David Yates Graham

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Nitrofurantoin quadruple therapy for Helicobacter pylori infection: effect of metronidazole resistance
    D Y Graham
    The VA Medical Center, Houston, TX 77030, USA
    Aliment Pharmacol Ther 15:513-8. 2001
  2. ncbi request reprint Therapy for Helicobacter pylori infection can be improved: sequential therapy and beyond
    David Y Graham
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
    Drugs 68:725-36. 2008
  3. pmc Gastric endoscopy in the 21st century: appropriate use of an invasive procedure in the era of non-invasive testing
    D Y Graham
    Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    Dig Liver Dis 40:497-503. 2008
  4. ncbi request reprint Meta-analysis: proton pump inhibitor or H2-receptor antagonist for Helicobacter pylori eradication
    D Y Graham
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    Aliment Pharmacol Ther 17:1229-36. 2003
  5. ncbi request reprint Furazolidone combination therapies for Helicobacter pylori infection in the United States
    D Y Graham
    The VA Medical Center, Houston, Texas 77030, USA
    Aliment Pharmacol Ther 14:211-5. 2000
  6. ncbi request reprint Practical rapid, minimally invasive, reliable nonendoscopic method to obtain Helicobacter pylori for culture
    David Y Graham
    Veterans Affairs Medical Center and Baylor College of Medicine, RM 3A 320 111D, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Helicobacter 10:1-3. 2005
  7. ncbi request reprint Thoughts about populations with unexpected low prevalences of Helicobacter pylori infection
    David Y Graham
    Department of Medicine, Michael E DeBakey VAMC, Texas 77030, USA
    Trans R Soc Trop Med Hyg 101:849-51. 2007
  8. ncbi request reprint Ulcer prevention in long-term users of nonsteroidal anti-inflammatory drugs: results of a double-blind, randomized, multicenter, active- and placebo-controlled study of misoprostol vs lansoprazole
    David Y Graham
    Veterans Affairs Medical Center 111D, 2002 Holcombe Blvd, Room 3A 320, Houston, TX 77030 4211, USA
    Arch Intern Med 162:169-75. 2002
  9. ncbi request reprint Early events in proton pump inhibitor-associated exacerbation of corpus gastritis
    D Y Graham
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Aliment Pharmacol Ther 17:193-200. 2003
  10. ncbi request reprint Visible small-intestinal mucosal injury in chronic NSAID users
    David Y Graham
    Department of Medicine, VA Medical Center, Room 3A 320 111D, 2002 Holcombe Boulevard, Houston, Texas 77030, USA
    Clin Gastroenterol Hepatol 3:55-9. 2005

Research Grants

  1. THE ROLE OF MYCOBACTERIA IN CROHN'S DISEASE
    David Graham; Fiscal Year: 2005

Collaborators

Detail Information

Publications126 found, 100 shown here

  1. ncbi request reprint Nitrofurantoin quadruple therapy for Helicobacter pylori infection: effect of metronidazole resistance
    D Y Graham
    The VA Medical Center, Houston, TX 77030, USA
    Aliment Pharmacol Ther 15:513-8. 2001
    ..Antibiotic resistance has increasingly been recognized as the major cause of treatment failure for Helicobacter pylori infection. New therapies for patients with metronidazole- or clarithromycin-resistant H. pylori are needed...
  2. ncbi request reprint Therapy for Helicobacter pylori infection can be improved: sequential therapy and beyond
    David Y Graham
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
    Drugs 68:725-36. 2008
    ..Ultimately, there is little or no justification for comparative testing that includes an arm with known unacceptably low results. H. pylori gastritis is an infectious disease and should be approached and treated as such...
  3. pmc Gastric endoscopy in the 21st century: appropriate use of an invasive procedure in the era of non-invasive testing
    D Y Graham
    Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    Dig Liver Dis 40:497-503. 2008
    ..The development of non-invasive methods to detect Helicobacter pylori and to estimate the extent and severity of gastritis has reduced the need for diagnostic endoscopy in asymptomatic individuals...
  4. ncbi request reprint Meta-analysis: proton pump inhibitor or H2-receptor antagonist for Helicobacter pylori eradication
    D Y Graham
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    Aliment Pharmacol Ther 17:1229-36. 2003
    ..To compare H2-receptor antagonists and proton pump inhibitors as adjuvants to triple therapy for Helicobacter pylori eradication...
  5. ncbi request reprint Furazolidone combination therapies for Helicobacter pylori infection in the United States
    D Y Graham
    The VA Medical Center, Houston, Texas 77030, USA
    Aliment Pharmacol Ther 14:211-5. 2000
    ..Antibiotic resistance has begun to impair the ability to cure Helicobacter pylori infection...
  6. ncbi request reprint Practical rapid, minimally invasive, reliable nonendoscopic method to obtain Helicobacter pylori for culture
    David Y Graham
    Veterans Affairs Medical Center and Baylor College of Medicine, RM 3A 320 111D, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Helicobacter 10:1-3. 2005
    ..Helicobacter pylori culture typically requires endoscopy...
