John B Holcomb

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Evaluation of trauma team performance using an advanced human patient simulator for resuscitation training
    John B Holcomb
    Joint Trauma Training Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
    J Trauma 52:1078-85; discussion 1085-6. 2002
  2. pmc Do-not-resuscitate orders in trauma patients may bias mortality-based effect estimates: an evaluation using the PROMMTT study
    Charles E Wade
    Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 75:S89-96. 2013
  3. doi request reprint Use of recombinant factor VIIa in US military casualties for a five-year period
    Charles E Wade
    Center for Translational Injury Research and Department of Surgery, University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma 69:353-9. 2010
  4. doi request reprint Impact of closure at the first take back: complication burden and potential overutilization of damage control laparotomy
    Quinton M Hatch
    Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma 71:1503-11. 2011
  5. pmc Resuscitate early with plasma and platelets or balance blood products gradually: findings from the PROMMTT study
    Deborah J Del Junco
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 75:S24-30. 2013
  6. doi request reprint Admission rapid thrombelastography predicts development of pulmonary embolism in trauma patients
    Bryan A Cotton
    Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 72:1470-5; discussion 1475-7. 2012
  7. pmc Early resuscitation intensity as a surrogate for bleeding severity and early mortality in the PROMMTT study
    Elaheh Rahbar
    Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, Texas, USA
    J Trauma Acute Care Surg 75:S16-23. 2013
  8. doi request reprint Cryoprecipitate use in the PROMMTT study
    John B Holcomb
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 75:S31-9. 2013
  9. pmc Purposeful variable selection and stratification to impute missing Focused Assessment with Sonography for Trauma data in trauma research
    Paul A Fuchs
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 75:S75-81. 2013
  10. pmc A latent class model for defining severe hemorrhage: experience from the PROMMTT study
    Mohammad H Rahbar
    Biostatistics Epidemiology Research Design Core, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, Texas, USA
    J Trauma Acute Care Surg 75:S82-8. 2013

Collaborators

Detail Information

Publications151 found, 100 shown here

  1. ncbi request reprint Evaluation of trauma team performance using an advanced human patient simulator for resuscitation training
    John B Holcomb
    Joint Trauma Training Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
    J Trauma 52:1078-85; discussion 1085-6. 2002
    ..Only recently has technology advanced to allow application to the complex field of trauma resuscitation. The purpose of our study was to validate an advanced HPS as an evaluation tool of trauma team resuscitation skills...
  2. pmc Do-not-resuscitate orders in trauma patients may bias mortality-based effect estimates: an evaluation using the PROMMTT study
    Charles E Wade
    Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 75:S89-96. 2013
    ..We determined the frequency, timing, and impact on mortality-based effect estimates for patients with DNR orders in the Prospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study...
  3. doi request reprint Use of recombinant factor VIIa in US military casualties for a five-year period
    Charles E Wade
    Center for Translational Injury Research and Department of Surgery, University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma 69:353-9. 2010
    ..This study was undertaken to assess how deployed physicians are using rFVIIa and its impact on casualty outcomes...
  4. doi request reprint Impact of closure at the first take back: complication burden and potential overutilization of damage control laparotomy
    Quinton M Hatch
    Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma 71:1503-11. 2011
    ....
  5. pmc Resuscitate early with plasma and platelets or balance blood products gradually: findings from the PROMMTT study
    Deborah J Del Junco
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 75:S24-30. 2013
    ..To differentiate the association of in-hospital mortality with early plasma or platelet transfusion from that with delayed but gradually balanced ratios, we developed a separate analytic approach...
  6. doi request reprint Admission rapid thrombelastography predicts development of pulmonary embolism in trauma patients
    Bryan A Cotton
    Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 72:1470-5; discussion 1475-7. 2012
    ..The purpose of this study was to identify whether admission rapid-thrombelastography (r-TEG) could identify patients at risk of developing pulmonary embolism (PE) during their hospital stay...
  7. pmc Early resuscitation intensity as a surrogate for bleeding severity and early mortality in the PROMMTT study
    Elaheh Rahbar
    Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, Texas, USA
    J Trauma Acute Care Surg 75:S16-23. 2013
    ....
  8. doi request reprint Cryoprecipitate use in the PROMMTT study
    John B Holcomb
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 75:S31-9. 2013
    ..Our objectives were to identify patterns and predictors of cryoprecipitate use and determine whether transfusing cryoprecipitate was associated with improved survival...
  9. pmc Purposeful variable selection and stratification to impute missing Focused Assessment with Sonography for Trauma data in trauma research
    Paul A Fuchs
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 75:S75-81. 2013
    ..Owing to variability in patients' injuries and trauma care, these data are unlikely to be missing completely at random, raising concern for validity when analyses exclude patients with missing values...
  10. pmc A latent class model for defining severe hemorrhage: experience from the PROMMTT study
    Mohammad H Rahbar
    Biostatistics Epidemiology Research Design Core, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, Texas, USA
    J Trauma Acute Care Surg 75:S82-8. 2013
    ..We show how a latent class model could improve the accuracy of identifying the SH patients...
