James Grotta

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc The University of Texas Houston Stroke Registry (UTHSR): implementation of enhanced data quality assurance procedures improves data quality
    Mohammad H Rahbar
    Division of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health at Houston, Houston, TX 77030, USA
    BMC Neurol 13:61. 2013
  2. doi request reprint Timing of thrombolysis for acute ischemic stroke: "timing is everything" or "everyone is different"
    James Grotta
    University of Texas Medical School, Houston, Texas, USA
    Ann N Y Acad Sci 1268:141-4. 2012
  3. doi request reprint Selecting stroke patients for intra-arterial therapy
    Clotilde Balucani
    Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY, USA
    Neurology 78:755-61. 2012
  4. ncbi request reprint Clinical deterioration following improvement in the NINDS rt-PA Stroke Trial
    J C Grotta
    Department of Neurology, University of Texas Medical School, Houston Texas 77030, USA
    Stroke 32:661-8. 2001
  5. ncbi request reprint Constraint-induced movement therapy
    James C Grotta
    Department of Neurology Stroke Program, University of Texas Houston Medical School, 6431 Fannin Street, Houston, TX 77030, USA
    Stroke 35:2699-701. 2004
  6. doi request reprint Intracerebral hemorrhage: effective therapy at last?
    James C Grotta
    The Univesity of Texas Houston Medical School, Houston, TX, USA
    Int J Stroke 1:30-1. 2006
  7. doi request reprint Stroke program review group: an interim report
    James C Grotta
    Department of Neurology, University of Texas Houston Medical School, 6431 Fannin St, Houston TX 77080, USA
    Stroke 39:1364-70. 2008
  8. ncbi request reprint Intravenous tissue-type plasminogen activator therapy for ischemic stroke: Houston experience 1996 to 2000
    J C Grotta
    Stroke Treatment Team, University of Texas Houston Medical School, Box 7 044, 6431 Fannin St, Houston, TX 77030, USA
    Arch Neurol 58:2009-13. 2001
  9. ncbi request reprint Combination Therapy Stroke Trial: recombinant tissue-type plasminogen activator with/without lubeluzole
    J Grotta
    University of Texas Houston Medical School, Houston, TX 77030, USA
    Cerebrovasc Dis 12:258-63. 2001
  10. pmc Intravenous rt-PA: a tenth anniversary reflection
    James Grotta
    Department of Neurology, University of Texas Houston Medical School, Houston, TX 77030, USA
    Surg Neurol 68:S12-6. 2007

Detail Information

Publications89

  1. pmc The University of Texas Houston Stroke Registry (UTHSR): implementation of enhanced data quality assurance procedures improves data quality
    Mohammad H Rahbar
    Division of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health at Houston, Houston, TX 77030, USA
    BMC Neurol 13:61. 2013
    ..We share our experience regarding the establishment of enhanced QA procedures for the University of Texas Houston Stroke Registry (UTHSR) and evaluate whether these QA procedures have improved data quality in UTHSR...
  2. doi request reprint Timing of thrombolysis for acute ischemic stroke: "timing is everything" or "everyone is different"
    James Grotta
    University of Texas Medical School, Houston, Texas, USA
    Ann N Y Acad Sci 1268:141-4. 2012
    ..Clinical factors as well as imaging should be used to select patients who may benefit from delayed attempts at reperfusion...
  3. doi request reprint Selecting stroke patients for intra-arterial therapy
    Clotilde Balucani
    Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY, USA
    Neurology 78:755-61. 2012
    ..Eventually it will be a combination of predictors that will enable us to most precisely identify the best patients for IAT and any other new revascularization therapies...
  4. ncbi request reprint Clinical deterioration following improvement in the NINDS rt-PA Stroke Trial
    J C Grotta
    Department of Neurology, University of Texas Medical School, Houston Texas 77030, USA
    Stroke 32:661-8. 2001
    ....
  5. ncbi request reprint Constraint-induced movement therapy
    James C Grotta
    Department of Neurology Stroke Program, University of Texas Houston Medical School, 6431 Fannin Street, Houston, TX 77030, USA
    Stroke 35:2699-701. 2004
    ..More acutely instituted constraint-induced movement therapy has both practical and theoretic risks and benefits that deserve further careful evaluation...
  6. doi request reprint Intracerebral hemorrhage: effective therapy at last?
    James C Grotta
    The Univesity of Texas Houston Medical School, Houston, TX, USA
    Int J Stroke 1:30-1. 2006
    ..Taken together, the impressive scope and progress of ongoing clinical and basic research demonstrate that there is no longer a place for nihilism in the approach to ICH...
  7. doi request reprint Stroke program review group: an interim report
    James C Grotta
    Department of Neurology, University of Texas Houston Medical School, 6431 Fannin St, Houston TX 77080, USA
    Stroke 39:1364-70. 2008
    ..What emerges from the first 2 reports is a clear set of priorities that have since been complemented by exciting advances that are likely to be the focus of a follow-up report from the next SPRG in 2010...