  7. ncbi request reprint Thoughts about populations with unexpected low prevalences of Helicobacter pylori infection
    David Y Graham
    Department of Medicine, Michael E DeBakey VAMC, Texas 77030, USA
    Trans R Soc Trop Med Hyg 101:849-51. 2007
    ..Why some populations apparently lost H. pylori infection remains an open question. However, the tools needed to resolve the dilemma are readily available and we hope investigators will soon rise to the challenge...
  8. ncbi request reprint Ulcer prevention in long-term users of nonsteroidal anti-inflammatory drugs: results of a double-blind, randomized, multicenter, active- and placebo-controlled study of misoprostol vs lansoprazole
    David Y Graham
    Veterans Affairs Medical Center 111D, 2002 Holcombe Blvd, Room 3A 320, Houston, TX 77030 4211, USA
    Arch Intern Med 162:169-75. 2002
    ....
  9. ncbi request reprint Early events in proton pump inhibitor-associated exacerbation of corpus gastritis
    D Y Graham
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Aliment Pharmacol Ther 17:193-200. 2003
    ..Antisecretory therapy may exacerbate Helicobacter pylori corpus gastritis. The rate and mechanism(s) remain unknown...
  10. ncbi request reprint Visible small-intestinal mucosal injury in chronic NSAID users
    David Y Graham
    Department of Medicine, VA Medical Center, Room 3A 320 111D, 2002 Holcombe Boulevard, Houston, Texas 77030, USA
    Clin Gastroenterol Hepatol 3:55-9. 2005
    ..The prevalence and severity of small-intestinal lesions remains unclear. Our aim was to assess the frequency of NSAID-induced small-bowel injury among chronic NSAID users...
  11. pmc The time to eradicate gastric cancer is now
    D Y Graham
    Michael E DeBakey Veterans Affairs Medical Center, RM 3A 320 111D, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Gut 54:735-8. 2005
    ..However, the plan for eradication of this important pathogen must be considered within the context of the prevalence and outcome within specific populations...
  12. ncbi request reprint Commentary: What remains to be done regarding transmission of Helicobacter pylori
    David Y Graham
    Department of Medicine, VA Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Int J Epidemiol 31:646-7. 2002
  13. ncbi request reprint Is the use of COX-2 inhibitors in gastroenterology cost-effective?
    David Y Graham
    Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030 USA
    Nat Clin Pract Gastroenterol Hepatol 1:60-1. 2004
  14. ncbi request reprint Accurate diagnosis of Helicobacter pylori. 13C-urea breath test
    D Y Graham
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA
    Gastroenterol Clin North Am 29:885-93, x. 2000
    ..g., those in whom cancer is not suspected) because it offers the combination of simplicity, accuracy, reliability, and absence of exposure to radioactivity. New versions of the test also offer increasing simplicity and lower costs...
  15. ncbi request reprint Rapid detection of anti-Helicobacter pylori IgG in urine using immunochromatography
    D Y Graham
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston TX 77030, USA
    Aliment Pharmacol Ther 15:699-702. 2001
    ..Non-invasive methods to detect the presence of H. pylori infection continue to be refined...
  16. ncbi request reprint Sequential therapy using high-dose esomeprazole-amoxicillin followed by gatifloxacin for Helicobacter pylori infection
    D Y Graham
    VAMC and Baylor College of Medicine, Houston, TX 77030, USA
    Aliment Pharmacol Ther 24:845-50. 2006
    ..The success rate of current anti-Helicobacter pylori triple therapies in now generally 80% or less. Sequential therapy has proved superior...
  17. ncbi request reprint Alendronate gastric ulcers
    D Y Graham
    Department of Medicine, Veterans Affairs Medical Center, Houston, TX 77030, USA
    Aliment Pharmacol Ther 13:515-9. 1999
    ..We have previously shown that the dose of alendronate used for Paget's disease (40 mg) causes gastric damage similar to NSAIDs. The usual dose for the treatment of postmenopausal osteoporosis is 10 mg per day...
  18. ncbi request reprint Ranitidine bismuth citrate, tetracycline, clarithromycin twice-a-day triple therapy for clarithromycin susceptible Helicobacter pylori infection
    D Y Graham
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA
    Aliment Pharmacol Ther 13:169-72. 1999
    ..Although many combination therapies have been proposed, there is still interest in identifying simple, inexpensive, effective protocols that have high rates of success...
  19. pmc Contemplating the future without Helicobacter pylori and the dire consequences hypothesis
    David Y Graham
    Department of Medicine, Michael E DeBakey VAMC and Baylor College of Medicine, Houston, Texas 77030, USA
    Helicobacter 12:64-8. 2007
    ..It is time to join together to eradicate it and to let H. pylori join smallpox and polio on the hit list of undesirables...
  20. pmc Efficient identification and evaluation of effective Helicobacter pylori therapies
    David Y Graham
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
    Clin Gastroenterol Hepatol 7:145-8. 2009
    ....