  11. doi request reprint Admission rapid thrombelastography can replace conventional coagulation tests in the emergency department: experience with 1974 consecutive trauma patients
    John B Holcomb
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Ann Surg 256:476-86. 2012
    ..We have previously shown that admission r-TEG results are available faster than CCTs and predict pulmonary embolism. We hypothesized that r-TEGs more reliably predict blood component transfusion than CCTs...
  12. doi request reprint Hyperfibrinolysis at admission is an uncommon but highly lethal event associated with shock and prehospital fluid administration
    Bryan A Cotton
    Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 73:365-70; discussion 370. 2012
    ..To further strengthen this hypothesis, we created an in vitro hemodilution model to improve our mechanistic understanding of the early HF...
  13. pmc Waiver of consent in noninterventional, observational emergency research: the PROMMTT experience
    Erin E Fox
    Biostatistics Epidemiology Research Design Core, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Trauma Acute Care Surg 75:S3-8. 2013
    ..The goal of this article was to examine the rationale and tradeoffs of using waiver of consent in PROMMTT...
  14. doi request reprint The effect of recombinant activated factor VII on mortality in combat-related casualties with severe trauma and massive transfusion
    Philip C Spinella
    US Army Institute of Surgical Research, San Antonio, Texas, USA
    J Trauma 64:286-93; discussion 293-4. 2008
    ....
  15. ncbi request reprint Evolution of burn resuscitation in operation Iraqi freedom
    Kevin K Chung
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Burn Care Res 27:606-11. 2006
  16. doi request reprint A novel biologic hemostatic dressing (fibrin patch) reduces blood loss and resuscitation volume and improves survival in hypothermic, coagulopathic Swine with grade V liver injury
    Angel V Delgado
    US Army Institute of Surgical Research, San Antonio, Texas, USA
    J Trauma 64:75-80. 2008
    ..This study evaluated the efficacy of a biologic hemostatic fibrin patch (FP) to control coagulopathic bleeding and prevent death in a porcine model of severe liver injury with hemodilution and hypothermia...
  17. pmc Aged plasma transfusion increases mortality in a rat model of uncontrolled hemorrhage
    Phillip A Letourneau
    Center for Translational Injury Research, University of Texas Health Science Center, Houston, Texas, USA
    J Trauma 71:1115-9. 2011
    ..We hypothesized that FFP5 would increase bleeding and mortality compared with FFP0 in a rodent bioassay model of uncontrolled liver hemorrhage...
  18. doi request reprint Influence of resuscitation fluids, fresh frozen plasma and antifibrinolytics on fibrinolysis in a thrombelastography-based, in-vitro, whole-blood model
    Vadim Kostousov
    Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Blood Coagul Fibrinolysis 24:489-97. 2013
    ..Low concentrations of TXA or ACA reversed hyperfibrinolysis, but the efficient concentrations were dependent on the degree of fibrinolysis and whole-blood dilution...
  19. pmc The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks
    John B Holcomb
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, University of Texas Health Science Center at Houston, 6410 Fannin, Ste 1100, Houston, TX 77030, USA
    JAMA Surg 148:127-36. 2013
    ..To relate in-hospital mortality to early transfusion of plasma and/or platelets and to time-varying plasma:red blood cell (RBC) and platelet:RBC ratios...
  20. doi request reprint Increased platelet:RBC ratios are associated with improved survival after massive transfusion
    John B Holcomb
    Division of Acute Care Surgery, Center for Translational Injury Research, University of Texas Health Sciences Center, Houston, Texas 77030, USA
    J Trauma 71:S318-28. 2011
    ..However, outcomes associated with platelet transfusions are poorly characterized. We hypothesized that increased platelet:red blood cells (RBC) ratios would decrease hemorrhagic death and improve survival after massive transfusion (MT)...
  21. pmc Do not resuscitate status, not age, affects outcomes after injury: an evaluation of 15,227 consecutive trauma patients
    Sasha D Adams
    Department of Surgery, University of Texas Health Science Center, Houston, Texas, USA
    J Trauma Acute Care Surg 74:1327-30. 2013
    ..We hypothesized that the increased likelihood of DNR status in older patients alters age-adjusted mortality rates in trauma...
  22. pmc An emergency department thawed plasma protocol for severely injured patients
    Zayde A Radwan
    Center for Translational Injury Research, The University of Texas Health Science Center, 6410 Fannin St, 1100 20 UPB, Houston, TX 77030, USA
    JAMA Surg 148:170-5. 2013
    ....
  23. pmc Coordination and management of multicenter clinical studies in trauma: Experience from the PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) Study
    Mohammad H Rahbar
    Biostatistics, Epidemiology, and Research Design Core, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA
    Resuscitation 83:459-64. 2012
    ....
  24. doi request reprint Global evacuation of burn patients does not increase the incidence of venous thromboembolic complications
    Kevin K Chung
    Clinical Division, U S Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 65:19-24. 2008
    ..We hypothesized global evacuation results in increased VTE rates...
