Margaret Goodell

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Altered phenotype and reduced function of muscle-derived hematopoietic stem cells
    Shannon L McKinney-Freeman
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Tex 77030, USA
    Exp Hematol 31:806-14. 2003
  2. ncbi request reprint Circulating hematopoietic stem cells do not efficiently home to bone marrow during homeostasis
    Shannon McKinney-Freeman
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    Exp Hematol 32:868-76. 2004
  3. pmc Molecular signatures of proliferation and quiescence in hematopoietic stem cells
    Teresa A Venezia
    Cell and Molecular Biology Program, Baylor College of Medicine, Houston, Texas, USA
    PLoS Biol 2:e301. 2004
  4. ncbi request reprint Stem cell plasticity in muscle and bone marrow
    M A Goodell
    Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, N1030, Houston, Texas 77030, USA
    Ann N Y Acad Sci 938:208-18; discussion 218-20. 2001
  5. ncbi request reprint Stem cells: is there a future in plastics?
    M A Goodell
    Center for Cell and Gene Therapy and Department of Pediatrics, Baylor College of Medicine, BCM 505, One Baylor Plaza, Houston, TX 77030, USA
    Curr Opin Cell Biol 13:662-5. 2001
  6. ncbi request reprint Stem-cell "plasticity": befuddled by the muddle
    Margaret A Goodell
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Opin Hematol 10:208-13. 2003
  7. pmc Muscle-derived hematopoietic stem cells are hematopoietic in origin
    Shannon L McKinney-Freeman
    Department of Pediatrics, Center for Cell and Gene Therapy, BCM 505, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 99:1341-6. 2002
  8. ncbi request reprint Techniques for the study of adult stem cells: be fruitful and multiply
    Carlos A Ramos
    Baylor College of Medicine, Houston, TX, USA
    Biotechniques 34:572-8, 580-4, 586-91. 2003
  9. pmc Distinct progenitor populations in skeletal muscle are bone marrow derived and exhibit different cell fates during vascular regeneration
    Susan M Majka
    Department of Pediatrics, Children s Nutrition Research Center, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Invest 111:71-9. 2003
  10. pmc Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners
    Fernando D Camargo
    Center for Cell and Gene Therapy, Baylor College of Medicinem Houston, Texas 77098, USA
    J Clin Invest 113:1266-70. 2004

Research Grants

  1. CD34 NEGATIVE HUMAN HEMATOPOIETIC STEM CELLS
    Margaret Goodell; Fiscal Year: 2000
  2. Hematopoietic Stem Cell Differentiation and Commitment
    Margaret Goodell; Fiscal Year: 2006
  3. Safe and Efficient Generation of hES-derived Bone Marrow
    Margaret Goodell; Fiscal Year: 2005
  4. Safe and Efficient Generation of hES-derived Bone Marrow
    Margaret Goodell; Fiscal Year: 2006
  5. Hematopoietic Stem Cell Differentiation and Commitment
    Margaret Goodell; Fiscal Year: 2007
  6. Safe and Efficient Generation of hES-derived Bone Marrow
    Margaret Goodell; Fiscal Year: 2007
  7. Hematopoietic Stem Cell Differentiation and Commitment
    Margaret Goodell; Fiscal Year: 2009
  8. Hematopoietic Stem Cell Differentiation and Commitment
    Margaret Goodell; Fiscal Year: 2009
  9. Conference on Molecular Regulation of Stem Cells
    Margaret Goodell; Fiscal Year: 2005
  10. MUSCLE-DERIVED HEMATOPOIETIC STEM CELLS
    Margaret Goodell; Fiscal Year: 2004

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Altered phenotype and reduced function of muscle-derived hematopoietic stem cells
    Shannon L McKinney-Freeman
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Tex 77030, USA
    Exp Hematol 31:806-14. 2003
    ..Here we sought to clarify contradictions in the literature regarding the phenotype of ms-HSC and precisely define the hematopoietic origin of these cells...
