baylor College of Medicine, SM 1273, 6550 Fannin St, Houston TX 77030
    Hypertension 41:1287-93. 2003
  5. ncbi request reprint Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?
    Richard J Johnson
    Division of Nephrology, Baylor College of Medicine, SM 1273, 6550 Fannin St, Houston, Tex 77030, USA
    Hypertension 41:1183-90. 2003
  6. ncbi request reprint Hypertension: a microvascular and tubulointerstitial disease
    Richard J Johnson
    Division of Nephrology, Department of Medicine, Baylor College of Medicine, SM 1273, 6550 Fannin Street, Houston, Texas 77030, USA
    J Hypertens Suppl 20:S1-7. 2002
  7. pmc Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice
    Tomoki Kosugi
    Division of Nephrology, University of Florida, Gainesville, Florida, USA
    Am J Physiol Renal Physiol 297:F481-8. 2009
  8. ncbi request reprint A role for uric acid in the progression of renal disease
    Duk Hee Kang
    Division of Nephrology, Baylor College of Medicine, Houston, Texas, USA
    J Am Soc Nephrol 13:2888-97. 2002
  9. pmc Dietary fructose causes tubulointerstitial injury in the normal rat kidney
    Takahiro Nakayama
    Division of Nephrology, University of Florida, Gainesville, Florida, USA
    Am J Physiol Renal Physiol 298:F712-20. 2010
  10. pmc Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism
    Wei Mu
    Division of Nephrology, University of Florida, Gainesville, FL, USA
    Am J Physiol Renal Physiol 296:F145-52. 2009

Collaborators

Detail Information

Publications102 found, 100 shown here

  1. ncbi request reprint Thiazide diuretics exacerbate fructose-induced metabolic syndrome
    Sirirat Reungjui
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Florida, USA
    J Am Soc Nephrol 18:2724-31. 2007
    ..Addition of potassium supplements and allopurinol with thiazides might be helpful in the management of metabolic syndrome...
  2. ncbi request reprint Hypothesis: dysregulation of immunologic balance resulting from hygiene and socioeconomic factors may influence the epidemiology and cause of glomerulonephritis worldwide
    Richard J Johnson
    Division of Nephrology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Kidney Dis 42:575-81. 2003
    ....
  3. ncbi request reprint Subtle acquired renal injury as a mechanism of salt-sensitive hypertension
    Richard J Johnson
    Division of Nephrology, Baylor College of Medicine, Houston 77030, USA
    N Engl J Med 346:913-23. 2002
  4. ncbi request reprint Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2
    John Kanellis
    Division of Nephrology, Baylor College of Medicine, SM 1273, 6550 Fannin St, Houston TX 77030
    Hypertension 41:1287-93. 2003
    ..Uric acid regulates critical proinflammatory pathways in VSMCs, suggesting it may have a role in the vascular changes associated with hypertension and vascular disease...
  5. ncbi request reprint Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?
    Richard J Johnson
    Division of Nephrology, Baylor College of Medicine, SM 1273, 6550 Fannin St, Houston, Tex 77030, USA
    Hypertension 41:1183-90. 2003
    ..Thus, it is time to reevaluate the role of uric acid as a risk factor for cardiovascular disease and hypertension and to design human studies to address this controversy...
  6. ncbi request reprint Hypertension: a microvascular and tubulointerstitial disease
    Richard J Johnson
    Division of Nephrology, Department of Medicine, Baylor College of Medicine, SM 1273, 6550 Fannin Street, Houston, Texas 77030, USA
    J Hypertens Suppl 20:S1-7. 2002
    ..We propose that subtle acquired renal injury may underlie the etiology of some forms of salt-sensitive hypertension...
  7. pmc Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice
    Tomoki Kosugi
    Division of Nephrology, University of Florida, Gainesville, Florida, USA
    Am J Physiol Renal Physiol 297:F481-8. 2009
    ..In conclusion, hyperuricemia has a pathogenic role in the mild tubulointerstitial injury associated with diabetic nephropathy but not glomerular damage in db/db mice. Lowering uric acid may reduce tubulointerstitial injury in diabetes...
  8. ncbi request reprint A role for uric acid in the progression of renal disease
    Duk Hee Kang
    Division of Nephrology, Baylor College of Medicine, Houston, Texas, USA
    J Am Soc Nephrol 13:2888-97. 2002
    ..These studies provide direct evidence that uric acid may be a true mediator of renal disease and progression...
