Paula Grammas

Summary

Affiliation: Texas Tech University Health Sciences Center
Country: USA

Publications

  1. pmc Acetaminophen protects brain endothelial cells against oxidative stress
    Debjani Tripathy
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th Street Stop 9424, Lubbock, TX 79430, USA
    Microvasc Res 77:289-96. 2009
  2. pmc Acetaminophen inhibits neuronal inflammation and protects neurons from oxidative stress
    Debjani Tripathy
    Garrison Institute on Aging, Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    J Neuroinflammation 6:10. 2009
  3. ncbi request reprint Thrombin and inflammatory proteins are elevated in Alzheimer's disease microvessels: implications for disease pathogenesis
    Paula Grammas
    Garrison Institute on Aging and Department of Neuropsychiatry and Behavioral Sciences, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    J Alzheimers Dis 9:51-8. 2006
  4. pmc Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease
    Paula Grammas
    Garrison Institute on Aging, and Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    J Neuroinflammation 8:26. 2011
  5. doi request reprint Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases
    Paula Grammas
    Garrison Institute on Aging, Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Expert Rev Mol Med 13:e19. 2011
  6. pmc Brain microvasculature and hypoxia-related proteins in Alzheimer's disease
    Paula Grammas
    Garrison Institute on Aging and Department of Neurology, Texas Tech University Health Sciences Center Lubbock, TX 79430, USA
    Int J Clin Exp Pathol 4:616-27. 2011
  7. doi request reprint Vascular signaling abnormalities in Alzheimer disease
    Paula Grammas
    Garrison Institute on Aging and Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Cleve Clin J Med 78:S50-3. 2011
  8. pmc Cerebrovascular expression of proteins related to inflammation, oxidative stress and neurotoxicity is altered with aging
    Debjani Tripathy
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    J Neuroinflammation 7:63. 2010
  9. pmc Blocking L-type calcium channels reduced the threshold of cAMP-induced steroidogenic acute regulatory gene expression in MA-10 mouse Leydig cells
    Akhilesh K Pandey
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    J Endocrinol 204:67-74. 2010
  10. doi request reprint Neurovascular unit and the effects of dosage in VEGF toxicity: role for oxidative stress and thrombin
    Alma Sanchez
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX 79413, USA
    J Alzheimers Dis 34:281-91. 2013

