Jian Hong

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. doi request reprint Regulatory effects of interferon-β on osteopontin and interleukin-17 expression in multiple sclerosis
    Jian Hong
    Department of Neurology and Baylor Multiple Sclerosis Center, Baylor College of Medicine, Houston, Texas 77030, USA
    J Interferon Cytokine Res 30:751-7. 2010
  2. ncbi request reprint Increased CD8+ cytotoxic T cell responses to myelin basic protein in multiple sclerosis
    Ying C Q Zang
    Multiple Sclerosis Research Unit, Department of Neurology and Baylor Multiple Sclerosis Center, Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 172:5120-7. 2004
  3. ncbi request reprint Ex vivo detection of myelin basic protein-reactive T cells in multiple sclerosis and controls using specific TCR oligonucleotide probes
    Jian Hong
    Department of Neurology and Baylor Methodist Multiple Sclerosis Center, Baylor College of Medicine, Houston, TX 77030, USA
    Eur J Immunol 34:870-81. 2004
  4. ncbi request reprint Cross-reactivity with myelin basic protein and human herpesvirus-6 in multiple sclerosis
    Maria V Tejada-Simon
    Multiple Sclerosis Research Unit, Department of Neurology and Baylor Multiple Sclerosis Center, Baylor College of Medicine, Houston, TX 77030, USA
    Ann Neurol 53:189-97. 2003
  5. pmc Regulatory and pro-inflammatory phenotypes of myelin basic protein-autoreactive T cells in multiple sclerosis
    Jian Hong
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Int Immunol 21:1329-40. 2009
  6. ncbi request reprint Human anti-idiotypic T cells induced by TCR peptides corresponding to a common CDR3 sequence motif in myelin basic protein-reactive T cells
    Ying C Q Zang
    Multiple Sclerosis Research Unit, Department of Neurology and Baylor Methodist Multiple Sclerosis Center, Baylor College of Medicine, Houston, TX 77030, USA
    Int Immunol 15:1073-80. 2003
  7. ncbi request reprint T cell vaccination in multiple sclerosis: results of a preliminary study
    Jingwu Z Zhang
    Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    J Neurol 249:212-8. 2002
  8. doi request reprint Regulatory effects of IFN-beta on production of osteopontin and IL-17 by CD4+ T Cells in MS
    Meiyue Chen
    Multiple Sclerosis Research Unit, Department of Neurology and Baylor Multiple Sclerosis Center, Baylor College of Medicine, Houston, TX 77030, USA
    Eur J Immunol 39:2525-36. 2009
  9. ncbi request reprint Altered expression of vasoactive intestinal peptide receptors in T lymphocytes and aberrant Th1 immunity in multiple sclerosis
    Wei Sun
    Department of Neurology, Baylor College of Medicine, Mail station NB302, One Baylor Plaza, Houston, TX 77030, USA
    Int Immunol 18:1691-700. 2006
  10. pmc CD4+ regulatory T cell responses induced by T cell vaccination in patients with multiple sclerosis
    Jian Hong
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:5024-9. 2006

Research Grants

Collaborators

  • Ying C Q Zang
  • Jingwu Zhang
  • Maria V Tejada-Simon
  • Meiyue Chen
  • Victor M Rivera
  • Wei Sun
  • James M Killian
  • Hassan H Salama
  • Sheri M Skinner
  • Xiaoyin Niu
  • Xin Zhang
  • Hong Nie
  • Guangjie Chen
  • Xin Liu
  • Azza El-Mongui