  25. ncbi request reprint Rapid thrombelastography delivers real-time results that predict transfusion within 1 hour of admission
    Bryan A Cotton
    Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma 71:407-14; discussion 414-7. 2011
    ..The purpose of this pilot study was to evaluate the timeliness of r-TEG results, their correlation with CCTs, and the ability of r-TEG to predict early blood transfusion...
  26. doi request reprint Association of hemodilution and blood pressure in uncontrolled bleeding
    Nicholas S Pawelczyk
    Department of Surgery and Center for Translational Injury Research, University of Texas Health Science Center, Houston, Texas
    J Surg Res 184:959-65. 2013
    ..We investigated interactions of isovolumic hemodilution on hemodynamics, coagulation, and blood loss after injury...
  27. pmc Seven deadly sins in trauma outcomes research: an epidemiologic post mortem for major causes of bias
    Deborah J Del Junco
    Biostatistics Epidemiology Research Design Core, University of Texas Health Science Center at Houston, Houston, Texas, USA
    J Trauma Acute Care Surg 75:S97-103. 2013
    ..The standard research design and analysis strategies applied in published observational studies are often inadequate to address these biases...
  28. pmc Modulation of syndecan-1 shedding after hemorrhagic shock and resuscitation
    Ricky J Haywood-Watson
    Department of Surgery, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
    PLoS ONE 6:e23530. 2011
    ..These data suggest that plasma based resuscitation preserved endothelial syndecan-1 and maintained endothelial integrity, and may help to explain the protective effects of fresh frozen plasma after hemorrhagic shock...
  29. doi request reprint A randomized controlled pilot trial of modified whole blood versus component therapy in severely injured patients requiring large volume transfusions
    Bryan A Cotton
    Departments of Surgery, Center for Translational Injury Research, and Pathology and Laboratory Medicine, University of Texas Health Science Center, Houston, TX and Gulf Coast Regional Blood Center, Houston, TX
    Ann Surg 258:527-32; discussion 532-3. 2013
    ..To determine whether resuscitation of severely injured patients with modified whole blood (mWB) resulted in fewer overall transfusions compared with component (COMP) therapy...
  30. pmc Creation, implementation, and maturation of a massive transfusion protocol for the exsanguinating trauma patient
    Timothy C Nunez
    Department of Surgery, Brooke Army Medical Center, Fort Sam Houston, Texas, USA
    J Trauma 68:1498-505. 2010
    ..Once implemented, this process may lead to improved clinical outcomes and decreased overall blood utilization with extremely small wastage of vital blood products...
  31. doi request reprint Effects of synthetic versus natural colloid resuscitation on inducing dilutional coagulopathy and increasing hemorrhage in rabbits
    Bijan S Kheirabadi
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 64:1218-28; discussion 1228-9. 2008
    ..We investigated the effects of resuscitation with this fluid, as well as other colloids, on coagulation and uncontrolled bleeding in rabbits subjected to a splenic injury...
  32. pmc Multiple levels of degradation diminish hemostatic potential of thawed plasma
    Nena Matijevic
    Department of Surgery and Center for Translational Injury Research, University of Texas Health Science Center Houston, Houston, Texas 77030, USA
    J Trauma 70:71-9; discussion 79-80. 2011
    ..However, there are no clinical data analyzing the effects of the approved 5-day storage on plasma. We hypothesize that the hemostatic potential (HP) of freshly thawed (FFP-0) was superior to plasma stored for 5 days (FFP-5)...
  33. doi request reprint US Army two-surgeon teams operating in remote Afghanistan--an evaluation of split-based Forward Surgical Team operations
    Shawn C Nessen
    US Army Institute of Surgical Research, San Antonio, Texas, USA
    J Trauma 66:S37-47. 2009
    ..The effectiveness of these 10-person teams is unknown and outcome data has not been previously reported in the literature. This article evaluates the effectiveness of one split FST during a 14-month period in remote Afghanistan...
  34. pmc Damage control resuscitation is associated with a reduction in resuscitation volumes and improvement in survival in 390 damage control laparotomy patients
    Bryan A Cotton
    Department of Surgery, The University of Texas Health Science Center, Houston, TX, USA
    Ann Surg 254:598-605. 2011
    ..To determine whether implementation of damage control resuscitation (DCR) in patients undergoing damage control laparotomy (DCL) translates into improved survival...
  35. doi request reprint Prolonged prothrombin time after recombinant activated factor VII therapy in critically bleeding trauma patients is associated with adverse outcomes
    Neil R McMullin
    US Army Institute of Surgical Research, BAMC Fort Sam Houston, Texas, USA
    J Trauma 69:60-9. 2010
    ....
  36. ncbi request reprint Prehospital triage of trauma patients using the Random Forest computer algorithm
    Michelle Scerbo
    Division of Acute Care Surgery, Department of Surgery, Center for Translational Injury Research CeTIR, University of Texas Houston, Houston, Texas
    J Surg Res 187:371-6. 2014
    ..This study aimed to validate the Random Forest computer model (RFM) as means of better triaging trauma patients to level 1 trauma centers...