Research Grants

Collaborators

Detail Information

Publications53

  1. pmc Acetaminophen protects brain endothelial cells against oxidative stress
    Debjani Tripathy
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th Street Stop 9424, Lubbock, TX 79430, USA
    Microvasc Res 77:289-96. 2009
    ....
  2. pmc Acetaminophen inhibits neuronal inflammation and protects neurons from oxidative stress
    Debjani Tripathy
    Garrison Institute on Aging, Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    J Neuroinflammation 6:10. 2009
    ..The objectives of this study are to determine the effects of acetaminophen on cultured brain neuronal survival and inflammatory factor expression when exposed to oxidative stress...
  3. ncbi request reprint Thrombin and inflammatory proteins are elevated in Alzheimer's disease microvessels: implications for disease pathogenesis
    Paula Grammas
    Garrison Institute on Aging and Department of Neuropsychiatry and Behavioral Sciences, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    J Alzheimers Dis 9:51-8. 2006
    ..These data suggest that in AD the cerebral microcirculation is a source of neurotoxic and inflammatory mediators and as such contributory to pathologic processes ongoing in the AD brain...
  4. pmc Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease
    Paula Grammas
    Garrison Institute on Aging, and Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    J Neuroinflammation 8:26. 2011
    ....
  5. doi request reprint Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases
    Paula Grammas
    Garrison Institute on Aging, Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Expert Rev Mol Med 13:e19. 2011
    ..Here, we discuss how greater understanding of the role of BBB function could lead to new therapeutic approaches for diseases of the CNS that target the dynamic properties of brain endothelial cells...
  6. pmc Brain microvasculature and hypoxia-related proteins in Alzheimer's disease
    Paula Grammas
    Garrison Institute on Aging and Department of Neurology, Texas Tech University Health Sciences Center Lubbock, TX 79430, USA
    Int J Clin Exp Pathol 4:616-27. 2011
    ..These data suggest the cerebromicrovasculature is an important target for the effects of hypoxia in the AD brain...
  7. doi request reprint Vascular signaling abnormalities in Alzheimer disease
    Paula Grammas
    Garrison Institute on Aging and Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Cleve Clin J Med 78:S50-3. 2011
    ..Thus, "vascular activation" could be a novel, unexplored therapeutic target in AD...
  8. pmc Cerebrovascular expression of proteins related to inflammation, oxidative stress and neurotoxicity is altered with aging
    Debjani Tripathy
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    J Neuroinflammation 7:63. 2010
    ..The objective of this study is to determine whether expression of proteins in the cerebromicrovasculature related to inflammation, oxidative stress and neurotoxicity is altered with aging...
  9. pmc Blocking L-type calcium channels reduced the threshold of cAMP-induced steroidogenic acute regulatory gene expression in MA-10 mouse Leydig cells
    Akhilesh K Pandey
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    J Endocrinol 204:67-74. 2010
    ..Blocking L-type Ca(2+) channel attenuated the inhibition and reduced the threshold of cAMP-induced Star gene expression in Leydig cells...
  10. doi request reprint Neurovascular unit and the effects of dosage in VEGF toxicity: role for oxidative stress and thrombin
    Alma Sanchez
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX 79413, USA
    J Alzheimers Dis 34:281-91. 2013
    ..These results suggest that despite literature supporting neuroprotective effects of this protein, caution is warranted prior to implementation of VEGF as a therapeutic in the brain...
  11. pmc RANTES upregulation in the Alzheimer's disease brain: a possible neuroprotective role
    Debjani Tripathy
    Garrison Institute on Aging, Department of Neuropsychiatry and Behavioral Sciences, Texas Tech University Health Sciences Center, 3601 4th Street Stop 9424, Lubbock, TX 79430, United States
    Neurobiol Aging 31:8-16. 2010
    ..Developing strategies to augment neuroprotection and diminish inflammatory activation of multifunctional mediators such as RANTES holds promise for the development of novel neuroprotective therapeutics in AD...
  12. pmc Age-related decrease in cerebrovascular-derived neuroprotective proteins: effect of acetaminophen
    Debjani Tripathy
