Genomes and Genes
B A Hassan
Affiliation: Texas Medical Center
- Doing the MATH: is the mouse a good model for fly development?B A Hassan
Department of Molecular and Human Genetics, The Howard Hughes Medical Institute, Houston, Texas 77030 USA
Genes Dev 14:1852-65. 2000
- Math1: an essential gene for the generation of inner ear hair cellsN A Bermingham
Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Science 284:1837-41. 1999..Embryonic Math1-null mice failed to generate cochlear and vestibular hair cells. This gene is thus required for the genesis of hair cells...
- Functional conservation of atonal and Math1 in the CNS and PNSN Ben-Arie
Howard Hughes Medical Institute and Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Development 127:1039-48. 2000..These data demonstrate that both the mouse and fly homologs encode lineage identity information and, more interestingly, that some of the cells dependent on this information serve similar mechanoreceptor functions...
- atonal regulates neurite arborization but does not act as a proneural gene in the Drosophila brainB A Hassan
Howard Hughes Medical Institute, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Neuron 25:549-61. 2000..In contrast to its function in the PNS, ato does not act as a proneural gene in the embryonic brain. Instead, ato performs a novel function, regulating arborization during larval and pupal development by interacting with Notch...
- Proprioceptor pathway development is dependent on Math1N A Bermingham
Howard Hughes Medical Institute, One Baylor Plaza, Houston, TX 77030, USA
Neuron 30:411-22. 2001..We also identify three downstream genes of Math1 (Lh2A, Lh2B, and Barhl1) and establish that Math1 governs the development of multiple components of the proprioceptive pathway...
- From skin to nerve: flies, vertebrates and the first helixX J Quan
Laboratory of Neurogenetics, Department of Human Genetics, VIB and University of Leuven School of Medicine, 3000, Leuven, Belgium
Cell Mol Life Sci 62:2036-49. 2005..This review will focus on current studies of neural development in vertebrate and invertebrate PNS and on understanding how the bHLH domain structure encodes multiple functions required for neural specification...
- skittles, a Drosophila phosphatidylinositol 4-phosphate 5-kinase, is required for cell viability, germline development and bristle morphology, but not for neurotransmitter releaseB A Hassan
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, 77030, USA
Genetics 150:1527-37. 1998..Our analysis indicates that skittles is required for cell viability, germline development, and the proper structural development of sensory bristles. Surprisingly, we found no evidence for PIP5KI involvement in neural secretion...