Ken Inoue

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Molecular mechanisms for genomic disorders
    Ken Inoue
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Annu Rev Genomics Hum Genet 3:199-242. 2002
  2. ncbi request reprint Genetics and genomics of behavioral and psychiatric disorders
    Ken Inoue
    Departments of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Rm 604B, Houston, Texas 77030, USA
    Curr Opin Genet Dev 13:303-9. 2003
  3. ncbi request reprint Role of genomic architecture in PLP1 duplication causing Pelizaeus-Merzbacher disease
    Jennifer A Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Room 604B, Houston, TX 77030, USA
    Hum Mol Genet 15:2250-65. 2006
  4. ncbi request reprint Spastic paraplegia type 2 associated with axonal neuropathy and apparent PLP1 position effect
    Jennifer A Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Ann Neurol 59:398-403. 2006
  5. ncbi request reprint Nonsense-mediated mRNA decay modulates clinical outcome of genetic disease
    Mehrdad Khajavi
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Eur J Hum Genet 14:1074-81. 2006
  6. ncbi request reprint Prenatal diagnosis of PLP1 copy number by array comparative genomic hybridization
    Jennifer A Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Prenat Diagn 25:1188-91. 2005
  7. ncbi request reprint Molecular mechanism for distinct neurological phenotypes conveyed by allelic truncating mutations
    Ken Inoue
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Room 604B, Houston, Texas 77030, USA
    Nat Genet 36:361-9. 2004
  8. pmc Curcumin treatment abrogates endoplasmic reticulum retention and aggregation-induced apoptosis associated with neuropathy-causing myelin protein zero-truncating mutants
    Mehrdad Khajavi
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA
    Am J Hum Genet 77:841-50. 2005
  9. ncbi request reprint Congenital hypomyelinating neuropathy, central dysmyelination, and Waardenburg-Hirschsprung disease: phenotypes linked by SOX10 mutation
    Ken Inoue
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Ann Neurol 52:836-42. 2002
  10. pmc Serial segmental duplications during primate evolution result in complex human genome architecture
    Pawełl Stankiewicz
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genome Res 14:2209-20. 2004

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Molecular mechanisms for genomic disorders
    Ken Inoue
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Annu Rev Genomics Hum Genet 3:199-242. 2002
    ..The human genome sequence project reveals that LCRs may account for 5% of the genome, suggesting that many novel genomic disorders might still remain to be recognized...
  2. ncbi request reprint Genetics and genomics of behavioral and psychiatric disorders
    Ken Inoue
    Departments of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Rm 604B, Houston, Texas 77030, USA
    Curr Opin Genet Dev 13:303-9. 2003
    ....
  3. ncbi request reprint Role of genomic architecture in PLP1 duplication causing Pelizaeus-Merzbacher disease
    Jennifer A Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Room 604B, Houston, TX 77030, USA
    Hum Mol Genet 15:2250-65. 2006
    ....
  4. ncbi request reprint Spastic paraplegia type 2 associated with axonal neuropathy and apparent PLP1 position effect
    Jennifer A Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Ann Neurol 59:398-403. 2006
    ..To report an association between spastic paraplegia type 2 with axonal peripheral neuropathy and apparent proteolipid protein gene (PLP1) silencing in a family...
  5. ncbi request reprint Nonsense-mediated mRNA decay modulates clinical outcome of genetic disease
    Mehrdad Khajavi
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Eur J Hum Genet 14:1074-81. 2006
    ..Here, we review the physiological role of this surveillance pathway, its implications for human diseases, and why knowledge of NMD is important to an understanding of genotype-phenotype correlations in various genetic disorders...
  6. ncbi request reprint Prenatal diagnosis of PLP1 copy number by array comparative genomic hybridization
    Jennifer A Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Prenat Diagn 25:1188-91. 2005
    ..To report a family with a history of Pelizaeus-Merzbacher disease (PMD) for which prenatal diagnosis of PLP1 gene duplication status was attempted by the use of custom array comparative genomic hybridization (aCGH)...