  8. ncbi request reprint Intravenous tissue-type plasminogen activator therapy for ischemic stroke: Houston experience 1996 to 2000
    J C Grotta
    Stroke Treatment Team, University of Texas Houston Medical School, Box 7 044, 6431 Fannin St, Houston, TX 77030, USA
    Arch Neurol 58:2009-13. 2001
    ..Our center is experienced in treating large numbers of stroke patients with intravenous tPA...
  9. ncbi request reprint Combination Therapy Stroke Trial: recombinant tissue-type plasminogen activator with/without lubeluzole
    J Grotta
    University of Texas Houston Medical School, Houston, TX 77030, USA
    Cerebrovasc Dis 12:258-63. 2001
    ..A neuroprotective drug may be safe and effective if given very early and in combination with recombinant tissue-type plasminogen activator (rt-PA) to acute stroke patients. No clinical trial has yet tested this hypothesis...
  10. pmc Intravenous rt-PA: a tenth anniversary reflection
    James Grotta
    Department of Neurology, University of Texas Houston Medical School, Houston, TX 77030, USA
    Surg Neurol 68:S12-6. 2007
    ..A large number of articles emanated from that study and have established the efficacy and generalizability of this treatment...
  11. ncbi request reprint Pilot dose-escalation study of caffeine plus ethanol (caffeinol) in acute ischemic stroke
    Paisith Piriyawat
    Stroke Program, Department of Neurology, University of Texas, Houston Medical School, USA
    Stroke 34:1242-5. 2003
    ..This study was designed to determine the safety and tolerability of ascending doses of this combination in stroke patients...
  12. ncbi request reprint Accuracy of serial National Institutes of Health Stroke Scale scores to identify artery status in acute ischemic stroke
    Robert Mikulik
    Department of Neurology, University of Texas Health Science Center at Houston, USA
    Circulation 115:2660-5. 2007
    ..We sought to determine the accuracy of serial National Institutes of Health Stroke Scale (NIHSS) scores to detect complete early recanalization of the middle cerebral artery...
  13. ncbi request reprint Is the benefit of early recanalization sustained at 3 months? A prospective cohort study
    Lise A Labiche
    Center for Noninvasive Brain Perfusion Studies, Stroke Program, University of Texas, Houston Medical School, Houston, USA
    Stroke 34:695-8. 2003
    ..Early arterial recanalization can lead to dramatic recovery (DR) during intravenous tissue plasminogen activator (tPA) therapy. However, it remains unclear whether this clinical recovery is sustained 3 months after stroke...
  14. pmc Does study enrollment delay treatment with intravenous thrombolytics for acute ischemic stroke?
    Sheryl Martin-Schild
    Department of Neurology, University of Texas Medical SchoolHouston Medical School, Houston, Texas 77030, USA
    Stroke 40:663. 2009
    ..Enrollment in acute stroke trials at a stroke center with multiple study protocols may delay the initiation of intravenous thrombolytics in patients who present within 3 hours of symptom onset...
  15. pmc Combined neuroprotective modalities coupled with thrombolysis in acute ischemic stroke: a pilot study of caffeinol and mild hypothermia
    Sheryl Martin-Schild
    Department of Neurology, University of Texas Houston Medical School, Houston, TX, USA
    J Stroke Cerebrovasc Dis 18:86-96. 2009
    ..We tested whether combining caffeinol and hypothermia with tissue plasminogen activator (t-PA) in patients with acute stroke is safe and feasible...
  16. doi request reprint Recovery after ischemic stroke: criteria for good outcome by level of disability at day 7
    Hen Hallevi
    Department of Neurology, Vascular Neurology Program, University of Texas at Houston Health Science Center, Houston, Texas 77030, USA
    Cerebrovasc Dis 28:341-8. 2009
    ..Ischemic stroke is a leading cause of morbidity. Assessing the chances of recovery is critical to optimize poststroke care...
  17. ncbi request reprint Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke
    Andrei V Alexandrov
    Stroke Treatment Team, University of Texas Houston Medical School, Houston 77030, USA
    N Engl J Med 351:2170-8. 2004
    ..Our objective was to determine whether ultrasonography can safely enhance the thrombolytic activity of t-PA...
  18. ncbi request reprint Is intra-arterial thrombolysis safe after full-dose intravenous recombinant tissue plasminogen activator for acute ischemic stroke?
    Hashem M Shaltoni
    Department of Neurology, University of Texas Houston Medical School, Houston, TX 77030, USA
    Stroke 38:80-4. 2007
    ..This study evaluated the safety and response to intra-arterial thrombolytics (IATs) in patients unresponsive to full-dose IV rt-PA...
  19. ncbi request reprint Ischemic stunning of the brain: early recanalization without immediate clinical improvement in acute ischemic stroke
    Andrei V Alexandrov
    Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, University of Texas Houston Medical School, 77030, USA
    Stroke 35:449-52. 2004
    ..Early arterial recanalization (ER) with intravenous tissue plasminogen activator (tPA) can lead to dramatic clinical recovery, whereas some patients do not experience immediate clinical improvement...