  21. pmc African, Asian or Indian enigma, the East Asian Helicobacter pylori: facts or medical myths
    David Y Graham
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    J Dig Dis 10:77-84. 2009
    ..We suggest that a better strategy would be to focus on the pathogenesis of underlying histopathologic differences which could also lead to the identification of specific chemoprevention strategies...
  22. pmc Eradication of gastric cancer and more efficient gastric cancer surveillance in Japan: two peas in a pod
    David Y Graham
    Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, RM 3A 320 111D, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    J Gastroenterol 45:1-8. 2010
    ..e., those with moderate or severe atrophy). This will also allow a much closer matching of surveillance capacity and surveillance need making surveillance more clinically- and cost-effective...
  23. pmc Clinical practice: diagnosis and evaluation of dyspepsia
    David Yates Graham
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine Houston, Texas, USA
    J Clin Gastroenterol 44:167-72. 2010
    ..Overall, from the patients stand point, symptomatic relief is often difficult to achieve and physicians must rely on reassurance along with empiric and individualized care...
  24. doi request reprint Dual proton pump inhibitor plus amoxicillin as an empiric anti-H. pylori therapy: studies from the United States
    David Y Graham
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, RM 3A 320 111D, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    J Gastroenterol 45:816-20. 2010
    ..Theoretically, the use of a PPI dose that provides equivalent acid suppression with fast metabolizers and slow metabolizers would achieve high cure rates irrespective of the CYP2C19 genotype...
  25. doi request reprint Helicobacter pylori treatment in the era of increasing antibiotic resistance
    David Y Graham
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Gut 59:1143-53. 2010
    ..Treatments needing further evaluation include those containing furazolidone or nitazoxanide, hybrids of sequential-concomitant therapies and amoxicillin-PPI dual therapy with PPI doses such that they maintain intragastric pH >6...
  26. pmc Understanding and appreciating sequential therapy for Helicobacter pylori eradication
    David Y Graham
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Gastroenterol 45:309-13. 2011
    ....
  27. pmc Rofecoxib and clinically significant upper and lower gastrointestinal events revisited based on documents from recent litigation
    David Y Graham
    Department of Medicine, Michael E DeBakey VAMC and Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Med Sci 342:356-64. 2011
    ..On the basis of published data, it is widely believed and cited that rofecoxib use is associated with approximately a 50% reduction in significant gastrointestinal (GI) complications such as bleeding...
  28. pmc Long-term proton pump inhibitor use and gastrointestinal cancer
    David Y Graham
    Michael E DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Curr Gastroenterol Rep 10:543-7. 2008
    ..Oxyntic cell hyperplasia, glandular dilatations, and fundic gland polyps may develop in patients not infected with H. pylori, but these changes are believed to be reversible and without significant cancer risk...
  29. ncbi request reprint H. pylori and cagA: relationships with gastric cancer, duodenal ulcer, and reflux esophagitis and its complications
    D Y Graham
    Department of Medicine, Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
    Helicobacter 3:145-51. 1998
    ..The aim of this study was to provide a framework for explaining the seemingly paradoxical associations between H. pylori and various gastrointestinal diseases...
  30. ncbi request reprint Twice daily (mid-day and evening) quadruple therapy for H. pylori infection in the United States
    D Y Graham
    Veterans Affairs Medical Center, Houston, TX 77030, USA
    Dig Liver Dis 36:384-7. 2004
    ..Quadruple therapy provided inadequate eradication rate when given twice-a-day at breakfast and evening meals...
  31. pmc Challenge model for Helicobacter pylori infection in human volunteers
    D Y Graham
    Veterans Affairs Medical Center, RM 3A 320 111D, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Gut 53:1235-43. 2004
    ..A reliable challenge model is needed to evaluate Helicobacter pylori vaccine candidates...
  32. ncbi request reprint Metronidazole containing quadruple therapy for infection with metronidazole resistant Helicobacter pylori: a prospective study
    D Y Graham
    Departments of Medicine, Paediatrics, Pathology, Molecular Virology and Microbiology, The VA Medical Center, Houston, Baylor College of Medicine, Houston, Texas 77030, USA
    Aliment Pharmacol Ther 14:745-50. 2000
    ..pylori infection therapy. It has been suggested that despite resistance, metronidazole may be effective when given at high dose with bismuth, tetracycline, and a proton pump inhibitor (quadruple therapy)...
  33. pmc New concepts of resistance in the treatment of Helicobacter pylori infections
    David Y Graham
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    Nat Clin Pract Gastroenterol Hepatol 5:321-31. 2008
    ..e. sequential therapy; four-drug, three-antibiotic, non-bismuth-containing 'concomitant' therapy; and bismuth-containing quadruple therapy) and how they might be further improved...
  34. ncbi request reprint Novel bismuth-metronidazole-tetracycline triple-layer tablet for treatment of Helicobacter pylori
    D Y Graham
    Department of Medicine, VA Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    Aliment Pharmacol Ther 21:165-8. 2005
    ..Current anti-Helicobacter pylori treatment regimens are costly and because of the increasing antibiotic resistance, are becoming ineffective...
