John B Holcomb

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital
    Matthew A Borgman
    Brooke Army Medical Center, Fort Sam Houston, TX, USA
    J Trauma 63:805-13. 2007
  2. pmc Admission hypo- or hyperthermia and survival after trauma in civilian and military environments
    Charles E Wade
    US Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    Int J Emerg Med 4:35. 2011
  3. ncbi request reprint Potential value of protocols in substantially bleeding trauma patients
    John B Holcomb
    Division of Acute Care Surgery, Center for Translational Injury Research, University of Texas Health Science Center, Houston, Texas, USA
    Curr Opin Anaesthesiol 26:215-20. 2013
  4. pmc The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks
    John B Holcomb
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, University of Texas Health Science Center at Houston, 6410 Fannin, Ste 1100, Houston, TX 77030, USA
    JAMA Surg 148:127-36. 2013
  5. doi request reprint Admission rapid thrombelastography can replace conventional coagulation tests in the emergency department: experience with 1974 consecutive trauma patients
    John B Holcomb
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Ann Surg 256:476-86. 2012
  6. pmc Duration of red blood cell storage is associated with increased incidence of deep vein thrombosis and in hospital mortality in patients with traumatic injuries
    Philip C Spinella
    Department of Pediatrics, Connecticut Children s Medical Center, 282 Washington Street, Hartford, CT 06106, USA
    Crit Care 13:R151. 2009
  7. pmc Traumatic brain injury and resuscitation with blood products: what should we do?
    Bryan C Oh
    Department of Neurosurgery, University of Texas Health Sciences Center, Houston, TX 77030, USA
    Crit Care 15:172. 2011
  8. doi request reprint Increased platelet:RBC ratios are associated with improved survival after massive transfusion
    John B Holcomb
    Division of Acute Care Surgery, Center for Translational Injury Research, University of Texas Health Sciences Center, Houston, Texas 77030, USA
    J Trauma 71:S318-28. 2011
  9. doi request reprint Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients
    John B Holcomb
    United States Army Institute of Surgical Research, Ft Sam Houston, TX 78234, USA
    Ann Surg 248:447-58. 2008
  10. pmc Optimal use of blood products in severely injured trauma patients
    John B Holcomb
    Division of Acute Care Surgery and Center for Translational Injury Research, University of Texas Health Science Center, Houston, TX 77030, USA
    Hematology Am Soc Hematol Educ Program 2010:465-9. 2010

Collaborators

Detail Information

Publications182 found, 100 shown here

  1. ncbi request reprint The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital
    Matthew A Borgman
    Brooke Army Medical Center, Fort Sam Houston, TX, USA
    J Trauma 63:805-13. 2007
    ..The risk of death from hemorrhagic shock increases in this population. To treat the coagulopathy of trauma, some have suggested early, aggressive correction using a 1:1 ratio of plasma to red blood cell (RBC) units...
  2. pmc Admission hypo- or hyperthermia and survival after trauma in civilian and military environments
    Charles E Wade
    US Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    Int J Emerg Med 4:35. 2011
    ..abstract:..
  3. ncbi request reprint Potential value of protocols in substantially bleeding trauma patients
    John B Holcomb
    Division of Acute Care Surgery, Center for Translational Injury Research, University of Texas Health Science Center, Houston, Texas, USA
    Curr Opin Anaesthesiol 26:215-20. 2013
    ..This review will discuss the recent changes and advancement of early traumatic coagulopathy and the important role of substantial bleeding protocols (SBPs)...
  4. pmc The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks
    John B Holcomb
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, University of Texas Health Science Center at Houston, 6410 Fannin, Ste 1100, Houston, TX 77030, USA
    JAMA Surg 148:127-36. 2013
    ..To relate in-hospital mortality to early transfusion of plasma and/or platelets and to time-varying plasma:red blood cell (RBC) and platelet:RBC ratios...
  5. doi request reprint Admission rapid thrombelastography can replace conventional coagulation tests in the emergency department: experience with 1974 consecutive trauma patients
    John B Holcomb
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Ann Surg 256:476-86. 2012
    ..We have previously shown that admission r-TEG results are available faster than CCTs and predict pulmonary embolism. We hypothesized that r-TEGs more reliably predict blood component transfusion than CCTs...
  6. pmc Duration of red blood cell storage is associated with increased incidence of deep vein thrombosis and in hospital mortality in patients with traumatic injuries
    Philip C Spinella
    Department of Pediatrics, Connecticut Children s Medical Center, 282 Washington Street, Hartford, CT 06106, USA
    Crit Care 13:R151. 2009
    ..To determine if duration of RBC storage is associated with adverse outcomes we studied critically ill trauma patients requiring transfusion...
  7. pmc Traumatic brain injury and resuscitation with blood products: what should we do?
    Bryan C Oh
    Department of Neurosurgery, University of Texas Health Sciences Center, Houston, TX 77030, USA
    Crit Care 15:172. 2011
    ..Currently, the optimum fluid resuscitation paradigm for patients with both severe traumatic brain injury and other injuries requiring significant volume resuscitation is not clear...
