PHILIP HASTINGS

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Adaptive amplification: an inducible chromosomal instability mechanism
    P J Hastings
    Department of Molecular and Human Genetics Baylor College of Medicine One Baylor Plaza Houston, TX 77030, USA
    Cell 103:723-31. 2000
  2. ncbi request reprint In pursuit of a molecular mechanism for adaptive gene amplification
    P J Hastings
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Room T809 Mail Stop 225, Houston, TX 77030 3411, USA
    DNA Repair (Amst) 1:111-23. 2002
  3. ncbi request reprint Antibiotic-induced lateral transfer of antibiotic resistance
    P J Hastings
    Department of Molecular and Human Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030 3411, USA
    Trends Microbiol 12:401-4. 2004
  4. pmc Adaptive amplification and point mutation are independent mechanisms: evidence for various stress-inducible mutation mechanisms
    P J Hastings
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    PLoS Biol 2:e399. 2004
  5. pmc A microhomology-mediated break-induced replication model for the origin of human copy number variation
    P J Hastings
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Genet 5:e1000327. 2009

Research Grants

  1. Mechanism of adaptive amplification
    PHILIP HASTINGS; Fiscal Year: 2004
  2. Mechanisms of Adaptive Amplification
    PHILIP HASTINGS; Fiscal Year: 2007
  3. Mechanisms of Adaptive Amplification
    Philip J Hastings; Fiscal Year: 2010
  4. Mechanisms of Adaptive Amplification
    PHILIP HASTINGS; Fiscal Year: 2009

Detail Information

Publications5

  1. ncbi request reprint Adaptive amplification: an inducible chromosomal instability mechanism
    P J Hastings
    Department of Molecular and Human Genetics Baylor College of Medicine One Baylor Plaza Houston, TX 77030, USA
    Cell 103:723-31. 2000
    ..Instead, adaptive mutation and amplification are parallel routes of inducible genetic instability allowing rapid evolution under stress, and escape from growth inhibition...
  2. ncbi request reprint In pursuit of a molecular mechanism for adaptive gene amplification
    P J Hastings
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Room T809 Mail Stop 225, Houston, TX 77030 3411, USA
    DNA Repair (Amst) 1:111-23. 2002
    ..We explore possible molecular mechanisms of adaptive amplification in the bacterial system and note parallels to chromosomal instability in other systems...
  3. ncbi request reprint Antibiotic-induced lateral transfer of antibiotic resistance
    P J Hastings
    Department of Molecular and Human Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030 3411, USA
    Trends Microbiol 12:401-4. 2004
    ..Several commonly used antibiotics induce the SOS response, potentially hastening genetic change and the evolution to resistance of pathogenic populations. The use of such antibiotics should be reconsidered...
  4. pmc Adaptive amplification and point mutation are independent mechanisms: evidence for various stress-inducible mutation mechanisms
    P J Hastings
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    PLoS Biol 2:e399. 2004
    ..We suggest that the availability of alternative pathways for genetic/evolutionary adaptation and clonal expansion under stress may be exploited during processes ranging from the evolution of drug resistance to cancer progression...
  5. pmc A microhomology-mediated break-induced replication model for the origin of human copy number variation
    P J Hastings
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Genet 5:e1000327. 2009
    ....

Research Grants9

  1. Mechanism of adaptive amplification
    PHILIP HASTINGS; Fiscal Year: 2004
    ..abstract_text> ..
  2. Mechanisms of Adaptive Amplification
    PHILIP HASTINGS; Fiscal Year: 2007
    ....
  3. Mechanisms of Adaptive Amplification
    Philip J Hastings; Fiscal Year: 2010
    ....
  4. Mechanisms of Adaptive Amplification
    PHILIP HASTINGS; Fiscal Year: 2009
    ....