Yong Jian Geng

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Atorvastatin treatment improves survival and effects of implanted mesenchymal stem cells in post-infarct swine hearts
    Yue jin Yang
    Department of Cardiology, Fu Wai Hospital and Cardiovascular Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, 167 BeiLiShi Rd, Beijing 100037, People s Republic of China
    Eur Heart J 29:1578-90. 2008
  2. pmc Linking immunity to atherosclerosis: implications for vascular pharmacology--a tribute to Göran K. Hansson
    Yong Jian Geng
    Center of Cardiovascular Biology and Atherosclerosis Research, University of Texas Medical School at Houston, TX 77030, USA
    Vascul Pharmacol 56:29-33. 2012
  3. ncbi request reprint Biologic effect and molecular regulation of vascular apoptosis in atherosclerosis
    Y J Geng
    Department of Internal Medicine, University of Texas Houston Health Science Center Medical School, 6431 Fannin Street, MSB 6 045, Houston, TX 77030, USA
    Curr Atheroscler Rep 3:234-42. 2001
  4. ncbi request reprint Molecular mechanisms for cardiovascular stem cell apoptosis and growth in the hearts with atherosclerotic coronary disease and ischemic heart failure
    Yong Jian Geng
    Center for Cardiovascular Biology and Atherosclerosis, Department of Internal Medicine, The University of Texas, Health Science Center at Houston, Medical School, Texas Heart Institute, Houston, Texas 77030, USA
    Ann N Y Acad Sci 1010:687-97. 2003
  5. ncbi request reprint Cholesterol crystallization and macrophage apoptosis: implication for atherosclerotic plaque instability and rupture
    Yong Jian Geng
    Center for Cardiovascular Biology and Atherosclerosis, University of Texas Health Science Center at Houston School of Medicine, 6431 Fannin Street, MSB 6 001, Houston, TX 77030, USA
    Biochem Pharmacol 66:1485-92. 2003
  6. ncbi request reprint Molecular signal transduction in vascular cell apoptosis
    Y J Geng
    Center for Cardiovascular Biology and Atherosclerosis Research, Department of Internal Medicine, University of Texas Houston Health Science Center Medical School, 77030, USA
    Cell Res 11:253-64. 2001
  7. ncbi request reprint Myocardin a enhances telomerase activities in adipose tissue mesenchymal cells and embryonic stem cells undergoing cardiovascular myogenic differentiation
    Rosalinda Madonna
    The University of Texas Health Science Center at Houston and the Texas Heart Institute, Houston, Texas, USA
    Stem Cells 26:202-11. 2008
  8. pmc Delivery of stem cells to porcine arterial wall with echogenic liposomes conjugated to antibodies against CD34 and intercellular adhesion molecule-1
    Stephanie M Herbst
    Division of Cardiology, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA
    Mol Pharm 7:3-11. 2010
  9. doi request reprint Clusterin induces CXCR4 expression and migration of cardiac progenitor cells
    Yangxin Li
    Texas Heart Institute at St Luke s Episcopal Hospital, Houston, TX 77030, USA
    Exp Cell Res 316:3435-42. 2010
  10. pmc Biologic function and clinical potential of telomerase and associated proteins in cardiovascular tissue repair and regeneration
    Rosalinda Madonna
    Texas Heart Institute at St Luke s Episcopal Hospital, Houston, TX, USA
    Eur Heart J 32:1190-6. 2011

Research Grants

  1. APOPTOTIC CASCADE IN ATHEROSCLEROSIS
    Yong Jian Geng; Fiscal Year: 1999
  2. CD1-restricted T cell response in atherosclerosis
    Yong Jian Geng; Fiscal Year: 2003
  3. CD1-restricted T cell response in atherosclerosis
    Yong Jian Geng; Fiscal Year: 2002
  4. CD1-restricted T cell response in atherosclerosis
    Yong Jian Geng; Fiscal Year: 2003
  5. APOPTOTIC CASCADE IN ATHEROSCLEROSIS
