S K Highlander

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Genome sequence of Fusobacterium nucleatum subspecies polymorphum - a genetically tractable fusobacterium
    Sandor E Karpathy
    Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America Department of Microbiology and Molecular Genetics, University of Texas Medical School, Houston, Texas, United States of America
    PLoS ONE 2:e659. 2007
  2. pmc Large scale variation in Enterococcus faecalis illustrated by the genome analysis of strain OG1RF
    Agathe Bourgogne
    Division of Infectious Diseases, Department of Medicine, University of Texas Medical School, Houston, Texas 77030, USA
    Genome Biol 9:R110. 2008
  3. ncbi request reprint Complete nucleotide sequence of a P2 family lysogenic bacteriophage, varphiMhaA1-PHL101, from Mannheimia haemolytica serotype A1
    Sarah K Highlander
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Virology 350:79-89. 2006
  4. ncbi request reprint Molecular genetic analysis of virulence in Mannheimia (pasteurella) haemolytica
    S K Highlander
    Baylor College of Medicine, Department of Molecular Virology and Microbiology, One Baylor Plaza, MS BCM280, Houston, TX 77030, USA
    Front Biosci 6:D1128-50. 2001
  5. pmc Inactivation of Pasteurella (Mannheimia) haemolytica leukotoxin causes partial attenuation of virulence in a calf challenge model
    S K Highlander
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Infect Immun 68:3916-22. 2000
  6. pmc A putative leucine zipper activator of Pasteurella haemolytica leukotoxin transcription and the potential for modulation of its synthesis by slipped-strand mispairing
    S K Highlander
    Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    Infect Immun 65:3970-5. 1997
  7. ncbi request reprint Isolation and characterization of the integration host factor genes of Pasteurella haemolytica
    S K Highlander
    Department of Microbiology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    FEMS Microbiol Lett 146:181-8. 1997
  8. ncbi request reprint The restriction-modification system of Pasteurella haemolytica is a member of a new family of type I enzymes
    S K Highlander
    Department of Microbiology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Gene 178:89-96. 1996
  9. pmc Use of operon fusions in Mannheimia haemolytica to identify environmental and cis-acting regulators of leukotoxin transcription
    A M Marciel
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Infect Immun 69:6231-9. 2001
  10. pmc Expression of the Pasteurella haemolytica leukotoxin is inhibited by a locus that encodes an ATP-binding cassette homolog
    S K Highlander
    Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas 77030
    Infect Immun 61:3942-51. 1993

Collaborators

  • George M Weinstock
  • Susan Kinder Haake
  • Joseph F Petrosino
  • Jason Gioia
  • Agathe Bourgogne
  • Huaiyang Jiang
  • Xiang Qin
  • Shailaja Yerrapragada
  • Sandor E Karpathy
  • A M Marciel
  • Guan Chen
  • Danielle A Garsin
  • Yue Shang
  • Kavindra V Singh
  • Jouko Sillanpaa
  • Cesar A Arias
  • Gabrielle Williams
  • Hua Shen
  • Donna Muzny
  • Sreedhar R Nallapareddy
  • Meng Zhao
  • Kristina A Fox
  • Christian Buhay
  • Lei Chen
  • Shannon Dugan-Rocha
  • Shahreen Chowdhury
  • Richard A Gibbs
  • Yan Ding
  • Vittal P Prakash
  • Barbara E Murray
  • Arash Maadani
  • George E Fox
  • Yamei Liu

Detail Information

Publications10

  1. pmc Genome sequence of Fusobacterium nucleatum subspecies polymorphum - a genetically tractable fusobacterium
    Sandor E Karpathy
    Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America Department of Microbiology and Molecular Genetics, University of Texas Medical School, Houston, Texas, United States of America
    PLoS ONE 2:e659. 2007
    ..These findings indicate that F. nucleatum subsp. polymorphum is proficient at horizontal gene transfer and that exchange with the Firmicutes, particularly the Clostridia, is common...
  2. pmc Large scale variation in Enterococcus faecalis illustrated by the genome analysis of strain OG1RF
    Agathe Bourgogne
    Division of Infectious Diseases, Department of Medicine, University of Texas Medical School, Houston, Texas 77030, USA
    Genome Biol 9:R110. 2008
    ..Enterococcus faecalis has emerged as a major hospital pathogen. To explore its diversity, we sequenced E. faecalis strain OG1RF, which is commonly used for molecular manipulation and virulence studies...
  3. ncbi request reprint Complete nucleotide sequence of a P2 family lysogenic bacteriophage, varphiMhaA1-PHL101, from Mannheimia haemolytica serotype A1
    Sarah K Highlander
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Virology 350:79-89. 2006
    ..Southern blot analysis revealed phiMhaA1-PHL101 sequences in other A1 isolates as well as in serotype A5, A6, A9, and A12 strains of M. haemolytica, but not in the related organisms, Mannheimia glucosida or Pasteurella trehalosi...
  4. ncbi request reprint Molecular genetic analysis of virulence in Mannheimia (pasteurella) haemolytica
    S K Highlander
    Baylor College of Medicine, Department of Molecular Virology and Microbiology, One Baylor Plaza, MS BCM280, Houston, TX 77030, USA
    Front Biosci 6:D1128-50. 2001
    ..haemolytica and will help to drive development of new vaccines to prevent shipping fever...
  5. pmc Inactivation of Pasteurella (Mannheimia) haemolytica leukotoxin causes partial attenuation of virulence in a calf challenge model
    S K Highlander
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Infect Immun 68:3916-22. 2000
    ..The wild-type and mutant strains were equally capable of colonizing the upper respiratory tracts of the calves. In this study, the P. haemolytica lktC mutant was shown to be less virulent than the parent strain...
  6. pmc A putative leucine zipper activator of Pasteurella haemolytica leukotoxin transcription and the potential for modulation of its synthesis by slipped-strand mispairing
    S K Highlander
    Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    Infect Immun 65:3970-5. 1997
    ..Extracts containing AlxA can bind to a leukotoxin promoter fragment...
  7. ncbi request reprint Isolation and characterization of the integration host factor genes of Pasteurella haemolytica
    S K Highlander
    Department of Microbiology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    FEMS Microbiol Lett 146:181-8. 1997
    ..haemolytica sequences are distantly related to those from other bacteria. Most significant amino acid differences were restricted to the amino-terminal domains of the predicted peptides...
  8. ncbi request reprint The restriction-modification system of Pasteurella haemolytica is a member of a new family of type I enzymes
    S K Highlander
    Department of Microbiology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Gene 178:89-96. 1996
    ..influenzae proteins into a new group which we labeled the Type Id R-M family. Expression of the P. haemolytica R-M genes in E. coli was inefficient and is likely to be a consequence of the unusual codon usage in P. haemolytica genes...
  9. pmc Use of operon fusions in Mannheimia haemolytica to identify environmental and cis-acting regulators of leukotoxin transcription
    A M Marciel
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Infect Immun 69:6231-9. 2001
    ..The lktC::cat operon fusion was also used to demonstrate that, like that of other RTX toxins, leukotoxin transcription is environmentally regulated. Roles for iron deprivation and temperature change were identified...
  10. pmc Expression of the Pasteurella haemolytica leukotoxin is inhibited by a locus that encodes an ATP-binding cassette homolog
    S K Highlander
    Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas 77030
    Infect Immun 61:3942-51. 1993
    ..LapA is predicted to be the nucleotide-binding component of this transport system and shares homology with the Clp family of proteases...