Detail Information

Publications16

  1. doi request reprint Regulatory effects of interferon-β on osteopontin and interleukin-17 expression in multiple sclerosis
    Jian Hong
    Department of Neurology and Baylor Multiple Sclerosis Center, Baylor College of Medicine, Houston, Texas 77030, USA
    J Interferon Cytokine Res 30:751-7. 2010
    ..This review discusses the role of OPN and IL-17 in the development of MS and how the downregulation of the levels of OPN and interleukin-17 contributes to the therapeutic effects of IFN-β in MS...
  2. ncbi request reprint Increased CD8+ cytotoxic T cell responses to myelin basic protein in multiple sclerosis
    Ying C Q Zang
    Multiple Sclerosis Research Unit, Department of Neurology and Baylor Multiple Sclerosis Center, Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 172:5120-7. 2004
    ..These findings support the potential role of CD8(+) CTLs recognizing MBP in the injury of oligodendrocytes expressing both MHC class I molecules and MBP...
  3. ncbi request reprint Ex vivo detection of myelin basic protein-reactive T cells in multiple sclerosis and controls using specific TCR oligonucleotide probes
    Jian Hong
    Department of Neurology and Baylor Methodist Multiple Sclerosis Center, Baylor College of Medicine, Houston, TX 77030, USA
    Eur J Immunol 34:870-81. 2004
    ..Furthermore, the study showed that MBP(83-99)-reactive T cells detected ex vivo belonged to CD45RA+, CD25+ and CD95- T cell subsets as evidenced by preferential expression of specific TCR transcripts in these cell fractions...
  4. ncbi request reprint Cross-reactivity with myelin basic protein and human herpesvirus-6 in multiple sclerosis
    Maria V Tejada-Simon
    Multiple Sclerosis Research Unit, Department of Neurology and Baylor Multiple Sclerosis Center, Baylor College of Medicine, Houston, TX 77030, USA
    Ann Neurol 53:189-97. 2003
    ..The study provides important evidence in the understanding of the potential role of HHV-6 infection/reactivation in the activation of autoimmune reactivity to MBP and its implication in the pathogenesis of MS...
  5. pmc Regulatory and pro-inflammatory phenotypes of myelin basic protein-autoreactive T cells in multiple sclerosis
    Jian Hong
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Int Immunol 21:1329-40. 2009
    ..The study provides new evidence that MBP-specific T cells are susceptible to pro-inflammatory cytokine milieu and act as either pro-inflammatory or regulatory T cells...
  6. ncbi request reprint Human anti-idiotypic T cells induced by TCR peptides corresponding to a common CDR3 sequence motif in myelin basic protein-reactive T cells
    Ying C Q Zang
    Multiple Sclerosis Research Unit, Department of Neurology and Baylor Methodist Multiple Sclerosis Center, Baylor College of Medicine, Houston, TX 77030, USA
    Int Immunol 15:1073-80. 2003
    ..The findings suggest that anti-idiotypic immune responses can be activated by selected TCR peptides and may play an important role in the in vivo regulation of MBP-reactive T cells...
  7. ncbi request reprint T cell vaccination in multiple sclerosis: results of a preliminary study
    Jingwu Z Zhang
    Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    J Neurol 249:212-8. 2002
    ..The findings suggest some potential clinical benefit of T cell vaccination in MS and encourage further investigations to evaluate the treatment efficacy of T cell vaccination in controlled trials...
  8. doi request reprint Regulatory effects of IFN-beta on production of osteopontin and IL-17 by CD4+ T Cells in MS
    Meiyue Chen
    Multiple Sclerosis Research Unit, Department of Neurology and Baylor Multiple Sclerosis Center, Baylor College of Medicine, Houston, TX 77030, USA
    Eur J Immunol 39:2525-36. 2009
    ..This study provides new insights into the mechanism of action of IFN-beta in the treatment of MS...
  9. ncbi request reprint Altered expression of vasoactive intestinal peptide receptors in T lymphocytes and aberrant Th1 immunity in multiple sclerosis
    Wei Sun
    Department of Neurology, Baylor College of Medicine, Mail station NB302, One Baylor Plaza, Houston, TX 77030, USA
    Int Immunol 18:1691-700. 2006
    ..This study has provided new evidence for an intrinsic mechanism associated with an aberrant, pro-inflammatory state of CD4+ T cells in MS...
  10. pmc CD4+ regulatory T cell responses induced by T cell vaccination in patients with multiple sclerosis
    Jian Hong
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:5024-9. 2006
    ..The findings have important implications in the understanding of the role of CD4(+) regulatory T cell response induced by T cell vaccination...
  11. pmc Skewed autoantibody reactivity to the extracellular domain of myelin oligodendrocyte glycoprotein in multiple sclerosis
    Maria V Tejada-Simon
    Multiple Sclerosis Research Unit, Baylor Methodist Multiple Sclerosis Center and Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    Immunology 107:403-10. 2002
    ..The study has important implications in the understanding of the autoimmune processes in MS...
  12. ncbi request reprint Gene expression profiling of relevant biomarkers for treatment evaluation in multiple sclerosis
    Jian Hong
    Department of Neurology and Baylor Methodist Multiple Sclerosis Center, Baylor College of Medicine, Houston, TX 77030, USA
    J Neuroimmunol 152:126-39. 2004
    ....
  13. pmc Detection of viral DNA and immune responses to the human herpesvirus 6 101-kilodalton virion protein in patients with multiple sclerosis and in controls
    Maria V Tejada-Simon
    Multiple Sclerosis Research Unit, Department of Neurology and Baylor Methodist Multiple Sclerosis Center, Baylor College of Medicine, Houston, Texas 77030, USA
    J Virol 76:6147-54. 2002
    ..The findings suggest that the decreased immune responses to HHV-6 may be responsible for ineffective clearance of HHV-6 in MS patients...
  14. ncbi request reprint Blocking effects of serum reactive antibodies induced by glatiramer acetate treatment in multiple sclerosis
    Hassan H Salama
    Multiple Sclerosis Research Unit, Department of Neurology, Baylor Methodist Multiple Sclerosis Center, Baylor College of Medicine, Houston, Texas, USA
    Brain 126:2638-47. 2003
    ..The study has important implications in our understanding of the potential role of high-titre GA antibodies in the treatment of multiple sclerosis...
  15. ncbi request reprint Immune regulatory properties and interactions of copolymer-I and beta-interferon 1a in multiple sclerosis
    Ying Zang
    Multiple Sclerosis Research Unit, Department of Neurology and Baylor Multiple Sclerosis Center, Baylor College of Medicine, 6501 Fannin Street, NB302, Houston, TX 77030, USA
    J Neuroimmunol 137:144-53. 2003
    ..The study has important clinical implications in the planned clinical trials to test treatment efficacy of combination therapy...
  16. ncbi request reprint Regulatory effects of estriol on T cell migration and cytokine profile: inhibition of transcription factor NF-kappa B
    Ying C Q Zang
    Multiple Sclerosis Research Unit, Baylor Methodist Multiple Sclerosis Center and Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    J Neuroimmunol 124:106-14. 2002
    ..This study provides new evidence that estriol is a potent regulator for the T cell functions potentially through its interaction with the NF-kappa B signaling pathway...

Research Grants1

  1. Role of CD4+ regulatory T cells in T cell vaccination
    Jian Hong; Fiscal Year: 2007
    ..The overall results will provide new insights into the role of IL- 2Ro_ in regulation of pro-inflammatory T cell response in autoimmune conditions. ..