    Yong Jian Geng; Fiscal Year: 2002
  6. APOPTOTIC CASCADE IN ATHEROSCLEROSIS
    Yong Jian Geng; Fiscal Year: 2002
  7. CD1-restricted T cell response in atherosclerosis
    Yong Jian Geng; Fiscal Year: 2002
  8. CD1-restricted T cell response in atherosclerosis
    Yong Jian Geng; Fiscal Year: 2001
  9. APOPTOTIC CASCADE IN ATHEROSCLEROSIS
    Yong Jian Geng; Fiscal Year: 2001
  10. APOPTOTIC CASCADE IN ATHEROSCLEROSIS
    Yong Jian Geng; Fiscal Year: 2000

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Atorvastatin treatment improves survival and effects of implanted mesenchymal stem cells in post-infarct swine hearts
    Yue jin Yang
    Department of Cardiology, Fu Wai Hospital and Cardiovascular Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, 167 BeiLiShi Rd, Beijing 100037, People s Republic of China
    Eur Heart J 29:1578-90. 2008
    ..To investigate whether Atorvastatin (Ator) treatment improves the cardiac micro-environment that facilitates survival and differentiation of bone-marrow-derived mesenchymal stem cells (MSCs) implanted in the post-infarct myocardium...
  2. pmc Linking immunity to atherosclerosis: implications for vascular pharmacology--a tribute to Göran K. Hansson
    Yong Jian Geng
    Center of Cardiovascular Biology and Atherosclerosis Research, University of Texas Medical School at Houston, TX 77030, USA
    Vascul Pharmacol 56:29-33. 2012
    ..This review briefly summarizes the discoveries in basic and translational sciences in this area and recent advances in clinical medicine against atherosclerotic vascular diseases...
  3. ncbi request reprint Biologic effect and molecular regulation of vascular apoptosis in atherosclerosis
    Y J Geng
    Department of Internal Medicine, University of Texas Houston Health Science Center Medical School, 6431 Fannin Street, MSB 6 045, Houston, TX 77030, USA
    Curr Atheroscler Rep 3:234-42. 2001
    ..Clarification of the molecular mechanism that regulates apoptosis may help design a new strategy for treatment of atherosclerosis and its major complication, the acute vascular syndromes...
  4. ncbi request reprint Molecular mechanisms for cardiovascular stem cell apoptosis and growth in the hearts with atherosclerotic coronary disease and ischemic heart failure
    Yong Jian Geng
    Center for Cardiovascular Biology and Atherosclerosis, Department of Internal Medicine, The University of Texas, Health Science Center at Houston, Medical School, Texas Heart Institute, Houston, Texas 77030, USA
    Ann N Y Acad Sci 1010:687-97. 2003
    ..Clarification of the molecular mechanisms may help us understand and design stem cell therapies...
  5. ncbi request reprint Cholesterol crystallization and macrophage apoptosis: implication for atherosclerotic plaque instability and rupture
    Yong Jian Geng
    Center for Cardiovascular Biology and Atherosclerosis, University of Texas Health Science Center at Houston School of Medicine, 6431 Fannin Street, MSB 6 001, Houston, TX 77030, USA
    Biochem Pharmacol 66:1485-92. 2003
    ..These results suggest that hyperthermia inhibits cholesterol crystallization and promotes apoptotic effects of oxysterols on macrophages...
  6. ncbi request reprint Molecular signal transduction in vascular cell apoptosis
    Y J Geng
    Center for Cardiovascular Biology and Atherosclerosis Research, Department of Internal Medicine, University of Texas Houston Health Science Center Medical School, 77030, USA
    Cell Res 11:253-64. 2001
    ..Clarification of the molecular mechanism that regulates apoptosis may help design a new strategy for treatment of atherosclerosis and its major complication, the acute vascular syndromes...