  9. pmc Dietary fructose causes tubulointerstitial injury in the normal rat kidney
    Takahiro Nakayama
    Division of Nephrology, University of Florida, Gainesville, Florida, USA
    Am J Physiol Renal Physiol 298:F712-20. 2010
    ..The effect is independent of total energy intake and is associated with focal tubulointerstitial injury. These studies may provide a mechanism by which metabolic syndrome causes renal disease...
  10. pmc Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism
    Wei Mu
    Division of Nephrology, University of Florida, Gainesville, FL, USA
    Am J Physiol Renal Physiol 296:F145-52. 2009
    ..However, its anti-angiogenic actions suggest countering effects that could partially offset its benefit in chronic kidney diseases...
  11. ncbi request reprint Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress
    Yuri Y Sautin
    Division of Nephrology, Hypertension, and Transplantation, Dept of Medicine, University of Florida, Gainesville, FL 32610 0224, USA
    Am J Physiol Cell Physiol 293:C584-96. 2007
    ....
  12. ncbi request reprint Role of ERK1/2 and p38 mitogen-activated protein kinases in the regulation of thrombospondin-1 by TGF-beta1 in rat proximal tubular cells and mouse fibroblasts
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 16:899-904. 2005
    ..Because TSP-1 is a major antiangiogenic molecule and an activator of TGF-beta1, this provides an important insight to the mechanism by which TGF-beta1 may mediate interstitial fibrosis and progressive renal disease...
  13. pmc Endothelial injury due to eNOS deficiency accelerates the progression of chronic renal disease in the mouse
    Takahiro Nakayama
    Division of Nephrology, Univ of Colorado Denver, P O Box C281, Aurora, CO 80045, USA
    Am J Physiol Renal Physiol 296:F317-27. 2009
    ..A lack of eNOS accelerates both glomerular and tubulointerstitial injury with a loss of glomerular capillaries and peritubular capillaries. Impaired endothelial function is likely a direct risk factor for renal disease...
  14. pmc Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society?
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA
    J Comp Physiol B 179:67-76. 2009
    ....
  15. ncbi request reprint Fructose, but not dextrose, accelerates the progression of chronic kidney disease
    Michael S Gersch
    Division of Nephrology, Dialysis and Transplantation, University of Florida, Gainesville, Florida 32610 0224, USA
    Am J Physiol Renal Physiol 293:F1256-61. 2007
    ..In conclusion, consumption of a high-fructose diet greatly accelerates progression of chronic kidney disease in the rat remnant kidney model...
  16. ncbi request reprint Uncoupling of vascular endothelial growth factor with nitric oxide as a mechanism for diabetic vasculopathy
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610, USA
    J Am Soc Nephrol 17:736-45. 2006
    ..These results may provide new insights into the understanding of the mechanism of diabetic vascular disease...
  17. pmc Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver
    Laura G Sanchez-Lozada
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL, USA
    Eur J Nutr 49:1-9. 2010
    ....
  18. ncbi request reprint Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity
    Susumu Watanabe
    Division of Nephrology, Baylor College of Medicine, Houston, Tex 77030, USA
    Hypertension 40:355-60. 2002
    ..Although it provided a survival advantage to early hominoids, hyperuricemia may have a major role in the current cardiovascular disease epidemic...
  19. pmc Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells
    Pietro Cirillo
    Division of Nephrology, Hypertension and Transplantation, Department of Medicine, University of Florida, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 20:545-53. 2009
    ..Fructose increased intracellular uric acid, and uric acid induced production of MCP-1 as well. In summary, postprandial concentrations of fructose stimulate redox- and urate-dependent inflammatory mediators in proximal tubular cells...
  20. pmc Fructose induces the inflammatory molecule ICAM-1 in endothelial cells
    Olena Glushakova
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 19:1712-20. 2008
    ..These data suggest that fructose induces inflammatory changes in vascular cells at physiologic concentrations...
  21. ncbi request reprint Uric acid--a uremic toxin?
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Blood Purif 24:67-70. 2006
    ..In progressive renal disease, such as cyclosporine nephropathy and remnant kidney in rat, uric acid accelerated the progression of renal disease. Thus, we concluded that uric acid is not a simple marker, but a cause of renal disease...
  22. ncbi request reprint Th1 inflammatory response with altered expression of profibrotic and vasoactive mediators in AT1A and AT1B double-knockout mice
    Xiaosen Ouyang
    Division of Nephrology, Dept of Medicine, Univ of Florida, Gainesville, FL 32610, USA
    Am J Physiol Renal Physiol 289:F902-10. 2005
    ..In conclusion, the absence of the AT(1) receptor is associated with marked renal alterations in vasoactive, profibrotic, and immune mediators with an inflammatory pattern favoring a Th1 phenotype...