  35. ncbi request reprint Salvage therapy after two or more prior Helicobacter pylori treatment failures: the super salvage regimen
    Maria Pina Dore
    Institute of Internal Medicine, University of Medicine, Sassari, Italy
    Helicobacter 8:307-9. 2003
    ..Although effective therapies are available for curing Helicobacter pylori infection, the problem persists about what to do for patients who fail two or more treatment courses despite a good compliance...
  36. pmc Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: studies in four different countries
    Y Yamaoka
    Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Microbiol 37:2274-9. 1999
    ..iceA status shows considerable geographic differences, and neither iceA nor combinations of iceA, vacA, and cagA were helpful in predicting the clinical presentation of an H. pylori infection...
  37. ncbi request reprint Eradication of Helicobacter pylori by 7-day triple-therapy regimens combining pantoprazole with clarithromycin, metronidazole, or amoxicillin in patients with peptic ulcer disease: results of two double-blind, randomized studies
    Wieslaw J Bochenek
    Wyeth Research, Philadelphia, PA, USA
    Helicobacter 8:626-42. 2003
    ....
  38. pmc CagA in Barrett's oesophagus in Colombia, a country with a high prevalence of gastric cancer
    M Kudo
    Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    J Clin Pathol 58:259-62. 2005
    ..Infection with Helicobacter pylori, especially a CagA positive strain, is unusual in patients with GERD/Barrett's oesophagus in the USA...
  39. ncbi request reprint The Helicobacter pylori restriction endonuclease-replacing gene, hrgA, and clinical outcome: comparison of East Asia and Western countries
    Hong Lu
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Dig Dis Sci 49:1551-5. 2004
    ..pylori from East Asia (29%) vs. those from the West (49%) (P < 0.001). The prevalence of the hrgA gene was not related to clinical outcome or to other important putative virulence factors...
  40. ncbi request reprint Gastric mucosal cytokine levels in relation to host interleukin-1 polymorphisms and Helicobacter pyloricagA genotype
    Ratha Korn Vilaichone
    Department of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand
    Scand J Gastroenterol 40:530-9. 2005
    ..pylori virulence factors and the H. pylori-induced mucosal response. The host inflammatory response is partly governed by polymorphisms in pro-inflammatory genes...
  41. pmc Detection of clarithromycin resistance in Helicobacter pylori following noncryogenic storage of rapid urease tests for 30 days
    Yuan Li
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center, Ben Taub General Hospital, Baylor College of Medicine, Houston, Texas, USA
    J Dig Dis 13:54-9. 2012
    ..We aimed to determine whether gastric biopsy specimens stored at room temperature for rapid urease test (RUT) were suitable for clarithromycin susceptibility testing of H. pylori...
  42. ncbi request reprint False negative urea breath tests with H2-receptor antagonists: interactions between Helicobacter pylori density and pH
    David Y Graham
    Department of Medicine, Veterans Affairs Medical Center, Houston, TX 77030, USA
    Helicobacter 9:17-27. 2004
    ..We studied the effects of famotidine, sodium bicarbonate, and citric acid on the 13C-urea breath test (UBT)...
  43. ncbi request reprint NSAIDs, Helicobacter pylori, and Pandora's Box
    David Y Graham
    N Engl J Med 347:2162-4. 2002
  44. doi request reprint OLGA gastritis staging in young adults and country-specific gastric cancer risk
    Massimo Rugge
    Department of Medical Diagnostic Sciences and Special Therapies II Pathology Unit, University of Padova, Italy
    Int J Surg Pathol 16:150-4. 2008
    ..In populations at different cancer risk, the gastritis OLGA stage mirrored the gastric cancer incidence. Gastritis staging identifies a subgroup of higher-risk patients...
  45. ncbi request reprint Diet, lifestyle and gender in gastro-esophageal reflux disease
    Maria Pina Dore
    Istituto di Clinica Medica, Universita di Sassari, Sassari, Italy
    Dig Dis Sci 53:2027-32. 2008
    ..Studies indicate that gastro-esophageal reflux disease (GERD) is associated with obesity, smoking, esophagitis, diet, and lifestyle...
  46. ncbi request reprint Molecular epidemiology and outcome of Helicobacter pylori infection in Thailand: a cultural cross roads
    Ratha Korn Vilaichone
    Gastroenterology Unit, Department of Medicine, Thammasat University Hospital, Pathumthani, Thailand
    Helicobacter 9:453-9. 2004
    ..pylori genotypes and host factors to outcome. Our data also support the hypothesis that the primary caretaker of the children is most likely the source of the infection...
  47. ncbi request reprint Histologic and serum risk markers for noncardia early gastric cancer
    Akiko Shiotani
    Health Administration Center, Wakayama University, Wakayama City, Japan
    Int J Cancer 115:463-9. 2005
    ..Annual endoscopic follow-up is warranted for patients with IM found at the greater curvature of the corpus...