  37. doi request reprint Early femur fracture fixation is associated with a reduction in pulmonary complications and hospital charges: a decade of experience with 1,376 diaphyseal femur fractures
    John A Harvin
    Departments of Surgery, The University of Texas Health Science Center at Houston, Houston, Texas
    J Trauma Acute Care Surg 73:1442-8; discussion 1448-9. 2012
    ..We hypothesized that early IMN fixation of femur fractures would be associated with a decreased incidence of PC, hospital stay, and overall charges...
  38. doi request reprint Hemostatically distinct FFPs equally improve abnormal TEG variables in an in vitro dilutional coagulopathy model
    Vadim Kostousov
    Department of Surgery, and Center for Translational Injury Research, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Thromb Res 130:429-34. 2012
    ..We hypothesized that smaller volumes of plasma with higher hemostatic potential (FFP-H) would be needed to restore normal thrombelastogram (TEG) values compared to plasma with lower hemostatic potential (FFP-L)...
  39. doi request reprint Death on the battlefield (2001-2011): implications for the future of combat casualty care
    Brian J Eastridge
    US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma Acute Care Surg 73:S431-7. 2012
    ..The impetus to produce this analysis was to develop a comprehensive perspective of battlefield death, concentrating on deaths that occurred in the pre-medical treatment facility (pre-MTF) environment...
  40. pmc Protective effects of fresh frozen plasma on vascular endothelial permeability, coagulation, and resuscitation after hemorrhagic shock are time dependent and diminish between days 0 and 5 after thaw
    Shibani Pati
    Department of Surgery and Center for Translational Injury Research, University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma 69:S55-63. 2010
    ..We further hypothesized that the beneficial effects of FFP would diminish over 5 days of routine storage at 4 degrees C...
  41. pmc Fresh frozen plasma lessens pulmonary endothelial inflammation and hyperpermeability after hemorrhagic shock and is associated with loss of syndecan 1
    Zhanglong Peng
    Department of Surgery, University of Texas Health Sciences Center at Houston, Houston, TX 77030, USA
    Shock 40:195-202. 2013
    ..Modulation of pulmonary syndecan 1 expression may mechanistically contribute to the beneficial effects FFP. ..
  42. ncbi request reprint Freeze-dried plasma at the point of injury: from concept to doctrine
    Elon Glassberg
    Surgeon General s Headquarters, Israel Defense Forces, and Department of Military Medicine, Hebrew University, Jerusalem, Israel Department of Pediatrics, Division of Critical Care, Washington University in St Louis, Missouri and US Army Institute of Surgical Research, Fort Sam Houston and Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, University of Texas Health Science Center at Houston, Houston, Texas
    Shock 40:444-50. 2013
    ..It is our hope that others will be able to learn from our experience, thus improving trauma casualty care around the world. ..
  43. doi request reprint Thrombelastography and rotational thromboelastometry early amplitudes in 182 trauma patients with clinical suspicion of severe injury
    Anna Sina P Meyer
    From the Section for Transfusion Medicine A S P M, M A S M, M B H, s r o, P I J, Capital Region Blood Bank, The Trauma Centre A M S, Centre of Head and Orthopaedics, and Department of Anaesthesia A M S, L S R, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark Department of Surgery A S P M, M A S M, J H B, B A C, C E W, P I J, Center for Translational Injury Research CeTIR, University of Texas Medical School at Houston, Houston, Texas
    J Trauma Acute Care Surg 76:682-90. 2014
    ..Viscoelastic hemostatic assays may provide means for earlier detection of trauma-induced coagulopathy (TIC)...
  44. doi request reprint Chasing 100%: the use of hypertonic saline to improve early, primary fascial closure after damage control laparotomy
    John A Harvin
    Department of Surgery, University of Texas Medical School at Houston, Houston, Texas, USA
    J Trauma Acute Care Surg 74:426-30; discussion 431-2. 2013
    ..We hypothesized that hypertonic saline (HTS), which attenuates resuscitation-induced intestinal edema in animals, would improve early primary fascial closure (EPFC) rates...
  45. pmc Bone marrow derived mesenchymal stem cells inhibit inflammation and preserve vascular endothelial integrity in the lungs after hemorrhagic shock
    Shibani Pati
    Department of Surgery and Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
    PLoS ONE 6:e25171. 2011
    ..These data are the first to demonstrate the therapeutic potential of MSCs in HS and have implications for the potential use of MSCs as a cellular therapy in HS-induced lung injury...
  46. ncbi request reprint Tracking the daily availability of burn beds for national emergencies
    David J Barillo
    US Army Institute of Surgical Research US Army Burn Center, Brooke Army Medical Center, Fort Sam Houston, Texas, USA
    J Burn Care Rehabil 26:174-82. 2005
    ..Although intended for military conflict, this system is equally applicable to civilian mass casualty situations. We advocate adoption of this or a similar bed tracking system by the ABA for use during burn mass casualty incidents...