  23. pmc The conundrum of hyperuricemia, metabolic syndrome, and renal disease
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL, 32610, USA
    Intern Emerg Med 3:313-8. 2008
    ..In this review, we discuss the clinical and experimental evidence for a causal role of hyperuricemia in renal diseases and potential relationships of hyperuricemia with metabolic syndrome...
  24. ncbi request reprint Effect of elevated serum uric acid on cisplatin-induced acute renal failure
    Carlos A Roncal
    Division of Nephrology, Hypertension, and Transplantation and North Florida South Georgia Veterans Health System, Pathology and Laboratory Medicine Service, University of Florida, Gainesville 32610 0224, USA
    Am J Physiol Renal Physiol 292:F116-22. 2007
    ..The mechanism may relate to a proinflammatory pathway involving chemokine expression with leukocyte infiltration...
  25. ncbi request reprint TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways
    Takahiko Nakagawa
    Division of Nephrology Medicine, Baylor College of Medicine, Houston, Texas, USA
    Kidney Int 66:605-13. 2004
    ..Recent studies have shown that VEGF-A as well as TSP-1 is regulated by transforming growth factor-beta1 (TGF-beta1), but the mechanism remains unclear...
  26. ncbi request reprint Lead, at low levels, accelerates arteriolopathy and tubulointerstitial injury in chronic kidney disease
    Carlos Roncal
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Am J Physiol Renal Physiol 293:F1391-6. 2007
    ..In conclusion, lead accelerates chronic renal disease, primarily by raising blood pressure and accelerating microvascular and tubulointerstitial injury...
  27. pmc Reactions of peroxynitrite with uric acid: formation of reactive intermediates, alkylated products and triuret, and in vivo production of triuret under conditions of oxidative stress
    Christine Gersch
    Division of Nephrology and Hypertension, Department of Medicine, University of Florida, Gainesville, Florida 32610 0224, USA
    Nucleosides Nucleotides Nucleic Acids 28:118-49. 2009
    ..These reactive intermediates could possibly explain how uric acid contributes to the pathogenesis of diseases such as the metabolic syndrome and hypertension...
  28. ncbi request reprint Increased oxidative stress following acute and chronic high altitude exposure
    J Ashley Jefferson
    University of Washington, Division of Nephrology, Seattle, WA 98195, USA
    High Alt Med Biol 5:61-9. 2004
    ..In conclusion, oxidative stress is increased following both acute exposure to high altitude without exercise and with chronic residence at high altitude...
  29. doi request reprint Lowering serum uric acid to prevent acute kidney injury
    A Ahsan Ejaz
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, USA
    Med Hypotheses 78:796-9. 2012
    ..Data from recent studies are presented to support the hypothesis that uric acid may have a role in AKI via a crystal-independent process in addition to its traditionally accepted role to induce injury via crystal-dependent pathways...
  30. doi request reprint Post-operative serum uric acid and acute kidney injury
    A Ahsan Ejaz
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    J Nephrol 25:497-505. 2012
    ..We hypothesized that post-operative serum uric acid (SUA) may be associated with acute kidney injury (AKI)...
  31. ncbi request reprint A single pathway for the development of essential hypertension
    John Kanellis
    Division of Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cardiol Rev 11:180-96. 2003
  32. ncbi request reprint Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 18:539-50. 2007
    ..It was postulated that endothelial dysfunction should predict nephropathy and that correction of the dysfunction may prevent these important complications...
  33. doi request reprint Effect of uric acid lowering therapy on the prevention of acute kidney injury in cardiovascular surgery
    A Ahsan Ejaz
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL, USA
    Int Urol Nephrol 45:449-58. 2013
    ..This pilot study investigated the effect of lowering SUA therapy on AKI, by using traditional and non-traditional markers...
  34. ncbi request reprint Differential regulation of VEGF by TGF-beta and hypoxia in rat proximal tubular cells
    Takahiko Nakagawa
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Am J Physiol Renal Physiol 287:F658-64. 2004
    ..Thus TGF-beta and hypoxia act via additive/synergistic but distinct pathways to stimulate VEGF in proximal tubular cells, a finding that may be important in understanding how VEGF is stimulated in renal disease...
  35. ncbi request reprint Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism
    Marilda Mazzali
    Division of Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Physiol Renal Physiol 282:F991-7. 2002
    ..Thus hyperuricemia induces a renal arteriolopathy in rats that is blood pressure independent and involves the renin-angiotensin system...
