L Gong

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint GNB1L, a gene deleted in the critical region for DiGeorge syndrome on 22q11, encodes a G-protein beta-subunit-like polypeptide
    L Gong
    Research Center for Cardiovascular Diseases, Institute of Molecular Medicine for the Prevention of Human Disease, The University of Texas Houston Health Science Center, 77030, USA
    Biochim Biophys Acta 1494:185-8. 2000
  2. ncbi request reprint Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins
    L Gong
    Research Center for Cardiovascular Diseases, Institute of Molecular Medicine for the Prevention of Human Diseases, and Division of Molecular Medicine, Department of Internal Medicine, University of Texas Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 275:14212-6. 2000
  3. ncbi request reprint Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex
    L Gong
    Research Center for Cardiovascular Diseases, Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Houston Health Science Center, 77030, USA
    FEBS Lett 448:185-9. 1999
  4. ncbi request reprint Preferential interaction of sentrin with a ubiquitin-conjugating enzyme, Ubc9
    L Gong
    Research Center for Cardiovascular Diseases, Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Houston Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 272:28198-201. 1997
  5. ncbi request reprint Differential regulation of sentrinized proteins by a novel sentrin-specific protease
    L Gong
    Research Center for Cardiovascular Diseases, Institute of Molecular Medicine for the Prevention of Human Diseases, Division of Molecular Medicine, The University of Texas Houston Health Science, Houston, USA
    J Biol Chem 275:3355-9. 2000
  6. ncbi request reprint Ubiquitin-like proteins: new wines in new bottles
    E T Yeh
    Divisions of Cardiology and Molecular Medicine, Medical School, and Research Center for Cardiovascular Diseases, Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Houston Health Science Center, Houston, USA
    Gene 248:1-14. 2000
  7. ncbi request reprint Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9
    W Xu
    Roy M and Phyllis Gough Huffington Center on Aging, Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza M320 and VAMC, Houston, Texas, 77030, USA
    Exp Cell Res 255:135-43. 2000
  8. ncbi request reprint Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway
    L Gong
    Research Center for Cardiovascular Diseases, Institute of Molecular Medicine for the Prevention of Human Diseases, Department of Internal Medicine, University of Texas Houston Health Science Center, Houston, TX, USA
    J Biol Chem 274:12036-42. 1999
  9. ncbi request reprint Translational control of puf operon expression in Rhodobacter sphaeroides 2.4.1
    L Gong
    Department of Microbiology and Molecular Genetics, University of Texas at Houston Medical School 77225, USA
    Microbiology 142:2057-69. 1996

Collaborators

Detail Information

Publications9

  1. ncbi request reprint GNB1L, a gene deleted in the critical region for DiGeorge syndrome on 22q11, encodes a G-protein beta-subunit-like polypeptide
    L Gong
    Research Center for Cardiovascular Diseases, Institute of Molecular Medicine for the Prevention of Human Disease, The University of Texas Houston Health Science Center, 77030, USA
    Biochim Biophys Acta 1494:185-8. 2000
    ..Northern blot analysis revealed GNB1L is highly expressed in the heart...
  2. ncbi request reprint Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins
    L Gong
    Research Center for Cardiovascular Diseases, Institute of Molecular Medicine for the Prevention of Human Diseases, and Division of Molecular Medicine, Department of Internal Medicine, University of Texas Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 275:14212-6. 2000
    ..Thus, USP21 is the first ubiquitin-specific protease shown to have dual specificity for both ubiquitin and NEDD8 and may play an important role in the regulation of cell growth...
  3. ncbi request reprint Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex
    L Gong
    Research Center for Cardiovascular Diseases, Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Houston Health Science Center, 77030, USA
    FEBS Lett 448:185-9. 1999
    ..Identification of human UBA2 and AOS1 should allow a more detailed analysis of the enzymology of the activation of ubiquitin-like proteins...
  4. ncbi request reprint Preferential interaction of sentrin with a ubiquitin-conjugating enzyme, Ubc9
    L Gong
    Research Center for Cardiovascular Diseases, Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Houston Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 272:28198-201. 1997
    ..Substitution of the conserved cysteine residue of Ubc9 by serine abolished the formation of the Ubc9-sentrin conjugate. Taken together, Ubc9 is a strong candidate to be the key conjugating enzyme in the sentrinization pathway...
  5. ncbi request reprint Differential regulation of sentrinized proteins by a novel sentrin-specific protease
    L Gong
    Research Center for Cardiovascular Diseases, Institute of Molecular Medicine for the Prevention of Human Diseases, Division of Molecular Medicine, The University of Texas Houston Health Science, Houston, USA
    J Biol Chem 275:3355-9. 2000
    ..The identification of a nuclear-localized, sentrin-specific protease will provide a unique tool to study the role of sentrinization in the biological function of PML and in the pathogenesis of acute promyelocytic leukemia...
  6. ncbi request reprint Ubiquitin-like proteins: new wines in new bottles
    E T Yeh
    Divisions of Cardiology and Molecular Medicine, Medical School, and Research Center for Cardiovascular Diseases, Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Houston Health Science Center, Houston, USA
    Gene 248:1-14. 2000
    ..This review will focus on the biology and biochemistry of the Sentrin/SUMO and NEDD8 modification pathways, which are clearly distinct from the ubiquitination pathway and have unique biological functions...
  7. ncbi request reprint Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9
    W Xu
    Roy M and Phyllis Gough Huffington Center on Aging, Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza M320 and VAMC, Houston, Texas, 77030, USA
    Exp Cell Res 255:135-43. 2000
    ..A lysine to arginine mutation abolished MITF (K201R) degradation by hUBC9 in vivo. Our experiments indicate that by targeting MITF for proteasome degradation, hUBC9 is a critical regulator of melanocyte differentiation...
  8. ncbi request reprint Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway
    L Gong
    Research Center for Cardiovascular Diseases, Institute of Molecular Medicine for the Prevention of Human Diseases, Department of Internal Medicine, University of Texas Houston Health Science Center, Houston, TX, USA
    J Biol Chem 274:12036-42. 1999
    ..Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway should allow for a more detailed study of the role of NEDD8 modification in health and disease...
  9. ncbi request reprint Translational control of puf operon expression in Rhodobacter sphaeroides 2.4.1
    L Gong
    Department of Microbiology and Molecular Genetics, University of Texas at Houston Medical School 77225, USA
    Microbiology 142:2057-69. 1996
    ..It is also revealed that the secondary structure at the 5' end of the large and small puf transcripts may play a role in mRNA stability and that stability of the small puf transcript is independent of translation...