Nikolaos Frangogiannis

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint The inflammatory response in myocardial infarction
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine and the DeBakey Heart Center, One Baylor Plaza M S F 602, Houston, TX 77030, USA
    Cardiovasc Res 53:31-47. 2002
  2. ncbi request reprint IL-10 is induced in the reperfused myocardium and may modulate the reaction to injury
    N G Frangogiannis
    DeBakey Heart Center, Section of Cardiovascular Sciences, Department of Medicine, The Methodist Hospital, Houston, TX 77030, USA
    J Immunol 165:2798-808. 2000
  3. ncbi request reprint Myocardial hibernation. Clinical and pathological perspectives
    N G Frangogiannis
    Section of Cardiovascular Sciences, Baylor College of Medicine, The Methodist Hospital and the DeBakey Heart Center, Houston, TX 77030, USA
    Minerva Cardioangiol 51:261-74. 2003
  4. ncbi request reprint Targeting the inflammatory response in healing myocardial infarcts
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, Baylor College of Medicine, Houston TX 77030, USA
    Curr Med Chem 13:1877-93. 2006
  5. ncbi request reprint Chemokines in ischemia and reperfusion
    Nikolaos G Frangogiannis
    Baylor College of Medicine, One Baylor Plaza M S F602, Houston, TX 77030, USA
    Thromb Haemost 97:738-47. 2007
  6. ncbi request reprint Critical role of monocyte chemoattractant protein-1/CC chemokine ligand 2 in the pathogenesis of ischemic cardiomyopathy
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, and DeBakey Heart Center, The Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA
    Circulation 115:584-92. 2007
  7. ncbi request reprint The role of the chemokines in myocardial ischemia and reperfusion
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, The Methodist Hospital, DeBakey Heart Center, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Vasc Pharmacol 2:163-74. 2004
  8. pmc The immune system and cardiac repair
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, Baylor College of Medicine, One Baylor Plaza BCM620, Houston, TX 77030, United States
    Pharmacol Res 58:88-111. 2008
  9. ncbi request reprint Chemokines in the ischemic myocardium: from inflammation to fibrosis
    N G Frangogiannis
    Section of Cardiovascular Sciences, The Methodist Hospital and the DeBakey Heart Center, One Baylor Plaza M S F 602, Houston TX 77030, USA
    Inflamm Res 53:585-95. 2004
  10. ncbi request reprint Critical role of endogenous thrombospondin-1 in preventing expansion of healing myocardial infarcts
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, Methodist Hospital and DeBakey Heart Center, Baylor College of Medicine, Houston, Tex, USA
    Circulation 111:2935-42. 2005

Research Grants

  1. Resolution of inflammation in healing myocardial infarcts
    Nikolaos Frangogiannis; Fiscal Year: 2009
  2. Chemokines in Healing Myocardial Infarcts
    Nikolaos Frangogiannis; Fiscal Year: 2009

