Affiliation: Texas Medical Center
Haidari M, Ali M, Gangehei L, Chen M, Zhang W, Cybulsky M. Increased oxidative stress in atherosclerosis-predisposed regions of the mouse aorta. Life Sci. 2010;87:100-10 pubmed publisher
..Our study for the first time demonstrated an augmented oxidative stress in atherosclerosis-susceptible regions of the normal mouse aorta. ..
Haidari M, Zhang W, Willerson J, Dixon R. Disruption of endothelial adherens junctions by high glucose is mediated by protein kinase C-Î²-dependent vascular endothelial cadherin tyrosine phosphorylation. Cardiovasc Diabetol. 2014;13:105 pubmed publisher
..Our findings show that the high-concentration glucose-induced disruption of endothelial adherens junctions is mediated by tyrosine phosphorylation of VE-cad through PKC-Î² and MLC phosphorylation. ..
Haidari M, Zhang W, Chen Z, Ganjehei L, Warier N, Vanderslice P, et al
. Myosin light chain phosphorylation facilitates monocyte transendothelial migration by dissociating endothelial adherens junctions. Cardiovasc Res. 2011;92:456-65 pubmed publisher
..However, the underlying molecular mechanism has not been determined. We tested the hypothesis that the phosphorylation of myosin light chain (MLC) in ECs is crucial for the dissociation of adherens junctions during TEM of monocytes...
Haidari M, Zhang W, Willerson J, Dixon R. Correction to: Disruption of endothelial adherens junctions by high glucose is mediated by protein kinase C-?-dependent vascular endothelial cadherin tyrosine phosphorylation. Cardiovasc Diabetol. 2017;16:136 pubmed publisher
..The following should be considered the version of record and used for citation purposes: "Mehran Haidari, Wei Zhang, James T Willerson and Richard AF Dixon, Disruption of endothelial adherens junctions by high ..
Haidari M, Hajilooi M, Rafiei A, Rezaii A, Hoseinipanah S. E-selectin genetic variation as a susceptibility factor for ischemic stroke. Cerebrovasc Dis. 2009;28:26-32 pubmed publisher
..89, 95% CI: 2.84-12.21, p = 0.0001). Our study demonstrates that the E-selectin S128R and L554F polymorphisms are associated with susceptibility to ischemic stroke. ..
Haidari M, Zhang W, Ganjehei L, Ali M, Chen Z. Inhibition of MLC phosphorylation restricts replication of influenza virus--a mechanism of action for anti-influenza agents. PLoS ONE. 2011;6:e21444 pubmed publisher
..Our studies provide evidence that modulation of MLC phosphorylation is an underlying mechanism for the inhibitory effects of many anti-influenza compounds. ..
Haidari M, Zhang W, Chen Z, Ganjehei L, Mortazavi A, Warier N, et al
. Atorvastatin preserves the integrity of endothelial adherens junctions by inhibiting vascular endothelial cadherin tyrosine phosphorylation. Exp Cell Res. 2012;318:1673-84 pubmed publisher
..Our study introduces a novel pleiotropic effect of atorvastatin and suggests that statins protect the integrity of AJs in ECs by inhibiting RhoA-mediated Tyr phosphorylation of VE-cad...
Haidari M, Zhang W, Caivano A, Chen Z, Ganjehei L, Mortazavi A, et al
. Integrin ?2?1 mediates tyrosine phosphorylation of vascular endothelial cadherin induced by invasive breast cancer cells. J Biol Chem. 2012;287:32981-92 pubmed
..Our study showed that the MDA-MB-231 cell-induced disruption of endothelial adherens junction integrity is triggered by MDA-MB-231 cell ?(2)?(1) integrin and is mediated by H-Ras/MLC-induced tyrosine phosphorylation of VE-cad. ..