R Heidelberger

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Roles of ATP in depletion and replenishment of the releasable pool of synaptic vesicles
    Ruth Heidelberger
    Department of Neurobiology and Anatomy and The W M Keck Center for the Neurobiology of Learning and Memory, University of Texas Medical School, Houston, Texas 77030, USA
    J Neurophysiol 88:98-106. 2002
  2. ncbi request reprint Differential distribution of synaptotagmin immunoreactivity among synapses in the goldfish, salamander, and mouse retina
    Ruth Heidelberger
    Department of Neurobiology and Anatomy and The W M Keck Center for the Neurobiology of Learning and Memory, University of Texas Houston Medical School, Houston, USA
    Vis Neurosci 20:37-49. 2003
  3. ncbi request reprint Vesicle priming and depriming: a SNAP decision
    Ruth Heidelberger
    Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, Houston, TX 77030 USA, USA
    Neuron 41:311-3. 2004
  4. ncbi request reprint Capacitance measurements in the mouse rod bipolar cell identify a pool of releasable synaptic vesicles
    Zhen Yu Zhou
    Department of Neurobiology and Anatomy, MSB 7 046, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77025, USA
    J Neurophysiol 96:2539-48. 2006
  5. pmc Mechanisms of tonic, graded release: lessons from the vertebrate photoreceptor
    Ruth Heidelberger
    Department of Neurobiology and Anatomy and the Graduate School of Biomedical Sciences, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77030, USA
    J Physiol 585:663-7. 2007
  6. pmc Regulation of presynaptic calcium in a mammalian synaptic terminal
    Qun Fang Wan
    Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, Houston, TX 77030, USA
    J Neurophysiol 108:3059-67. 2012
  7. ncbi request reprint Mechanisms contributing to tonic release at the cone photoreceptor ribbon synapse
    Barbara Innocenti
    The W M Keck Center for the Neurobiology of Learning and Memory, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77025, USA
    J Neurophysiol 99:25-36. 2008
  8. ncbi request reprint ATP is required at an early step in compensatory endocytosis in synaptic terminals
    R Heidelberger
    Department of Neurobiology and Anatomy, W M Keck Center for the Neurobiology of Learning and Memory, University of Texas Houston Health Science Center, Houston, Texas 77030, USA
    J Neurosci 21:6467-74. 2001
  9. ncbi request reprint Multiple components of membrane retrieval in synaptic terminals revealed by changes in hydrostatic pressure
    Ruth Heidelberger
    Department of Neurobiology, The W M Keck Center for the Neurobiology of Learning and Memory, University of Texas Medical School, Houston, Texas 77030, USA
    J Neurophysiol 88:2509-17. 2002
  10. pmc Quantitative analysis of synaptic release at the photoreceptor synapse
    Gabriel Duncan
    Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, Houston, Texas, USA
    Biophys J 98:2102-10. 2010

Research Grants

  1. MECHANISMS OF NEUROTRANSMISSION IN VERTEBRATE RETINA
    Ruth Heidelberger; Fiscal Year: 2007
  2. Mechanisms of Neurotransmisson in Vertebrate Retina
    Ruth Heidelberger; Fiscal Year: 2010