  8. doi request reprint Increased platelet:RBC ratios are associated with improved survival after massive transfusion
    John B Holcomb
    Division of Acute Care Surgery, Center for Translational Injury Research, University of Texas Health Sciences Center, Houston, Texas 77030, USA
    J Trauma 71:S318-28. 2011
    ..However, outcomes associated with platelet transfusions are poorly characterized. We hypothesized that increased platelet:red blood cells (RBC) ratios would decrease hemorrhagic death and improve survival after massive transfusion (MT)...
  9. doi request reprint Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients
    John B Holcomb
    United States Army Institute of Surgical Research, Ft Sam Houston, TX 78234, USA
    Ann Surg 248:447-58. 2008
    ....
  10. pmc Optimal use of blood products in severely injured trauma patients
    John B Holcomb
    Division of Acute Care Surgery and Center for Translational Injury Research, University of Texas Health Science Center, Houston, TX 77030, USA
    Hematology Am Soc Hematol Educ Program 2010:465-9. 2010
    ....
  11. doi request reprint Challenges to effective research in acute trauma resuscitation: consent and endpoints
    John B Holcomb
    Center for Translational Injury Research, University of Texas Health Science Center at Houston, 6410 Fannin St, Houston, TX, USA
    Shock 35:107-13. 2011
    ..The consensus was that more discussion was needed and that consideration of new endpoints for clinical trials in emergency trauma research was a worthwhile and necessary goal...
  12. pmc Optimal use of blood in trauma patients
    John B Holcomb
    Division of Acute Care Surgery, Center for Translational Injury Research, University of Texas Health Science Center, 6410 Fannin St, Suite 1100 Houston, TX 77030, USA
    Biologicals 38:72-7. 2010
    ..This review will address the issues raised above and describe recent trauma patient outcome data utilizing predetermined plasma:platelet:RBC transfusion ratios and an ongoing prospective observational trauma transfusion study...
  13. pmc Traditional transfusion practices are changing
    John B Holcomb
    Center for Translational Injury Research, University of Texas Health Science Center, 6410 Fannin, Suite 1100, Houston, TX 77030, USA
    Crit Care 14:162. 2010
    ..Finally, it appears that transfusion therapy is becoming driven by physiology...
  14. doi request reprint Use of recombinant factor VIIa in US military casualties for a five-year period
    Charles E Wade
    Center for Translational Injury Research and Department of Surgery, University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma 69:353-9. 2010
    ..This study was undertaken to assess how deployed physicians are using rFVIIa and its impact on casualty outcomes...
  15. doi request reprint Admission rapid thrombelastography predicts development of pulmonary embolism in trauma patients
    Bryan A Cotton
    Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 72:1470-5; discussion 1475-7. 2012
    ..The purpose of this study was to identify whether admission rapid-thrombelastography (r-TEG) could identify patients at risk of developing pulmonary embolism (PE) during their hospital stay...
  16. doi request reprint The impact of missing trauma data on predicting massive transfusion
    Amber W Trickey
    Department of Surgery, Inova Fairfax Hospital, Falls Church, Virginia, USA
    J Trauma Acute Care Surg 75:S68-74. 2013
    ..Three blood transfusion prediction models were evaluated using an observational trauma data set with valid missing data...
  17. pmc Application of the Berlin definition in PROMMTT patients: the impact of resuscitation on the incidence of hypoxemia
    Bryce R H Robinson
    Division of Trauma Critical Care, Department of Surgery, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Trauma Acute Care Surg 75:S61-7. 2013
    ..Acute lung injury following trauma resuscitation remains a concern despite recent advances. With the use of the PROMMTT study population, the risk of hypoxemia and potential modifiable risk factors are studied...
  18. pmc Do-not-resuscitate orders in trauma patients may bias mortality-based effect estimates: an evaluation using the PROMMTT study
    Charles E Wade
    Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 75:S89-96. 2013
    ..We determined the frequency, timing, and impact on mortality-based effect estimates for patients with DNR orders in the Prospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study...
  19. doi request reprint Impact of closure at the first take back: complication burden and potential overutilization of damage control laparotomy
    Quinton M Hatch
    Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma 71:1503-11. 2011
    ....
  20. pmc A latent class model for defining severe hemorrhage: experience from the PROMMTT study
    Mohammad H Rahbar
    Biostatistics Epidemiology Research Design Core, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, Texas, USA
    J Trauma Acute Care Surg 75:S82-8. 2013
    ..We show how a latent class model could improve the accuracy of identifying the SH patients...
  21. pmc Resuscitate early with plasma and platelets or balance blood products gradually: findings from the PROMMTT study
    Deborah J Del Junco
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 75:S24-30. 2013
    ..To differentiate the association of in-hospital mortality with early plasma or platelet transfusion from that with delayed but gradually balanced ratios, we developed a separate analytic approach...