  36. pmc Inhibition of p38 mitogen-activated protein kinase augments progression of remnant kidney model by activating the ERK pathway
    Ryuji Ohashi
    Division of Nephrology, Baylor College of Medicine, Houston Texas 77030, USA
    Am J Pathol 164:477-85. 2004
    ..We conclude that blocking p38-dependent inflammation may have resulted in enhanced proliferation and increased ERK1/2 activation, and thereby explains the worse renal lesions observed...
  37. doi request reprint The role of uric acid in the pathogenesis of human cardiovascular disease
    Mehmet Kanbay
    Department of Medicine, Division of Nephrology, Medeniyet University School of Medicine, Kadikoy, Istanbul, Turkey
    Heart 99:759-66. 2013
    ..More studies need to be performed on the pathophysiology and clinical consequences of hyperuricaemia in cardiovascular disease...
  38. ncbi request reprint Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link?
    Richard J Johnson
    University of Florida, Division of Nephrology, Hypertension, and Transplantation, 1600 SW Archer Road, Gainesville, FL 32610, USA
    J Am Soc Nephrol 16:1909-19. 2005
    ..Understanding the pathogenetic pathways mediating renal progression in hypertensive subjects should help identify those subjects at highest risk and may provide insights into new therapeutic maneuvers to slow or prevent progression...
  39. ncbi request reprint Tubulointerstitial disease: role of ischemia and microvascular disease
    Takahiko Nakagawa
    Division of Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Opin Nephrol Hypertens 12:233-41. 2003
    ..Here we summarize recent studies on the pathogenesis and consequences of tubulointerstitial disease, emphasizing the role of ischemia and the microvasculature...
  40. ncbi request reprint Serum uric acid: a risk factor and a target for treatment?
    Daniel I Feig
    Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, TX 77030, USA
    J Am Soc Nephrol 17:S69-73. 2006
    ..Although the investigations are still preliminary, serum uric acid represents a possible new and intriguing target for the reduction of morbidity and mortality associated with hypertension and CV disease...
  41. pmc Pathogenesis of essential hypertension: historical paradigms and modern insights
    Richard J Johnson
    Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, Florida 32610 0224, USA
    J Hypertens 26:381-91. 2008
    ....
  42. ncbi request reprint Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model
    Hui Y Lan
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Am Soc Nephrol 14:1535-48. 2003
    ..TGF-beta-mediated renal fibrosis is regulated positively by Smad2/3, but negatively by Smad7. Target blockade of TGF-beta/Smad signaling by expression of Smad7 may provide a new therapeutic potential for renal fibrosis...
  43. pmc Inhibition of CXCL16 attenuates inflammatory and progressive phases of anti-glomerular basement membrane antibody-associated glomerulonephritis
    Gabriela E Garcia
    Section of Nephrology, Baylor Collage of Medicine, Alkek N520, One Baylor Plaza, Houston, TX 77030, USA
    Am J Pathol 170:1485-96. 2007
    ..Blocking CXCL16 actions limits the progression of anti-GBM glomerulonephritis even when the disease is established...
  44. ncbi request reprint Role of JAK/STAT pathway in IL-6-induced activation of vascular smooth muscle cells
    Susumu Watanabe
    Baylor College of Medicine, Houston, Tex, USA
    Am J Nephrol 24:387-92. 2004
    ..We hypothesized that this stimulation occurs via the JAK (janus-activated kinase)/STAT (signal and transducers and activators of transcription) signaling pathway...
  45. ncbi request reprint Microvascular and tubulointerstitial injury associated with chronic hypoxia-induced hypertension
    Marilda Mazzali
    Division of Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
    Kidney Int 63:2088-93. 2003
    ..We examined whether chronic hypoxia might induce subtle renal injury since studies in other animal models of hypertension suggest this may cause persistent hypertension...
  46. ncbi request reprint Advanced glycation end products activate Smad signaling via TGF-beta-dependent and independent mechanisms: implications for diabetic renal and vascular disease
    Jin H Li
    Department of Medicine Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
    FASEB J 18:176-8. 2004
    ..Thus, AGEs act by activating Smad signaling to mediate diabetic complications via both TGF-beta-dependent and -independent pathways, shedding new light on the pathogenesis of diabetic organ injury...
  47. ncbi request reprint Could uric acid have a role in acute renal failure?
    A Ahsan Ejaz
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Clin J Am Soc Nephrol 2:16-21. 2007
    ..It is suggested that studies are needed to investigate the role of chronic hyperuricemia on renal outcomes after acute tubular injury...