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Roles of ATP in depletion and replenishment of the releasable pool of synaptic vesicles
    Ruth Heidelberger
    Department of Neurobiology and Anatomy and The W M Keck Center for the Neurobiology of Learning and Memory, University of Texas Medical School, Houston, Texas 77030, USA
    J Neurophysiol 88:98-106. 2002
    ....
  2. ncbi request reprint Differential distribution of synaptotagmin immunoreactivity among synapses in the goldfish, salamander, and mouse retina
    Ruth Heidelberger
    Department of Neurobiology and Anatomy and The W M Keck Center for the Neurobiology of Learning and Memory, University of Texas Houston Medical School, Houston, USA
    Vis Neurosci 20:37-49. 2003
    ..Labeling with these antibodies in the salamander and mouse retina revealed species-specific differences, indicating that synaptotagmin epitopes can vary across species as well as among synapses...
  3. ncbi request reprint Vesicle priming and depriming: a SNAP decision
    Ruth Heidelberger
    Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, Houston, TX 77030 USA, USA
    Neuron 41:311-3. 2004
    ..Pre- and posttranslational modifications of SNAP-25 may therefore affect synaptic strength...
  4. ncbi request reprint Capacitance measurements in the mouse rod bipolar cell identify a pool of releasable synaptic vesicles
    Zhen Yu Zhou
    Department of Neurobiology and Anatomy, MSB 7 046, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77025, USA
    J Neurophysiol 96:2539-48. 2006
    ..The robustness of this measure suggests that capacitance measurements may be used in the mouse rod bipolar cell to compare pool size across treatment conditions...
  5. pmc Mechanisms of tonic, graded release: lessons from the vertebrate photoreceptor
    Ruth Heidelberger
    Department of Neurobiology and Anatomy and the Graduate School of Biomedical Sciences, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77030, USA
    J Physiol 585:663-7. 2007
    ....
  6. pmc Regulation of presynaptic calcium in a mammalian synaptic terminal
    Qun Fang Wan
    Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, Houston, TX 77030, USA
    J Neurophysiol 108:3059-67. 2012
    ..Given its roles in the regulation of intraterminal Ca(2+) at rest and after a stimulus-evoked Ca(2+) rise, the PMCA is poised to modulate luminance coding and adaptation to background illumination in the mammalian rod bipolar cell...
  7. ncbi request reprint Mechanisms contributing to tonic release at the cone photoreceptor ribbon synapse
    Barbara Innocenti
    The W M Keck Center for the Neurobiology of Learning and Memory, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77025, USA
    J Neurophysiol 99:25-36. 2008
    ..Along with lower rates of depletion, additional mechanisms, such as replenishment from distal reserve pools and the fast recycling of vesicles, may further contribute to the maintenance of graded, tonic release from cone photoreceptors...
  8. ncbi request reprint ATP is required at an early step in compensatory endocytosis in synaptic terminals
    R Heidelberger
    Department of Neurobiology and Anatomy, W M Keck Center for the Neurobiology of Learning and Memory, University of Texas Houston Health Science Center, Houston, Texas 77030, USA
    J Neurosci 21:6467-74. 2001
    ..Given that the capacitance technique detects changes in membrane surface area, ATP must be required for the membrane fission step or at a step that is a prerequisite for membrane fission...
  9. ncbi request reprint Multiple components of membrane retrieval in synaptic terminals revealed by changes in hydrostatic pressure
    Ruth Heidelberger
    Department of Neurobiology, The W M Keck Center for the Neurobiology of Learning and Memory, University of Texas Medical School, Houston, Texas 77030, USA
    J Neurophysiol 88:2509-17. 2002
    ..Given its dramatic inhibitory effect on membrane retrieval, we suggest that hydrostatic pressure be carefully controlled when studying endocytosis in the whole cell recording configuration...
  10. pmc Quantitative analysis of synaptic release at the photoreceptor synapse
    Gabriel Duncan
    Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, Houston, Texas, USA
    Biophys J 98:2102-10. 2010
    ..In addition, partial sensor occupancy due to slow unbinding may contribute to the linearization of the first synapse in vision...
  11. pmc Syntaxin 3B is essential for the exocytosis of synaptic vesicles in ribbon synapses of the retina
    L Curtis
    Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, TX 77030, USA
    Neuroscience 166:832-41. 2010
    ..These experiments demonstrate that syntaxin 3B is an important factor for synaptic vesicle exocytosis in ribbon synapses of the vertebrate retina...
  12. pmc SV2 acts via presynaptic calcium to regulate neurotransmitter release
    Qun Fang Wan
    The Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, Houston, TX 77030, USA
    Neuron 66:884-95. 2010
    ..Thus, SV2 controls key aspects of synaptic functionality via its ability to regulate presynaptic Ca(2+), suggesting a potential new target for therapeutic intervention in the treatment of epilepsy...
  13. ncbi request reprint Distribution of proteins associated with synaptic vesicle endocytosis in the mouse and goldfish retina
    David M Sherry
    University of Houston College of Optometry, Houston, Texas 77204 2020, USA
    J Comp Neurol 484:440-57. 2005
    ..Thus, as with exocytosis, mechanisms of synaptic membrane retrieval may be tuned by the precise complement of proteins expressed within the synaptic terminal...
  14. pmc Synaptic transmission at retinal ribbon synapses
    Ruth Heidelberger
    Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Prog Retin Eye Res 24:682-720. 2005
    ..We also consider the modulation of exocytosis at photoreceptor synapses, with an emphasis on the regulation of calcium channels...
  15. pmc Synaptic vesicle dynamics in mouse rod bipolar cells
    Qun Fang Wan
    Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, Texas 77025, USA
    Vis Neurosci 25:523-33. 2008
    ..A major difference is that the number of vesicles available for release is significantly smaller in the mouse rod bipolar cell, both as a function of the total number per neuron and on a per active zone basis...
  16. pmc Synaptotagmin-2 controls regulated exocytosis but not other secretory responses of mast cells
    Ernestina Melicoff
    Department of Pulmonary Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 284:19445-51. 2009
    ..Unlike neurons, the lack of Synaptotagmin-2 in mast cells was not associated with increased spontaneous exocytosis...
  17. ncbi request reprint Neuroscience: sensors and synchronicity
    Ruth Heidelberger
    Nature 450:623-5. 2007
  18. ncbi request reprint Illuminating the calcium sensor for exocytosis in a flash
    Ruth Heidelberger
    Nat Neurosci 8:402-4. 2005
  19. pmc A highly Ca2+-sensitive pool of vesicles contributes to linearity at the rod photoreceptor ribbon synapse
    Wallace B Thoreson
    Department of Ophthalmology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Neuron 42:595-605. 2004
    ..The low-order [Ca(2+)] dependence of release promotes a linear relationship between Ca(2+) entry and exocytosis that permits rods to relay information about small changes in illumination with high fidelity at the first synapse in vision...
  20. pmc Calcium-dependent binding of calmodulin to neuronal gap junction proteins
    Gary S Burr
    Department of Ophthalmology and Visual Science, University of Texas Health Science Center at Houston, USA
    Biochem Biophys Res Commun 335:1191-8. 2005
    ..The micromolar K(1/2)'s and rapid on and off rates suggest that this interaction may change dynamically in neurons, and may occur transiently when Ca2+ is elevated to a level that would occur in the near vicinity of an activated synapse...

Research Grants8

  1. MECHANISMS OF NEUROTRANSMISSION IN VERTEBRATE RETINA
    Ruth Heidelberger; Fiscal Year: 2007
    ..This will position us to study presynaptic mechanisms at the molecular level and examine the role of specific synaptic proteins implicated in disorders of vision. ..
  2. Mechanisms of Neurotransmisson in Vertebrate Retina
    Ruth Heidelberger; Fiscal Year: 2010
    ..In addition, it will provide general information about how neurons communicate that is critical for understanding brain diseases such as epilepsy, dementia and schizophrenia. ..