Jose M Garcia

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Hypogonadism in male patients with cancer
    Jose M Garcia
    Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine and Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
    Cancer 106:2583-91. 2006
  2. ncbi request reprint Active ghrelin levels and active to total ghrelin ratio in cancer-induced cachexia
    Jose M Garcia
    Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism and The Huffington Center on Aging, Baylor College of Medicine, and Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 90:2920-6. 2005
  3. ncbi request reprint Effect on body weight and safety of RC-1291, a novel, orally available ghrelin mimetic and growth hormone secretagogue: results of a phase I, randomized, placebo-controlled, multiple-dose study in healthy volunteers
    Jose M Garcia
    Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Oncologist 12:594-600. 2007
  4. doi request reprint Pharmacodynamic hormonal effects of anamorelin, a novel oral ghrelin mimetic and growth hormone secretagogue in healthy volunteers
    Jose M Garcia
    Division of Diabetes, Endocrinology and Metabolism, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
    Growth Horm IGF Res 19:267-73. 2009
  5. pmc Inhibition of cisplatin-induced lipid catabolism and weight loss by ghrelin in male mice
    Jose M Garcia
    Department of Medicine and Molecular and Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 154:3118-29. 2013
  6. doi request reprint Adipokines in patients with cancer anorexia and cachexia
    Joanna Smiechowska
    The Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    J Investig Med 58:554-9. 2010
  7. pmc Weight and metabolic effects of CPAP in obstructive sleep apnea patients with obesity
    Jose M Garcia
    Division of Pulmonary, Critical Care and Sleep Medicine, Michael E DeBakey Veterans Affairs Medical Center, 2002 Holcombe Blvd, Houston, TX 77025, USA
    Respir Res 12:80. 2011
  8. doi request reprint Low testosterone levels and increased inflammatory markers in patients with cancer and relationship with cachexia
    Basil O Burney
    Division of Endocrinology, Diabetes, and Metabolism, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, 2002 Holcombe Boulevard, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 97:E700-9. 2012
  9. doi request reprint Therapeutic potential of anamorelin, a novel, oral ghrelin mimetic, in patients with cancer-related cachexia: a multicenter, randomized, double-blind, crossover, pilot study
    Jose M Garcia
    Division of Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, Houston, TX, USA
    Support Care Cancer 21:129-37. 2013
  10. ncbi request reprint Rise of plasma ghrelin with weight loss is not sustained during weight maintenance
    Jose M Garcia
    Translational Metabolism Unit, Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA
    Obesity (Silver Spring) 14:1716-23. 2006

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Hypogonadism in male patients with cancer
    Jose M Garcia
    Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine and Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
    Cancer 106:2583-91. 2006
    ..Patients with cancer often develop anorexia, fatigue, and decreased muscle mass. These signs and symptoms are nonspecific, and they frequently occur in other conditions, including hypogonadism...
  2. ncbi request reprint Active ghrelin levels and active to total ghrelin ratio in cancer-induced cachexia
    Jose M Garcia
    Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism and The Huffington Center on Aging, Baylor College of Medicine, and Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 90:2920-6. 2005
    ..Changes in the active to total ghrelin ratio suggest that a mechanism other than increased secretion must be responsible for the increase in active ghrelin levels. PYY is unlikely to play an important role in cancer-induced cachexia...
  3. ncbi request reprint Effect on body weight and safety of RC-1291, a novel, orally available ghrelin mimetic and growth hormone secretagogue: results of a phase I, randomized, placebo-controlled, multiple-dose study in healthy volunteers
    Jose M Garcia
    Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Oncologist 12:594-600. 2007
    ..This randomized, double-blind, placebo-controlled, multiple-dose, dose-escalation phase I study in healthy volunteers evaluated RC-1291 once daily (qd) and twice daily (bid) for effect on body weight and safety...
  4. doi request reprint Pharmacodynamic hormonal effects of anamorelin, a novel oral ghrelin mimetic and growth hormone secretagogue in healthy volunteers
    Jose M Garcia
    Division of Diabetes, Endocrinology and Metabolism, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
    Growth Horm IGF Res 19:267-73. 2009
    ..Anamorelin is a novel, orally active, non-peptidic ghrelin mimetic and growth hormone secretagogue. Our objective was to evaluate its hormonal effects in healthy subjects...
  5. pmc Inhibition of cisplatin-induced lipid catabolism and weight loss by ghrelin in male mice
    Jose M Garcia
    Department of Medicine and Molecular and Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 154:3118-29. 2013
    ..Thus, ghrelin prevents cisplatin-induced weight and fat loss by restoring adipose tissue functionality. An increase in caloric intake further enhances the anabolic effects of ghrelin...
  6. doi request reprint Adipokines in patients with cancer anorexia and cachexia
    Joanna Smiechowska
    The Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    J Investig Med 58:554-9. 2010
    ..The objective of this study was to determine the levels of adipokines and their relation to appetite, weight loss, insulin resistance, and other hormones in cancer cachexia...