  2. ncbi request reprint Circulating hematopoietic stem cells do not efficiently home to bone marrow during homeostasis
    Shannon McKinney-Freeman
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    Exp Hematol 32:868-76. 2004
    ..Accordingly, recent data suggest that circulating HSC may be unable to stably engraft WBM under homeostatic conditions. The purpose of this study was to explore these dynamics in detail using parabiosis and bone marrow transplantation...
  3. pmc Molecular signatures of proliferation and quiescence in hematopoietic stem cells
    Teresa A Venezia
    Cell and Molecular Biology Program, Baylor College of Medicine, Houston, Texas, USA
    PLoS Biol 2:e301. 2004
    ..These data will be of use in attempts to recapitulate the HSC self renewal process for therapeutic expansion of stem cells, and our model may correlate with acquisition of self renewal characteristics by cancer stem cells...
  4. ncbi request reprint Stem cell plasticity in muscle and bone marrow
    M A Goodell
    Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, N1030, Houston, Texas 77030, USA
    Ann N Y Acad Sci 938:208-18; discussion 218-20. 2001
    ..The engrafted stem cells or their progeny differentiated into cardiomyocytes and endothelial cells and contributed to the formation of functional tissue...
  5. ncbi request reprint Stem cells: is there a future in plastics?
    M A Goodell
    Center for Cell and Gene Therapy and Department of Pediatrics, Baylor College of Medicine, BCM 505, One Baylor Plaza, Houston, TX 77030, USA
    Curr Opin Cell Biol 13:662-5. 2001
    ....
  6. ncbi request reprint Stem-cell "plasticity": befuddled by the muddle
    Margaret A Goodell
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Opin Hematol 10:208-13. 2003
    ..The evidence for and against stem-cell plasticity is reviewed here as well as some of the possible sources of the experimental variation...
  7. pmc Muscle-derived hematopoietic stem cells are hematopoietic in origin
    Shannon L McKinney-Freeman
    Department of Pediatrics, Center for Cell and Gene Therapy, BCM 505, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 99:1341-6. 2002
    ..Although CD45-negative cells were highly myogenic in vitro and in vivo, CD45-positive muscle-derived cells displayed only very limited myogenic activity and only in vivo...
  8. ncbi request reprint Techniques for the study of adult stem cells: be fruitful and multiply
    Carlos A Ramos
    Baylor College of Medicine, Houston, TX, USA
    Biotechniques 34:572-8, 580-4, 586-91. 2003
  9. pmc Distinct progenitor populations in skeletal muscle are bone marrow derived and exhibit different cell fates during vascular regeneration
    Susan M Majka
    Department of Pediatrics, Children s Nutrition Research Center, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Invest 111:71-9. 2003
    ..Thus, distinct populations of vascular progenitors are resident within skeletal muscle, are derived from bone marrow, and exhibit different cell fates during injury-induced vascular regeneration...
  10. pmc Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners
    Fernando D Camargo
    Center for Cell and Gene Therapy, Baylor College of Medicinem Houston, Texas 77098, USA
    J Clin Invest 113:1266-70. 2004
    ..Our findings raise the possibility that differentiated myeloid cells may be useful for future therapeutic applications of in vivo cellular fusion...
  11. ncbi request reprint Anti-CD45-mediated cytoreduction to facilitate allogeneic stem cell transplantation
    Gerald G Wulf
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Blood 101:2434-9. 2003
    ..Monoclonal antibodies of this type may therefore have an adjunctive role in nonmyeloablative conditioning regimens for allogeneic stem cell transplantation...
  12. ncbi request reprint Stem cells: a minireview
    Kathyjo A Jackson
    Center for Cell and Gene Therapy and Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Cell Biochem Suppl 38:1-6. 2002
    ..Caution is urged when interpreting these types of experiments because although they are stimulating, limitations of the technologies may provide misleading results...