  20. ncbi request reprint Early dramatic recovery during intravenous tissue plasminogen activator infusion: clinical pattern and outcome in acute middle cerebral artery stroke
    Robert A Felberg
    Stroke Program, Department of Neurology, University of Texas Houston Medical School, USA
    Stroke 33:1301-7. 2002
    ..The prevalence, clinical characteristics, and outcome of patients experiencing dramatic recovery is not well described...
  21. ncbi request reprint Sustained benefit of a community and professional intervention to increase acute stroke therapy
    Lewis B Morgenstern
    Stroke Program, Department of Neurology, The University of Texas Medical School at Houston, USA
    Arch Intern Med 163:2198-202. 2003
    ..The ultimate test of an educational intervention is the sustainability of the effect after the intervention ceases...
  22. ncbi request reprint Endovascular recanalization of internal carotid artery occlusion in acute ischemic stroke
    Rebecca M Sugg
    Department of Neurology, University of Texas Houston Medical School, Houston, TX 77030, USA
    AJNR Am J Neuroradiol 26:2591-4. 2005
    ..We report our experience in endovascular recanalization of acute stroke patients with ICA occlusion...
  23. ncbi request reprint Safety and feasibility of a lower dose intravenous TPA therapy for ischemic stroke beyond the first three hours
    Ken Uchino
    Stroke Program, Department of Neurology, University of Texas Houston Medical School, USA
    Cerebrovasc Dis 19:260-6. 2005
    ..The risk/benefit ratio is more unfavorable beyond this time, but some patients might still benefit. We designed a pilot study with the hypothesis that lower dose TPA might be safe in selected patients treated beyond 3 h...
  24. ncbi request reprint Houston paramedic and emergency stroke treatment and outcomes study (HoPSTO)
    Anne W Wojner-Alexandrov
    Department of Neurology, University of Texas Houston, Houston, TX 77030, USA
    Stroke 36:1512-8. 2005
    ..We wanted to measure and improve paramedic and hospital performance through implementation of the Brain Attack Coalition and American Stroke Association guidelines...
  25. ncbi request reprint Argatroban tPA stroke study: study design and results in the first treated cohort
    Rebecca M Sugg
    Department of Neurology, University of Texas Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
    Arch Neurol 63:1057-62. 2006
    ..Argatroban is a direct thrombin inhibitor that safely augments the benefit of rtPA in animal stroke models. There are no human data on this combination...
  26. pmc Aggressive blood pressure-lowering treatment before intravenous tissue plasminogen activator therapy in acute ischemic stroke
    Sheryl Martin-Schild
    Vascular Neurology Program, Department of Neurology, University of Texas Health Science Center at Houston, 6431 Fannin St, Medical School Bldg Room 7 128, Houston, TX 77030, USA
    Arch Neurol 65:1174-8. 2008
    ..We evaluated the effect of elevated BP and its management on clinical outcomes after tPA therapy in AIS...
  27. ncbi request reprint Combining insulin-like growth factor derivatives plus caffeinol produces robust neuroprotection after stroke in rats
    Xiurong Zhao
    Vascular Neurology Program, Department of Neurology, University of Texas Houston Medical School, Houston, Tex 77030, USA
    Stroke 36:129-34. 2005
    ..Insulin-like growth factor-1 (IGF-1) and caffeinol are both neuroprotective and probably have different mechanisms of action; therefore, they may be more effective in combination...
  28. ncbi request reprint Arterial reocclusion in stroke patients treated with intravenous tissue plasminogen activator
    Andrei V Alexandrov
    Stroke Treatment Team, University of Texas Houston Medical School, Houston, TX 77030, USA
    Neurology 59:862-7. 2002
    ....
  29. ncbi request reprint Safety of tissue plasminogen activator for acute stroke in menstruating women
    Theodore H Wein
    Stroke Program, Department of Neurology, University of Texas at Houston Medical School, USA
    Stroke 33:2506-8. 2002
    ..Menses is a theoretical contraindication to intravenous tissue plasminogen activator (tPA) treatment. We sought to establish the safety of intravenous tPA in the treatment of acute ischemic stroke in women who are actively menstruating...
  30. doi request reprint The complications of cardioembolic stroke: lessons from the VISTA database
    Hen Hallevi
    University of Texas at Houston, Vascular Neurology Program, Houston, Tex 77030, USA
    Cerebrovasc Dis 26:38-40. 2008
    ..Cardioembolic stroke (CES) accounts for 20-30% of ischemic strokes. We attempted to describe the complications of CES...
  31. ncbi request reprint Using telemedicine to facilitate thrombolytic therapy for patients with acute stroke
    John Y Choi
    Department of Neurology, University of Texas Health Science Center, Houston, USA
    Jt Comm J Qual Patient Saf 32:199-205. 2006
    ..Given their incomplete neurology coverage, the remote-site hospitals identified telemedicine as the best option, with the University of Texas Health Science Center at Houston stroke team as the provider of expertise...
  32. ncbi request reprint Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages
    Xiurong Zhao
    Stroke Program, Department of Neurology, University of Texas Houston Medical School, Houston, TX 77030, USA
    Ann Neurol 61:352-62. 2007
    ..Promotion of phagocytosis in a timely and efficient manner may limit the toxic effects of persistent blood products on surrounding tissue and may be important for recovery after ICH...
