Francesco Gentile

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. doi request reprint Size and shape effects in the biodistribution of intravascularly injected particles
    P Decuzzi
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center, Houston, TX, USA
    J Control Release 141:320-7. 2010
  2. doi request reprint Nanoparticle microinjection and Raman spectroscopy as tools for nanotoxicology studies
    Patrizio Candeloro
    BIONEM laboratory, Experimental and Clinical Medicine Department, University Magna Graecia of Catanzaro, 88100 Loc Germaneto, Catanzaro, Italy
    Analyst 136:4402-8. 2011
  3. pmc Geometrical confinement of gadolinium-based contrast agents in nanoporous particles enhances T1 contrast
    Jeyarama S Ananta
    Department of Chemistry, Smalley Institute for Nanoscale Science and Technology, Center for Biological and Environmental Nanotechnology, Rice University, Houston, Texas 77251 1892, USA
    Nat Nanotechnol 5:815-21. 2010
  4. doi request reprint Intravascular delivery of particulate systems: does geometry really matter?
    Paolo Decuzzi
    School of Health Information Sciences, The University of Texas Health Science Center, Houston, Texas 77030, USA
    Pharm Res 26:235-43. 2009
  5. pmc The receptor-mediated endocytosis of nonspherical particles
    P Decuzzi
    Center of Bio Nanotechnology and Engineering for Medicine, University of Magna Graecia, Catanzaro, Italy
    Biophys J 94:3790-7. 2008
  6. doi request reprint Modulating cellular adhesion through nanotopography
    Paolo Decuzzi
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center Houston, Houston, TX, USA
    Biomaterials 31:173-9. 2010
  7. pmc The margination propensity of spherical particles for vascular targeting in the microcirculation
    Francesco Gentile
    Center of Bio Nanotechnology and Engineering for Medicine University of Magna Graecia at Catanzaro, Viale Europa Loc, Germaneto, 88100, Catanzaro, Italy
    J Nanobiotechnology 6:9. 2008
  8. pmc Tailoring the degradation kinetics of mesoporous silicon structures through PEGylation
    Biana Godin
    Department of Nanomedicine and BioMedical Engineering, School of Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Biomed Mater Res A 94:1236-43. 2010
  9. pmc An integrated approach for the rational design of nanovectors for biomedical imaging and therapy
    Biana Godin
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center, Houston, Texas, USA
    Adv Genet 69:31-64. 2010
  10. doi request reprint On the synergistic effects of ligand-mediated and phage-intrinsic properties during in vivo selection
    Wouter H P Driessen
    David H Koch Center, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Adv Genet 69:115-33. 2010