  13. pmc Primitive adult hematopoietic stem cells can function as osteoblast precursors
    Elizabeth A Olmsted-Davis
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:15877-82. 2003
    ..This property not only elucidates a previously unrecognized step in osteoblast development, but also has intriguing implications for the use of SP cells in clinical orthopedics and stem cell-based disorders of bone...
  14. ncbi request reprint Phenotype and hematopoietic potential of side population cells throughout embryonic development
    Brian M Nadin
    Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Blood 102:2436-43. 2003
    ....
  15. ncbi request reprint Complement-fixing CD45 monoclonal antibodies to facilitate stem cell transplantation in mouse and man
    Malcolm K Brenner
    Center for Cell and Gene Therapy and Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Ann N Y Acad Sci 996:80-8. 2003
    ..These pre-clinical and clinical results warrant further evaluation of anti-CD45 MAbs in subablative preparative regimens for stem cell transplantation...
  16. pmc Hematopoietic fingerprints: an expression database of stem cells and their progeny
    Stuart M Chambers
    Interdepartmental Program of Cell and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Stem Cell 1:578-91. 2007
    ....
  17. ncbi request reprint Use of CD9 expression to enrich for porcine hematopoietic progenitors
    Matthew Heinz
    Baylor College of Medicine, Center for Cell and Gene Therapy, Houston, TX 77098, USA
    Exp Hematol 30:809-15. 2002
    ..The aim of this study was to develop novel markers for enrichment of hematopoietic progenitors from bone marrow of swine...
  18. pmc Identification and characterization of side population cells in embryonic stem cell cultures
    Diego S Vieyra
    Stem Cells and Regenerative Medicine Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Stem Cells Dev 18:1155-66. 2009
    ....
  19. pmc Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1
    Grant A Challen
    Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Stem Cell 6:265-78. 2010
    ....
  20. ncbi request reprint Isolation and characterization of side population cells
    Margaret A Goodell
    Center for Cell and Gene Therapy, Department of Immunology and Cell and Molecular Biology Program, Baylor College of Medicine, Houston, TX, USA
    Methods Mol Biol 290:343-52. 2005
    ..The protocols outlined in this chapter describe the isolation of murine SP cells from both bone marrow and skeletal muscle using the fluorescent DNA-binding dye Hoechst 33342. In these tissues, the SP cells that are isolated are HSCs...
  21. pmc Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection
    Megan T Baldridge
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 465:793-7. 2010
    ..Our studies contribute to a deeper understanding of haematological responses in patients with chronic infections such as HIV/AIDS or tuberculosis...
  22. pmc Hematopoietic stem cells do not engraft with absolute efficiencies
    Fernando D Camargo
    Program in Cell and Molecular Biology and the Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77098, USA
    Blood 107:501-7. 2006
    ..Altogether, our results indicate that even an extremely homogeneous HSC population, based on phenotype and dye efflux, cannot reconstitute mice at absolute efficiencies...
  23. pmc CD150- side population cells represent a functionally distinct population of long-term hematopoietic stem cells
    David C Weksberg
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Blood 111:2444-51. 2008
    ..Interestingly, these 2 subpopulations are functionally distinct, with respect to lineage output as well as proliferative status...
  24. doi request reprint Stem cell identification and sorting using the Hoechst 33342 side population (SP)
    Margaret A Goodell
    Baylor College of Medicine, Houston, Texas, USA
    Curr Protoc Cytom . 2005
    ..Particular attention is given to the critical aspects of Hoechst concentration, cell concentration, staining time, and staining temperature...
  25. pmc Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells
    Grant A Challen
    Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, Tex 77030, USA
    Exp Hematol 38:403-16. 2010
    ..We hypothesized that the rare Runx1c isoform has a distinct role in hematopoietic stem cells (HSCs)...
  26. pmc Mouse hematopoietic stem cell identification and analysis
    Grant A Challen
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    Cytometry A 75:14-24. 2009
    ..The purpose of this review is to provide insight into some of the recent experimental and technical advances in mouse hematopoietic stem cell biology...