  48. ncbi request reprint Studies regarding the mechanism of false negative urea breath tests with proton pump inhibitors
    David Y Graham
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Gastroenterol 98:1005-9. 2003
    ..We studied the time course of PPI-associated negative UBT, the relation to Helicobacter pylori density, and whether gastric acidification would prevent false negative UBT results...
  49. ncbi request reprint Traces of human migrations in Helicobacter pylori populations
    Daniel Falush
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, 10117 Berlin, Germany
    Science 299:1582-5. 2003
    ..Subsequent spread can be attributed to human migratory fluxes such as the prehistoric colonization of Polynesia and the Americas, the neolithic introduction of farming to Europe, the Bantu expansion within Africa, and the slave trade...
  50. pmc Helicobacter pylori environmental interactions: effect of acidic conditions on H. pylori-induced gastric mucosal interleukin-8 production
    Il Ju Choi
    Department of Medicine Gastroenterology, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    Cell Microbiol 9:2457-69. 2007
    ..These results might explain the clinical studies in which patients with duodenal ulcers had higher levels of IL-8 in the antral gastric mucosa than patients with simple H. pylori gastritis...
  51. ncbi request reprint Critical effect of Helicobacter pylori infection on the effectiveness of omeprazole for prevention of gastric or duodenal ulcers among chronic NSAID users
    David Y Graham
    Department of Medicine, Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
    Helicobacter 7:1-8. 2002
    ..The recently reported OMNIUM and ASTRONAUT NSAID ulcer prevention trials using omeprazole to prevent endoscopic ulcer recurrence among chronic NSAID users suggested superiority over misoprostol or ranitidine...
  52. ncbi request reprint Noninvasive versus histologic detection of gastric atrophy in a Hispanic population in North America
    David Y Graham
    Department of Medicine, Veterans Affairs Medical Center, and Baylor College of Medicine, Houston, Texas, USA
    Clin Gastroenterol Hepatol 4:306-14. 2006
    ..The aim of this study was to compare targeted histology with noninvasive testing for the identification of antral and/or corpus atrophy in North America...
  53. pmc Antibody against Helicobacter pylori CagA and VacA and the risk for gastric cancer
    Y Yamaoka
    Department of Medicine, Veterans Affairs Medical Center 111D, Houston, Texas 77030, USA
    J Clin Pathol 52:215-8. 1999
    ..Helicobacter pylori is associated with gastric cancer. Our aim was to investigate whether CagA or VacA seropositivity provides additional risk for gastric cancer...
  54. ncbi request reprint Conservation of Helicobacter pylori genotypes in different ethnic groups in Houston, Texas
    Y Yamaoka
    Department of Medicine, Veterans Affairs Medical Center, Houston, TX 77030, USA
    J Infect Dis 181:2083-6. 2000
    ..Conservation of an H. pylori genotype within ethnic groups over the course of generations will prove useful for epidemiological study of the coevolution of humans and H. pylori...
  55. ncbi request reprint NSAID gastric ulceration: predictive value of gastric pH, mucosal density of polymorphonuclear leukocytes, or levels of IL-8 or nitrite
    Akiko Shiotani
    Department of Medicine, VA Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Dig Dis Sci 47:38-43. 2002
    ..In conclusion, there was no relation between mucosal PMN density and endoscopic mucosa injury. PMN infiltration, while not predictive, may be a surrogate for an H. pylori infection-related increased risk of NSAID ulcers...
  56. ncbi request reprint Dramatic changes in the prevalence of Helicobacter pylori infection during childhood: a 10-year follow-up study in Russia
    Mikhail A Tkachenko
    Department of Pediatrics 1, Russia
    J Pediatr Gastroenterol Nutr 45:428-32. 2007
    ..This phenomenon has been related to differences in socioeconomic status, sanitation, and household hygiene. Russia is in the process of transforming from an underdeveloped to a developed country...
  57. ncbi request reprint The QUADRATE study: a proposal for a change in the reporting of pharmaceutical supported trials
    David Y Graham
    Gastroenterology 125:639; author reply 640-1. 2003
  58. pmc Comparison of genotyping Helicobacter pylori directly from biopsy specimens and genotyping from bacterial cultures
    Chang Young Park
    Department of Medicine, Veterans Affairs Medical Center, and Baylor College of Medicine, Houston, Texas, USA
    J Clin Microbiol 41:3336-8. 2003
    ..Inconsistent results were associated with low H. pylori density in biopsies. A higher proportion of mixed infection was found when biopsies were used...
  59. ncbi request reprint The changing epidemiology of GERD: geography and Helicobacter pylori
    David Y Graham
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Gastroenterol 98:1462-70. 2003
    ..In the last century GERD became increasingly recognized in the West and it has become evident that the prevalence of GERD is now occurring in many previously underdeveloped countries...
  60. pmc Gastritis staging in clinical practice: the OLGA staging system
    Massimo Rugge
    Anatomia Patologica, Universita degli Studi di Padova, Istituto Oncologico del Veneto IOV IRCCS, Via Aristide Gabelli, 61, 35121 Padova, Italia
    Gut 56:631-6. 2007
    ..Gastritis staging integrates the atrophy score (obtained by biopsy) and the atrophy topography (achieved through directed biopsy mapping)...
