Susan L Hamilton

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Ryanodine receptors
    Susan L Hamilton
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell Calcium 38:253-60. 2005
  2. ncbi request reprint RyR1 modulation by oxidation and calmodulin
    S L Hamilton
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Antioxid Redox Signal 2:41-5. 2000
  3. pmc A Ca2+-binding domain in RyR1 that interacts with the calmodulin binding site and modulates channel activity
    Liangwen Xiong
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, USA
    Biophys J 90:173-82. 2006
  4. ncbi request reprint Identification of cysteines involved in S-nitrosylation, S-glutathionylation, and oxidation to disulfides in ryanodine receptor type 1
    Paula Aracena-Parks
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 281:40354-68. 2006
  5. pmc Apocalmodulin and Ca2+ calmodulin-binding sites on the CaV1.2 channel
    Wei Tang
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    Biophys J 85:1538-47. 2003
  6. ncbi request reprint Regulation of voltage-gated Ca2+ channels by calmodulin
    D Brent Halling
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Sci STKE 2005:re15. 2005
  7. pmc RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice
    William J Durham
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 133:53-65. 2008
  8. pmc Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+* calmodulins
    Jennifer L Fallon
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:5135-40. 2009
  9. pmc Determinants in CaV1 channels that regulate the Ca2+ sensitivity of bound calmodulin
    D Brent Halling
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 284:20041-51. 2009
  10. ncbi request reprint Suramin interacts with the calmodulin binding site on the ryanodine receptor, RYR1
    Rao V L Papineni
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:49167-74. 2002

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Ryanodine receptors
    Susan L Hamilton
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell Calcium 38:253-60. 2005
    ..This review examines the current state of structural understanding of the RyR channel activation...
  2. ncbi request reprint RyR1 modulation by oxidation and calmodulin
    S L Hamilton
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Antioxid Redox Signal 2:41-5. 2000
    ..NO also has both a direct and an indirect effect: it blocks the ability of oxidants to generate intersubunit disulfide bonds and prevents apocalmodulin binding...
  3. pmc A Ca2+-binding domain in RyR1 that interacts with the calmodulin binding site and modulates channel activity
    Liangwen Xiong
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, USA
    Biophys J 90:173-82. 2006
    ....
  4. ncbi request reprint Identification of cysteines involved in S-nitrosylation, S-glutathionylation, and oxidation to disulfides in ryanodine receptor type 1
    Paula Aracena-Parks
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 281:40354-68. 2006
    ..In summary, we have identified a discrete subset of cysteines that are likely to be involved in the functional response of RyR1 to different redox modifications (S-nitrosylation, S-glutathionylation, and oxidation to disulfides)...
  5. pmc Apocalmodulin and Ca2+ calmodulin-binding sites on the CaV1.2 channel
    Wei Tang
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    Biophys J 85:1538-47. 2003
    ..Our data are consistent with a model in which apoCaM binding to the region around the IQ motif is necessary for the rapid binding of Ca(2+) to the C-lobe of CaM. Upon Ca(2+) binding, this lobe is likely to engage the A-C region...
  6. ncbi request reprint Regulation of voltage-gated Ca2+ channels by calmodulin
    D Brent Halling
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Sci STKE 2005:re15. 2005
    ..This review addresses the functional regulation of Cav1.2 and Cav2.1 by calmodulin and discusses how Ca2+ binding to a single calmodulin molecule can regulate opposing functions of the voltage-gated Ca2+ channels...
  7. pmc RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice
    William J Durham
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 133:53-65. 2008
    ..We propose a feed-forward cyclic mechanism that increases the temperature sensitivity of RyR1 activation and underlies heat stroke and sudden death. The cycle eventually produces a myopathy with damaged mitochondria...
  8. pmc Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+* calmodulins
    Jennifer L Fallon
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:5135-40. 2009
    ..2 channels...
  9. pmc Determinants in CaV1 channels that regulate the Ca2+ sensitivity of bound calmodulin
    D Brent Halling
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 284:20041-51. 2009
    ..Those residues appear to allow an interaction with calmodulin with one lobe Ca(2+)-bound and one lobe Ca(2+)-free. Our data also provide evidence for lobe-lobe interactions in calmodulin bound to Ca(V)1.2...
  10. ncbi request reprint Suramin interacts with the calmodulin binding site on the ryanodine receptor, RYR1
    Rao V L Papineni
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:49167-74. 2002
    ....
  11. ncbi request reprint Calmodulin interactions with IQ peptides from voltage-dependent calcium channels
    D J Black
    Department of Molecular Physiology and Biophysics, BCM 335, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Am J Physiol Cell Physiol 288:C669-76. 2005
    ....