Collaborators

Detail Information

Publications32

  1. doi request reprint Size and shape effects in the biodistribution of intravascularly injected particles
    P Decuzzi
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center, Houston, TX, USA
    J Control Release 141:320-7. 2010
    ..These preliminary results support the notion of using sub-micrometer discoidal particles as intravascular carriers to maximize accumulation in the target organ whilst reducing sequestration by the liver...
  2. doi request reprint Nanoparticle microinjection and Raman spectroscopy as tools for nanotoxicology studies
    Patrizio Candeloro
    BIONEM laboratory, Experimental and Clinical Medicine Department, University Magna Graecia of Catanzaro, 88100 Loc Germaneto, Catanzaro, Italy
    Analyst 136:4402-8. 2011
    ..The achieved results demonstrate the suitability of the proposed method as a new tool for nanotoxicity studies...
  3. pmc Geometrical confinement of gadolinium-based contrast agents in nanoporous particles enhances T1 contrast
    Jeyarama S Ananta
    Department of Chemistry, Smalley Institute for Nanoscale Science and Technology, Center for Biological and Environmental Nanotechnology, Rice University, Houston, Texas 77251 1892, USA
    Nat Nanotechnol 5:815-21. 2010
    ..Thus, nanoscale confinement offers a new and general strategy for enhancing the contrast of gadolinium-based contrast agents...
  4. doi request reprint Intravascular delivery of particulate systems: does geometry really matter?
    Paolo Decuzzi
    School of Health Information Sciences, The University of Texas Health Science Center, Houston, Texas 77030, USA
    Pharm Res 26:235-43. 2009
    ..The integration of mathematical modeling with in-vitro and in-vivo testing provides the tools for establishing a rational design of nanoparticles...
  5. pmc The receptor-mediated endocytosis of nonspherical particles
    P Decuzzi
    Center of Bio Nanotechnology and Engineering for Medicine, University of Magna Graecia, Catanzaro, Italy
    Biophys J 94:3790-7. 2008
    ..Given the pleomorphism of viruses and the broad spectrum of shapes for nanosized biomimetic particles, the results presented may be of interest to virologists, pharmacologists, toxicologists, and nanotechnologists...
  6. doi request reprint Modulating cellular adhesion through nanotopography
    Paolo Decuzzi
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center Houston, Houston, TX, USA
    Biomaterials 31:173-9. 2010
    ..The model proposed supports the notion for rationally designing substrates where topography and physico-chemical properties are tailored to favour cellular proliferation whilst repelling bacterial adhesion...
  7. pmc The margination propensity of spherical particles for vascular targeting in the microcirculation
    Francesco Gentile
    Center of Bio Nanotechnology and Engineering for Medicine University of Magna Graecia at Catanzaro, Viale Europa Loc, Germaneto, 88100, Catanzaro, Italy
    J Nanobiotechnology 6:9. 2008
    ....
  8. pmc Tailoring the degradation kinetics of mesoporous silicon structures through PEGylation
    Biana Godin
    Department of Nanomedicine and BioMedical Engineering, School of Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Biomed Mater Res A 94:1236-43. 2010
    ....
  9. pmc An integrated approach for the rational design of nanovectors for biomedical imaging and therapy
    Biana Godin
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center, Houston, Texas, USA
    Adv Genet 69:31-64. 2010
    ....
  10. doi request reprint On the synergistic effects of ligand-mediated and phage-intrinsic properties during in vivo selection
    Wouter H P Driessen
    David H Koch Center, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Adv Genet 69:115-33. 2010
    ..Lastly, we examine the physical properties of the total phage particle that facilitate improved delivery and targeting in vivo compared to free peptides...
  11. ncbi request reprint Selective on site separation and detection of molecules in diluted solutions with super-hydrophobic clusters of plasmonic nanoparticles
    Francesco Gentile
    BioNEM, University Magna Graecia of Catanzaro, Catanzaro, 88100, Italy
    Nanoscale 6:8208-25. 2014
    ..The presented platform, coupled to Raman or other spectroscopy techniques, is a realistic candidate for the protein expression profiling of biological fluids. ..
  12. doi request reprint Raman database of amino acids solutions: a critical study of extended multiplicative signal correction
    Patrizio Candeloro
    BIONEM laboratory, Experimental and Clinical Medicine Department, University Magna Graecia of Catanzaro, 88100 Loc Germaneto, Catanzaro, Italy
    Analyst 138:7331-40. 2013
    ..A critical review of the results is presented, showing that EMSC has to be carefully handled for complex biological systems. ..
  13. pmc Probing the mechanical properties of TNF-α stimulated endothelial cell with atomic force microscopy
    Sei Young Lee
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Medical School at Houston, Houston, TX, USA
    Int J Nanomedicine 6:179-95. 2011
    ....
  14. doi request reprint Shaping nano-/micro-particles for enhanced vascular interaction in laminar flows
    Sei Young Lee
    Department of Nanomedicine and BioMedical Engineering, University of Texas Health Science Center at Houston, Houston, TX, USA
    Nanotechnology 20:495101. 2009
    ....
  15. doi request reprint Engineering discoidal polymeric nanoconstructs with enhanced magneto-optical properties for tumor imaging
    Jaehong Key
    Department of Translational Imaging, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Biomaterials 34:5402-10. 2013
    ..These nanoconstructs suggest a general strategy to engineer theranostic systems for anti-angiogenic treatment and vascular imaging...
  16. doi request reprint In situ X-ray scattering studies of protein solution droplets drying on micro- and nanopatterned superhydrophobic PMMA surfaces
    Angelo Accardo
    Center of Bio Nanotechnology and Engineering for Medicine, University Magna Græcia, Viale Europa, Catanzaro 88100, Italy
    Langmuir 26:15057-64. 2010
    ..Such surfaces represent nearly contact-free sample supports for studies of inorganic and organic solution droplets, which find applications in biochips...
  17. pmc Enabling individualized therapy through nanotechnology
    Jason H Sakamoto
    The University of Texas Health Science Center, Department of Nanomedicine and BioMedical Engineering, Houston, TX 77030, USA