  48. ncbi request reprint Role of uric acid in hypertension, renal disease, and metabolic syndrome
    Marcelo Heinig
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville 32610, USA
    Cleve Clin J Med 73:1059-64. 2006
    ..Furthermore, we suggest that the recent increased intake in the American diet of fructose, which is a known cause of hyperuricemia, may be contributing to the current epidemic of obesity and diabetes...
  49. ncbi request reprint Hyperuricemia causes glomerular hypertrophy in the rat
    Takahiko Nakagawa
    Department of Medicine Nephrology, Baylor College of Medicine, Houston, Tex 77030, USA
    Am J Nephrol 23:2-7. 2003
    ..Am J Physiol 2002;6:F991-F997]. We hypothesized that hyperuricemia might also induce glomerular changes...
  50. ncbi request reprint A breakthrough in diabetic nephropathy: the role of endothelial dysfunction
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610 0224, USA
    Nephrol Dial Transplant 22:2775-7. 2007
  51. doi request reprint Adenosine A(2A) receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation
    Gabriela E Garcia
    Division of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas 80045, USA
    Kidney Int 80:378-88. 2011
    ..Thus, A(2A)R activation can arrest GN and prevent progressive fibrosis in established pathological lesions...
  52. ncbi request reprint Uric acid, the metabolic syndrome, and renal disease
    Pietro Cirillo
    Division of Nephrology, Hypertension and Transplantation, Department of Medicine, University of Florida, PO Box 100224, Gainesville, FL 32608, USA
    J Am Soc Nephrol 17:S165-8. 2006
    ..It is proposed that fructose- and purine-rich foods that have in common the raising of uric acid may have a role in the epidemic of metabolic syndrome and renal disease that is occurring throughout the world...
  53. ncbi request reprint Human vascular smooth muscle cells express a urate transporter
    Karen L Price
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, Florida, USA
    J Am Soc Nephrol 17:1791-5. 2006
    ..It is proposed that URAT1 may provide a mechanism by which uric acid enters the human vascular smooth muscle cell, a finding that may be relevant to the role of uric acid in cardiovascular disease...
  54. pmc Nitric oxide modulates vascular disease in the remnant kidney model
    Duk Hee Kang
    Division of Nephrology, Baylor College of Medicine, Houston, Texas, USA
    Am J Pathol 161:239-48. 2002
    ..Interestingly, inhibition of NO synthesis did not lead to a loss of the preglomerular endothelium, which may relate to the effect of NO blockade to stimulate VEGF synthesis in the adjacent vascular smooth muscle cell...
  55. ncbi request reprint Uric acid and hypertension
    Daniel I Feig
    Department of Pediatrics, Renal Section, MC3 2482, Baylor College of Medicine, 1102 Bates Street, Houston, TX 77030, USA
    Curr Hypertens Rep 8:111-5. 2006
    ..Ongoing clinical trials will elucidate the role of uric acid in human hypertension and will determine whether control of uric acid may be a new way to prevent or treat essential hypertension...
  56. pmc Uric acid and cardiovascular risk
    Daniel I Feig
    Baylor College of Medicine, Houston, TX 77030, USA
    N Engl J Med 359:1811-21. 2008
  57. pmc Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver
    Miguel A Lanaspa
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado, Denver, CO 80045, USA
    J Biol Chem 287:40732-44. 2012
    ..Uric acid is an independent risk factor in fructose-induced fatty liver, but whether it is a marker or a cause remains unknown...
  58. pmc Inactivation of nitric oxide by uric acid
    Christine Gersch
    Department of Medicine, Division of Nephrology and Hypertension, University of Florida, Gainesville, Florida 32610, USA
    Nucleosides Nucleotides Nucleic Acids 27:967-78. 2008
    ..This study shows a potential mechanism by which UA may deplete NO and cause endothelial dysfunction, particularly under conditions of oxidative stress in which UA is elevated and intracellular glutathione is depleted...
  59. ncbi request reprint A causal role for uric acid in fructose-induced metabolic syndrome
    Takahiko Nakagawa
    Division of Nephrology, Hypertension, and Transplantation, PO Box 100224, University of Florida, Gainesville, FL 32610, USA
    Am J Physiol Renal Physiol 290:F625-31. 2006
    ..Fructose may have a major role in the epidemic of metabolic syndrome and obesity due to its ability to raise uric acid...
  60. ncbi request reprint Uric acid, evolution and primitive cultures
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA
    Semin Nephrol 25:3-8. 2005
    ..Although other mechanisms certainly contribute to the pathogenesis of hypertension, the possibility that serum uric acid level may have a major role is suggested by these studies...
