Lan Guan

Summary

Affiliation: Texas Tech University Health Sciences Center
Country: USA

Publications

  1. pmc Role of Gly117 in the cation/melibiose symport of MelB of Salmonella typhimurium
    Lan Guan
    Department of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Biochemistry 51:2950-7. 2012
  2. pmc Mechanism of melibiose/cation symport of the melibiose permease of Salmonella typhimurium
    Lan Guan
    Department of Cell Physiology and Molecular Biophysics, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    J Biol Chem 286:6367-74. 2011
  3. pmc Reduced Na+ affinity increases turnover of Salmonella enterica serovar Typhimurium MelB
    S Vivek Jakkula
    Department of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    J Bacteriol 194:5538-44. 2012
  4. pmc A transcription blocker isolated from a designed repeat protein combinatorial library by in vivo functional screen
    Elena B Tikhonova
    Department of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, Texas 79430
    Sci Rep 5:8070. 2015
  5. pmc Thermodynamic mechanism for inhibition of lactose permease by the phosphotransferase protein IIAGlc
    Parameswaran Hariharan
    Department of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430
    Proc Natl Acad Sci U S A 112:2407-12. 2015

Collaborators

  • Parameswaran Hariharan
  • Elena B Tikhonova
  • S Vivek Jakkula
  • H Ronald Kaback
  • Shicong Xie
  • Abdul S Ethayathulla
  • Dhandayuthapani Balasubramaniam
  • Yue Su
  • Alan Peterkofsky

Detail Information

Publications5

  1. pmc Role of Gly117 in the cation/melibiose symport of MelB of Salmonella typhimurium
    Lan Guan
    Department of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Biochemistry 51:2950-7. 2012
    ..Taken together, the findings are consistent with the notion that Gly117 plays an important role in cation binding and translocation...
  2. pmc Mechanism of melibiose/cation symport of the melibiose permease of Salmonella typhimurium
    Lan Guan
    Department of Cell Physiology and Molecular Biophysics, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    J Biol Chem 286:6367-74. 2011
    ....
  3. pmc Reduced Na+ affinity increases turnover of Salmonella enterica serovar Typhimurium MelB
    S Vivek Jakkula
    Department of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    J Bacteriol 194:5538-44. 2012
    ..Thus, the P148L mutation specifically inhibits transport velocity and thereby blocks the lethal effect of elevated melibiose transport in the Gly117 mutants...
  4. pmc A transcription blocker isolated from a designed repeat protein combinatorial library by in vivo functional screen
    Elena B Tikhonova
    Department of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, Texas 79430
    Sci Rep 5:8070. 2015
    ..Overall, our results show that the established library is a useful tool for the discovery of novel bioactive reagents. ..
  5. pmc Thermodynamic mechanism for inhibition of lactose permease by the phosphotransferase protein IIAGlc
    Parameswaran Hariharan
    Department of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430
    Proc Natl Acad Sci U S A 112:2407-12. 2015
    ..The precise mechanism of the inhibition of LacY by IIA(Glc) elucidated by ITC differs from the inhibition of melibiose permease (MelB), supporting the idea that permeases can differ in their thermodynamic response to binding IIA(Glc). ..