  27. ncbi request reprint Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population
    Bryan E Welm
    Program in Cell and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77035, USA
    Dev Biol 245:42-56. 2002
    ..Finally, the Sca-1(pos) population is enriched for functional stem/progenitor cells, as demonstrated by its increased regenerative potential compared with Sca-1(neg) cells when transplanted into the cleared mammary fat pads of host mice...
  28. ncbi request reprint Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates
    Fernando D Camargo
    Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, BCM505, Houston, Texas 77030, USA
    Nat Med 9:1520-7. 2003
    ..Our results indicate that circulating myeloid cells, in response to inflammatory cues, migrate to regenerating skeletal muscle and stochastically incorporate into mature myofibers...
  29. ncbi request reprint Failure of bone marrow cells to transdifferentiate into neural cells in vivo
    Raymond F Castro
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Science 297:1299. 2002
  30. pmc Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation
    Stuart M Chambers
    Program for Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Biol 5:e201. 2007
    ..Instead, loss of epigenetic regulation at the chromatin level may drive both functional attenuation of cells, as well as other manifestations of aging, including the increased propensity for neoplastic transformation...
  31. pmc Efficacy of delayed administration of post-chemotherapy granulocyte colony-stimulating factor: evidence from murine studies of bone marrow cell kinetics
    Maxim Yankelevich
    Texas Children s Cancer Center, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA
    Exp Hematol 36:9-16. 2008
    ..Given the high cost of G-CSF prophylaxis, its delayed administration may potentially result in substantial economic benefits...
  32. ncbi request reprint Transient RNA interference in hematopoietic progenitors with functional consequences
    Daniela M Oliveira
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    Genesis 36:203-8. 2003
    ..These results demonstrate that transient transfection of siRNA to primary cells can have substantial functional consequences. This technology may be applicable to a variety of primary cell types...
  33. ncbi request reprint Cells of the hepatic side population contribute to liver regeneration and can be replenished with bone marrow stem cells
    Gerald G Wulf
    Center for Cell and Gene Therapy Department of Pediatrics Baylor College of Medicine, Houston, TX 77030, USA
    Haematologica 88:368-78. 2003
    ....
  34. ncbi request reprint Adenoviral transduction of mouse hematopoietic stem cells
    Steven B Bradfute
    Department of Immunology, Center for Gene and Cell Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Ther 7:334-40. 2003
    ..Therefore, adenoviral transduction of mouse HSC can be achieved without ablation of the hematopoietic repopulating activity...
  35. ncbi request reprint Tracing the origin of non-hematopoietic cells using CD45 PCR restriction fragment length polymorphisms
    Carlos A Ramos
    Baylor College of Medicine, Houston, TX, USA
    Biotechniques 34:160-2. 2003
  36. ncbi request reprint Molecular profiling of hematopoietic stem cells
    Teresa V Bowman
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA
    Methods Mol Med 134:1-16. 2007
    ..Using these methods, we have characterized the gene expression signatures of HSC quiescence and proliferation and have constructed a molecular model of HSC activation and self-renewal...
  37. pmc Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival
    George P Souroullas
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell Stem Cell 4:180-6. 2009
    ..The function of HSCs could be rescued by a single allele of Lyl1 but not Scl. These results show that expression of at least one of these factors is essential for maintenance of adult HSC function...
  38. ncbi request reprint Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage
    Yibing Qyang
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    Biochemistry 43:5352-9. 2004
    ..These results establish a critical role of PS in myelopoiesis. Our finding that this activity can be directly modulated by its gamma-secretase activity has important safety implications concerning these inhibitors...
  39. pmc The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging
    Melissa Dumble
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, and Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, OH, USA
    Blood 109:1736-42. 2007
    ..Thus, alteration of p53 activity affects stem-cell numbers, proliferation potential, and hematopoiesis in older organisms, supporting a model in which aging is caused in part by a decline in tissue stem cell regenerative function...