  22. doi request reprint Hyperfibrinolysis at admission is an uncommon but highly lethal event associated with shock and prehospital fluid administration
    Bryan A Cotton
    Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 73:365-70; discussion 370. 2012
    ..To further strengthen this hypothesis, we created an in vitro hemodilution model to improve our mechanistic understanding of the early HF...
  23. doi request reprint Fasciotomy rates in operations enduring freedom and iraqi freedom: association with injury severity and tourniquet use
    John F Kragh
    US Army Institute of Surgical Research USAISR, Fort Sam Houston, TX, USA
    J Orthop Trauma 25:134-9. 2011
    ..To compare fasciotomy rates and Injury Severity Scores (ISSs) before and after tourniquets were fielded for combat casualties in March 2005...
  24. pmc Purposeful variable selection and stratification to impute missing Focused Assessment with Sonography for Trauma data in trauma research
    Paul A Fuchs
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 75:S75-81. 2013
    ..Owing to variability in patients' injuries and trauma care, these data are unlikely to be missing completely at random, raising concern for validity when analyses exclude patients with missing values...
  25. pmc Clinical and mechanistic drivers of acute traumatic coagulopathy
    Mitchell Jay Cohen
    Division of General Surgery, Department of Surgery, School of Medicine, University of California San Francisco, San Francisco, California, USA
    J Trauma Acute Care Surg 75:S40-7. 2013
    ..The PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study provided a unique opportunity to characterize coagulation and the effects of resuscitation on ATC after severe trauma...
  26. doi request reprint Cryoprecipitate use in the PROMMTT study
    John B Holcomb
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 75:S31-9. 2013
    ..Our objectives were to identify patterns and predictors of cryoprecipitate use and determine whether transfusing cryoprecipitate was associated with improved survival...
  27. pmc Early resuscitation intensity as a surrogate for bleeding severity and early mortality in the PROMMTT study
    Elaheh Rahbar
    Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, Texas, USA
    J Trauma Acute Care Surg 75:S16-23. 2013
    ....
  28. pmc Coordination and management of multicenter clinical studies in trauma: Experience from the PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) Study
    Mohammad H Rahbar
    Biostatistics, Epidemiology, and Research Design Core, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA
    Resuscitation 83:459-64. 2012
    ....
  29. doi request reprint The effect of recombinant activated factor VII on mortality in combat-related casualties with severe trauma and massive transfusion
    Philip C Spinella
    US Army Institute of Surgical Research, San Antonio, Texas, USA
    J Trauma 64:286-93; discussion 293-4. 2008
    ....
  30. ncbi request reprint Evolution of burn resuscitation in operation Iraqi freedom
    Kevin K Chung
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Burn Care Res 27:606-11. 2006
  31. pmc Waiver of consent in noninterventional, observational emergency research: the PROMMTT experience
    Erin E Fox
    Biostatistics Epidemiology Research Design Core, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Trauma Acute Care Surg 75:S3-8. 2013
    ..The goal of this article was to examine the rationale and tradeoffs of using waiver of consent in PROMMTT...
  32. ncbi request reprint Fresh frozen plasma should be given earlier to patients requiring massive transfusion
    Ernest A Gonzalez
    Department of Surgery, University of Texas Houston Medical School, Houston, Texas, USA
    J Trauma 62:112-9. 2007
    ..The hypothesis for this study is that our pre-intensive care unit (ICU) massive transfusion (MT) protocol does not adequately correct coagulopathy, and that early uncorrected coagulopathy is predictive of mortality...
  33. doi request reprint Global evacuation of burn patients does not increase the incidence of venous thromboembolic complications
    Kevin K Chung
    Clinical Division, U S Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 65:19-24. 2008
    ..We hypothesized global evacuation results in increased VTE rates...
  34. doi request reprint Effect of recombinant factor VIIa as an adjunctive therapy in damage control for wartime vascular injuries: a case control study
    Charles J Fox
    Department of Surgery, Walter Reed Army Medical Center, Washington, DC 20307, USA
    J Trauma 66:S112-9. 2009
    ..The primary aim of this study was to assess the effect of rFVIIa use during DCR for vascular trauma and the impact on vessel repair...
  35. doi request reprint A novel biologic hemostatic dressing (fibrin patch) reduces blood loss and resuscitation volume and improves survival in hypothermic, coagulopathic Swine with grade V liver injury
    Angel V Delgado
    US Army Institute of Surgical Research, San Antonio, Texas, USA
    J Trauma 64:75-80. 2008
    ..This study evaluated the efficacy of a biologic hemostatic fibrin patch (FP) to control coagulopathic bleeding and prevent death in a porcine model of severe liver injury with hemodilution and hypothermia...
  36. ncbi request reprint Infectious complications of noncombat trauma patients provided care at a military trauma center
    Heather C Yun
    San Antonio Military Medical Center, Fort Sam Houston, TX, USA
    Mil Med 175:317-23. 2010
    ..In burned patients, infection was associated with total body surface area burned and preexisting conditions (p < 0.01). Enhanced infection control in targeted trauma populations may improve outcomes...