  7. ncbi request reprint Myocardin a enhances telomerase activities in adipose tissue mesenchymal cells and embryonic stem cells undergoing cardiovascular myogenic differentiation
    Rosalinda Madonna
    The University of Texas Health Science Center at Houston and the Texas Heart Institute, Houston, Texas, USA
    Stem Cells 26:202-11. 2008
    ..The data from this study indicate a potentially novel function of myocardin A in maintaining the myogenic stemness in developing MSCs and EBs by enhancing telomerase activation and promoting myogenic gene expression...
  8. pmc Delivery of stem cells to porcine arterial wall with echogenic liposomes conjugated to antibodies against CD34 and intercellular adhesion molecule-1
    Stephanie M Herbst
    Division of Cardiology, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA
    Mol Pharm 7:3-11. 2010
    ..Thus, under ultrasound enhancement, BF-ELIP bound CD34+ stem cells selectively bind to the ICAM-1 expressing endothelium of atherosclerotic lesions...
  9. doi request reprint Clusterin induces CXCR4 expression and migration of cardiac progenitor cells
    Yangxin Li
    Texas Heart Institute at St Luke s Episcopal Hospital, Houston, TX 77030, USA
    Exp Cell Res 316:3435-42. 2010
    ..Thus, CST expression may increase CPCs migration via increasing CXCR4 expression and SDF-1/chemokine receptor signaling in a PI3/Akt-dependent manner...
  10. pmc Biologic function and clinical potential of telomerase and associated proteins in cardiovascular tissue repair and regeneration
    Rosalinda Madonna
    Texas Heart Institute at St Luke s Episcopal Hospital, Houston, TX, USA
    Eur Heart J 32:1190-6. 2011
    ..Understanding the roles of telomerase and its associated proteins in the functional regulation of cardiovascular cells and their progenitors may lead to new strategies for cardiovascular tissue repair and regeneration...
  11. doi request reprint Myocardin-A enhances expression of promyogenic genes without depressing telomerase activity in adipose tissue-derived mesenchymal stem cells
    Rosalinda Madonna
    Texas Heart Institute, Houston, TX, United States
    Int J Cardiol 167:2912-21. 2013
    ..The stromal compartment of adult adipose tissue consists of mesenchymal stem cells (MSCs) characterized by co-expression of myocardin-A (McA) and telomerase reverse transcriptase (TERT)...
  12. ncbi request reprint Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model
    Guilherme V Silva
    Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Tex 77030, USA
    Circulation 111:150-6. 2005
    ..Bone marrow-derived stem cells are under investigation as a treatment for ischemic heart disease. Mesenchymal stem cells (MSCs) have been used preferentially in the acute ischemia model; data in the chronic ischemia model are lacking...
  13. doi request reprint IGF-1 prevents oxidative stress induced-apoptosis in induced pluripotent stem cells which is mediated by microRNA-1
    Yangxin Li
    The Texas Heart Institute and Center for Cardiovascular and Atherosclerosis Research, Department of Internal Medicine, University of Texas Medical School at Houston, TX 77030, USA
    Biochem Biophys Res Commun 426:615-9. 2012
    ..In conclusion, IGF-1 inhibits H(2)O(2)-induced mitochondrial dysfunction, cytochrome-c release and apoptosis. IGF-1's effect is, at least partially, regulated by miR-1 in iPS cells...
  14. pmc MicroRNA-221 regulates high glucose-induced endothelial dysfunction
    Yangxin Li
    Texas Heart Institute and The University of Texas Medical School, Heart Failure and Stem Cell, P O Box 20345, MC 2 255, 6770 Bertner Avenue, Houston, TX 77030, USA
    Biochem Biophys Res Commun 381:81-3. 2009
    ..These findings suggest that manipulation of the miR-221-c-kit pathway may offer a novel strategy for treatment of vascular dysfunction in diabetic patients...
