Vera Gorbunova

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Telomerase as a growth-promoting factor
    Vera Gorbunova
    Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA
    Cell Cycle 2:534-7. 2003
  2. ncbi request reprint Evidence that high telomerase activity may induce a senescent-like growth arrest in human fibroblasts
    Vera Gorbunova
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:7692-8. 2003
  3. pmc Genome-wide demethylation promotes triplet repeat instability independently of homologous recombination
    Vincent Dion
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    DNA Repair (Amst) 7:313-20. 2008
  4. pmc DNA end joining becomes less efficient and more error-prone during cellular senescence
    Andrei Seluanov
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:7624-9. 2004
  5. ncbi request reprint Genome-wide demethylation destabilizes CTG.CAG trinucleotide repeats in mammalian cells
    Vera Gorbunova
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 13:2979-89. 2004
  6. pmc Selectable system for monitoring the instability of CTG/CAG triplet repeats in mammalian cells
    Vera Gorbunova
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 23:4485-93. 2003
  7. ncbi request reprint Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis
    Vera Gorbunova
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:38540-9. 2002
  8. ncbi request reprint CLK-1 protein has DNA binding activity specific to O(L) region of mitochondrial DNA
    Vera Gorbunova
    Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    FEBS Lett 516:279-84. 2002
  9. pmc Cell divisions are required for L1 retrotransposition
    Xi Shi
    University of Rochester, 213 Hutchison Hall, River Campus, Rochester, NY 14627 0211, USA
    Mol Cell Biol 27:1264-70. 2007
  10. pmc Telomerase activity coevolves with body mass not lifespan
    Andrei Seluanov
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Aging Cell 6:45-52. 2007

Collaborators

  • John H Wilson
  • Vincent Dion
  • David Mittelman
  • Yunfu Lin
  • Andrei Seluanov
  • Zhiyong Mao
  • Xi Shi
  • Michael Bozzella
  • Daven C Presgraves
  • Kenneth C Catania
  • Christopher Hine
  • Jacquelynn Danek
  • Zhuoxun Chen
  • Tais H C Sasahara
  • Nola Hause
  • Antonio A C M Ribeiro
  • Olivia M Pereira-Smith

Detail Information

Publications13

  1. ncbi request reprint Telomerase as a growth-promoting factor
    Vera Gorbunova
    Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA
    Cell Cycle 2:534-7. 2003
    ..As some of these functions can be dissociated from telomere lengthening, the question arises as to how the mere presence of telomerase can serve as a survival and growth-promoting factor...
  2. ncbi request reprint Evidence that high telomerase activity may induce a senescent-like growth arrest in human fibroblasts
    Vera Gorbunova
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:7692-8. 2003
    ..Thus, there must be a critical threshold of telomerase activity that permits cell proliferation...
  3. pmc Genome-wide demethylation promotes triplet repeat instability independently of homologous recombination
    Vincent Dion
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    DNA Repair (Amst) 7:313-20. 2008
    ..The subtle influences of demethylation on HR at the Aprt locus are not sufficient to account for its dramatic effects on repeat instability. We conclude that 5-aza-CdR promotes triplet repeat instability independently of HR...
  4. pmc DNA end joining becomes less efficient and more error-prone during cellular senescence
    Andrei Seluanov
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:7624-9. 2004
    ..We hypothesize that inefficient and aberrant end joining is a likely mechanism underlying the age-related genomic instability and higher incidence of cancer in the elderly...
  5. ncbi request reprint Genome-wide demethylation destabilizes CTG.CAG trinucleotide repeats in mammalian cells
    Vera Gorbunova
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 13:2979-89. 2004
    ..The dramatic destabilizing effect of DNA methyltransferase inhibitors supports the hypothesis that changes in methylation patterns during epigenetic reprogramming may trigger the intergenerational repeat expansions that lead to disease...
  6. pmc Selectable system for monitoring the instability of CTG/CAG triplet repeats in mammalian cells
    Vera Gorbunova
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 23:4485-93. 2003
    ..We also discuss how the effect of long CTG/CAG repeat tracts on splicing may contribute to the progression of polyglutamine diseases...
  7. ncbi request reprint Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis
    Vera Gorbunova
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:38540-9. 2002
    ..We hypothesize that healing of DNA breaks by telomerase inhibits the induction of cell death, but because healing does not provide legitimate DNA repair, it does not protect cells from SIPS...
  8. ncbi request reprint CLK-1 protein has DNA binding activity specific to O(L) region of mitochondrial DNA
    Vera Gorbunova
    Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    FEBS Lett 516:279-84. 2002
    ..Our results suggest that, in addition to its enzymatic function in ubiquinone biosynthesis, CLK-1 is involved in the regulation of mtDNA replication or transcription...
  9. pmc Cell divisions are required for L1 retrotransposition
    Xi Shi
    University of Rochester, 213 Hutchison Hall, River Campus, Rochester, NY 14627 0211, USA
    Mol Cell Biol 27:1264-70. 2007
    ..We hypothesize that inhibition of retrotransposition in nondividing cells protects somatic tissues from accumulation of deleterious mutations caused by L1 elements...
  10. pmc Telomerase activity coevolves with body mass not lifespan
    Andrei Seluanov
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Aging Cell 6:45-52. 2007
    ..These results suggest that large body mass presents a greater risk of cancer than long lifespan, and large animals evolve repression of telomerase activity to mitigate that risk...
  11. pmc Changes in the level and distribution of Ku proteins during cellular senescence
    Andrei Seluanov
    Department of Biology, University of Rochester, Rochester, NY 14627 0211, United States
    DNA Repair (Amst) 6:1740-8. 2007
    ....
  12. ncbi request reprint Making ends meet in old age: DSB repair and aging
    Vera Gorbunova
    Department of Biology, University of Rochester, NY 14627, USA
    Mech Ageing Dev 126:621-8. 2005
    ....
  13. pmc DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells
    Zhiyong Mao
    Department of Biology, University of Rochester, Rochester, New York 14627, USA
    Cell Cycle 7:2902-6. 2008
    ..We conclude that human somatic cells utilize error-prone NHEJ as the major DSB repair pathway at all cell cycle stages, while HR is used, primarily, in the S phase...