  40. pmc The therapeutic potential of stem cells from adults
    Ingrid Kuehnle
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030 USA
    BMJ 325:372-6. 2002
  41. pmc Mechanisms of hematopoietic stem cell aging
    Aysegul V Ergen
    Baylor College of Medicine, TX 77030, USA
    Exp Gerontol 45:286-90. 2010
    ..Understanding of the interactions between niche cells and HSCs and changes in them with aging, may give us insights into the lineage skewing phenotype observed in the aged, and also other immune dysfunctions...
  42. pmc Enhanced generation of myeloid lineages in hematopoietic differentiation from embryonic stem cells by silencing transcriptional repressor Twist-2
    Andrew B Sharabi
    Department of Immunology, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA
    Cloning Stem Cells 11:523-33. 2009
    ..This study also suggests a potential strategy for directional differentiation of ESC by inhibiting a transcriptional repressor...
  43. ncbi request reprint Roles of Sca-1 in hematopoietic stem/progenitor cell function
    Steven B Bradfute
    Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Exp Hematol 33:836-43. 2005
    ..This study was focused on studying the role of Sca-1 (Ly-6 A/E) in hematopoietic stem/progenitor cell self-renewal, activation, and lineage fate...
  44. ncbi request reprint Differential mRNA processing in hematopoietic stem cells
    Teresa V Bowman
    Cell and Gene Therapy Center, Baylor College of Medicine, N1030, One Baylor Plaza, Houston, Texas 77030, USA
    Stem Cells 24:662-70. 2006
    ..This change in unspliced transcript level coordinated with increases in gene expression of splicing machinery components. Combined, these results suggest that post-transcriptional regulation is important in HSC activation in vivo...
  45. ncbi request reprint Purification of hematopoietic stem cells using the side population
    K K Lin
    Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, Texas, USA
    Methods Enzymol 420:255-64. 2006
    ..This chapter will discuss different enrichment methods for HSCs and provide a detailed protocol for staining HSC with Hoechst 33342 for the side population (SP)...
  46. pmc Evidence for diversity in transcriptional profiles of single hematopoietic stem cells
    Carlos A Ramos
    Department of Medicine, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Genet 2:e159. 2006
    ..The capacity to accurately interrogate individual cells for global gene expression will facilitate a systems approach to biological processes at a single-cell level...
  47. ncbi request reprint An argument against a role for Oct4 in somatic stem cells
    Jonathan S Berg
    Department of Molecular and Human Genetics, Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Stem Cell 1:359-60. 2007
    ..In this issue of Cell Stem Cell, Lengner et al. (2007) provide compelling evidence that Oct4 is neither expressed in nor required for somatic stem cell function...
  48. ncbi request reprint Skeletal muscle fiber-specific green autofluorescence: potential for stem cell engraftment artifacts
    Kathyjo A Jackson
    Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    Stem Cells 22:180-7. 2004
    ..We suggest this autofluorescence artifact may account for some of the discrepancies in this field, particularly those describing skeletal muscle engraftment...
  49. ncbi request reprint Plasticity and tissue regenerative potential of bone marrow-derived cells
    Diego S Vieyra
    Department of Pediatrics, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Stem Cell Rev 1:65-9. 2005
    ..In this review, we focus on results from several studies from our laboratory, and discuss their conclusions and implications...
  50. pmc Selective depletion of a minor subpopulation of B-chronic lymphocytic leukemia cells is followed by a delayed but progressive loss of bulk tumor cells and disease regression
    Aaron E Foster
    Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children s Hospital, Houston, TX, 77030 USA
    Mol Cancer 8:106. 2009
    ..This outcome supports the presence of a rare population of precursor/progenitor cells in human malignancies, and suggests benefit from their removal...
  51. pmc Chk1 haploinsufficiency results in anemia and defective erythropoiesis
    Nathan C Boles
    Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 5:e8581. 2010
    ..Checkpoint Kinase 1 (Chk1) is best known for its role in the cell cycle and DNA damage pathways, and it has been shown to play a part in several pathways which when disrupted can lead to anemia...