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Microvasc Res 84:278-85. 2012
    ..If a low dose of acetaminophen can counteract the decrease in vascular-derived neurotrophic factors evoked by age and oxidative stress, this drug might be useful for improving brain function in the elderly...
  13. doi request reprint Chrysin, a natural flavonoid enhances steroidogenesis and steroidogenic acute regulatory protein gene expression in mouse Leydig cells
    Kuladip Jana
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    J Endocrinol 197:315-23. 2008
    ..These results suggest that while chrysin itself is unable to induce StAR gene expression and steroidogenesis, it appears to function by increasing the sensitivity of Leydig cells to cAMP stimulation...
  14. pmc Effects of apigenin on steroidogenesis and steroidogenic acute regulatory gene expression in mouse Leydig cells
    Wei Li
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    J Nutr Biochem 22:212-8. 2011
    ..The present study suggests a potential application of apigenin to improve StAR protein expression and steroidogenic sensitivity of aging Leydig cells...
  15. pmc A blood-based algorithm for the detection of Alzheimer's disease
    Sid E O'Bryant
    Department of Neurology, F Marie Hall Institute for Rural and Community Health, Texas Tech University Health Sciences Center, Lubbock, Tex, USA sid obryant ttuhsc edu
    Dement Geriatr Cogn Disord 32:55-62. 2011
    ..The current project was designed to refine that algorithm by reducing the number of serum proteins and by including clinical labs. The link between the biomarker risk score and neuropsychological performance was also examined...
  16. pmc Sunitinib enhances neuronal survival in vitro via NF-κB-mediated signaling and expression of cyclooxygenase-2 and inducible nitric oxide synthase
    Alma Sanchez
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA
    J Neuroinflammation 10:93. 2013
    ..The objective of this study is to explore the effects of sunitinib on neuronal survival as well as on the expression of inflammatory protein mediators in primary cerebral neuronal cultures...
  17. pmc Involvement of the thromboxane A2 receptor in the regulation of steroidogenic acute regulatory gene expression in murine Leydig cells
    Akhilesh K Pandey
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Endocrinology 150:3267-73. 2009
    ....
  18. doi request reprint Endothelin-1 is elevated in Alzheimer's disease brain microvessels and is neuroprotective
    Jinhua Luo
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    J Alzheimers Dis 21:887-96. 2010
    ..These data demonstrate that in the brain microvasculature dysfunctional or stressed endothelial cells express ET-1 and that this protein promotes the survival of brain neurons exposed to injury...
  19. pmc Brain endothelial cells synthesize neurotoxic thrombin in Alzheimer's disease
    Xiangling Yin
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Am J Pathol 176:1600-6. 2010
    ....
  20. doi request reprint p38 MAPK: a mediator of hypoxia-induced cerebrovascular inflammation
    Alma Sanchez
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    J Alzheimers Dis 32:587-97. 2012
    ..These data demonstrate that pp38 MAPK is a key regulator of hypoxia in the cerebrovasculature and suggest that control of this signaling pathway could have therapeutic value in AD and other disorders where hypoxia is involved...
  21. pmc Involvement of PGE2 and PGDH but not COX-2 in thrombin-induced cortical neuron apoptosis
    Lakshmi Thirumangalakudi
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th Street, MS9424, Lubbock, TX 79430, United States
    Neurosci Lett 452:172-5. 2009
    ..NS398, a COX-2 specific inhibitor, protects neurons against thrombin toxicity, by inducing active PGDH. These data implicate PGDH in thrombin-mediated neuronal cell death...
  22. pmc Transduction of PACAP38 protects primary cortical neurons from neurotoxic injury
    Alma Sanchez
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Neurosci Lett 448:52-5. 2008
    ..These results support the feasibility of using AAV-mediated delivery of PACAP38 to enhance neuronal survival and suggest that AAV-delivered PACAP38 maybe a therapeutic strategy for neurodegenerative diseases...
  23. pmc PACAP38 protects rat cortical neurons against the neurotoxicity evoked by sodium nitroprusside and thrombin
    Alma Sanchez
    Department of Neuropsychiatry, Texas Tech University Health Sciences Center, Lubbock TX 79430, USA
    Regul Pept 152:33-40. 2009
