Genomes and Genes

Species

George I Henderson

Summary

Affiliation: Texas Tech University Health Sciences Center
Country: USA

Publications

  1. pmc Overexpression of Nrf2 protects cerebral cortical neurons from ethanol-induced apoptotic death
    Madhusudhanan Narasimhan
    Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Mol Pharmacol 80:988-99. 2011

Collaborators

  • Madhusudhanan Narasimhan
  • Mary Latha Rathinam
  • Amanjot Kaur Riar
  • Lenin Mahimainathan

Detail Information

Publications1

  1. pmc Overexpression of Nrf2 protects cerebral cortical neurons from ethanol-induced apoptotic death
    Madhusudhanan Narasimhan
    Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Mol Pharmacol 80:988-99. 2011
    ..These studies illustrate the importance of Nrf2-dependent maintenance of GSH homeostasis in cerebral cortical neurons in the defense against oxidative stress and apoptotic death elicited by ETOH exposure...

Research Grants20

  1. ETOH Teratogenesis: Apoptotic Death of Cortical Neurons
    George Henderson; Fiscal Year: 2007
    ..abstract_text> ..
  2. ALCOHOL TERATOGENESIS--APOPTOSIS AND TOXIC ALDEHYDES
    George Henderson; Fiscal Year: 2002
    ..These studies are based on new/novel developments and should significantly add to our understanding of the toxic effects of E on fetal tissues. ..
  3. Neuroprotection from ETOH-mediated apoptosis: Nrf2/ARE control of GSH homeostasis
    George I Henderson; Fiscal Year: 2010
    ..It is mediated by Nrf2/ARE driven gene expressions which can be controlled. Linterventions will utilize augmentation of the "3-glutamyl cycle" or its components which will be manipulated at the molecular level. ..
  4. Astrocyte Control of Toxin-Mediated Neuron Death: Role of the Gamma-Glutamyl Path
    George I Henderson; Fiscal Year: 2010
    ..We will determine how the toxins damage it (to prevent this from happening), and how this system is normally controlled. ..