P Huang

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Superoxide dismutase as a target for the selective killing of cancer cells
    P Huang
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nature 407:390-5. 2000
  2. ncbi request reprint 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine: a novel anticancer nucleoside analog that causes both DNA strand breaks and G(2) arrest
    A Azuma
    Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Pharmacol 59:725-31. 2001
  3. ncbi request reprint S-Phase arrest by nucleoside analogues and abrogation of survival without cell cycle progression by 7-hydroxystaurosporine
    Z Shi
    Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center and The University of Texas Graduate School of Biomedical Sciences, Houston 77030, USA
    Cancer Res 61:1065-72. 2001
  4. ncbi request reprint Gemcitabine: preclinical pharmacology and mechanisms of action
    W Plunkett
    Department of Clinical Investigation, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Semin Oncol 23:3-15. 1996
  5. ncbi request reprint Cellular pharmacokinetics and pharmacodynamics of the deoxycytidine analog 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine (CNDAC)
    A Azuma
    Department of Experimental Therapeutics, Box 71, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Biochem Pharmacol 61:1497-507. 2001
  6. ncbi request reprint Incorporation of fludarabine and 1-beta-D-arabinofuranosylcytosine 5'-triphosphates by DNA polymerase alpha: affinity, interaction, and consequences
    V Gandhi
    Department of Clinical Investigation, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 3:1347-55. 1997
  7. ncbi request reprint Interaction of p53 and DNA-PK in response to nucleoside analogues: potential role as a sensor complex for DNA damage
    G Achanta
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 61:8723-9. 2001
  8. pmc Telephone assistance for smoking cessation: one year cost effectiveness estimations
    A L McAlister
    Center for Health Promotion and Prevention Research, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    Tob Control 13:85-6. 2004
  9. ncbi request reprint Texas Tobacco Prevention Pilot Initiative: processes and effects
    A F Meshack
    Center for Health Promotion and Prevention Research, School of Public Health, University of Texas Health Science Center, 7000 Fannin, Houston, TX 77030, USA
    Health Educ Res 19:657-68. 2004

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Superoxide dismutase as a target for the selective killing of cancer cells
    P Huang
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nature 407:390-5. 2000
    ..Our results indicate that targeting SOD may be a promising approach to the selective killing of cancer cells, and that mechanism-based combinations of SOD inhibitors with free-radical-producing agents may have clinical applications...
  2. ncbi request reprint 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine: a novel anticancer nucleoside analog that causes both DNA strand breaks and G(2) arrest
    A Azuma
    Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Pharmacol 59:725-31. 2001
    ..It is likely that DNA strand breaks trigger cell cycle arrest in G(2)...
  3. ncbi request reprint S-Phase arrest by nucleoside analogues and abrogation of survival without cell cycle progression by 7-hydroxystaurosporine
    Z Shi
    Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center and The University of Texas Graduate School of Biomedical Sciences, Houston 77030, USA
    Cancer Res 61:1065-72. 2001
    ..These results differ from those in cells arrested at the G2 checkpoint, in which UCN-01 abrogates cell cycle arrest, permitting cells to progress in the cell cycle before apoptosis...
  4. ncbi request reprint Gemcitabine: preclinical pharmacology and mechanisms of action
    W Plunkett
    Department of Clinical Investigation, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Semin Oncol 23:3-15. 1996
    ..Most importantly, the ratio of the cellular concentrations of gemcitabine triphosphate to deoxycytidine triphosphate increases, favoring analog incorporation into DNA, which is strongly associated with loss of viability...
  5. ncbi request reprint Cellular pharmacokinetics and pharmacodynamics of the deoxycytidine analog 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine (CNDAC)
    A Azuma
    Department of Experimental Therapeutics, Box 71, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Biochem Pharmacol 61:1497-507. 2001
    ....
  6. ncbi request reprint Incorporation of fludarabine and 1-beta-D-arabinofuranosylcytosine 5'-triphosphates by DNA polymerase alpha: affinity, interaction, and consequences
    V Gandhi
    Department of Clinical Investigation, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 3:1347-55. 1997
    ..Based on these results and the intracellular pharmacokinetics of ara-CTP and F-ara-ATP in leukemia blasts, we propose a pharmacodynamic model to explain interactions between these analogues during combination chemotherapy...
  7. ncbi request reprint Interaction of p53 and DNA-PK in response to nucleoside analogues: potential role as a sensor complex for DNA damage
    G Achanta
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 61:8723-9. 2001
    ..These data suggest that DNA-PK and p53 may form a sensor complex that detects the disruption of DNA replication caused by nucleoside analogue incorporation and may subsequently signal for apoptosis...
  8. pmc Telephone assistance for smoking cessation: one year cost effectiveness estimations
    A L McAlister
    Center for Health Promotion and Prevention Research, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    Tob Control 13:85-6. 2004
    ..Counselling nearly doubles a smokers' odds of quitting and maintaining cessation for one year. The estimated cost for each case of maintained smoking cessation attributable to counselling availability is approximately 1300 dollars...
  9. ncbi request reprint Texas Tobacco Prevention Pilot Initiative: processes and effects
    A F Meshack
    Center for Health Promotion and Prevention Research, School of Public Health, University of Texas Health Science Center, 7000 Fannin, Houston, TX 77030, USA
    Health Educ Res 19:657-68. 2004
    ..The most consistent changes, at least short-term, to reduce teen tobacco use, susceptibility to smoking and pro-smoking attitudes were achieved by combining the intensive media campaign with the comprehensive community program condition...