  15. doi request reprint MicroRNA-133a regulates insulin-like growth factor-1 receptor expression and vascular smooth muscle cell proliferation in murine atherosclerosis
    Song Gao
    The Texas Heart Institute at St Luke s Hospital, Houston, TX, USA The University of Texas Medical School at Houston, Houston, TX, USA
    Atherosclerosis 232:171-9. 2014
    ..This study tested whether miR-133a affects expression of IGF-1 receptor (IGF-1R) and proliferation of IGF-1-stimulated vascular smooth muscle cells (VSMC) in a murine model of atherosclerosis...
  16. pmc Apolipoprotein-J prevention of fetal cardiac myoblast apoptosis induced by ethanol
    Yangxin Li
    Texas Heart Institute and The University of Texas Health Science Center, Houston, TX 77030, USA
    Biochem Biophys Res Commun 357:157-61. 2007
    ..Thus, ApoJ serves as a cytoprotective protein that protects cardiac stem cells against EtOH cytotoxicity...
  17. ncbi request reprint Adult stem cell therapy in perspective
    Emerson C Perin
    Department of Cardiology, Texas Heart Institute, and the University of Texas Health Science Center, Houston, USA
    Circulation 107:935-8. 2003
  18. pmc Liposomal modular complexes for simultaneous targeted delivery of bioactive gases and therapeutics
    Melvin E Klegerman
    Division of Cardiology, Department of Internal Medicine, University of Texas Health Science Center, 6431 Fannin Street, MSB 1 246, Houston, Texas 77030, USA
    J Control Release 142:326-31. 2010
    ..It was concluded that this novel multi-functional conjugation methodology provides a platform technology for site-specific co-delivery of bioactive gases and other agents...
  19. ncbi request reprint Characterization of a novel ubiquitin-conjugating enzyme that regulates beta1,4-galactosyltransferase-1 in embryonic stem cells
    Michael J Wassler
    Center for Cardiovascular Biology and Atherosclerosis Research, Division of Cardiology, Department of Internal Medicine, The University of Texas Health Science Center at Houston, School of Medicine, Houston 77030, USA
    Stem Cells 26:2006-18. 2008
    ..Thus, GTAP functions as an evolutionarily conserved E2 enzyme, which may participate in intercellular adhesion and embryonic development. Disclosure of potential conflicts of interest is found at the end of this article...
  20. ncbi request reprint Dysregulated response to mycobacterial cord factor trehalose-6,6'-dimycolate in CD1D-/- mice
    J K Actor
    Department of Pathology, University of Texas Houston Medical School, Houston, TX 77030, USA
    J Interferon Cytokine Res 21:1089-96. 2001
    ..CD1D(-/-) mice also demonstrated elevated mRNA for both inflammatory cytokines and chemokines by day 1 after administration, significantly earlier than responses seen in the heterozygous controls...
  21. ncbi request reprint Near-infrared spectroscopic characterization of human advanced atherosclerotic plaques
    Jing Wang
    Vascular Cell Biology Laboratory, Texas Heart Institute, Houston, Texas, USA
    J Am Coll Cardiol 39:1305-13. 2002
    ..OBJECTIVES; Living human carotid atherosclerotic plaques were examined in vitro by near-infrared (NIR) spectroscopy to determine the spectral features of plaque vulnerability...
  22. pmc Angiotensin receptor agonistic autoantibody-mediated tumor necrosis factor-alpha induction contributes to increased soluble endoglin production in preeclampsia
    Cissy Chenyi Zhou
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, TX 77030, USA
    Circulation 121:436-44. 2010
    ....
  23. doi request reprint Erythropoietin protects myocardin-expressing cardiac stem cells against cytotoxicity of tumor necrosis factor-alpha
    Rosalinda Madonna
    The Center for Cardiovascular Biology and Atherosclerosis Research, The University of Texas Health Science Center, Houston, Texas, USA
    Exp Cell Res 315:2921-8. 2009
    ..Thus, Epo protects cardiac myocyte progenitors or myoblasts against the cytotoxic effects of TNF-alpha by inhibiting NF-kappaB-mediated iNOS expression and NO production and by preventing caspase-3 activation...