  37. ncbi request reprint Both primary and secondary abdominal compartment syndrome can be predicted early and are harbingers of multiple organ failure
    Zsolt Balogh
    Department of Surgery, Memorial Hermann Hospital, University of Texas at Houston Medical School, 77030, USA
    J Trauma 54:848-59; discussion 859-61. 2003
    ..The purpose of this study was to compare the epidemiology of primary and secondary ACS and develop early prediction models in a high-risk cohort who were treated in a similar fashion...
  38. ncbi request reprint Fresh whole blood transfusions in coalition military, foreign national, and enemy combatant patients during Operation Iraqi Freedom at a U.S. combat support hospital
    Philip C Spinella
    U S Army Institute of Surgical Research, San Antonio, Texas, USA
    World J Surg 32:2-6. 2008
    ....
  39. ncbi request reprint Rapid thrombelastography delivers real-time results that predict transfusion within 1 hour of admission
    Bryan A Cotton
    Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma 71:407-14; discussion 414-7. 2011
    ..The purpose of this pilot study was to evaluate the timeliness of r-TEG results, their correlation with CCTs, and the ability of r-TEG to predict early blood transfusion...
  40. doi request reprint Abdominal complications after severe burns
    Katharine W Markell
    United States Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    J Am Coll Surg 208:940-7; discussion 947-9. 2009
    ..We sought to define incidence, outcomes, and associated factors, such as excessive resuscitation volume and treatment issues...
  41. pmc An emergency department thawed plasma protocol for severely injured patients
    Zayde A Radwan
    Center for Translational Injury Research, The University of Texas Health Science Center, 6410 Fannin St, 1100 20 UPB, Houston, TX 77030, USA
    JAMA Surg 148:170-5. 2013
    ....
  42. doi request reprint Prolonged prothrombin time after recombinant activated factor VII therapy in critically bleeding trauma patients is associated with adverse outcomes
    Neil R McMullin
    US Army Institute of Surgical Research, BAMC Fort Sam Houston, Texas, USA
    J Trauma 69:60-9. 2010
    ....
  43. doi request reprint Better hemostatic profiles of never-frozen liquid plasma compared with thawed fresh frozen plasma
    Nena Matijevic
    Center for Translational Injury Research, Department of Surgery, University of Texas Health Science Center at Houston, Texas 77030, USA
    J Trauma Acute Care Surg 74:84-90; discussion 90-1. 2013
    ..We characterized changes in LQP hemostatic potential during 26 days of cold storage...
  44. doi request reprint Incidence and severity of combat hand burns after All Army Activity message
    Travis L Hedman
    United States Army Institute of Surgical Research, Burn Center, Fort Sam Houston, TX 78234, USA
    J Trauma 64:S169-72; discussion S172-3. 2008
    ..Our purpose was to assess the effectiveness of the ALARACT in reducing the incidence and severity of hand burns...
  45. doi request reprint A predictive model for massive transfusion in combat casualty patients
    Daniel F McLaughlin
    United States Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    J Trauma 64:S57-63; discussion S63. 2008
    ..We postulated that evaluation of clinical variables routinely assessed upon admission would allow identification of these patients for earlier, more effective intervention...
  46. doi request reprint Damage control resuscitation for vascular surgery in a combat support hospital
    Charles J Fox
    Department of Surgery, Walter Reed Army Medical Center, Washington, DC, USA
    J Trauma 65:1-9. 2008
    ..We hypothesized that limb preservation could be successful when the damage control approach combines advanced resuscitative strategies and modern vascular techniques...
  47. doi request reprint Glucose variability is associated with high mortality after severe burn
    Heather F Pidcoke
    Department of Surgery, University of Texas Health Science Center, San Antonio, Texas 78234 6315, USA
    J Trauma 67:990-5. 2009
    ..High glucose variability creates challenges to glycemic control and may be a marker of poor outcome. We wondered whether glycemic variability alone might identify patients at higher risk of death...
  48. doi request reprint Thrombelastography is better than PT, aPTT, and activated clotting time in detecting clinically relevant clotting abnormalities after hypothermia, hemorrhagic shock and resuscitation in pigs
    Wenjun Z Martini
    The US Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue, Ft Sam Houston, TX 78234, USA
    J Trauma 65:535-43. 2008
    ..In this study, we investigated the independent and combined effects of hypothermia and hemorrhage with resuscitation on coagulation in swine and evaluated clinically relevant tests of coagulation...
  49. pmc Aged plasma transfusion increases mortality in a rat model of uncontrolled hemorrhage
    Phillip A Letourneau
    Center for Translational Injury Research, University of Texas Health Science Center, Houston, Texas, USA
    J Trauma 71:1115-9. 2011
    ..We hypothesized that FFP5 would increase bleeding and mortality compared with FFP0 in a rodent bioassay model of uncontrolled liver hemorrhage...