  52. pmc Promiscuous expression of H2B-GFP transgene in hematopoietic stem cells
    Grant A Challen
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 3:e2357. 2008
    ..In this study, we sought to use these mice to fluorescently label hematopoietic stem cells to study niche interactions...
  53. pmc Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways
    Olga S Kustikova
    Department of Experimental Hematology, Hannover Medical School, Germany
    Blood 109:1897-907. 2007
    ..The IDDb forms a powerful resource for the identification of genes that stimulate or transform hematopoietic stem/progenitor cells and is an important reference for vector biosafety studies in human gene therapy...
  54. pmc Isolation and characterization of functional mammary gland stem cells
    Bryan Welm
    Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA
    Cell Prolif 36:17-32. 2003
    ..These data suggest that the heterogeneity of mouse models of breast cancer may partially reflect the selection or expansion of different progenitors...
  55. ncbi request reprint Advancing the fast-paced field of stem cell research: stem cells increases from 6 to 10 issues in its 23rd year of publication
    Curt I Civin
    Stem Cells 23:1-2. 2005
  56. ncbi request reprint Bringing cardiovascular cell-based therapy to clinical application: perspectives based on a National Heart, Lung, and Blood Institute Cell Therapy Working Group meeting
    E Marc Jolicoeur
    Duke University, Durham, NC 27710, USA
    Am Heart J 153:732-42. 2007
    ..We present the perspectives of experts in stem cell biology, cardiovascular physiology, cardiology, clinical research, and regulatory issues confronting the field of cell therapy for cardiovascular disease...

Research Grants27

  1. CD34 NEGATIVE HUMAN HEMATOPOIETIC STEM CELLS
    Margaret Goodell; Fiscal Year: 2000
    ..Conclusive evidence for CD34negative stem cell would transform our view of human hematopoietic stem cell biology, lead to improved bone marrow transplantation methods, and provide an important target for gene therapy. ..
  2. Hematopoietic Stem Cell Differentiation and Commitment
    Margaret Goodell; Fiscal Year: 2006
    ..These insights will be essential for moving towards therapeutic applications of stem cell-based therapies. ..
  3. Safe and Efficient Generation of hES-derived Bone Marrow
    Margaret Goodell; Fiscal Year: 2005
    ..Abstract Not Provided. ..
  4. Safe and Efficient Generation of hES-derived Bone Marrow
    Margaret Goodell; Fiscal Year: 2006
    ..Abstract Not Provided. ..
  5. Hematopoietic Stem Cell Differentiation and Commitment
    Margaret Goodell; Fiscal Year: 2007
    ..These insights will be essential for moving towards therapeutic applications of stem cell-based therapies. ..
  6. Safe and Efficient Generation of hES-derived Bone Marrow
    Margaret Goodell; Fiscal Year: 2007
    ..Abstract Not Provided. ..
  7. Hematopoietic Stem Cell Differentiation and Commitment
    Margaret Goodell; Fiscal Year: 2009
    ..These insights will be essential for moving towards therapeutic applications of stem cell-based therapies. ..
  8. Hematopoietic Stem Cell Differentiation and Commitment
    Margaret Goodell; Fiscal Year: 2009
    ..These insights will be essential for moving towards therapeutic applications of stem cell-based therapies. ..
  9. Conference on Molecular Regulation of Stem Cells
    Margaret Goodell; Fiscal Year: 2005
    ..This conference will bring together top stem cell biologists, particularly in the areas of embryonic, neural, and hematopoietic stem cells, to discuss molecular mechanisms of stem cell function. ..
  10. MUSCLE-DERIVED HEMATOPOIETIC STEM CELLS
    Margaret Goodell; Fiscal Year: 2004
    ..Successful completion of these aims will not only provide an estimate of the hematopoietic potential of adult muscle-derived stem cells, but also a foundation for future studies into the mechanisms of stem cell transdifferentiation. ..