  7. pmc Weight and metabolic effects of CPAP in obstructive sleep apnea patients with obesity
    Jose M Garcia
    Division of Pulmonary, Critical Care and Sleep Medicine, Michael E DeBakey Veterans Affairs Medical Center, 2002 Holcombe Blvd, Houston, TX 77025, USA
    Respir Res 12:80. 2011
    ..We postulated that CPAP will decrease IR, ghrelin and resistin and increase adiponectin levels in this setting...
  8. doi request reprint Low testosterone levels and increased inflammatory markers in patients with cancer and relationship with cachexia
    Basil O Burney
    Division of Endocrinology, Diabetes, and Metabolism, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, 2002 Holcombe Boulevard, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 97:E700-9. 2012
    ..These symptoms are seen in men with hypogonadism and/or inflammatory conditions. However, the relative contribution of testosterone and inflammation to symptom burden in cancer has not been well-established...
  9. doi request reprint Therapeutic potential of anamorelin, a novel, oral ghrelin mimetic, in patients with cancer-related cachexia: a multicenter, randomized, double-blind, crossover, pilot study
    Jose M Garcia
    Division of Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, Houston, TX, USA
    Support Care Cancer 21:129-37. 2013
    ..Anamorelin, an oral mimetic of ghrelin, has been shown to increase body weight and anabolic hormone levels in healthy volunteers and is being investigated to treat cancer cachexia...
  10. ncbi request reprint Rise of plasma ghrelin with weight loss is not sustained during weight maintenance
    Jose M Garcia
    Translational Metabolism Unit, Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA
    Obesity (Silver Spring) 14:1716-23. 2006
    ..The objective of this study was to investigate the relationship of plasma ghrelin concentrations to active WL and weight maintenance in obese subjects...
  11. pmc Ghrelin prevents cisplatin-induced mechanical hyperalgesia and cachexia
    Jose M Garcia
    Division of Endocrinology, Diabetes and Metabolism, Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
    Endocrinology 149:455-60. 2008
    ..Attenuation of mechanical hyperalgesia in the rat by the hormone ghrelin provides a unique model for elucidating the mechanisms involved, which are essential toward our understanding of these complications...
  12. pmc Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance
    Yuxiang Sun
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Endocrinology 149:843-50. 2008
    ..These results support our hypothesis that the primary metabolic function of ghrelin in adult mice is to modulate glucose sensing and insulin sensitivity, rather than directly regulate energy intake and energy expenditure...
  13. ncbi request reprint Sarcopenia, cachexia and aging: diagnosis, mechanisms and therapeutic options - a mini-review
    Sumbul Ali
    Division of Diabetes, Endocrinology and Metabolism, MCL, Center for Translational Research in Inflammatory Diseases, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Tex, USA
    Gerontology 60:294-305. 2014
    ..We also shed light on newer agents being developed as potential therapeutic options for wasting diseases. © 2014 S. Karger AG, Basel. ..
  14. doi request reprint Clinical development of ghrelin axis-derived molecules for cancer cachexia treatment
    Sumbul Ali
    aDivision of Diabetes, Endocrinology and Metabolism, MCL, Center for Translational Research in Inflammatory Diseases, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA bDepartment of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, China cDept of Molecular and Cell Biology and Huffington Center on Aging, Baylor College of Medicine, Houston, Texas, USA Sumbul Ali and Ji an Chen contributed equally to the writing of this article
    Curr Opin Support Palliat Care 7:368-75. 2013
    ..Here we review the clinical development of ghrelin and ghrelin mimetics (also known as growth hormone secretagogues or GHS) for cancer cachexia treatment...
  15. pmc Predicting survival in cancer patients: the role of cachexia and hormonal, nutritional and inflammatory markers
    Anne E Utech
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX, USA
    J Cachexia Sarcopenia Muscle 3:245-51. 2012
    ..Cancer can lead to weight loss, anorexia, and poor nutritional status, which are associated with decreased survival in cancer patients...
  16. pmc Hypogonadism in male cancer patients
    Basil O Burney
    Division of Endocrinology, Diabetes and Metabolism, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, 2002 Holcombe Blvd, Bldg 109, Rm 210, Houston, TX, 77030, USA
    J Cachexia Sarcopenia Muscle 3:149-55. 2012
    ..Prospective and interventional trials are needed to test the efficacy and safety of testosterone treatment in improving quality of life of these patients...
  17. ncbi request reprint Prevalence of aberrant methylation of p14ARF over p16INK4a in some human primary tumors
    Gemma Dominguez
    Department of Medical Oncology, Hospital Universitario Puerta de Hierro, C San Martin de Porres 4, E 28035, Madrid, Spain
    Mutat Res 530:9-17. 2003
    ....
  18. ncbi request reprint Tumor DNA in plasma at diagnosis of breast cancer patients is a valuable predictor of disease-free survival
    Jose M Silva
    Department of Medical Oncology, Hospital Universitario Puerta de Hierro, E 28035 Madrid, Spain
    Clin Cancer Res 8:3761-6. 2002
    ..We examine prospectively whether the presence of plasma DNA with tumor characteristics before mastectomy is a predictive factor related to recurrence and disease-free survival (DFS)...