  50. doi request reprint Predictors of early acute lung injury at a combat support hospital: a prospective observational study
    Jason W Edens
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    J Trauma 69:S81-6. 2010
    ..The purpose of this study was to determine whether this strategy is associated with an increased incidence of ALI...
  51. doi request reprint Causes of mortality by autopsy findings of combat casualties and civilian patients admitted to a burn unit
    Ruben Gomez
    Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA
    J Am Coll Surg 208:348-54. 2009
    ..Approximately 5% of combat-related injuries include burns. Previous studies have shown similar mortality rates between military and civilian burn casualties; but causes of death were not detailed...
  52. doi request reprint Influence of resuscitation fluids, fresh frozen plasma and antifibrinolytics on fibrinolysis in a thrombelastography-based, in-vitro, whole-blood model
    Vadim Kostousov
    Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Blood Coagul Fibrinolysis 24:489-97. 2013
    ..Low concentrations of TXA or ACA reversed hyperfibrinolysis, but the efficient concentrations were dependent on the degree of fibrinolysis and whole-blood dilution...
  53. pmc Prehospital intravenous fluid is associated with increased survival in trauma patients
    David A Hampton
    Division of Trauma, Critical Care and Acute Care Surgery, Department of Surgery, School of Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Trauma Acute Care Surg 75:S9-15. 2013
    ..We hypothesized that receiving any prehospital IVF is associated with increased survival in trauma patients compared with receiving no prehospital IVF...
  54. doi request reprint Effects of synthetic versus natural colloid resuscitation on inducing dilutional coagulopathy and increasing hemorrhage in rabbits
    Bijan S Kheirabadi
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 64:1218-28; discussion 1228-9. 2008
    ..We investigated the effects of resuscitation with this fluid, as well as other colloids, on coagulation and uncontrolled bleeding in rabbits subjected to a splenic injury...
  55. ncbi request reprint Longterm outcomes after combat casualty emergency department thoracotomy
    Jason W Edens
    United States Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    J Am Coll Surg 209:188-97. 2009
    ..The incidence, survival, and blood product use after emergency department thoracotomy (EDT) in combat casualties is unknown...
  56. doi request reprint Anemia causes hypoglycemia in intensive care unit patients due to error in single-channel glucometers: methods of reducing patient risk
    Heather F Pidcoke
    United States Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    Crit Care Med 38:471-6. 2010
    ..We hypothesized that point-of-care glucometer error due to anemia is prevalent, can be corrected mathematically, and correction uncovers occult hypoglycemia during intensive insulin therapy...
  57. ncbi request reprint The impact of intensive insulin protocols and restrictive blood transfusion strategies on glucose measurement in American Burn Association (ABA) verified burn centers
    Elizabeth A Mann
    United States Army Institute of Surgical Research, Brooke Army Medical Center, San Antonio, TX, USA
    J Burn Care Res 29:718-23. 2008
    ..The combination of a higher prevalence of hypoglycemia in the presence of near universal anemia is concerning, particularly given the pervasiveness of glucometer use among burn centers...
  58. pmc Damage control resuscitation is associated with a reduction in resuscitation volumes and improvement in survival in 390 damage control laparotomy patients
    Bryan A Cotton
    Department of Surgery, The University of Texas Health Science Center, Houston, TX, USA
    Ann Surg 254:598-605. 2011
    ..To determine whether implementation of damage control resuscitation (DCR) in patients undergoing damage control laparotomy (DCL) translates into improved survival...
  59. doi request reprint Survival with emergency tourniquet use to stop bleeding in major limb trauma
    John F Kragh
    US Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    Ann Surg 249:1-7. 2009
    ..The purpose of this study was to determine if emergency tourniquet use saved lives...
  60. doi request reprint Differential expression of the immunoinflammatory response in trauma patients: burn vs. non-burn
    James E Mace
    U S Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    Burns 38:599-606. 2012
    ..Although previous studies evaluated cytokine levels after trauma, differences between patients with burn and non-burn trauma have not been assessed systematically...
  61. doi request reprint Combining early coagulation and inflammatory status improves prediction of mortality in burned and nonburned trauma patients
    Myung S Park
    US Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    J Trauma 64:S188-94. 2008
    ..We hypothesized that combining markers of these processes and standard clinical indices would improve early prediction of in- hospital mortality in burned and nonburned trauma patients...
  62. doi request reprint Incidence of systemic fungal infection and related mortality following severe burns
    Clinton K Murray
    Infectious Disease Service, San Antonio Military Medical Center, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA
    Burns 34:1108-12. 2008
    ....
  63. pmc Do not resuscitate status, not age, affects outcomes after injury: an evaluation of 15,227 consecutive trauma patients
    Sasha D Adams
    Department of Surgery, University of Texas Health Science Center, Houston, Texas, USA
    J Trauma Acute Care Surg 74:1327-30. 2013
    ..We hypothesized that the increased likelihood of DNR status in older patients alters age-adjusted mortality rates in trauma...