  7. ncbi request reprint Molecular mechanism for distinct neurological phenotypes conveyed by allelic truncating mutations
    Ken Inoue
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Room 604B, Houston, Texas 77030, USA
    Nat Genet 36:361-9. 2004
    ..We observe similar results for truncating mutations of MPZ that convey distinct myelinopathies. Our experiments show that triggering NMD and escaping NMD may cause distinct neurological phenotypes...
  8. pmc Curcumin treatment abrogates endoplasmic reticulum retention and aggregation-induced apoptosis associated with neuropathy-causing myelin protein zero-truncating mutants
    Mehrdad Khajavi
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA
    Am J Hum Genet 77:841-50. 2005
    ..Our findings suggest that curcumin treatment is sufficient to relieve the toxic effect of mutant aggregation-induced apoptosis and may potentially have a therapeutic role in treating selected forms of inherited peripheral neuropathies...
  9. ncbi request reprint Congenital hypomyelinating neuropathy, central dysmyelination, and Waardenburg-Hirschsprung disease: phenotypes linked by SOX10 mutation
    Ken Inoue
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Ann Neurol 52:836-42. 2002
    ..In contrast with the SOX10 loss-of-function mutations causing only WS4, mutations associated with both peripheral and central dysmyelination may affect pathology through a dominant-negative mechanism...
  10. pmc Serial segmental duplications during primate evolution result in complex human genome architecture
    Pawełl Stankiewicz
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genome Res 14:2209-20. 2004
    ....
  11. pmc Genomic rearrangements resulting in PLP1 deletion occur by nonhomologous end joining and cause different dysmyelinating phenotypes in males and females
    Ken Inoue
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 71:838-53. 2002
    ..In one family, junction sequences revealed a complex recombination event. Our data suggest that PLP1 deletions are likely caused by nonhomologous end joining...
  12. doi request reprint Neurologic phenotype of Schimke immuno-osseous dysplasia and neurodevelopmental expression of SMARCAL1
    Kimiko Deguchi
    Department of Pathology, Baylor College of Medicine, Houston, Texas, USA
    J Neuropathol Exp Neurol 67:565-77. 2008
    ..These observations suggest that SMARCAL1 deficiency may influence brain development and function in addition to its previously recognized effect on cerebral circulation...
  13. ncbi request reprint [Chromosomal abnormalities and genomic disorders]
    Ken Inoue
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP
    Nihon Rinsho 63:64-9. 2005
  14. ncbi request reprint Suicidal tendencies among the elderly in Mie Prefecture, Japan, between 1996 and 2002
    Ken Inoue
    Department of Psychiatry, Mie University Graduate School of Medicine, Tsu 514 8507
    Leg Med (Tokyo) 9:134-8. 2007
    ..In addition, medical staff and the general public should be educated on the factors that can influence elderly persons' mental condition, and should be cautioned to observe elderly persons for suicidal signs and symptoms...
  15. ncbi request reprint Significant correlation of psychiatric disorders with leave of absence among teachers in Japan
    Ken Inoue
    Psychiatry Clin Neurosci 61:334. 2007
  16. doi request reprint Associations between psychotic-like experiences and mental health status and other psychopathologies among Japanese early teens
    Atsushi Nishida
    Department of Psychiatry, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Schizophr Res 99:125-33. 2008
    ..3, 95% CI 1.1-1.5; irritability when exchanging e-mails: OR = 1.3, 95% CI 1.0-1.6). Adolescents with PLEs in the community suffer from a wide range of psychopathological problems during crucial developmental periods [corrected]..
  17. ncbi request reprint Causative factors as cues for addressing the rapid increase in suicide in Mie Prefecture, Japan: comparison of trends between 1996-2002 and 1989-1995
    Ken Inoue
    Department of Psychiatry, Graduate School of Medcine, Tsu, Tokyo, Japan
    Psychiatry Clin Neurosci 60:736-45. 2006
    ..To prevent suicide, social cooperation as well as a plenitude of visiting nurses and psychiatric care is required, and early detection and treatment are also important...