  61. pmc Relation between seroreactivity to low-molecular-weight Helicobacter pylori-specific antigens and disease presentation
    Ratha Korn Vilaichone
    Gastroenterology Unit, Department of Medicine, Thammasat University Hospital, Pathumthani, Bangkok, Thailand
    Clin Diagn Lab Immunol 10:1025-8. 2003
    ..pylori-related diseases or have specific active or protective roles in H. pylori-related diseases...
  62. ncbi request reprint Appropriate use of intravenous proton pump inhibitors in the management of bleeding peptic ulcer
    Venodhar R Julapalli
    Department of Medicine, Michael E DeBakey VA Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Dig Dis Sci 50:1185-93. 2005
    ..g., 80 mg) followed by a constant infusion (e.g., 8 mg/hr). Whether the combination of endoscopic hemostasis and pH control is equal or superior to selected second-look endoscopy is unknown. A treatment algorithm is suggested...
  63. pmc Helicobacter pylori BabA expression, gastric mucosal injury, and clinical outcome
    Saori Fujimoto
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Gastroenterol Hepatol 5:49-58. 2007
    ..The blood grou...
  64. pmc Functional and intracellular signaling differences associated with the Helicobacter pylori AlpAB adhesin from Western and East Asian strains
    Hong Lu
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 282:6242-54. 2007
    ..Known geographical differences in H. pylori-related clinical outcomes may relate to differential effects of East Asian and Western types of AlpAB on NF-kappaB-related proinflammatory signaling pathways...
  65. ncbi request reprint Evidence-based examination of the African enigma in relation to Helicobacter pylori infection
    Aamer Agha
    Department of Medicine, VA Medical Center and Baylor College of Medicine, Houston, TX, USA
    Scand J Gastroenterol 40:523-9. 2005
    ..pylori-related diseases. The aim of this study was to use an evidence-based review of endoscopic data from African countries to test whether there are data to support the concept of an African enigma...
  66. pmc Regulation of interleukin-6 promoter activation in gastric epithelial cells infected with Helicobacter pylori
    Hong Lu
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    Mol Biol Cell 16:4954-66. 2005
    ..Combination of different pathways by the cag PAI and OipA will lead to the maximum IL-6 induction...
  67. ncbi request reprint Genomic fingerprinting and genotyping of Helicobacter pylori strains from patients with duodenal ulcer or gastric cancer from different geographic regions
    Li Li
    Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA
    Dig Dis Sci 47:2512-8. 2002
    ..We did not detect any association between disease presentation and H. pylori genotypes using either DNA fingerprinting or candidate single gene virulence factors...
  68. ncbi request reprint Obesity is an independent risk factor for GERD symptoms and erosive esophagitis
    Hashem B El-Serag
    Section of Gastroenterology at the Houston Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Gastroenterol 100:1243-50. 2005
    ..An association between obesity and GERD symptoms has been reported; however, study results have been inconsistent and it is not known whether an association persists after adjusting for other known GERD risk factors...
  69. pmc Pattern of transcription factor activation in Helicobacter pylori-infected Mongolian gerbils
    Takahiko Kudo
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Gastroenterology 132:1024-38. 2007
    ..We investigated the roles of transcription factors in the gastric mucosa of H pylori-infected gerbils over the course of the infection...
  70. ncbi request reprint Comparison of the Etest and the NCCLS-approved agar dilution method to detect metronidazole and clarithromycin resistant Helicobacter pylori
    M S Osato
    Gastroenterology Microbiology Laboratory, Department of Medicine, Veterans Affairs Medical Center, Baylor College of Medicine, MS 111D, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Antimicrob Agents 17:39-44. 2001
    ..Neither method is reliable in determining metronidazole resistance in H. pylori...
  71. ncbi request reprint Geographic differences in the distribution of intestinal metaplasia in duodenal ulcer patients
    O Gutierrez
    Department of Medicine, VA Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Gastroenterol 96:666-72. 2001
    ..These findings suggest that duodenal ulcer and gastric cancer are not mutually exclusive diseases but are rather ends of the spectrum of H. pylori infection...
  72. pmc Comparison of four serological tests to determine the CagA or VacA status of Helicobacter pylori strains
    Y Yamaoka
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Microbiol 36:3433-4. 1998
    ..None can be recommended for determining CagA or VacA status...
  73. pmc Nucleotide sequence analysis and seroreactivities of the 65K heat shock protein from Mycobacterium paratuberculosis
    F A El-Zaatari
    Inflammatory Bowel Disease Laboratory, Veterans Affairs Medical Center, Houston, TX 77030, USA
    Clin Diagn Lab Immunol 2:657-64. 1995
    ..However, in humans, the high intensity of antibody reactions of some sera from Crohn's disease patients compared with that from noninflammatory bowel disease patients showed a positive correlation with mycobacterial diseases...