  64. pmc Thromboelastography as a better indicator of hypercoagulable state after injury than prothrombin time or activated partial thromboplastin time
    Myung S Park
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 67:266-75; discussion 275-6. 2009
    ..We hypothesized that a hypercoagulable state exists in patients early after severe injury and that the pattern of clotting and fibrinolysis are similar between burned and nonburn trauma patients...
  65. doi request reprint Red blood cells accelerate the onset of clot formation in polytrauma and hemorrhagic shock
    Nicholas J Spoerke
    Division of Trauma, Critical Care, and Acute Care Surgery, Department of Surgery, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Trauma 69:1054-9; discussion 1059-61. 2010
    ..We aimed to determine the effect of RBCs on clotting parameters by comparing resuscitation regimens containing RBCs and plasma with those containing plasma alone...
  66. ncbi request reprint Contribution of bacterial and viral infections to attributable mortality in patients with severe burns: an autopsy series
    Laurie C D'Avignon
    Infectious Disease Service, San Antonio Military Medical Center, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA
    Burns 36:773-9. 2010
    ..aureus remain the most common cause of bacteria related mortality early in the hospital course. Viral infections are also associated with mortality and numbers have remained stable when compared to data from prior years...
  67. doi request reprint Variations between level I trauma centers in 24-hour mortality in severely injured patients requiring a massive transfusion
    Charles E Wade
    Department of Surgery, and The Center for Translational Injury Research, The University of Texas Health Science Center at Houston, Houston, Texas, USA
    J Trauma 71:S389-93. 2011
    ..We hypothesized differences among centers in 24-hour mortality could predominantly be accounted for by differences in transfusion practices as well as patient characteristics...
  68. doi request reprint US Army two-surgeon teams operating in remote Afghanistan--an evaluation of split-based Forward Surgical Team operations
    Shawn C Nessen
    US Army Institute of Surgical Research, San Antonio, Texas, USA
    J Trauma 66:S37-47. 2009
    ..The effectiveness of these 10-person teams is unknown and outcome data has not been previously reported in the literature. This article evaluates the effectiveness of one split FST during a 14-month period in remote Afghanistan...
  69. doi request reprint Management of coagulopathy in the patients with multiple injuries: results from an international survey of clinical practice
    David B Hoyt
    Department of Surgery, University of California, Irvine, Orange, CA 92868, USA
    J Trauma 65:755-64; discussion 764-5. 2008
    ..Bleeding is one of the leading causes of preventable death after traumatic injury. Trauma-associated coagulopathy complicates the control of bleeding. The published approaches on the management of this coagulopathy differ significantly...
  70. doi request reprint Joint Theater Trauma System implementation of burn resuscitation guidelines improves outcomes in severely burned military casualties
    Jody L Ennis
    United States Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    J Trauma 64:S146-51; discussion S151-2. 2008
    ..To help standardize care, burn resuscitation guidelines (BRG) were devised along with a burn flow sheet (BFS) and disseminated via the new operational Joint Theater Trauma System to assist deployed providers...
  71. pmc Multiple levels of degradation diminish hemostatic potential of thawed plasma
    Nena Matijevic
    Department of Surgery and Center for Translational Injury Research, University of Texas Health Science Center Houston, Houston, Texas 77030, USA
    J Trauma 70:71-9; discussion 79-80. 2011
    ..However, there are no clinical data analyzing the effects of the approved 5-day storage on plasma. We hypothesize that the hemostatic potential (HP) of freshly thawed (FFP-0) was superior to plasma stored for 5 days (FFP-5)...
  72. doi request reprint Injuries from explosions: physics, biophysics, pathology, and required research focus
    Howard R Champion
    Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    J Trauma 66:1468-77; discussion 1477. 2009
    ....
  73. doi request reprint Long range transport of war-related burn casualties
    Evan M Renz
    United States Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    J Trauma 64:S136-44; discussion S144-5. 2008
    ..This study characterizes the military burn casualties transported by each team and reports associated outcomes...
  74. pmc Modulation of syndecan-1 shedding after hemorrhagic shock and resuscitation
    Ricky J Haywood-Watson
    Department of Surgery, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
    PLoS ONE 6:e23530. 2011
    ..These data suggest that plasma based resuscitation preserved endothelial syndecan-1 and maintained endothelial integrity, and may help to explain the protective effects of fresh frozen plasma after hemorrhagic shock...
  75. doi request reprint Battle casualty survival with emergency tourniquet use to stop limb bleeding
    John F Kragh
    US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Emerg Med 41:590-7. 2011
    ..In a previous study conducted at a combat support hospital in Iraq, we reported the major lifesaving benefits of emergency tourniquets to stop bleeding in major limb trauma. Morbidity associated with tourniquet use was minor...
  76. doi request reprint Trauma, transfusions, and use of recombinant factor VIIa: A multicenter case registry report of 380 patients from the Western Trauma Association
    M Margaret Knudson
    Department of Surgery, University of California, San Francisco, USA
    J Am Coll Surg 212:87-95. 2011
    ..We hypothesized that we could describe the setting in which rFVIIa would be most successful in arresting hemorrhage after injury...