  24. doi request reprint Simvastatin-enhanced expression of promyogenic nuclear factors and cardiomyogenesis of murine embryonic stem cells
    Chenmin Yang
    The Center for Cardiovascular Biology and Atherosclerosis Research, The University of Texas Medical School at Houston, Houston, TX USA The Department of Obstetrics and Gynecology, Ruijin Hospital, Jiao Tong University Medical School, Shanghai, China Texas Heart Institute, Houston, TX, USA
    Vascul Pharmacol 60:8-16. 2014
    ..Thus, simvastatin treatment enhances ESC myogenesis during early development perhaps via a mechanism inhibiting the mevalonate-FPP/GGPP pathway. ..
  25. doi request reprint LOX-1: a male hormone-regulated scavenger receptor for atherosclerosis
    Song Gao
    The Center of Cardiovascular Biology and Atherosclerosis Research, University of Texas Medical School at Houston, Houston, TX 77030, USA
    Vascul Pharmacol 59:138-43. 2013
    ....
  26. ncbi request reprint Failure of CD1D-/- mice to elicit hypersensitive granulomas to mycobacterial cord factor trehalose 6,6'-dimycolate
    Tera V Guidry
    Department of Pathology, University of Texas Houston Medical School, Houston, TX 77030, USA
    J Interferon Cytokine Res 24:362-71. 2004
    ..These experiments provide evidence for a role for CD1d in mediation of pathology during hypersensitive responses to the mycobacterial glycolipid TDM...
  27. ncbi request reprint Characterization of the inflammatory and apoptotic cells in the aortas of patients with ascending thoracic aortic aneurysms and dissections
    Rumin He
    Department of Internal Medicine, The University of Texas Medical School at Houston, Houston, Tex 77030, USA
    J Thorac Cardiovasc Surg 131:671-8. 2006
    ..This study sought to determine whether inflammatory cells are present in medial degeneration and assess any possible contribution of these cells to apoptosis of smooth muscle cells...
  28. ncbi request reprint Progression of atheroma: a struggle between death and procreation
    Yong Jian Geng
    Cardiology Division, Department of Internal Medicine, University of Texas Houston Medical School, USA
    Arterioscler Thromb Vasc Biol 22:1370-80. 2002
    ..A clarification of the molecular mechanisms responsible for vascular cell death may aid in the development of novel therapeutic strategies to treat atherosclerosis and its complications, including the acute coronary syndromes...
  29. doi request reprint A potential role for insulin-like growth factor signaling in induction of pluripotent stem cell formation
    Yangxin Li
    Texas Heart Institute, Houston, TX 77030, USA
    Growth Horm IGF Res 20:391-8. 2010
    ....
  30. doi request reprint Insulin-like growth factor-1 receptor activation prevents high glucose-induced mitochondrial dysfunction, cytochrome-c release and apoptosis
    Yangxin Li
    Texas Heart Institute and The University of Texas Medical School, Houston, TX 77030, USA
    Biochem Biophys Res Commun 384:259-64. 2009
    ..These results may have therapeutic implications in preventing/reducing diabetes associated endothelial dysfunction...
  31. doi request reprint Nitric oxide bioactivity of traditional Chinese medicines used for cardiovascular indications
    Yaoping Tang
    Brown Foundation Institute of Molecular Medicine, Health Science Center, The University of Texas at Houston, Houston, TX 77030, USA
    Free Radic Biol Med 47:835-40. 2009
    ..Repletion of biological nitrite and nitrate by these extracts and providing a natural system for NO generation in both endothelium-dependent and -independent mechanisms may account for some of the therapeutic effects of TCMs...
  32. ncbi request reprint Enhanced iNOS function in myocytes one day after brief ischemic episode
    Song Jung Kim
    Cardiovascular Research Institute and Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark 07103, USA
    Am J Physiol Heart Circ Physiol 282:H423-8. 2002
    ....