  47. pmc Thromboelastography as a better indicator of hypercoagulable state after injury than prothrombin time or activated partial thromboplastin time
    Myung S Park
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 67:266-75; discussion 275-6. 2009
    ..We hypothesized that a hypercoagulable state exists in patients early after severe injury and that the pattern of clotting and fibrinolysis are similar between burned and nonburn trauma patients...
  48. doi request reprint The utility of intravascular ultrasound compared to angiography in the diagnosis of blunt traumatic aortic injury
    Ali Azizzadeh
    University of Texas Medical School Houston, Memorial Hermann Heart and Vascular Institute, Houston, Tex, USA
    J Vasc Surg 53:608-14. 2011
    ..Additional imaging is required when CTA studies are equivocal. The purpose of this study is to evaluate the utility of intravascular ultrasound (IVUS) versus angiography in the diagnosis of TAI...
  49. pmc Decline in platelet microparticles contributes to reduced hemostatic potential of stored plasma
    Nena Matijevic
    Center for Translational Injury Research and Department of Surgery, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Thromb Res 128:35-41. 2011
    ..We report on MP changes in TP between its initial thaw (FFP-0) and five days (FFP-5) of storage...
  50. doi request reprint Variations between level I trauma centers in 24-hour mortality in severely injured patients requiring a massive transfusion
    Charles E Wade
    Department of Surgery, and The Center for Translational Injury Research, The University of Texas Health Science Center at Houston, Houston, Texas, USA
    J Trauma 71:S389-93. 2011
    ..We hypothesized differences among centers in 24-hour mortality could predominantly be accounted for by differences in transfusion practices as well as patient characteristics...
  51. pmc Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries
    Philip C Spinella
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 66:S69-76. 2009
    ..We hypothesized that warm fresh whole blood (WFWB) transfusion would be associated with improved survival in patients with trauma compared with those transfused only stored component therapy (CT)...
  52. doi request reprint Battle casualty survival with emergency tourniquet use to stop limb bleeding
    John F Kragh
    US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Emerg Med 41:590-7. 2011
    ..In a previous study conducted at a combat support hospital in Iraq, we reported the major lifesaving benefits of emergency tourniquets to stop bleeding in major limb trauma. Morbidity associated with tourniquet use was minor...
  53. pmc Unique pattern of complications in elderly trauma patients at a Level I trauma center
    Sasha D Adams
    Department of Surgery, Center for Translational Injury Research, The University of Texas Health Science Center, Houston, Texas, USA
    J Trauma Acute Care Surg 72:112-8. 2012
    ..We hypothesized that elderly patients would have different complication patterns than their younger counterparts...
  54. ncbi request reprint Fresh frozen plasma should be given earlier to patients requiring massive transfusion
    Ernest A Gonzalez
    Department of Surgery, University of Texas Houston Medical School, Houston, Texas, USA
    J Trauma 62:112-9. 2007
    ..The hypothesis for this study is that our pre-intensive care unit (ICU) massive transfusion (MT) protocol does not adequately correct coagulopathy, and that early uncorrected coagulopathy is predictive of mortality...
  55. ncbi request reprint Radiologic diagnosis of explosion casualties
    Brian J Eastridge
    US Army Institute for Surgical Research, Fort Sam Houston, Texas, USA
    Am J Disaster Med 3:301-5. 2008
    ..With this caveat, the appropriate utilization of radiology resources has the potential to impact in-hospital diagnosis and triage and is an essential element in optimizing the management of the explosive-injured patients...
  56. ncbi request reprint Establishment of methods for performing thrombelastography and calibrated automated thrombography in rats
    Maria del Pilar Huby
    Department of Surgery and Center for Translational Injury Research, University of Texas Health Science Center, Houston, Texas
    Shock 42:27-30. 2014
    ..We conclude that blood collection methods have a profound effect on hemostatic potential, and standardization of these practices is necessary to define the effects of shock on coagulation in rodents. ..
  57. ncbi request reprint Are we delivering two standards of care for pelvic trauma? Availability of angioembolization after hours and on weekends increases time to therapeutic intervention
    Diane A Schwartz
    From the Departments of Surgery D A S, M M, B A C, E R, C E W, J B H, Diagnostic and Interventional Radiology A M C, and Orthopedic Surgery A R B, and the Center for Translational Injury Research B A C, C E W, A M B, J B H, The University of Texas Health Science Center, Houston, Texas
    J Trauma Acute Care Surg 76:134-9. 2014
    ....
  58. ncbi request reprint Potential value of protocols in substantially bleeding trauma patients
    John B Holcomb
    Division of Acute Care Surgery, Center for Translational Injury Research, University of Texas Health Science Center, Houston, Texas, USA
    Curr Opin Anaesthesiol 26:215-20. 2013
    ..This review will discuss the recent changes and advancement of early traumatic coagulopathy and the important role of substantial bleeding protocols (SBPs)...