  61. pmc Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, Florida 32620 0224, USA
    Endocr Rev 30:96-116. 2009
    ..If diabetes might result from excessive intake of fructose, then simple public health measures could have a major impact on improving the overall health of our populace...
  62. ncbi request reprint Stanniocalcin-1, an inhibitor of macrophage chemotaxis and chemokinesis
    John Kanellis
    Renal Section, Deptartment of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Physiol Renal Physiol 286:F356-62. 2004
    ..MCP-1 and STC1 transcripts were both upregulated following ureteric obstruction, suggesting a functional association between the two genes. Our data suggest a role for mammalian STC1 in modulating the immune/inflammatory response...
  63. ncbi request reprint A unifying pathway for essential hypertension
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, PO Box 100224, University of Florida, Gainesville, FL 32610, USA
    Am J Hypertens 18:431-40. 2005
    ..This pathway unites many of the previous hypotheses on the etiology of hypertension, and offers insights into ways to prevent, ameliorate, or cure the underlying process...
  64. ncbi request reprint Subtle renal injury is likely a common mechanism for salt-sensitive essential hypertension
    Richard J Johnson
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, P O Box 100224, Gainesville, FL 32610, USA
    Hypertension 45:326-30. 2005
  65. pmc Fructose consumption as a risk factor for non-alcoholic fatty liver disease
    Xiaosen Ouyang
    Division of Nephrology, University of Florida, Gainesville, FL, USA
    J Hepatol 48:993-9. 2008
    ..Furthermore, the hepatic metabolism of fructose favors de novo lipogenesis and ATP depletion. We hypothesize that increased fructose consumption contributes to the development of NAFLD...
  66. ncbi request reprint Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome
    Takahiko Nakagawa
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32610, USA
    Nat Clin Pract Nephrol 1:80-6. 2005
    ..Studies in humans should be performed to address whether lowering uric acid levels will help to prevent this condition...
  67. pmc Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial
    Daniel I Feig
    Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, TX 77030, USA
    JAMA 300:924-32. 2008
    ..Experimentally increasing uric acid levels using a uricase inhibitor causes systemic hypertension in animal models...
  68. pmc Modulation of inflammation by slit protein in vivo in experimental crescentic glomerulonephritis
    John Kanellis
    Department of Nephrology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Pathol 165:341-52. 2004
    ....
  69. ncbi request reprint Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activation
    Jin H Li
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Am Soc Nephrol 13:1464-72. 2002
    ....
  70. pmc The role of uric acid in pediatric hypertension
    Daniel I Feig
    Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, Texas 77030, USA
    J Ren Nutr 17:79-83. 2007
    ..Future studies will be needed to determine whether the mechanisms shown in animal models can be extrapolated to children...
  71. pmc Hyperuricemia in childhood primary hypertension
    Daniel I Feig
    Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, TX 77030, USA
    Hypertension 42:247-52. 2003
    ..These results are consistent with the hypothesis that uric acid might have a role in the early pathogenesis of primary hypertension...
  72. ncbi request reprint Hyperuricemia induces endothelial dysfunction
    Uday M Khosla
    Baylor College of Medicine, Department of Medicine, Division of Nephrology, Houston, Texas 77030, USA
    Kidney Int 67:1739-42. 2005
    ..Therefore, we hypothesized that uric acid induces endothelial dysfunction by inhibiting nitric oxide production...
  73. ncbi request reprint Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertension
    Daniel I Feig
    Renal Section, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    Kidney Int 66:281-7. 2004
    ..Genetic, physiologic, and epidemiologic studies provide clues to its origins, but a clear understanding has been elusive. Recent experimental and clinical studies have implicated uric acid in the onset of essential hypertension...
  74. ncbi request reprint Role of the microvascular endothelium in progressive renal disease
    Duk Hee Kang
    Baylor College of Medicine, Houston, Texas, USA
    J Am Soc Nephrol 13:806-16. 2002
    ..Therefore, angiogenic agents may represent a novel therapeutic approach for slowing the progression of renal disease...
  75. ncbi request reprint IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease
    Wei Mu
    Division of Nephrology, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA
    J Am Soc Nephrol 16:3651-60. 2005
    ..The feasibility of long-term overexpression of a gene using the AAV serotype 1 vector system in a model of renal disease is also demonstrated...
  76. pmc Uric acid: the oxidant-antioxidant paradox
    Yuri Y Sautin
    Division of Nephrology, Hypertension and Transplantation, Department of Medicine, University of Florida, Gainesville, Florida 32610 0224, USA
    Nucleosides Nucleotides Nucleic Acids 27:608-19. 2008
    ..We suggest that it is the pro-oxidative effects of uric acid that occur in cardiovascular disease and may have a contributory role in the pathogenesis of these conditions...