  74. ncbi request reprint Practical advice on eradicating Helicobacter pylori infection
    D Y Graham
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Postgrad Med 105:137-40, 145-8. 1999
    ..Considerations for anti-H pylori treatment in a managed care environment mirror those for good medical practice in general, with special attention to stringent cost-control or outcomes-driven measures...
  75. ncbi request reprint Alendronate and naproxen are synergistic for development of gastric ulcers
    D Y Graham
    Veterans Affairs Medical Center (111D, 2002 Holcombe Blvd, Houston, TX 77030, USA
    Arch Intern Med 161:107-10. 2001
    ..CONCLUSIONS: Both alendronate and naproxen can cause gastric ulcers. The combination appears synergistic. Alendronate should be used with caution in those who simultaneously require nonsteroidal anti-inflammatory drugs...
  76. pmc One- or two-week triple therapy for Helicobacter pylori: questions of efficacy and inclusion of a dual therapy treatment arm
    David Y Graham
    Gut 56:1021-3; author reply 1022-3. 2007
  77. pmc Regulation of IL-18 in Helicobacter pylori infection
    Kazuyoshi Yamauchi
    Department of Medicine Gastroenterology, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 180:1207-16. 2008
    ..In addition, OipA and its related p38 pathway may be closely involved in IL-18 induction in H. pylori-infected gastric mucosa and may contribute to gastric injury...
  78. pmc Genetic analysis of Helicobacter pylori strain populations colonizing the stomach at different times postinfection
    Nina R Salama
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Bacteriol 189:3834-45. 2007
    ....
  79. pmc Duodenal ulcer promoting gene of Helicobacter pylori
    Hong Lu
    Department of Medicine Gastroenterology, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Gastroenterology 128:833-48. 2005
    ..Identification of a disease-specific H pylori virulence factors predictive of the outcome of infection remains unachieved...
  80. ncbi request reprint Ethical considerations of comparing sequential and traditional anti Helicobacter pylori therapy
    David Y Graham
    Ann Intern Med 147:434-5. 2007
  81. pmc Regulation of RANTES promoter activation in gastric epithelial cells infected with Helicobacter pylori
    Takahiko Kudo
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center, 2002 Holcombe Blvd, 111D Rm 3A 320, Houston, TX 77030, USA
    Infect Immun 73:7602-12. 2005
    ..The mucosal inflammatory response to H. pylori infection involves different signaling pathways for activation of the RANTES promoter, with both OipA and the cag PAI being required for full activation of the RANTES promoter...
  82. ncbi request reprint A pilot study of Helicobacter pylori infection and risk of laryngopharyngeal cancer
    Zhannat Z Nurgalieva
    Department of Gastroenterology Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Head Neck 27:22-7. 2005
    ..The aim of this study was to investigate whether H. pylori infection also protects against laryngopharyngeal carcinoma...
  83. ncbi request reprint Clinical presentation in relation to diversity within the Helicobacter pylori cag pathogenicity island
    Ping I Hsu
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Gastroenterol 97:2231-8. 2002
    ..This study investigated the genetic diversity of the cag pathogenicity island (PAI) in Helicobacter pylori (H. pylori) in relation to clinical outcome and interleukin (IL)-8 production...
  84. pmc New serological assay for detection of putative Helicobacter pylori virulence factors
    Chang Young Park
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA
    J Clin Microbiol 40:4753-6. 2002
    ..The test accurately detected H. pylori infection and VacA status, but improvements in the interpretation criteria are required before it can be recommended for determination of CagA status...
  85. ncbi request reprint Helicobacter pylori strain and the pattern of gastritis among first-degree relatives of patients with gastric carcinoma
    Li Li
    Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Helicobacter 7:349-55. 2002
    ..Relatives of gastric cancer patients have an increased risk of gastric cancer, possibly related to genetically-related strains of Helicobacter pylori or a common environment...
  86. ncbi request reprint Interleukin-6 genetic polymorphisms are not related to Helicobacter pylori-associated gastroduodenal diseases
    Il Ran Hwang
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Helicobacter 8:142-8. 2003
    ..Inter-individual variation in the severity of gastric inflammation may be important in determining the clinical outcome of an Helicobacter pylori infection and relate to polymorphisms in this region...
  87. pmc Evaluation of the effects of strain-specific antigen variation on the accuracy of serologic diagnosis of Helicobacter pylori infection
    Patrice A Marchildon
    Enteric Products, Inc, Stony Brook, New York, USA
    J Clin Microbiol 41:1480-5. 2003
    ..pylori-positive patients (accuracies, 97.2 and 92.3%, respectively), suggesting that variations in performance between both antigen source and patient population might be reduced by using antigens pooled from several strains...
  88. ncbi request reprint The effect of galE gene inactivation on lipopolysaccharide profile of Helicobacter pylori
    D H Kwon
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Microbiol 37:144-8. 1998
    ..The LPS profile from the galE-knockout H. pylori strain showed a lower molecular weight than that of the parental strain, indicating the involvement of the galE gene in LPS biosynthesis of H. pylori...