  33. ncbi request reprint Alteplase for acute ischemic stroke
    Nicole R Gonzales
    University of Texas, Houston Medical School, 6431 Fannin, MSB 7 118, Houston TX 7703, USA
    Expert Rev Cardiovasc Ther 4:301-18. 2006
    ..For patients with acute ischemic stroke within the first 3 h of symptom onset, rt-PA remains the first step in accomplishing this goal...
  34. pmc Anticoagulation after cardioembolic stroke: to bridge or not to bridge?
    Hen Hallevi
    Department of Neurology, University of Texas Health Science Center at Houston, 6431 Fannin St, MSB 7 044, Houston, TX 77030, USA
    Arch Neurol 65:1169-73. 2008
    ..Outcome measures and adverse events were collected prospectively. Laboratory values were captured from the records...
  35. ncbi request reprint Kids Identifying and Defeating Stroke (KIDS): design of a school-based intervention to improve stroke awareness
    Nicole R Gonzales
    Department of Neurology, University of Texas Houston Health Science Center, Houston, TX 77030, USA
    Ethn Dis 17:320-6. 2007
    ..Increasing awareness in this group may increase the number of patients eligible for acute stroke treatment by encouraging emergency medical services (EMS) activation...
  36. ncbi request reprint Does clinical-CT 'mismatch' predict early response to treatment with recombinant tissue plasminogen activator?
    John Y Choi
    Stroke Program, University of Texas Houston Medical School, Houston, TX 77030, USA
    Cerebrovasc Dis 22:384-8. 2006
    ..e., clinical-CT mismatch) may respond better to intravenous recombinant tissue plasminogen activator (i.v. rt-PA) within 3 h of symptom onset...
  37. ncbi request reprint Established treatments for acute ischaemic stroke
    Aslam M Khaja
    Department of Neurology, University of Texas, Houston, TX 77030, USA
    Lancet 369:319-30. 2007
    ..Acute medical and neurological complications in stroke patients are analysed, along with recommendations for treatment...
  38. ncbi request reprint Constraint-induced movement therapy during early stroke rehabilitation
    Corwin Boake
    Department of Physical Medicine, Baylor College of Medicine University of Texas Houston Medical School, Houston, TX, USA
    Neurorehabil Neural Repair 21:14-24. 2007
    ..Limited data are available about the effectiveness of early rehabilitation after stroke...
  39. ncbi request reprint Distinct patterns of intracerebral hemorrhage-induced alterations in NF-kappaB subunit, iNOS, and COX-2 expression
    Xiurong Zhao
    Department of Neurology, Stroke Program, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Neurochem 101:652-63. 2007
    ..In summary, NF-kappaB activation occurs within minutes and persists for at least a week in response to ICH. This reaction utilizes different NF-kappaB regulatory subunits and is associated with the expression of selected target genes...
  40. pmc Thrombus burden is associated with clinical outcome after intra-arterial therapy for acute ischemic stroke
    Andrew D Barreto
    Department of Neurology, Stroke Division, University of Texas, Houston Health Science Center, Houston, TX 77030, USA
    Stroke 39:3231-5. 2008
    ..The aim of the study was to determine the impact of intra-arterial thrombus burden on intra-arterial treatment (IAT) and clinical outcome...
  41. ncbi request reprint Cell death in experimental intracerebral hemorrhage: the "black hole" model of hemorrhagic damage
    Robert A Felberg
    Stroke Program, Department of Neurology, University of Texas Houston Medical School, 77030, USA
    Ann Neurol 51:517-24. 2002
    ..We have termed this continued destruction of neurons, which occurs over at least 3 days as the neurons come into proximity to the hematoma, the "black hole" model of hemorrhagic damage...
  42. ncbi request reprint Ethanol plus caffeine (caffeinol) for treatment of ischemic stroke: preclinical experience
    Jaroslaw Aronowski
    Stroke Program, Department of Neurology, University of Texas at Houston Medical School, Houston, 77030, USA
    Stroke 34:1246-51. 2003
    ..The purpose of our present study was to further characterize the properties of caffeinol as a possible treatment for ischemic stroke...
  43. ncbi request reprint Intravenous tissue plasminogen activator and flow improvement in acute ischemic stroke patients with internal carotid artery occlusion
    Ioannis Christou
    Department of Neurology, University of Texas Houston Medical School, 6431 Fannin, MSB 7 044, Houston, TX 77030, USA
    J Neuroimaging 12:119-23. 2002
    ..Vascular imaging, safety, and outcome of TPA therapy for ICA occlusion is not well described. Our goal was to determine the site of occlusion, early recanalization after TPA infusion, and its relationship to outcome...
  44. pmc Thrombolysis with intravenous tissue plasminogen activator predicts a favorable discharge disposition in patients with acute ischemic stroke
    Nneka L Ifejika-Jones
    Department of Neurology, University of Texas Houston Medical School, 6431 Fannin, MSB 7 044, Houston, TX 77030, USA
    Stroke 42:700-4. 2011
    ..There are no studies assessing the role of recombinant tissue plasminogen activator use as a predictor of poststroke discharge disposition...