  77. ncbi request reprint Risks associated with fresh whole blood and red blood cell transfusions in a combat support hospital
    Philip C Spinella
    U S Army Institute of Surgical Research, San Antonio, TX, USA
    Crit Care Med 35:2576-81. 2007
    ..Fresh whole blood (FWB) and red blood cells (RBCs) are transfused to injured casualties in combat support hospitals. We evaluated the risks of FWB and RBCs transfused to combat-related casualties...
  78. doi request reprint Impact of extremity amputation on combat wounded undergoing exploratory laparotomy
    Christopher E White
    United States Army Institute of Surgical Research, Fort Sam Houston, San Antonio, Texas 78234, USA
    J Trauma 66:S86-92. 2009
    ..The purpose of this study was to determine the association of TA on blood/blood product usage, emergency department (ED) and operating room (OR) times, and mortality in those undergoing exploratory laparotomy after combat injury...
  79. doi request reprint Impact of improved combat casualty care on combat wounded undergoing exploratory laparotomy and massive transfusion
    John W Simmons
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    J Trauma 71:S82-6. 2011
    ..The objective was to evaluate the evolution and impact of improved combat casualty care at different time periods of combat operations...
  80. ncbi request reprint Evaluation of tris-hydroxymethylaminomethane on reversing coagulation abnormalities caused by acidosis in pigs
    Wenjun Z Martini
    U S Army Institute of Surgical Research, Ft Sam Houston, TX, USA
    Crit Care Med 35:1568-74. 2007
    ..To investigate the effect of tris-hydroxymethylaminomethane (THAM) pH neutralization on reversing coagulation abnormalities caused by acidosis...
  81. doi request reprint Military return to duty and civilian return to work factors following burns with focus on the hand and literature review
    Ted T Chapman
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    J Burn Care Res 29:756-62. 2008
    ..There is a need for a consensus data set and corresponding statistical approach used to evaluate RTW and duty outcomes after burn injury...
  82. ncbi request reprint The military emergency tourniquet program's lessons learned with devices and designs
    John F Kragh
    U S Army Institute of Surgical Research, 3611 Rawley E Chambers Avenue, Fort Sam Houston, TX 78234, USA
    Mil Med 176:1144-52. 2011
    ..The purpose of this study is to report the device lessons learned from an emergency tourniquet program and, in particular, to emphasize analysis of discarded devices recovered after clinical use...
  83. pmc Defining when to initiate massive transfusion: a validation study of individual massive transfusion triggers in PROMMTT patients
    Rachael A Callcut
    Division of General Surgery, Department of Surgery, School of Medicine, University of California San Francisco, San Francisco, California 94110, USA
    J Trauma Acute Care Surg 74:59-65, 67-8; discussion 66-7. 2013
    ..Early predictors of massive transfusion (MT) would prevent undertriage of patients likely to require MT. This study validates triggers using the Prospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study...
  84. ncbi request reprint Manual vital signs reliably predict need for life-saving interventions in trauma patients
    John B Holcomb
    US Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    J Trauma 59:821-8; discussion 828-9. 2005
    ..In this study, we determined whether the addition of diagnostic equipment improved the predictive power of vital signs and scores obtained only by physical examination...
  85. pmc Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries
    Philip C Spinella
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 66:S69-76. 2009
    ..We hypothesized that warm fresh whole blood (WFWB) transfusion would be associated with improved survival in patients with trauma compared with those transfused only stored component therapy (CT)...
  86. doi request reprint Association of shock, coagulopathy, and initial vital signs with massive transfusion in combat casualties
    Claire R Larson
    Department of Surgery, United States Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    J Trauma 69:S26-32. 2010
    ..The objective of this study was to compare the results of an MT prediction model and actual MT incidence in combat casualties...
  87. pmc Protective effects of fresh frozen plasma on vascular endothelial permeability, coagulation, and resuscitation after hemorrhagic shock are time dependent and diminish between days 0 and 5 after thaw
    Shibani Pati
    Department of Surgery and Center for Translational Injury Research, University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma 69:S55-63. 2010
    ..We further hypothesized that the beneficial effects of FFP would diminish over 5 days of routine storage at 4 degrees C...
  88. pmc Creation, implementation, and maturation of a massive transfusion protocol for the exsanguinating trauma patient
    Timothy C Nunez
    Department of Surgery, Brooke Army Medical Center, Fort Sam Houston, Texas, USA
    J Trauma 68:1498-505. 2010
    ..Once implemented, this process may lead to improved clinical outcomes and decreased overall blood utilization with extremely small wastage of vital blood products...
  89. ncbi request reprint Incidence of primary blast injury in US military overseas contingency operations: a retrospective study
    Amber E Ritenour
    US Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    Ann Surg 251:1140-4. 2010
    ..The present retrospective study was performed to determine the incidence and outcome of primary blast injury and to identify possible changes over the course of the conflicts between 2003 and 2006...