  12. ncbi request reprint Structure of calmodulin bound to the hydrophobic IQ domain of the cardiac Ca(v)1.2 calcium channel
    Jennifer L Fallon
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Structure 13:1881-6. 2005
    ..These findings suggest that this structure could represent the conformation that calmodulin assumes in CDF...
  13. pmc AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation
    Johanna T Lanner
    Department of Molecular Physiology and Biophysics Baylor College of Medicine, Houston, Texas, USA
    Nat Med 18:244-51. 2012
    ..Our findings suggest that AICAR is probably effective in prophylactic treatment of humans with enhanced susceptibility to exercise- and/or heat-induced sudden death associated with RYR1 mutations...
  14. pmc The pore structure of the closed RyR1 channel
    Steven J Ludtke
    National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Structure 13:1203-11. 2005
    ..The kinked inner helix closely resembles the inner helix of the open MthK channel, suggesting that kinking alone does not open RyR1, as proposed for K+ channels...
  15. ncbi request reprint Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse
    Mihail G Chelu
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    FASEB J 20:329-30. 2006
    ..We conclude that the heterozygous expression of the Y522S mutation confers susceptibility to both heat- and anesthetic-induced MH responses...
  16. pmc Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior
    Charles A Hoeffer
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 60:832-45. 2008
    ..Our results indicate that FKBP12 plays a critical role in the regulation of mTOR-Raptor interactions, LTP, memory, and perseverative behaviors...
  17. pmc Biochemical properties of V91G calmodulin: A calmodulin point mutation that deregulates muscle contraction in Drosophila
    Bo Wang
    Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77251, USA
    Protein Sci 13:3285-97. 2004
    ..The predicted functional consequences of these changes are consonant with the in vivo phenotype, and indicate that D-RyR is one, if not the major, target affected by the V91G mutation in CaM...
  18. pmc Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel
    Irina I Serysheva
    National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:9610-5. 2008
    ..Taken together, these results provide a structural context for both channel gating and the consequences of certain malignant hyperthermia and central core disease-associated mutations in RyR1...
  19. ncbi request reprint Sites on calmodulin that interact with the C-terminal tail of Cav1.2 channel
    Liangwen Xiong
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 280:7070-9. 2005
    ..In conclusion, Ca(2+)-calmodulin assumes a novel conformation when part of a complex with the C-terminal tail of the Ca(V)1.2 alpha(1) subunit that is not duplicated by synthetic peptides corresponding to the putative binding motifs...
  20. ncbi request reprint A noncontiguous, intersubunit binding site for calmodulin on the skeletal muscle Ca2+ release channel
    Hongwei Zhang
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:8348-55. 2003
    ..G., Williams, B. Y., Strasburg, G. M., Beckingham, K., and Hamilton, S. L. (2000) Biochemistry 39, 7807-7812)...
  21. pmc Ryanodine receptors: structure, expression, molecular details, and function in calcium release
    Johanna T Lanner
    Baylor College of Medicine, Department of Molecular Physiology and Biophysics, Houston, Texas 77030, USA
    Cold Spring Harb Perspect Biol 2:a003996. 2010
    ..This chapter examines the current concepts of the structure, function and regulation of RyRs and assesses the current state of understanding of their roles in associated disorders...
  22. doi request reprint Superoxide-induced potentiation in the hippocampus requires activation of ryanodine receptor type 3 and ERK
    A Tara Huddleston
    Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA
    J Neurophysiol 99:1565-71. 2008
    ..Thus superoxide-induced potentiation requires the redox targeting of RyR3 and the subsequent activation of ERK...
  23. ncbi request reprint Regulation of voltage-gated Ca2+ channels by calmodulin
    D Brent Halling
    Department of Molecular Physiology and Biophysics, Baylor College Medicine, Houston, TX 77030, USA
    Sci STKE 2006:er1. 2006
    ..This review addresses the functional regulation of Cav1.2 and Cav2.1 by calmodulin and discusses how Ca2+ binding to a single calmodulin molecule can regulate opposing functions of the voltage-gated Ca2+ channels...
  24. pmc The skeletal muscle Ca2+ release channel has an oxidoreductase-like domain
    Matthew L Baker
    Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 99:12155-60. 2002
    ..Consistent with the prediction of an oxidoreductase domain, RyR1 binds [3H]NAD+, supporting a model in which RyR1 has a oxidoreductase-like domain that could function as a type of redox sensor...
  25. ncbi request reprint Altered excitation-contraction coupling with skeletal muscle specific FKBP12 deficiency
    Wei Tang
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    FASEB J 18:1597-9. 2004
    ..In highly used muscles such as the diaphragm, adaptation to the loss of FKBP12 occurs, possibly due to the increased Ca2+ influx...