    Pharmacol Res 62:57-89. 2010
    ....
  18. ncbi request reprint The association of silicon microparticles with endothelial cells in drug delivery to the vasculature
    Rita E Serda
    Brown Institute of Molecular Medicine, University of Texas Health Science Center, Nanomedicine Division, 1825 Pressler, Suite 537, Houston, TX 77030, USA
    Biomaterials 30:2440-8. 2009
    ..These findings suggest that it may be possible to bioengineer silicon microparticles to favor opsonization with proteins that enhance uptake by endothelial cells, without a concurrent enhanced uptake by macrophages...
  19. ncbi request reprint Shaping the micromechanical behavior of multi-phase composites for bone tissue engineering
    Shivakumar I Ranganathan
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center, Houston, TX, USA
    Acta Biomater 6:3448-56. 2010
    ....
  20. pmc Selective modulation of cell response on engineered fractal silicon substrates
    Francesco Gentile
    BioNEM Center of BioNanotechnology and Engineering for Medicine, University of Magna Graecia, Italy
    Sci Rep 3:1461. 2013
    ..2). Higher proliferation occurson substrates exhibiting densely packed and sharp peaks, whereas more regular ridges favor adhesion. These results suggest that randomly roughtopographies can selectively modulate cell behavior...
  21. ncbi request reprint Antibiological barrier nanovector technology for cancer applications
    Jason Sakamoto
    Alliance for NanoHealth, 1825 Herman Pressler Street, Suite 537A, Houston, Texas 77030, USA
    Expert Opin Drug Deliv 4:359-69. 2007
    ..This novel, multi-stage strategy enables efficient localised delivery of chemotoxic drugs that may lead to significant improvements in therapy efficacy, reduced systemic toxicity and decreased total amount of injected drugs...
  22. ncbi request reprint Design maps for nanoparticles targeting the diseased microvasculature
    Paolo Decuzzi
    BioNEM Center of Bio Nanotechnology and Engineering for Medicine, University of Magna Graecia, Viale Europa Loc Germaneto, 88100 Catanzaro, Italy
    Biomaterials 29:377-84. 2008
    ....
  23. doi request reprint Design of bio-mimetic particles with enhanced vascular interaction
    Sei Young Lee
    Department of Biomedical Engineering, Center of Nanomedicine, University of Texas Health Science Center at Houston, TX, USA
    J Biomech 42:1885-90. 2009
    ....
  24. ncbi request reprint The role of specific and non-specific interactions in receptor-mediated endocytosis of nanoparticles
    P Decuzzi
    BioNEM Center of Bio Nanotechnology and Engineering for Medicine, University of Magna Graecia, Viale Europa Loc Germaneto 88100 Catanzaro, Italy
    Biomaterials 28:2915-22. 2007
    ..It is shown that the contribution of F is as important as that of C and G. General and ready to use formulas are presented that can be a guide in designing nanoparticles with controlled endocytic performances...
  25. doi request reprint Differential cell adhesion on mesoporous silicon substrates
    Francesco Gentile
    Laboratory of Proteomics and Mass Spectrometry, Department of Experimental and Clinical Medicine, University of Magna Graecia, Catanzaro 88100, Italy
    ACS Appl Mater Interfaces 4:2903-11. 2012
    ..These results have implications in the rational development of PSi substrates for supporting cell adhesion and controlling drug release in implants and scaffolds for tissue engineering applications. ..
  26. doi request reprint Nano-patterned SERS substrate: application for protein analysis vs. temperature
    Gobind Das
    Dipartimento di Medicina Sperimentale e Clinica, Lab BIONEM, Universita Magna Graecia di Catanzaro, Catanzaro, Italy
    Biosens Bioelectron 24:1693-9. 2009
    ....
  27. doi request reprint Nanotechnology for breast cancer therapy
    Takemi Tanaka
    Brown Institute of Molecular Medicine, Department of Biomedical Engineering, University of Texas Houston Health Science Center, 1825 Herman Pressler Street, Suite 537D, Houston, TX, 77030, USA
    Biomed Microdevices 11:49-63. 2009
    ....
  28. pmc Flow chamber analysis of size effects in the adhesion of spherical particles
    P Decuzzi
    Center of Bio Nanotechnology and Engineering for Medicine University of Magna Graecia at Catanzaro, Viale Europa Loc Germaneto, Catanzaro, Italy
    Int J Nanomedicine 2:689-96. 2007
    ..3). From these results and considering solely non-specific particles, the following hypothesis are generated (i) use the smallest possible particles in biomedical imaging and (ii) use the largest possible particles in drug delivery...
  29. ncbi request reprint The adhesive strength of non-spherical particles mediated by specific interactions
    P Decuzzi
    Center of Bio Nanotechnology and Engineering for Medicine, University of Magna Graecia, 88100 Catanzaro, Italy
    Biomaterials 27:5307-14. 2006
    ..The formulae and the procedures described in the present work can guide the optimal design of intravascularly injectable micro/nano carriers...
  30. ncbi request reprint The effective dispersion of nanovectors within the tumor microvasculature
    P Decuzzi
    Center of Bio Nanotechnology and Bio Engineering for Medicine, University of Magna Graecia, Catanzaro, 88100, Italy
    Ann Biomed Eng 34:633-41. 2006
    ..Finally, it has been emphasized that the size of the vector should be selected depending on the body district where the tumoral mass is developing and on the type, malignancy, and state of the tumor...
  31. doi request reprint The effect of shape on the margination dynamics of non-neutrally buoyant particles in two-dimensional shear flows
    F Gentile
    BioNEM Center of Bio Nanotechnology and Engineering for Medicine, University of Magna Graecia at Catanzaro, Viale Europa, loc Germaneto, 88100 Catanzaro, Italy
    J Biomech 41:2312-8. 2008
    ..These results may be of interest in drug delivery and bio-imaging applications, where particles are expected to drift towards and interact with the walls of the blood vessels...
  32. ncbi request reprint A theoretical model for the margination of particles within blood vessels
    P Decuzzi
    Center of Excellence in Computational Mechanics, Politecnico di Bari, Bari 70125, Italy
    Ann Biomed Eng 33:179-90. 2005
    ..While particles used as nanoharvesting agents in proteomics or genomics analysis should have a radius close to the critical value to minimize margination and increase their circulation time...