  59. ncbi request reprint Recombinant factor VIIa reduces rebleed hemorrhage volume in a swine aortotomy model: a randomized double-blinded study
    Neil R McMullin
    US Army Institute of Surgical Research, San Antonio, Texas, USA
    Shock 29:703-8. 2008
    ....
  60. doi request reprint Combat wounds in operation Iraqi Freedom and operation Enduring Freedom
    Brett D Owens
    U S Army Institute of Surgical Research, Ft Sam Houston, Texas, USA
    J Trauma 64:295-9. 2008
    ..There have been no large cohort reports detailing the wounding patterns and mechanisms in the current conflicts in Iraq and Afghanistan...
  61. ncbi request reprint Current use of damage-control laparotomy, closure rates, and predictors of early fascial closure at the first take-back
    Quinton M Hatch
    Department of Surgery and the Center for Translational Injury Research, The University of Texas Health Science Center, Houston, Texas, USA
    J Trauma 70:1429-36. 2011
    ..The purpose of the current study was to determine (1) the current rate of DCL, (2) the percentage of DCLs that are closed at first take-back, and (3) possible physiologic and resuscitative parameters predicting early fascial closure...
  62. doi request reprint Thromboembolic complications following trauma
    Daniel F McLaughlin
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    Transfusion 49:256S-63S. 2009
    ..Some studies have reported an increased incidence of thromboembolic complications following trauma...
  63. ncbi request reprint Acidosis and coagulopathy: the differential effects on fibrinogen synthesis and breakdown in pigs
    Wenjun Z Martini
    US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    Ann Surg 246:831-5. 2007
    ..This study was designed to investigate the effects of acidosis on fibrinogen metabolism and coagulation function in a swine model...
  64. ncbi request reprint Combat burn life support: a military burn-education program
    David J Barillo
    US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Burn Care Rehabil 26:162-5. 2005
    ..Although intended for a military audience, the course material is equally applicable to civilian terrorist or mass casualty situations...
  65. ncbi request reprint Fresh whole blood transfusions in coalition military, foreign national, and enemy combatant patients during Operation Iraqi Freedom at a U.S. combat support hospital
    Philip C Spinella
    U S Army Institute of Surgical Research, San Antonio, Texas, USA
    World J Surg 32:2-6. 2008
    ....
  66. doi request reprint A clinical comparison of penetrating and blunt traumatic brain injuries
    Luis A Santiago
    Center for Translational Injury Research, The University of Texas Health Science Center, Houston, TX, USA
    Brain Inj 26:107-25. 2012
    ..Many studies on the prognostic factors of mortality and functional outcome after TBI exclude penetrating brain injuries from their series because they are believed to have a different pathophysiology...
  67. pmc Traumatic brain injury and resuscitation with blood products: what should we do?
    Bryan C Oh
    Department of Neurosurgery, University of Texas Health Sciences Center, Houston, TX 77030, USA
    Crit Care 15:172. 2011
    ..Currently, the optimum fluid resuscitation paradigm for patients with both severe traumatic brain injury and other injuries requiring significant volume resuscitation is not clear...
  68. doi request reprint Clinical outcomes from the war: introduction
    John B Holcomb
    US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 64:S1. 2008
  69. doi request reprint Preventing hypothermia: comparison of current devices used by the US Army in an in vitro warmed fluid model
    Paul B Allen
    US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 69:S154-61. 2010
    ....
  70. doi request reprint Progress in the treatment of blunt thoracic aortic injury: 12-year single-institution experience
    Anthony L Estrera
    Cardiothoracic and Vascular Surgery, Memorial Hermann Heart and Vascular Institute, Houston, Texas, USA
    Ann Thorac Surg 90:64-71. 2010
    ..With consideration of these advancements, we analyzed our level 1 trauma experience with blunt traumatic aortic injury...
  71. doi request reprint Emergency department blood transfusion predicts early massive transfusion and early blood component requirement
    Timothy C Nunez
    Department of Surgery, Brooke Army Medical Center, Fort Sam Houston, Texas, USA
    Transfusion 50:1914-20. 2010
    ..The purpose of this study was to evaluate the ability of uncrossmatched transfusions in the emergency department (ED) to predict early (< 6 hr) massive transfusion (MT) of red blood cells (RBCs) and blood components...
  72. ncbi request reprint Does bicarbonate correct coagulation function impaired by acidosis in swine?
    Wenjun Z Martini
    US Army Institute of Surgical Research, Ft Sam Houston, Texas, USA
    J Trauma 61:99-106. 2006
    ..Acidosis can be neutralized with intravascular bicarbonate, but it is unclear if the coagulation defect is rapidly reversed. The effects of acidosis and bicarbonate neutralization on coagulation function were investigated in vivo...
  73. ncbi request reprint Cost-utility analysis of levetiracetam and phenytoin for posttraumatic seizure prophylaxis
    Bryan A Cotton
    Department of Surgery and the Center for Translational Injury Research, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma 71:375-9. 2011
    ..The purpose of this study was to evaluate whether phenytoin or levetiracetam would be more cost-effective in preventing early post-TBI seizures and reducing their negative impact on TBI outcomes...