  89. ncbi request reprint Cytokeratin subsets for distinguishing Barrett's esophagus from intestinal metaplasia in the cardia using endoscopic biopsy specimens
    H M El-Zimaity
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Gastroenterol 96:1378-82. 2001
    ..CONCLUSIONS: These results do not support keratin phenotyping as a tool for differentiating intestinal metaplasia originating in the cardia from intestinal metaplasia of Barrett's...
  90. ncbi request reprint Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance
    J Versalovic
    Digestive Diseases, Veterans Affairs Medical Center, Houston, TX 77030, USA
    J Antimicrob Chemother 40:283-6. 1997
    ..9%) of isolates with the A2143G mutation had MICs exceeding 64 mg/L. Peptic ulcer disease recurred in a substantial proportion of patients infected with H. pylori strains containing either the A2143G or the A2144G mutation...
  91. ncbi request reprint Effect of interleukin 1 polymorphisms on gastric mucosal interleukin 1beta production in Helicobacter pylori infection
    Il Ran Hwang
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Gastroenterology 123:1793-803. 2002
    ....
  92. ncbi request reprint Histological patterns of gastritis in H. pylori-infected individuals with a family history of gastric cancer
    A Sepulveda
    Department of Pathology, University of Pittsburgh, Pennsylvania 15213 2582, USA
    Am J Gastroenterol 97:1365-70. 2002
    ..Specific patterns of H. pylori gastritis that might characterize individuals with family histories of noncardia gastric cancer (GC) were investigated...
  93. ncbi request reprint Helicobacter pylori eradication and its effect on iron stores: a reappraisal
    Victor M Cardenas
    J Infect Dis 194:714; author reply 715-6. 2006
  94. ncbi request reprint Antibiotic resistance in Helicobacter pylori: implications for therapy
    D Y Graham
    Department of Medicine, Veterans Affairs Medical Center and Division of Molecular Virology, Baylor College of Medicine, Houston, Texas
    Gastroenterology 115:1272-7. 1998
    ..Acquired resistance of H. pylori to clarithromycin, metronidazole, tetracycline, and amoxicillin have all been described...
  95. ncbi request reprint Relationship of vacA genotypes of Helicobacter pylori to cagA status, cytotoxin production, and clinical outcome
    Y Yamaoka
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Helicobacter 3:241-53. 1998
    ..The aim of this study was to evaluate the role of vacA genotyping with respect to gastric inflammation and injury, cytotoxin activity, and clinical presentation...
  96. pmc Sensitivity of amoxicillin-resistant Helicobacter pylori to other penicillins
    M P Dore
    Department of Medicine, VA Medical Center, and Baylor College of Medicine, Houston, Texas 77030, USA
    Antimicrob Agents Chemother 43:1803-4. 1999
    ..High-level resistance was associated with the smallest zone size for all penicillins tested...
  97. ncbi request reprint Relationship between the cagA 3' repeat region of Helicobacter pylori, gastric histology, and susceptibility to low pH
    Y Yamaoka
    VA Medical Center and Baylor College of Medicine, Houston, Texas, USA
    Gastroenterology 117:342-9. 1999
    ..We investigated whether structural subtypes of the cagA 3' region are associated with presentation of the infection or to susceptibility to acid...
  98. ncbi request reprint Metronidazole and clarithromycin resistance amongst Helicobacter pylori isolates from a large metropolitan hospital in the United States
    M S Osato
    Department of Medicine, Veterans Affairs Medical Center, Houston, TX 77030, USA
    Int J Antimicrob Agents 12:341-7. 1999
    ..pylori isolates from this metropolitan hospital is such that antimicrobial susceptibility data should be available so that informed choice can be made for specific eradication therapies, especially in patients who fail treatment...
  99. ncbi request reprint Natural history of Helicobacter pylori infection in childhood: 12-year follow-up cohort study in a biracial community
    H M Malaty
    Department of Laboratory Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Infect Dis 28:279-82. 1999
    ..H. pylori infection in childhood is affected by both acquisition and loss of infection in different ethnic groups. This observation is critical for understanding the epidemiology and transmission of H. pylori infection...
  100. pmc Houseflies are an unlikely reservoir or vector for Helicobacter pylori
    M S Osato
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Microbiol 36:2786-8. 1998
    ..pylori. These results suggest that the domestic housefly is not a vector for transmission or a reservoir for H. pylori infection...
  101. ncbi request reprint Amoxycillin resistance is one reason for failure of amoxycillin-omeprazole treatment of Helicobacter pylori infection
    M P Dore
    Institute of Internal Medicine, University of Medicine, Sassari, Italy
    Aliment Pharmacol Ther 12:635-9. 1998
    ..The aim of this study was to assess the role of pre-treatment amoxycillin resistance in the efficacy of omeprazole and amoxycillin dual therapy...

Research Grants4

  1. THE ROLE OF MYCOBACTERIA IN CROHN'S DISEASE
    David Graham; Fiscal Year: 2005
    ..The results of this study should either confirm or refute the proposed etiologic association of M. paratuberculosis and Crohn's disease as well as the identification of patients with Crohn's disease and M. paratuberculosis. ..