    ..Our results support the possibility that PACAP could be a useful therapeutic agent for reducing neuronal cell death in neurodegenerative diseases...
  24. pmc Inhibition of thromboxane a synthase activity enhances steroidogenesis and steroidogenic acute regulatory gene expression in MA-10 mouse Leydig cells
    XingJia Wang
    Garrison Institute on Aging, Department of Neuropsychiatry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Endocrinology 149:851-7. 2008
    ....
  25. ncbi request reprint Expression of macrophage inflammatory protein 1-alpha is elevated in Alzheimer's vessels and is regulated by oxidative stress
    Debjani Tripathy
    Garrison Institute on Aging and Department of Neuropsychiatry and Behavioral Sciences, Texas Tech University Health Sciences Center, Lubbock, TX, USA
    J Alzheimers Dis 11:447-55. 2007
    ..These results suggest that oxidative and lipid insults to the brain microvasculature are likely to contribute to the inflammatory milieu of the AD brain...
  26. pmc Multiple neurotrophic effects of VEGF on cultured neurons
    Alma Sanchez
    Garrison Institute on Aging, Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Neuropeptides 44:323-31. 2010
    ....
  27. pmc Serum brain-derived neurotrophic factor levels are specifically associated with memory performance among Alzheimer's disease cases
    Sid E O'Bryant
    Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Dement Geriatr Cogn Disord 31:31-6. 2011
    ..Our purpose was to study the link between serum brain-derived neurotrophic factor (BDNF) levels and neuropsychological functioning through the Texas Alzheimer's Research Consortium cohort...
  28. doi request reprint Purification of endothelial cells from rat brain
    Jinhua Luo
    Department of Neurology, Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA
    Methods Mol Biol 1135:357-64. 2014
    ..Unlike MV-EC, RV-EC cultures are capable of serial cultivation for up to 15 passages. Primary MV-ECs are able to retain their characteristic endothelial morphology for 6-8 weeks. ..
  29. pmc Thrombin, a mediator of cerebrovascular inflammation in AD and hypoxia
    Debjani Tripathy
    Garrison Institute on Aging, Department of Neurology, Texas Tech University Health Sciences Center Lubbock, TX, USA
    Front Aging Neurosci 5:19. 2013
    ..Taken together, these results suggest that inhibiting thrombin generation could have therapeutic value in AD and other disorders where hypoxia, inflammation, and oxidative stress are involved...
  30. doi request reprint Gene expression profiling in Alzheimer's disease brain microvessels
    Shu Wang
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    J Alzheimers Dis 31:193-205. 2012
    ..These data may help elucidate heretofore unknown molecular alterations in the AD cerebromicrovasculature...
  31. ncbi request reprint IL-8 induces expression of matrix metalloproteinases, cell cycle and pro-apoptotic proteins, and cell death in cultured neurons
    Lakshmi Thirumangalakudi
    Garrison Institute on Aging and Department of Neuropsychiatry and Behavioral Sciences, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    J Alzheimers Dis 11:305-11. 2007
    ..These results suggest that IL-8 could be an important mediator of neuronal death in AD both via its effects on release of neurotoxins such as MMPs as well as by induction of cell cycle and pro-apoptotic proteins...
  32. pmc Cyclin C and cyclin dependent kinases 1, 2 and 3 in thrombin-induced neuronal cell cycle progression and apoptosis
    Haripriya Vittal Rao
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th Street Stop 9424, Lubbock, TX 79430, USA
    Neurosci Lett 450:347-50. 2009
    ..These results suggest that decreases in G1-S regulators cyclin C and cdks 3, cdk2 and cdk1 in response to thrombin could make conditions unfavorable for S phase entry and favor neuronal apoptosis...
  33. pmc Oxidative stress impairs learning and memory in apoE knockout mice
    Marianne Evola
    Garrison Institute on Aging, Department of Neurology, Department of Pharmacology and Neurosciences Texas Tech University Health Sciences Center, and Department of Psychology Texas Tech University, Lubbock, TX 79430, United States
    Pharmacol Biochem Behav 96:181-6. 2010
    ..These results are consistent with the hypothesis that an oxidative-inflammatory cycle in the cerebral vasculature could have deleterious consequences for cognition...
  34. ncbi request reprint Cyclin D1, cdk4, and Bim are involved in thrombin-induced apoptosis in cultured cortical neurons