  74. doi request reprint Tympanic membrane perforation and hearing loss from blast overpressure in Operation Enduring Freedom and Operation Iraqi Freedom wounded
    Amber E Ritenour
    United States Army Institute of Surgical Research, San Antonio, Texas, USA
    J Trauma 64:S174-8; discussion S178. 2008
    ..We wanted to determine the severity of perforation and its effect on hearing and combat readiness...
  75. ncbi request reprint The effect of recombinant factor VIIa on coagulopathic pigs with grade V liver injuries
    Martin A Schreiber
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, University of Texas at Houston, Houston, Texas, USA
    J Trauma 53:252-7; discussion 257-9. 2002
    ....
  76. pmc Human mesenchymal stem cells inhibit vascular permeability by modulating vascular endothelial cadherin/β-catenin signaling
    Shibani Pati
    Department of Surgery, University of Texas Health Sciences Center, Houston, TX, USA
    Stem Cells Dev 20:89-101. 2011
    ..Further, our results suggest that the mediator(s) of these vascular protective effects is a secreted factor(s) released as a result of direct MSC-EC interaction...
  77. pmc Plasma restoration of endothelial glycocalyx in a rodent model of hemorrhagic shock
    Rosemary A Kozar
    Department of Surgery, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Anesth Analg 112:1289-95. 2011
    ..We hypothesize that endothelial cell protection by plasma is due, in part, to its restoration of the endothelial glycocalyx and preservation of syndecan-1 after hemorrhagic shock...
  78. doi request reprint Ocular injury reduction from ocular protection use in current combat operations
    Roger Thomas
    Brooke Army Medical Center, Fort Sam Houston, Texas, USA
    J Trauma 66:S99-103. 2009
    ..This study attempts to quantify the effect of military combat eye protection on the incidence of ocular injury among US service members engaged in current combat operations...
  79. doi request reprint Guidelines for the prevention of infection after combat-related injuries
    Duane R Hospenthal
    Brooke Army Medical Center, US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 64:S211-20. 2008
    ....
  80. ncbi request reprint An emergency medical bag set for long-range aeromedical transportation
    David J Barillo
    Burn Flight Team, US Army Institute of Surgical Research, Ft Sam, Houston, Texas, USA
    Am J Disaster Med 3:79-86. 2008
    ....
  81. pmc Methods for improved hemorrhage control
    John B Holcomb
    Trauma Division, US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    Crit Care 8:S57-60. 2004
    ..The most important of these new drugs are injectable hemostatics, fibrin foams, and dressings. The available animal studies are encouraging and human studies are required...
  82. pmc Optimal use of blood in trauma patients
    John B Holcomb
    Division of Acute Care Surgery, Center for Translational Injury Research, University of Texas Health Science Center, 6410 Fannin St, Suite 1100 Houston, TX 77030, USA
    Biologicals 38:72-7. 2010
    ..This review will address the issues raised above and describe recent trauma patient outcome data utilizing predetermined plasma:platelet:RBC transfusion ratios and an ongoing prospective observational trauma transfusion study...
  83. ncbi request reprint Effects of low temperature on shear-induced platelet aggregation and activation
    Jian ning Zhang
    Section of Thrombosis Research, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Trauma 57:216-23. 2004
    ....
  84. ncbi request reprint Superior mesenteric artery occlusion models shock-induced gut ischemia-reperfusion
    Rosemary A Kozar
    Department of Surgery, University of Texas Houston, Houston, TX 77030, USA
    J Surg Res 116:145-50. 2004
    ..The purpose of the current study was to compare SMAO to a standard model of controlled hemorrhage (CH) and uncontrolled hemorrhage (UH)...
  85. pmc Admission hypo- or hyperthermia and survival after trauma in civilian and military environments
    Charles E Wade
    US Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    Int J Emerg Med 4:35. 2011
    ..abstract:..
  86. ncbi request reprint Risk factors for hepatic morbidity following nonoperative management: multicenter study
    Rosemary A Kozar
    University of Texas, Houston 77030, USA
    Arch Surg 141:451-8; discussion 458-9. 2006
    ..Early risk factors for hepatic-related morbidity in patients undergoing initial nonoperative management of complex blunt hepatic injuries can be accurately identified...
  87. doi request reprint Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients
    John B Holcomb
    United States Army Institute of Surgical Research, Ft Sam Houston, TX 78234, USA
    Ann Surg 248:447-58. 2008
    ....
  88. pmc Traditional transfusion practices are changing
    John B Holcomb
    Center for Translational Injury Research, University of Texas Health Science Center, 6410 Fannin, Suite 1100, Houston, TX 77030, USA
    Crit Care 14:162. 2010
    ..Finally, it appears that transfusion therapy is becoming driven by physiology...