  77. ncbi request reprint Effects of cyclosporine in osteopontin null mice
    Marilda Mazzali
    Division of Nephrology, Department of Pathology, University of Washington, Seattle, Washington, USA
    Kidney Int 62:78-85. 2002
    ..This study tested the hypothesis that the absence of OPN would ameliorate CsA nephropathy...
  78. ncbi request reprint Is the fructose index more relevant with regards to cardiovascular disease than the glycemic index?
    Mark S Segal
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL, USA
    Eur J Nutr 46:406-17. 2007
    ..We propose the use of a fructose index to categorize foods and propose studies to determine the effect of low fructose diets as a means to prevent obesity, diabetes, and cardiovascular disease in the population...
  79. doi request reprint Prophylactic nesiritide does not prevent dialysis or all-cause mortality in patients undergoing high-risk cardiac surgery
    A Ahsan Ejaz
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    J Thorac Cardiovasc Surg 138:959-64. 2009
    ....
  80. ncbi request reprint ET(B) receptor protects the tubulointerstitium in experimental thrombotic microangiopathy
    Masaomi Nangaku
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Kidney Int 62:922-8. 2002
    ..The endothelin ET(B) receptor has been shown to mediate both endothelial cell proliferation and vasodilation, and we therefore hypothesized that blockade of this receptor might promote more severe injury in this model...
  81. ncbi request reprint Sustained expression of thrombospondin-1 is associated with the development of glomerular and tubulointerstitial fibrosis in the remnant kidney model
    Christian Hugo
    Medizinische Klinik IV, Universitat Erlangen Nurnberg, Germany
    Nephron 90:460-70. 2002
    ..We studied the expression of TSP-1 mRNA and protein during the development of glomerular and tubulointerstitial nephrosclerosis in the renal ablation model particularly in relation to TGF-beta1 expression...
  82. ncbi request reprint Mild hyperuricemia induces glomerular hypertension in normal rats
    Laura G Sanchez-Lozada
    Department of Nephrology, Instituto Nacional de Cardiologia I Chavez, 14080 Mexico City, Mexico
    Am J Physiol Renal Physiol 283:F1105-10. 2002
    ..Glomerular hypertension may be partially mediated by an abnormal vascular response to systemic hypertension due to arteriolopathy of the afferent arteriole...
  83. pmc The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, and the Foundation of Applied Molecular Evolution, Gainesville, FL 32610 0224, United States
    Med Hypotheses 71:22-31. 2008
    ....
  84. ncbi request reprint Endothelin a receptor blockade and endothelin B receptor blockade improve hypokalemic nephropathy by different mechanisms
    Shin Ichi Suga
    National Cardiovascular Center Research Institute, Department of Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    J Am Soc Nephrol 14:397-406. 2003
    ..Thus, ETA as well as ETB blockade may be renoprotective in hypokalemic nephropathy...
  85. ncbi request reprint Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: aminopeptidase p and podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vessels
    Katsuyuki Matsui
    Institute of Clinical Pathology, University of Vienna, Allgemeines Krankenhaus, Vienna, Austria
    J Am Soc Nephrol 14:1981-9. 2003
    ..As lymphatic endothelial cells secrete chemokines that attract dendritic cells, it is possible that the increase in lymphatic vascularization could enhance the immunologic surveillance of remnant kidneys...
  86. ncbi request reprint Editorial comment--Elevated uric acid and ischemic stroke: accumulating evidence that it is injurious and not neuroprotective
    John Kanellis
    Stroke 34:1956-7. 2003
  87. pmc Inflammation, angiotensin II, and hypertension
    Bernardo Rodriguez-Iturbe
    Hypertension 52:e135; author reply e136. 2008
  88. ncbi request reprint J-shaped mortality relationship for uric acid in CKD
    Mohamed E Suliman
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Am J Kidney Dis 48:761-71. 2006
    ..Hyperuricemia has been associated with increased cardiovascular mortality in the general population, but less is known about this association in patients with CKD...
  89. ncbi request reprint Endothelial dysfunction: a link among preeclampsia, recurrent pregnancy loss, and future cardiovascular events?
    Alfredo M Germain
    Departmentos de Obstetricia Ginecología, Escuela de Medicina Pontificia Universidad Católica, Santiago, Chile
    Hypertension 49:90-5. 2007
    ..The identification and correction of endothelial dysfunction detected during the reproductive stage on obstetric outcome and on cardiovascular diseases needs to be elucidated...