    Haripriya Vittal Rao
    Garrison Institute on Aging and Department of Neuropsychiatry and Behavioral Sciences, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    J Neurochem 101:498-505. 2007
    ..Thus, cell cycle proteins could be therapeutic targets in diseases such as AD where thrombin has been implicated...
  35. ncbi request reprint Angiogenic proteins are expressed by brain blood vessels in Alzheimer's disease
    Lakshmi Thirumangalakudi
    Garrison Institute on Aging and Department of Neuropsychiatry and Behavioral Sciences, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    J Alzheimers Dis 10:111-8. 2006
    ....
  36. pmc RANTES release contributes to the protective action of PACAP38 against sodium nitroprusside in cortical neurons
    Alma Sanchez
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th Street Stop 9424, Lubbock, TX 79430, United States
    Neuropeptides 43:315-20. 2009
    ....
  37. ncbi request reprint The involvement of epoxygenase metabolites of arachidonic acid in cAMP-stimulated steroidogenesis and steroidogenic acute regulatory protein gene expression
    XingJia Wang
    Department of Neuropsychiatry, Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    J Endocrinol 190:871-8. 2006
    ..This study suggests that cAMP stimulation of MA-10 cells increases epoxygenase-generated AA metabolites and the co-action of these metabolites with PKA significantly increases StAR gene expression and steroid hormone production...
  38. ncbi request reprint Structural changes in Alzheimer's disease brain microvessels
    Alexander Christov
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th Street Stop 9424, Lubbock, Texas 79430, USA
    Curr Alzheimer Res 5:392-5. 2008
    ..These data demonstrate that changes in the amount and type of collagen occur in AD brain and suggest that cerebral vessel injury is part of AD pathology...
  39. pmc A serum protein-based algorithm for the detection of Alzheimer disease
    Sid E O'Bryant
    Texas Tech University Health Science Center, Department of Neurology, Lubbock, TX 79430, USA
    Arch Neurol 67:1077-81. 2010
    ..To develop an algorithm that separates patients with Alzheimer disease (AD) from controls...
  40. pmc Cerebrovascular transforming growth factor-beta contributes to inflammation in the Alzheimer's disease brain
    Paula Grammas
    Department of Pathology and the Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Am J Pathol 160:1583-7. 2002
    ..Our results suggest that vessel-derived TGF-beta contributes to inflammatory processes in the Alzheimer brain...
  41. ncbi request reprint HIV-1 gp120 proteins alter tight junction protein expression and brain endothelial cell permeability: implications for the pathogenesis of HIV-associated dementia
    Georgette D Kanmogne
    Department of Pharmacology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
    J Neuropathol Exp Neurol 64:498-505. 2005
    ....
  42. ncbi request reprint CAP37, a neutrophil-derived inflammatory mediator, augments leukocyte adhesion to endothelial monolayers
    Taunia D Lee
    Department of Pathology, University of Oklahoma Health Sciences Center, P O Box 26901, BMSB 434, Oklahoma City, OK 73190, USA
    Microvasc Res 66:38-48. 2003
    ..The cell-specific kinetics of adhesion molecule upregulation by CAP37 may influence selective leukocyte migration in certain inflammatory situations...
  43. ncbi request reprint Vascular inflammatory, oxidative and protease-based processes: implications for neuronal cell death in Alzheimer's disease
    Alexander Christov
    Department of Pathology and the Oklahoma Center for Neuroscience, University of Oklahoma Health Science Center, Oklahoma City, OK, USA
    Neurol Res 26:540-6. 2004
    ....
  44. ncbi request reprint Injured brain endothelial cells release neurotoxic thrombin
    Paula Grammas
    Department of Pathology, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    J Alzheimers Dis 6:275-81. 2004
    ..These data demonstrate that endothelial cell injury results in thrombin release and suggest that the brain microcirculation could be a source of neurotoxic factors in AD...
  45. pmc Chronic thrombin exposure results in an increase in apolipoprotein-E levels
    Molina Mhatre
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, 73104, USA
    J Neurosci Res 84:444-9. 2006
    ..These findings suggest that thrombin released during brain injury may contribute to an increase in apolipoprotein-E levels. Such increase in Apolipoprotein-E4 isoform facilitates beta-amyloid deposition and cognitive deficits...