  89. doi request reprint Complications after fasciotomy revision and delayed compartment release in combat patients
    Amber E Ritenour
    United States Army Institute of Surgical Research, San Antonio, Texas, USA
    J Trauma 64:S153-61; discussion S161-2. 2008
    ..Rapid air evacuation may delay treatment of patients with evolving extremity compartment syndrome. We investigated the impact of fasciotomy revision and delayed compartment release on combat casualties after air evacuation...
  90. doi request reprint Challenges to effective research in acute trauma resuscitation: consent and endpoints
    John B Holcomb
    Center for Translational Injury Research, University of Texas Health Science Center at Houston, 6410 Fannin St, Houston, TX, USA
    Shock 35:107-13. 2011
    ..The consensus was that more discussion was needed and that consideration of new endpoints for clinical trials in emergency trauma research was a worthwhile and necessary goal...
  91. pmc Optimal use of blood products in severely injured trauma patients
    John B Holcomb
    Division of Acute Care Surgery and Center for Translational Injury Research, University of Texas Health Science Center, Houston, TX 77030, USA
    Hematology Am Soc Hematol Educ Program 2010:465-9. 2010
    ....
  92. ncbi request reprint Complications of nonoperative management of high-grade blunt hepatic injuries
    Rosemary A Kozar
    Department of Surgery, University of Texas Houston, Houston, TX 77030, USA
    J Trauma 59:1066-71. 2005
    ..The purpose of the present study was therefore to define hepatic-related complications and associated treatment modalities in patients undergoing nonoperative management of high-grade blunt hepatic injuries...
  93. doi request reprint A clarion to recommit and reaffirm burn rehabilitation
    Reginald L Richard
    Burn Rehabilitation Department, Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Burn Care Res 29:425-32. 2008
    ..The article discusses areas for change and the challenges facing burn rehabilitation. Finally, the relegation and acceptance of this responsibility are addressed...
  94. ncbi request reprint Treatment of an acquired coagulopathy with recombinant activated factor VII in a damage-control patient
    John B Holcomb
    Department of Trauma and Critical Care, University of Texas Health Science Center, Houston, TX 77030, USA
    Mil Med 170:287-90. 2005
    ..We report the use of recombinant activated factor VII for a male patient who was injured in a motor vehicle accident. We also summarize the animal studies and clinical trials that have been reported...
  95. ncbi request reprint Application of a granular mineral-based hemostatic agent (QuikClot) to reduce blood loss after grade V liver injury in swine
    Anthony E Pusateri
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 57:555-62; discussion 562. 2004
    ..This study determined the efficacy of QuikClot, a hemostatic agent, in reducing blood loss and mortality in a standardized model of severe liver injury as well as the consequences of its use...
  96. ncbi request reprint The Pope Air Force Base aircraft crash and burn disaster
    David W Mozingo
    US Army Institute of Surgical Research, Brooke Army Medical Center, Fort Sam Houston, Texas, USA
    J Burn Care Rehabil 26:132-40. 2005
    ..Lessons learned from this incident have utility in the planning of future response to such disasters...
  97. pmc Fresh frozen plasma increases adhesion molecule expression on human pulmonary endothelial cells
    Phillip A Letourneau
    Department of Surgery, University of Texas Medical School at Houston, Houston, Texas 77030, USA
    J Surg Res 163:317-22. 2010
    ..We hypothesized that aged plasma (d 5 FFP) would be pro-inflammatory to the endothelium compared with fresh plasma (d 0 FFP)...
  98. doi request reprint ABO blood group as a potential risk factor for venous thromboembolism in acutely injured patients
    Sarah K Muellner
    Center for Translational Injury Research, Houston, TX, USA
    Thromb Haemost 105:5-13. 2011
    ..In addition, ABH antigens alter plasma levels of vWF via clearance mechanisms, which are in turn mediated by ADAMTS13. ABO blood group is a risk factor for VTE that warrants further investigation in trauma patients...
  99. doi request reprint Error rates resulting from anemia can be corrected in multiple commonly used point-of-care glucometers
    Elizabeth A Mann
    US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 64:15-20; discussion 20-1. 2008
    ..The purpose of this study was to analyze error rates of three additional POC glucometer brands and determine mathematical correction formulas for each...
  100. ncbi request reprint Effects of recombinant activated factor VII in traumatic nonsurgical intracranial hemorrhage
    Christopher E White
    U S Army of Surgical Research, Brooke Army Medical Center, San Antonio, Texas, USA
    Curr Surg 63:310-7. 2006
    ..To determine whether treatment with recombinant activated factor VII (rFVIIa) will prevent progression of bleeding in nonsurgical hemorrhagic traumatic brain injury (TBI)...
  101. ncbi request reprint In vivo bleeding time and in vitro thrombelastography measurements are better indicators of dilutional hypothermic coagulopathy than prothrombin time
    Bijan S Kheirabadi
    US Army Institute of Surgical Research, Fort Sam, Houston, Texas 78234 6315, USA
    J Trauma 62:1352-9; discussion 1359-61. 2007
    ..5. However, the utility of these values as a screening test is unknown. We examined different coagulation tests to determine the best predictor of coagulopathic bleeding and mortality in a small animal hemorrhage model...