  26. pmc Structure of Ca2+ release channel at 14 A resolution
    Irina I Serysheva
    National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Mol Biol 345:427-31. 2005
    ..This putative structure was computationally localized to the clamp-shaped region of RyR1, which has been implicated to have a regulatory role in the channel activity...
  27. ncbi request reprint Phosphorylation of ryanodine receptors
    Cristina I Danila
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Biol Res 37:521-5. 2004
    ..For example, PKA also phosphorylates phospholamban (PLB), altering the Sarco-endoplasmic reticulum Ca2+ ATPase (SERCA) activity. This review summarizes the major findings and controversies associated with phosphorylation of RyRs...
  28. ncbi request reprint FK506 binding protein 12/12.6 depletion increases endothelial nitric oxide synthase threonine 495 phosphorylation and blood pressure
    Cheng Long
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Tex 77030, USA
    Hypertension 49:569-76. 2007
    ..This molecular mechanism may, in part, explain rapamycin-induced hypertension...
  29. ncbi request reprint Regulation of ryanodine receptors by FK506 binding proteins
    Mihail G Chelu
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    Trends Cardiovasc Med 14:227-34. 2004
    ..6 could play a role in heart failure, CPVT, and ARVD2. Also discussed are the consequences of FKBP12 depletion to skeletal muscle and the possibility of FKBP12 involvement in certain forms of MH or CCD...
  30. ncbi request reprint Lobe-dependent regulation of ryanodine receptor type 1 by calmodulin
    Liang Wen Xiong
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    J Biol Chem 277:40862-70. 2002
    ..This interaction apparently depends on the native sequence or structure of the first few amino acids at the N terminus of calmodulin...
  31. ncbi request reprint Calmodulin modulation of proteins involved in excitation-contraction coupling
    Wei Tang
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, USA
    Front Biosci 7:d1583-9. 2002
    ..These findings raise questions about the role of calmodulin in excitation-contraction coupling in skeletal muscle...
  32. ncbi request reprint Effects of S-glutathionylation and S-nitrosylation on calmodulin binding to triads and FKBP12 binding to type 1 calcium release channels
    Paula Aracena
    FONDAP Center for Molecular Studies of the Cell, Facultad de Medicina, Universidad de Chile, Casilla 70005, Santiago 7, Chile
    Antioxid Redox Signal 7:870-81. 2005
    ..We discuss possible consequences of these redox modifications on RyR1-mediated Ca2+ release in physiological or pathological conditions...
  33. ncbi request reprint Dihydropyridine and ryanodine receptor binding after eccentric contractions in mouse skeletal muscle
    Christopher P Ingalls
    Muscle Biology Laboratory, Department of Kinesiology and Health, Georgia State University, Atlanta, GA 30303, USA
    J Appl Physiol (1985) 96:1619-25. 2004
    ..We also concluded that the loss in ryanodine receptors 3 days after injury is not the primary cause of excitation-contraction uncoupling at that time...
  34. ncbi request reprint S-glutathionylation decreases Mg2+ inhibition and S-nitrosylation enhances Ca2+ activation of RyR1 channels
    Paula Aracena
    Centro Fondo de Investigación Avanzada en Areas Prioritarias de Estudios Moleculares de la Célula, Facultad de Medicina, Universidad de Chile, Casilla 70005, Santiago 7, Chile
    J Biol Chem 278:42927-35. 2003
    ..Possible physiological and pathological implications of the activation of skeletal Ca2+ release channels by endogenous redox species are discussed...
  35. pmc Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy
    Prince J Kannankeril
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 103:12179-84. 2006
    ..Our results suggest that the R176Q mutation in RyR2 predisposes the heart to catecholamine-induced oscillatory calcium-release events that trigger a calcium-dependent ventricular arrhythmia...

Research Grants4

  1. Calcium Release and Cellular Calcium Signaling Domains
    Susan Hamilton; Fiscal Year: 2003
    ..We anticipate that a network of scientific collaborations will begin to develop as a consequence of this workshop. ..
  2. 2006 Muscle: Excitation/Contraction Coupling Gordan Conference
    Susan Hamilton; Fiscal Year: 2005
    ..This has become particularly relevant since recent work has demonstrated the muscle possesses calcium refilling pathways similar to those of non-excitable cells. ..
  3. MOLECULAR EXCITABILITY IN THE CARDIOVASCULAR SYSTEM
    Susan Hamilton; Fiscal Year: 2007
    ..We feel that our combination of faculty, curriculum and students will continue to yield high-quality scientist-educators. ..
  4. Basis of Muscle Dysfunction in Malignant Hyperthermia and Central Core Disease
    Susan Hamilton; Fiscal Year: 2006
    ....