  90. ncbi request reprint Nephron number, uric acid, and renal microvascular disease in the pathogenesis of essential hypertension
    Daniel I Feig
    Hypertension 48:25-6. 2006
  91. ncbi request reprint Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells
    Duk Hee Kang
    Division of Nephrology, Ewha Women s University Hospital, Seoul, Korea
    J Am Soc Nephrol 16:3553-62. 2005
    ..The observation that UA alters the proliferation/migration and NO release of human vascular cells, mediated by the expression of CRP, calls for careful reconsideration of the role of UA in hypertension and vascular disease...
  92. ncbi request reprint Everolimus inhibits glomerular endothelial cell proliferation and VEGF, but not long-term recovery in experimental thrombotic microangiopathy
    Katja Keller
    Division of Nephrology, Universitat Erlangen Nurnberg, Loschgestrasse 8, 91054 Erlangen, Germany
    Nephrol Dial Transplant 21:2724-35. 2006
    ..The effects of an everolimus therapy were investigated in a model of renal thrombotic microangiopathy (TMA) with specific endothelial cell (EC) injury in the rat in vivo as well as in glomerular ECs in vitro...
  93. ncbi request reprint Hemodynamics of hyperuricemia
    Laura G Sanchez-Lozada
    Department of Nephrology, Instituto Nacional de Cardiologia, Ignacio Chavez, 14080 Mexico City, Mexico
    Semin Nephrol 25:19-24. 2005
    ..Lumen obliteration induced by vascular wall thickening results in severe vasoconstriction. The resulting ischemia is a potent stimulus that induces tubulointerstitial inflammation and fibrosis as well as arterial hypertension...
  94. ncbi request reprint Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease
    Richard J Johnson
    Division of Nephrology and Department of Medicine, University of Florida, Gainesville, FL, USA
    Am J Clin Nutr 86:899-906. 2007
    ..Finally, we suggest that high intakes of fructose in African Americans may explain their greater predisposition to develop cardiorenal disease, and we provide a list of testable predictions to evaluate this hypothesis...
  95. ncbi request reprint Treatment with the xanthine oxidase inhibitor febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricaemia
    Laura G Sanchez-Lozada
    Department of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 1, 14080 Mexico City, Mexico
    Nephrol Dial Transplant 23:1179-85. 2008
    ..We therefore tested the hypothesis that Fx might be useful in treating hyperuricemia-induced hypertension and renal damage...
  96. pmc Hypokalemic nephropathy is associated with impaired angiogenesis
    Sirirat Reungjui
    Division of Nephrology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    J Am Soc Nephrol 19:125-34. 2008
    ..In conclusion, hypokalemic nephropathy is associated with impaired renal angiogenesis, evidenced by progressive capillary loss, reduced endothelial cell proliferation, and loss of VEGF expression...
  97. doi request reprint Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome
    Laura G Sanchez-Lozada
    Dept of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 1, 14080 Mexico City, Mexico
    Am J Physiol Renal Physiol 294:F710-8. 2008
    ..These results provide further evidence for a pathogenic role of hyperuricemia in fructose-mediated metabolic syndrome...
  98. ncbi request reprint How does angiotensin II cause renal injury?
    David A Long
    Hypertension 43:722-3. 2004
  99. doi request reprint Effect of febuxostat on the progression of renal disease in 5/6 nephrectomy rats with and without hyperuricemia
    Laura G Sanchez-Lozada
    Department of Nephrology, INC Ignacio Chavez, Mexico City, Mexico
    Nephron Physiol 108:p69-78. 2008
    ..The effect of febuxostat (Fx), a non-purine and selective xanthine oxidase inhibitor, on glomerular microcirculatory changes in 5/6 nephrectomy (5/6 Nx) Wistar rats with and without oxonic acid (OA)-induced hyperuricemia was evaluated...
  100. ncbi request reprint Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury
    Sekiko Taneda
    Department of Pathology, University of Washington, Seattle, Washington, USA
    J Am Soc Nephrol 14:2544-55. 2003
    ..These observations suggest that PDGF-D plays an important role in the pathogenesis of tubulointerstitial injury through binding of PDGF-Rbeta in both human obstructive nephropathy and the corresponding murine model of UUO...
  101. ncbi request reprint A murine model of site-specific renal microvascular endothelial injury and thrombotic microangiopathy
    Bernd Hohenstein
    Department of Nephrology and Hypertension, University Erlangen Nuremberg, Loschgestrasse 8, 91054 Erlangen, Germany
    Nephrol Dial Transplant 23:1144-56. 2008
    ....