  33. ncbi request reprint Induction of apoptosis and fibrillin 1 expression in human dermal endothelial cells by scleroderma sera containing anti-endothelial cell antibodies
    S Sohail Ahmed
    Boston University School of Medicine, Arthritis Center E 5, 715 Albany Street, Boston, MA 02118, USA
    Arthritis Rheum 54:2250-62. 2006
    ....

Research Grants12

  1. APOPTOTIC CASCADE IN ATHEROSCLEROSIS
    Yong Jian Geng; Fiscal Year: 1999
    ..Specific Aim 3 will examine the function of fragments of actin an gelsolin in mediating apoptosis. Arteries from mice deficient in expression of functional Fas (MRC/lpr/lpr) or gelsolin will be examined. ..
  2. CD1-restricted T cell response in atherosclerosis
    Yong Jian Geng; Fiscal Year: 2003
    ..Fulfillment of the above objectives will provide novel mechanisms by which lipid antigens activate immune cells and cause inflammation in the arteries with atherosclerosis. ..
  3. CD1-restricted T cell response in atherosclerosis
    Yong Jian Geng; Fiscal Year: 2002
    ..Accomplishment of this project is anticipated to generate valuable information that help understand the immune mechanisms underlying vascular injury during atherogenesis. ..
  4. CD1-restricted T cell response in atherosclerosis
    Yong Jian Geng; Fiscal Year: 2003
    ..Accomplishment of this project is anticipated to generate valuable information that help understand the immune mechanisms underlying vascular injury during atherogenesis. ..
  5. APOPTOTIC CASCADE IN ATHEROSCLEROSIS
    Yong Jian Geng; Fiscal Year: 2002
    ..Specific Aim 3 will examine the function of fragments of actin an gelsolin in mediating apoptosis. Arteries from mice deficient in expression of functional Fas (MRC/lpr/lpr) or gelsolin will be examined. ..
  6. APOPTOTIC CASCADE IN ATHEROSCLEROSIS
    Yong Jian Geng; Fiscal Year: 2002
    ..Specific Aim 3 will examine the function of fragments of actin an gelsolin in mediating apoptosis. Arteries from mice deficient in expression of functional Fas (MRC/lpr/lpr) or gelsolin will be examined. ..
  7. CD1-restricted T cell response in atherosclerosis
    Yong Jian Geng; Fiscal Year: 2002
    ..Accomplishment of this project is anticipated to generate valuable information that help understand the immune mechanisms underlying vascular injury during atherogenesis. ..
  8. CD1-restricted T cell response in atherosclerosis
    Yong Jian Geng; Fiscal Year: 2001
    ..Accomplishment of this project is anticipated to generate valuable information that help understand the immune mechanisms underlying vascular injury during atherogenesis. ..
  9. APOPTOTIC CASCADE IN ATHEROSCLEROSIS
    Yong Jian Geng; Fiscal Year: 2001
    ..Specific Aim 3 will examine the function of fragments of actin an gelsolin in mediating apoptosis. Arteries from mice deficient in expression of functional Fas (MRC/lpr/lpr) or gelsolin will be examined. ..
  10. APOPTOTIC CASCADE IN ATHEROSCLEROSIS
    Yong Jian Geng; Fiscal Year: 2000
    ..Specific Aim 3 will examine the function of fragments of actin an gelsolin in mediating apoptosis. Arteries from mice deficient in expression of functional Fas (MRC/lpr/lpr) or gelsolin will be examined. ..
  11. APOPTOTIC CASCADE IN ATHEROSCLEROSIS
    Yong Jian Geng; Fiscal Year: 2000
    ..Specific Aim 3 will examine the function of fragments of actin an gelsolin in mediating apoptosis. Arteries from mice deficient in expression of functional Fas (MRC/lpr/lpr) or gelsolin will be examined. ..
  12. CD1-restricted T cell response in atherosclerosis
    Yong Jian Geng; Fiscal Year: 2004
    ..Accomplishment of this project is anticipated to generate valuable information that help understand the immune mechanisms underlying vascular injury during atherogenesis. ..