  46. ncbi request reprint The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain
    Kelly S Williamson
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Nitric Oxide 6:221-7. 2002
    ..The findings are discussed in reference to the neuroinflammatory hypothesis of AD and the possible role of gamma-tocopherol as a major lipid-phase scavenger of reactive nitrogen species...
  47. pmc CAP37, a novel inflammatory mediator: its expression in endothelial cells and localization to atherosclerotic lesions
    Taunia D Lee
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Am J Pathol 160:841-8. 2002
    ..We suggest that, because of its induction and location in the endothelium and its known monocyte- and endothelial-activating capabilities, CAP37 has potential to modulate monocyte/endothelial dynamics at the vessel wall in inflammation...
  48. ncbi request reprint The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice
    Melinda West
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Neurochem 91:133-43. 2004
    ..Thus, TNFalpha antagonists and especially 5LOX inhibitors might offer new opportunities for treatment of ALS...
  49. ncbi request reprint Infection of baboon microglia with SIV-HIV recombinant viruses: role of CD4 and chemokine receptors
    Georgette D Kanmogne
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    AIDS Res Hum Retroviruses 18:557-65. 2002
    ..This study demonstrating the feasibility of infecting baboon microglia with SHIV isolates is an important first step in using the baboon as an alternative nonhuman primate model to study HIV neuropathogenesis...
  50. ncbi request reprint HIV-1 gp120 proteins and gp160 peptides are toxic to brain endothelial cells and neurons: possible pathway for HIV entry into the brain and HIV-associated dementia
    Georgette D Kanmogne
    Department of Pathology, University of Oklahoma Health Science Center, Oklahoma City 73104, USA
    J Neuropathol Exp Neurol 61:992-1000. 2002
    ..This study suggests that HIV proteins and peptides that are shed in vivo may be directly involved in blood-brain barrier damage and neuronal cell death in HIV-associated dementia...
  51. ncbi request reprint Retinal endothelial cells are more susceptible to oxidative stress and increased permeability than brain-derived endothelial cells
    Paula Grammas
    Department of Pathology and the Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Microvasc Res 65:18-23. 2003
    ..These findings suggest that greater oxidative stress and lower junctional protein levels in retinal endothelial cells may contribute to blood/retinal barrier dysfunction in diabetic retinopathy...
  52. ncbi request reprint Functional modulation of smooth muscle cells by the inflammatory mediator CAP37
    Melva L Gonzalez
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Microvasc Res 67:168-81. 2004
    ..We suggest that due to its localization to atherosclerotic plaques and its ability to modulate smooth muscle cells, CAP37 may play a role in the progression of this disease...
  53. ncbi request reprint Thrombin, a mediator of neurotoxicity and memory impairment
    Molina Mhatre
    Department of Pathology, University of Oklahoma Health Sciences Center, 975 NE 10th Street, Oklahoma City, OK 73104, USA
    Neurobiol Aging 25:783-93. 2004
    ..These findings demonstrate that thrombin is a mediator of neurotoxicity and cognitive deficits and suggest that inhibition of thrombin may be a treatment strategy for AD- or head trauma-associated cognitive deficits...

Research Grants17

  1. Vascular inflammation and neurotoxicity in aging brain
    Paula Grammas; Fiscal Year: 2009
    ....
  2. Vascular inflammation and neurotoxicity in aging brain
    Paula Grammas; Fiscal Year: 2007
    ....
  3. Vascular-Mediated Neuronal Cell Death Alzheimer's
    Paula Grammas; Fiscal Year: 2007
    ..Thus, clinical studies with angiogenesis inhibitors could be rapidly designed and implemented in AD patients. ..
  4. Is There a Link Between Alzheimer's and Atheroclerosis
    Paula Grammas; Fiscal Year: 2007
    ..abstract_text> ..
  5. VASCULAR-MEDIATED NEURONAL CELL DEATH IN ALZHEIMER'S
    Paula Grammas; Fiscal Year: 2002
    ..abstract_text> ..
  6. CORE--CENTRALIZED RESEARCH
    Paula Grammas; Fiscal Year: 2001
    ..subproject abstract not available ..
  7. Vascular-Mediated Neuronal Cell Death Alzheimer's
    Paula Grammas; Fiscal Year: 2010
    ..Thus, clinical studies with angiogenesis inhibitors could be rapidly designed and implemented in AD patients. ..