  45. pmc Pharmacological deep vein thrombosis prophylaxis does not lead to hematoma expansion in intracerebral hemorrhage with intraventricular extension
    Tzu Ching Wu
    Department of Neurology, The University of Texas Houston Medical School, 6431 Fannin Street Suite, Houston, TX 77030, USA
    Stroke 42:705-9. 2011
    ..However, insufficient data exist on hematoma volume in patients with ICH before and after pharmacological deep venous thrombosis prophylaxis, leaving physicians with uncertainty regarding the safety of this practice...
  46. pmc Increased blood-brain barrier permeability on perfusion CT might predict malignant middle cerebral artery infarction
    Hesna Bektas
    Department of Neurology, The University of Texas Houston Medical School, Houston, TX 77030, USA
    Stroke 41:2539-44. 2010
    ..The purpose of this study was to determine the predictive value of blood-brain barrier permeability measured using perfusion CT for development of malignant middle cerebral artery infarction requiring hemicraniectomy (HC)...
  47. ncbi request reprint Aggressive mechanical clot disruption: a safe adjunct to thrombolytic therapy in acute stroke?
    Elizabeth A Noser
    Department of Neurology, University of Texas Houston Medical School, USA
    Stroke 36:292-6. 2005
    ..This study evaluated the safety and efficacy of aggressive mechanical clot disruption (AMCD) in acute stroke patients with persisting middle cerebral artery (MCA) or internal carotid artery (ICA) occlusion after thrombolytic therapy...
  48. ncbi request reprint Feasibility of carotid artery stenting in patients with angiographic string sign
    Colin M Barker
    University of Texas Health Science Center, Houston, TX, USA
    Catheter Cardiovasc Interv 75:1104-9. 2010
    ..We describe our experience with CAS in a case series of symptomatic patients with severe carotid stenosis and angiographic SS...
  49. pmc Caffeinol at the receptor level: anti-ischemic effect of N-methyl-D-aspartate receptor blockade is potentiated by caffeine
    Xiurong Zhao
    Stroke Program, Department of Neurology, University of Texas Medical School at Houston, Houston, TX 77030, USA
    Stroke 41:363-7. 2010
    ....
  50. doi request reprint Identifying patients at high risk for poor outcome after intra-arterial therapy for acute ischemic stroke
    Hen Hallevi
    Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Stroke 40:1780-5. 2009
    ..Despite high rates of recanalization, the outcome is variable. We attempted to identify predictors of outcome that will enable better patient selection for IAT...
  51. pmc Thrombolytic therapy for patients who wake-up with stroke
    Andrew D Barreto
    Stroke Division, Department of Neurology, University of Texas Houston Medical School, Houston, USA
    Stroke 40:827-32. 2009
    ..The purpose of this study was to describe our center's experience with off-label, compassionate thrombolysis for wake-up stroke (WUS) patients...
  52. ncbi request reprint Improving delivery of acute stroke therapy: The TLL Temple Foundation Stroke Project
    Lewis B Morgenstern
    Stroke Program, Department of Neurology, University of Texas Medical School, Houston 77030, USA
    Stroke 33:160-6. 2002
    ..We performed a community and professional behavioral intervention project to increase the proportion of stroke patients treated with approved acute stroke therapy...
  53. ncbi request reprint Paramedic and emergency department care of stroke: baseline data from a citywide performance improvement study
    Anne W Wojner
    Stroke Program, Department of Neurology, University of Texas Houston Health Science Center, USA
    Am J Crit Care 12:411-7. 2003
    ..Rapid diagnosis and transport by paramedics and efficient, effective emergency management are essential to improving care of acute stroke patients...
  54. ncbi request reprint 15d-Prostaglandin J2 activates peroxisome proliferator-activated receptor-gamma, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats
    Xiurong Zhao
    Stroke Program, Department of Neurology, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Cereb Blood Flow Metab 26:811-20. 2006
    ..All these events predicted reduced behavioral deficit and neuronal damage...
  55. doi request reprint Endovascular therapeutic hypothermia for acute ischemic stroke: ICTuS 2/3 protocol
    Patrick D Lyden
    Department of Neurology, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Int J Stroke 9:117-25. 2014
    ..An Investigational Device Exemption has been obtained and an initial group of sites initiated. ..
  56. pmc Determinants of effective cooling during endovascular hypothermia
    Patrick Lyden
    Department of Neurology, Cedars Sinai Medical Center, Thalians E240, 8730 Alden Drive, Los Angeles, CA 90048, USA
    Neurocrit Care 16:413-20. 2012
    ..We demonstrated the feasibility of thrombolysis combined with endovascular hypothermia, but not all patients achieved effective cooling. We sought to identify the factors that determined effective cooling...
  57. pmc Phase IIB/III trial of tenecteplase in acute ischemic stroke: results of a prematurely terminated randomized clinical trial
    E Clarke Haley
    Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA
    Stroke 41:707-11. 2010
    ..If promise was established, then the trial would continue as a Phase III efficacy trial comparing the selected tenecteplase dose to standard rtPA...