  11. Hematopoietic Stem Cell Differentiation and Commitment
    Margaret Goodell; Fiscal Year: 2005
    ..These insights will be essential for moving towards therapeutic applications of stem cell-based therapies. ..
  12. MUSCLE-DERIVED HEMATOPOIETIC STEM CELLS
    Margaret Goodell; Fiscal Year: 2000
    ..Successful completion of these aims will not only provide an estimate of the hematopoietic potential of adult muscle-derived stem cells, but also a foundation for future studies into the mechanisms of stem cell transdifferentiation. ..
  13. CD34 NEGATIVE HUMAN HEMATOPOIETIC STEM CELLS
    Margaret Goodell; Fiscal Year: 2001
    ..Conclusive evidence for CD34negative stem cell would transform our view of human hematopoietic stem cell biology, lead to improved bone marrow transplantation methods, and provide an important target for gene therapy. ..
  14. MUSCLE-DERIVED HEMATOPOIETIC STEM CELLS
    Margaret Goodell; Fiscal Year: 2001
    ..Successful completion of these aims will not only provide an estimate of the hematopoietic potential of adult muscle-derived stem cells, but also a foundation for future studies into the mechanisms of stem cell transdifferentiation. ..
  15. CD34 NEGATIVE HUMAN HEMATOPOIETIC STEM CELLS
    Margaret Goodell; Fiscal Year: 2002
    ..Conclusive evidence for CD34negative stem cell would transform our view of human hematopoietic stem cell biology, lead to improved bone marrow transplantation methods, and provide an important target for gene therapy. ..
  16. MUSCLE-DERIVED HEMATOPOIETIC STEM CELLS
    Margaret Goodell; Fiscal Year: 2002
    ..Successful completion of these aims will not only provide an estimate of the hematopoietic potential of adult muscle-derived stem cells, but also a foundation for future studies into the mechanisms of stem cell transdifferentiation. ..
  17. ABI PRISM 7900 Sequence Detection System
    Margaret Goodell; Fiscal Year: 2003
    ....
  18. MUSCLE-DERIVED HEMATOPOIETIC STEM CELLS
    Margaret Goodell; Fiscal Year: 2003
    ..Successful completion of these aims will not only provide an estimate of the hematopoietic potential of adult muscle-derived stem cells, but also a foundation for future studies into the mechanisms of stem cell transdifferentiation. ..
  19. CD34 NEGATIVE HUMAN HEMATOPOIETIC STEM CELLS
    Margaret Goodell; Fiscal Year: 2003
    ..Conclusive evidence for CD34negative stem cell would transform our view of human hematopoietic stem cell biology, lead to improved bone marrow transplantation methods, and provide an important target for gene therapy. ..
  20. CD34 NEGATIVE HUMAN HEMATOPOIETIC STEM CELLS
    Margaret Goodell; Fiscal Year: 2004
    ..Conclusive evidence for CD34negative stem cell would transform our view of human hematopoietic stem cell biology, lead to improved bone marrow transplantation methods, and provide an important target for gene therapy. ..
  21. MUSCLE-DERIVED HEMATOPOIETIC STEM CELLS
    Margaret Goodell; Fiscal Year: 2004
    ..Successful completion of these aims will not only provide an estimate of the hematopoietic potential of adult muscle-derived stem cells, but also a foundation for future studies into the mechanisms of stem cell transdifferentiation. ..
  22. MUSCLE-DERIVED HEMATOPOIETIC STEM CELLS
    Margaret Goodell; Fiscal Year: 2003
    ..Successful completion of these aims will not only provide an estimate of the hematopoietic potential of adult muscle-derived stem cells, but also a foundation for future studies into the mechanisms of stem cell transdifferentiation. ..
  23. Hematopoietic Stem Cell Differentiation and Commitment
    Margaret Goodell; Fiscal Year: 2010
    ..These insights will be essential for moving towards therapeutic applications of stem cell-based therapies. ..