  90. doi request reprint The utility of intravascular ultrasound compared to angiography in the diagnosis of blunt traumatic aortic injury
    Ali Azizzadeh
    University of Texas Medical School Houston, Memorial Hermann Heart and Vascular Institute, Houston, Tex, USA
    J Vasc Surg 53:608-14. 2011
    ..Additional imaging is required when CTA studies are equivocal. The purpose of this study is to evaluate the utility of intravascular ultrasound (IVUS) versus angiography in the diagnosis of TAI...
  91. ncbi request reprint Burns sustained in combat explosions in Operations Iraqi and Enduring Freedom (OIF/OEF explosion burns)
    David S Kauvar
    United States Army Institute of Surgical Research, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA
    Burns 32:853-7. 2006
    ..Many OIF/OEF burns result from the enemy's detonation of explosives. We reviewed these to evaluate mission impact and provide recommendations for improved combat burn protection. Data were compared to those from the Vietnam War...
  92. doi request reprint Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage
    Carl J Hauser
    Department of Surgery, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02216, USA
    J Trauma 69:489-500. 2010
    ..Traumatic coagulopathy contributes to early death by exsanguination and late death in multiple organ failure. Recombinant Factor VIIa (rFVIIa, NovoSeven) is a procoagulant that might limit bleeding and improve trauma outcomes...
  93. ncbi request reprint The effect of recombinant factor VIIa on noncoagulopathic pigs with grade V liver injuries
    Martin A Schreiber
    Department of Surgery and Medicine, Baylor College of Medicine, Houston, TX, USA
    J Am Coll Surg 196:691-7. 2003
    ..This study was performed to determine if rFVIIa would reduce blood loss after a Grade V liver injury in noncoagulopathic pigs when used as sole therapy...
  94. doi request reprint High ratios of plasma and platelets to packed red blood cells do not affect mortality in nonmassively transfused patients
    Chitra N Sambasivan
    Division of Trauma, Critical Care and Acute Care Surgery, Department of Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Trauma 71:S329-36. 2011
    ..We aimed to determine the effect of high ratios of fresh frozen plasma (FFP) and platelets (PLT) to packed red blood cells (PRBC) in nonmassively transfused patients...
  95. ncbi request reprint Current use of damage-control laparotomy, closure rates, and predictors of early fascial closure at the first take-back
    Quinton M Hatch
    Department of Surgery and the Center for Translational Injury Research, The University of Texas Health Science Center, Houston, Texas, USA
    J Trauma 70:1429-36. 2011
    ..The purpose of the current study was to determine (1) the current rate of DCL, (2) the percentage of DCLs that are closed at first take-back, and (3) possible physiologic and resuscitative parameters predicting early fascial closure...
  96. pmc Comparison between civilian burns and combat burns from Operation Iraqi Freedom and Operation Enduring Freedom
    Steven E Wolf
    Burn Center, United States Army Institute of Surgical Research, 3400 Rawley E Chambers, Fort Sam Houston, TX 79234, USA
    Ann Surg 243:786-92; discussion 792-5. 2006
    ..To assess outcome differences between locally burned civilians and military personnel burned in a distant combat zone treated in the same facility...
  97. doi request reprint The effect of a hypobaric, hypoxic environment on acute skeletal muscle edema after ischemia-reperfusion injury in rats
    Amber E Ritenour
    United States Army Institute of Surgical Research, San Antonio, Texas 78234 6315, USA
    J Surg Res 160:253-9. 2010
    ..The present study investigated whether the mild hypobaric, hypoxic conditions of simulated flight during muscle reperfusion worsened muscle edema and muscle injury in an established animal model...
  98. ncbi request reprint Wartime burn care in Iraq: 28th Combat Support Hospital, 2003
    Louis R Stout
    U S Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    Mil Med 172:1148-53. 2007
    ..Shortly after arrival, it was designated as the hospital primarily responsible for burn care for the U.S. military in Iraq. This report reviews the experience of the CSH with burn care during combat operations...
  99. ncbi request reprint The clinical and laboratory response to recombinant factor VIIA in trauma and surgical patients with acquired coagulopathy
    Neil R McMullin
    United States Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    Curr Surg 63:246-51. 2006
    ..In bleeding patients who are coagulopathic, the clinical response to administration of recombinant factor VIIa (rFVIIa) relates to the changes in prothrombin time (PT)...
  100. doi request reprint Continuous renal replacement therapy improves survival in severely burned military casualties with acute kidney injury
    Kevin K Chung
    United States Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX 78234, USA
    J Trauma 64:S179-85; discussion S185-7. 2008
    ..We wondered whether early use of continuous renal replacement therapy (CRRT) changes outcomes in severely burned military casualties with predetermined criteria for acute kidney injury...
  101. doi request reprint Combat wounds in operation Iraqi Freedom and operation Enduring Freedom
    Brett D Owens
    U S Army Institute of Surgical Research, Ft Sam Houston, Texas, USA
    J Trauma 64:295-9. 2008
    ..There have been no large cohort reports detailing the wounding patterns and mechanisms in the current conflicts in Iraq and Afghanistan...