  58. ncbi request reprint Intravenous TPA for very old stroke patients
    Chin I Chen
    Stroke Treatment Team, The University of Texas, Houston, USA
    Eur Neurol 54:140-4. 2005
    ..We studied safety and recanalization/recovery in patients older than 80 years treated with TPA and compared them with younger stroke patients...
  59. ncbi request reprint Treatment of acute intracerebral hemorrhage with epsilon-aminocaproic acid: a pilot study
    Paisith Piriyawat
    Stroke Program, Department of Neurology, University of Texas at Houston, Houston, TX 77030, USA
    Neurocrit Care 1:47-51. 2004
    ..Up to 40% of primary intracerebral hemorrhages (ICHs) expand within the first 24 hours (natural history). The authors aimed to study the safety and preliminary efficacy of epsilon-aminocaproic acid (EACA) in halting ICH enlargement...
  60. pmc Bone marrow mononuclear cells protect neurons and modulate microglia in cell culture models of ischemic stroke
    Sushil Sharma
    Department of Neurology, University of Texas Medical School at Houston, Houston, Texas 77030, USA
    J Neurosci Res 88:2869-76. 2010
    ..MNCs provide broad neuroprotection against a variety of injuries relevant to stroke...
  61. pmc Neuronal PPARgamma deficiency increases susceptibility to brain damage after cerebral ischemia
    Xiurong Zhao
    Stroke Program, Department of Neurology, University of Texas, Houston, Medical School, Houston, Texas 77030, USA
    J Neurosci 29:6186-95. 2009
    ..Therefore, we conclude that PPARgamma in neurons play an essential protective function and that PPARgamma agonists may have utility in neuronal self-defense, in addition to their well established anti-inflammatory effect...
  62. pmc Clinical trials for cytoprotection in stroke
    Lise A Labiche
    Stroke Program, University of Texas at Houston Medical School, 6431 Fannin Street, Houston, Texas 77030, USA
    NeuroRx 1:46-70. 2004
    ..This review will focus on individual therapeutic strategies and we will emphasize what we have learned from these trials both in terms of trial design and the biologic effect (or lack thereof) of these agents...
  63. pmc Autologous bone marrow mononuclear cells enhance recovery after acute ischemic stroke in young and middle-aged rats
    Miranda Brenneman
    Department ofNeurology, University of Texas, Houston Medical School, Houston, Texas 77030, USA
    J Cereb Blood Flow Metab 30:140-9. 2010
    ..Autologous bone marrow MNCs can be safely harvested from rodents after stroke, migrate to the peri-infarct area, enhance recovery, and modulate the post-ischemic inflammatory response...
  64. doi request reprint Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model
    Daniel M Rosenbaum
    Department of Neurology, SUNY Downstate Medical Center, Brooklyn, New York, USA
    J Neurosci Res 88:1569-76. 2010
    ..Conclusion: Necroptosis is an important mode of neuronal cell death and involves autophagy in a model of retinal ischemia...
  65. ncbi request reprint Telemedicine-guided carotid and transcranial ultrasound: a pilot feasibility study
    Robert Mikulik
    Department of Neurology, University of Texas Health Science Center, Houston, TX 77030, USA
    Stroke 37:229-30. 2006
    ..We explored the feasibility of telemedicine (TM)-guided TCD/CD administered by a health care provider inexperienced with ultrasound...
  66. ncbi request reprint Latest advances in intracerebral hemorrhage
    Marc Ribo
    Vascular Neurology, University of Texas Houston Medical School, 6431 Fannin Street, Houston, TX 77030, USA
    Curr Neurol Neurosci Rep 6:17-22. 2006
    ..This review comments on some of the most relevant publications during the past year in any field related to ICH...
  67. ncbi request reprint Ultrasound-enhanced thrombolysis for acute ischemic stroke: phase I. Findings of the CLOTBUST trial
    Andrei V Alexandrov
    Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, University of Texas Houston Medical School, Houston, TX, USA
    J Neuroimaging 14:113-7. 2004
    ..The authors present Phase I data of the CLOTBUST (Combined Lysis of Thrombus in Brain ischemia using transcranial Ultrasound and Systemic TPA)...
  68. ncbi request reprint Functional reorganization and recovery after constraint-induced movement therapy in subacute stroke: case reports
    Tony Ro
    Department of Psychology, Rice University, Houston, Texas 77005, USA
    Neurocase 12:50-60. 2006
    ....
  69. ncbi request reprint Neuronal expression of peroxisome proliferator-activated receptor-gamma (PPARgamma) and 15d-prostaglandin J2--mediated protection of brain after experimental cerebral ischemia in rat
    Zhishuo Ou
    University of Texas Health Science Center Houston, Medical School, Department of Neurology, Stroke Program, Houston, 77030, USA
    Brain Res 1096:196-203. 2006
    ..Activation of PPARgamma in neurons at an early stage after ischemia may represent a pro-survival mechanism against ischemic injury...
  70. ncbi request reprint CLOTBUST: design of a randomized trial of ultrasound-enhanced thrombolysis for acute ischemic stroke
    Andrei V Alexandrov
    Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, University of Texas Houston Medical School, Houston, TX, USA
    J Neuroimaging 14:108-12. 2004
    ....
  71. ncbi request reprint Yield and accuracy of urgent combined carotid/transcranial ultrasound testing in acute cerebral ischemia
    Oleg Y Chernyshev
    Stroke Treatment Team, University of Texas Houston, Texas 77005, USA
    Stroke 36:32-7. 2005
    ..We aimed to determine the yield and accuracy of NVUE to identify lesions amenable for interventional treatment (LAITs)...
  72. ncbi request reprint Peroxisome-proliferator-activated receptor-gamma (PPARgamma) activation protects neurons from NMDA excitotoxicity
    Xiurong Zhao
    Stroke Program, Department of Neurology, University of Texas Houston Medical School, 6431 Fannin, Rm 7 044, Houston, TX 77030, USA
    Brain Res 1073:460-9. 2006
    ..Our data demonstrate that PPARgamma activation may represent a potential target for treatment of numerous acute and chronic neurological diseases with pathologies that involve excitotoxic damage...
  73. pmc Therapeutic time window and dose dependence of xenon delivered via echogenic liposomes for neuroprotection in stroke
    Tao Peng
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA
    CNS Neurosci Ther 19:773-84. 2013
    ..We investigated the time window for Xe-ELIP therapeutic effect and the most efficacious dose for neuroprotection. Molecular mechanisms for Xe neuroprotection were investigated...
  74. pmc The IVH score: a novel tool for estimating intraventricular hemorrhage volume: clinical and research implications
    Hen Hallevi
    Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, USA
    Crit Care Med 37:969-74, e1. 2009
    ..Intraventricular extension of intracerebral hemorrhage (IVH) is an independent predictor of poor outcome. IVH volume may be important in outcome prediction and management; however, it is difficult to measure routinely...
  75. ncbi request reprint Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials
    Werner Hacke
    Medical University at Heidelberg, Germany
    Lancet 363:768-74. 2004
    ..Quick administration of intravenous recombinant tissue plasminogen activator (rt-PA) after stroke improved outcomes in previous trials. We aimed to analyse combined data for individual patients to confirm the importance of rapid treatment...
  76. ncbi request reprint Adding to the effectiveness of intravenous tissue plasminogen activator for treating acute stroke
    James C Grotta
    Circulation 107:2769-70. 2003
  77. ncbi request reprint Safety and tolerability of arundic acid in acute ischemic stroke
    L Creed Pettigrew
    Stroke Program, Sanders Brown Center on Aging, and Department of Neurology, 101 Sanders Brown Building, University of Kentucky Medical Center, Lexington, KY 40536 0230, USA
    J Neurol Sci 251:50-6. 2006
    ..023 vs. placebo), 7 (p=0.002), 10 (p=0.003), and 40 (p=0.018). A dose of 8 mg/kg/h AA produced a favorable trend in reduction of NIHSS that should be confirmed in a future clinical trial...
  78. ncbi request reprint The impact of imbalances in baseline stroke severity on outcome in the National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke Study
    Thomas Kwiatkowski
    Department of Emergency Medicine, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
    Ann Emerg Med 45:377-84. 2005
    ..Stroke severity was based on the NIH Stroke Scale. We also compare early mortality (2-week and 30-day) in the tPA and placebo groups...
  79. ncbi request reprint A randomized, controlled trial to teach middle school children to recognize stroke and call 911: the kids identifying and defeating stroke project
    Lewis B Morgenstern
    Stroke Program, University of Michigan Health System, 1500 E Medical Center Dr, TC 1920 0316, Ann Arbor, MI 48109 0316, USA
    Stroke 38:2972-8. 2007
    ..We present the primary results of a pilot, randomized, controlled trial to encourage calling 911 for witnessed stroke among middle school children and their parents...
  80. ncbi request reprint Safety and tolerability of NXY-059 for acute intracerebral hemorrhage: the CHANT Trial
    Patrick D Lyden
    UCSD Stroke Center, San Diego, CA 92103, USA
    Stroke 38:2262-9. 2007
    ..To facilitate prompt administration of treatment, potentially before neuroimaging, we investigated the safety of NXY-059 in patients with intracerebral hemorrhage (ICH)...
  81. pmc The effect of activated factor VII for intracerebral hemorrhage beyond 3 hours versus within 3 hours
    Hen Hallevi
    Stroke 39:473-5. 2008
    ..Recombinant-activated factor VII (rFVIIa) is an investigational treatment for intracerebral hemorrhage (ICH). We have evaluated the drug's treatment effect based on time to treatment...
  82. pmc LOAD: a pilot study of the safety of loading of aspirin and clopidogrel in acute ischemic stroke and transient ischemic attack
    Dawn M Meyer
    Neurology Department, University of Texas Health Science Center at Houston, Texas, USA
    J Stroke Cerebrovasc Dis 17:26-9. 2008
    ..Clopidogrel and aspirin loading is commonly used to prevent deterioration in other acute vascular occlusive events. This pilot study examined the safety of antiplatelet loading in acute ischemic stroke and transient ischemic attack...
  83. ncbi request reprint SITS-MOST: old myths laid to rest
    Hen Hallevi
    Lancet Neurol 6:292-3. 2007
  84. pmc A pilot randomized clinical safety study of sonothrombolysis augmentation with ultrasound-activated perflutren-lipid microspheres for acute ischemic stroke
    Andrei V Alexandrov
    Comprehensive Stroke Center Neurology, The University of Alabama at Birmingham, RWUH M226, 619 19th St South, Birmingham, AL 35249 3280, USA
    Stroke 39:1464-9. 2008
    ..Ultrasound transiently expands perflutren-lipid microspheres (muS), transmitting energy momentum to surrounding fluids. We report a pilot safety/feasibility study of ultrasound-activated muS with systemic tissue plasminogen activator (tPA)...
  85. pmc Antiplatelet therapy and the risk of intracranial hemorrhage after intravenous tissue plasminogen activator therapy for acute ischemic stroke
    Hen Hallevi
    Arch Neurol 65:575-6. 2008
  86. ncbi request reprint Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable
    Marc Fisher
    UMass Memorial Healthcare Center, 119 Belmont St, Worcester, MA 01605, USA
    Stroke 36:1808-13. 2005
    ..A fourth (STAIR-IV) was held to discuss relevant issues related to acute stroke drug development and regulatory approval...
  87. ncbi request reprint Beyond subgroup analysis: improving the clinical interpretation of treatment effects in stroke research
    Mei Lu
    Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, MI 48202, USA
    J Neurosci Methods 143:209-16. 2005
    ..Results of NINDS t-PA stroke studies confirmed our previous conclusions on the treatment t-PA benefit within 3-h therapeutic window. No subgroup of patients would lead a physician to withhold the t-PA treatment...
  88. ncbi request reprint Safety outcomes of Alteplase among acute ischemic stroke patients with special characteristics
    P N Sylaja
    Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Center, University of Calgary, Calgary, Alberta, Canada
    Neurocrit Care 6:181-5. 2007
    ....
  89. ncbi request reprint Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial
    Scott E Kasner
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Stroke 33:130-4. 2002
    ..Elevated core body temperature (CBT), even if mild, may exacerbate neuronal injury and worsen outcome, whereas hypothermia is potentially neuroprotective. The antipyretic effects of acetaminophen were hypothesized to reduce CBT...

Research Grants23

  1. THE UNIVERSITY OF TEXAS HOUSTON STROKE TRAINING PROGRAM
    James Grotta; Fiscal Year: 2007
    ..The current faculty and their areas of special focus includes James Grotta MD (Director, laboratory and clinical research in acute stroke therapy), Jaroslaw Aronowski PhD (animal stroke ..
  2. CALCIUM BLOCKER AND RELATED THERAPY FOR STROKE RECOVERY
    James Grotta; Fiscal Year: 2001
    ....
  3. CALCIUM BLOCKER AND RELATED THERAPY FOR STROKE RECOVERY
    James Grotta; Fiscal Year: 2002
    ....
  4. CALCIUM BLOCKER AND RELATED THERAPY FOR STROKE RECOVERY
    James Grotta; Fiscal Year: 2003
    ....
  5. CALCIUM BLOCKER AND RELATED THERAPY FOR STROKE RECOVERY
    James Grotta; Fiscal Year: 2004
    ....
  6. University of Texas Specialized Program in Acute Stroke
    James Grotta; Fiscal Year: 2006
    ..3. Development of Clinical, Statistical, Human Tissue, and Training "Cores" that will facilitate the accomplishment of Specific Aims # 1 and 2. These cores will also provide important new resources for fellowship training...
  7. University of Texas Specialized Program in Acute Stroke
    James Grotta; Fiscal Year: 2006
    ..3. Development of Clinical, Statistical, Human Tissue, and Training "Cores" that will facilitate the accomplishment of Specific Aims # 1 and 2. These cores will also provide important new resources for fellowship training...
  8. CALCIUM BLOCKER AND RELATED THERAPY FOR STROKE RECOVERY
    James Grotta; Fiscal Year: 2000
    ....
  9. CALCIUM BLOCKER AND RELATED THERAPY FOR STROKE RECOVERY
    James Grotta; Fiscal Year: 1999
    ....
  10. CALCIUM BLOCKER & RELATED THERAPY FOR CEREBRAL ISCHEMIA
    James Grotta; Fiscal Year: 1992
    ..Studies will be designed to correlate calcium calmodulin binding studies with CaM Kinase II activity and explore the behavior of this kinase after various ischemic intervals...
  11. CALCIUM BLOCKER & RELATED THERAPY FOR CEREBRAL ISCHEMIA
    James Grotta; Fiscal Year: 1993
    ..Studies will be designed to correlate calcium calmodulin binding studies with CaM Kinase II activity and explore the behavior of this kinase after various ischemic intervals...
  12. CALCIUM BLOCKER & RELATED THERAPY FOR CEREBRAL ISCHEMIA
    James Grotta; Fiscal Year: 1991
    ..Studies will be designed to correlate calcium calmodulin binding studies with CaM Kinase II activity and explore the behavior of this kinase after various ischemic intervals...