Collaborators

Detail Information

Publications43

  1. ncbi request reprint The inflammatory response in myocardial infarction
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine and the DeBakey Heart Center, One Baylor Plaza M S F 602, Houston, TX 77030, USA
    Cardiovasc Res 53:31-47. 2002
    ..Elucidating the complex interactions and regulatory mechanisms responsible for cardiac repair may allow us to design effective inflammation-related interventions for the treatment of myocardial infarction...
  2. ncbi request reprint IL-10 is induced in the reperfused myocardium and may modulate the reaction to injury
    N G Frangogiannis
    DeBakey Heart Center, Section of Cardiovascular Sciences, Department of Medicine, The Methodist Hospital, Houston, TX 77030, USA
    J Immunol 165:2798-808. 2000
    ..Our findings suggest that lymphocytes infiltrating the ischemic and reperfused myocardium express IL-10 and may have a significant role in healing by modulating mononuclear cell phenotype and inducing TIMP-1 expression...
  3. ncbi request reprint Myocardial hibernation. Clinical and pathological perspectives
    N G Frangogiannis
    Section of Cardiovascular Sciences, Baylor College of Medicine, The Methodist Hospital and the DeBakey Heart Center, Houston, TX 77030, USA
    Minerva Cardioangiol 51:261-74. 2003
    ..Understanding of the specific molecular signals involved in the pathogenesis of myocardial hibernation is crucial in order to design strategies preventing irreversible dysfunction...
  4. ncbi request reprint Targeting the inflammatory response in healing myocardial infarcts
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, Baylor College of Medicine, Houston TX 77030, USA
    Curr Med Chem 13:1877-93. 2006
    ....
  5. ncbi request reprint Chemokines in ischemia and reperfusion
    Nikolaos G Frangogiannis
    Baylor College of Medicine, One Baylor Plaza M S F602, Houston, TX 77030, USA
    Thromb Haemost 97:738-47. 2007
    ..This manuscript reviews the evidence suggesting a role for chemokine-mediated effects in ischemia/reperfusion and discusses the potential significance of these interactions in injury and repair of ischemic tissues...
  6. ncbi request reprint Critical role of monocyte chemoattractant protein-1/CC chemokine ligand 2 in the pathogenesis of ischemic cardiomyopathy
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, and DeBakey Heart Center, The Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA
    Circulation 115:584-92. 2007
    ..We hypothesized that MCP-1 may mediate fibrotic remodeling through recruitment of mononuclear cells and direct effects on fibroblasts...
  7. ncbi request reprint The role of the chemokines in myocardial ischemia and reperfusion
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, The Methodist Hospital, DeBakey Heart Center, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Vasc Pharmacol 2:163-74. 2004
    ..Understanding of their role in myocardial infarction may allow us to design specific therapeutic strategies aiming at optimizing cardiac repair and preventing ventricular remodeling...
  8. pmc The immune system and cardiac repair
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, Baylor College of Medicine, One Baylor Plaza BCM620, Houston, TX 77030, United States
    Pharmacol Res 58:88-111. 2008
    ..In addition, understanding the role of the immune system in cardiac repair is necessary in order to design optimal strategies for cardiac regeneration...
  9. ncbi request reprint Chemokines in the ischemic myocardium: from inflammation to fibrosis
    N G Frangogiannis
    Section of Cardiovascular Sciences, The Methodist Hospital and the DeBakey Heart Center, One Baylor Plaza M S F 602, Houston TX 77030, USA
    Inflamm Res 53:585-95. 2004
    ....
  10. ncbi request reprint Critical role of endogenous thrombospondin-1 in preventing expansion of healing myocardial infarcts
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, Methodist Hospital and DeBakey Heart Center, Baylor College of Medicine, Houston, Tex, USA
    Circulation 111:2935-42. 2005
    ....
  11. ncbi request reprint Chemokines in myocardial ischemia
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, The Methodist Hospital and the DeBakey Heart Center, Baylor College of Medicine, One Baylor Plaza M S F 602, Houston, TX 77030, USA
    Trends Cardiovasc Med 15:163-9. 2005
    ..Understanding of the role of chemokines in myocardial ischemia may result in novel strategies in the treatment of patients with ischemic heart disease...
  12. ncbi request reprint The mechanistic basis of infarct healing
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, Baylor College of Medicine, Houston, Texas 77030, USA
    Antioxid Redox Signal 8:1907-39. 2006
    ..The molecular and cellular changes associated with infarct healing directly influence ventricular remodeling and affect prognosis in patients with myocardial infarction...
  13. ncbi request reprint MCSF expression is induced in healing myocardial infarcts and may regulate monocyte and endothelial cell phenotype
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, Department of Medicine, Methodist Hospital and DeBakey Heart Center, One Baylor Plaza, M S F 602, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 285:H483-92. 2003
    ..We suggest that upregulation of MCSF in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression...
  14. ncbi request reprint The pathological basis of myocardial hibernation
    N G Frangogiannis
    Section of Cardiovascular Sciences, Baylor College of Medicine and the DeBakey Heart Center, The Methodist Hospital, Houston, Texas 77030, USA
    Histol Histopathol 18:647-55. 2003
    ..Understanding the role of inflammatory mediators in the development and progression of the cardiomyopathic process may lead to the development of specific therapeutic strategies aiming at preventing irreversible fibrosis and dysfunction...
  15. ncbi request reprint Myofibroblasts in reperfused myocardial infarcts express the embryonic form of smooth muscle myosin heavy chain (SMemb)
    N G Frangogiannis
    Section of Cardiovascular Sciences, Baylor College of Medicine and the De Bakey Heart Center, The Methodist Hospital, Houston TX, USA
    Cardiovasc Res 48:89-100. 2000
    ..The purpose of this study is to examine the cellular content of healing myocardial infarcts and study the phenotypic characteristics of fibroblasts during scar formation utilizing a canine model of coronary occlusion and reperfusion...
  16. ncbi request reprint Induction of the synthesis of the C-X-C chemokine interferon-gamma-inducible protein-10 in experimental canine endotoxemia
    N G Frangogiannis
    Section of Cardiovascular Sciences, Department of Medicine, One Baylor Plaza M S F 602, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Tissue Res 302:365-76. 2000
    ..TNF-alpha, IL-1 beta, and M-CSF are potent inducers of IP-10 in canine endothelial cells and may indirectly mediate lymphocyte chemotaxis and activation in inflammatory processes...
  17. ncbi request reprint Active interstitial remodeling: an important process in the hibernating human myocardium
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Am Coll Cardiol 39:1468-74. 2002
    ....
  18. pmc Evidence for an active inflammatory process in the hibernating human myocardium
    Nikolaos G Frangogiannis
    Department of Medicine, Baylor College of Medicine, The Methodist Hospital, Houston, Texas 77030, USA
    Am J Pathol 160:1425-33. 2002
    ..We postulate that revascularization may promote resolution of the ongoing inflammation, preventing further tissue injury and fibrosis...
  19. pmc The role of TGF-beta signaling in myocardial infarction and cardiac remodeling
    Marcin Bujak
    Section of Cardiovascular Sciences, One Baylor Plaza M S F 602, Baylor College of Medicine, and Methodist DeBakey Heart Center, Houston, TX 77030, USA
    Cardiovasc Res 74:184-95. 2007
    ..In this review we summarize the current knowledge on the role of TGF-beta in infarct healing and cardiac remodeling...
  20. pmc Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice
    Sandra B Haudek
    DeBakey Heart Center, Baylor College of Medicine, Methodist Hospital, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:18284-9. 2006
    ..Our data suggest that SAP interferes with assumption of a fibroblast phenotype in a subset of monocytes and that SAP may be an important regulator in the linkage between inflammation and nonadaptive fibrosis in the heart...
  21. pmc Interleukin-10 is not a critical regulator of infarct healing and left ventricular remodeling
    Pawel Zymek
    Section of Cardiovascular Sciences, Baylor College of Medicine and The Methodist Hospital, One Baylor Plaza M S F 602, Houston TX 77030, United States
    Cardiovasc Res 74:313-22. 2007
    ..We hypothesized that endogenous IL-10 may regulate infarct healing and left ventricular remodeling by promoting resolution of the post-infarction inflammatory response and by modulating extracellular matrix metabolism...
  22. ncbi request reprint The role of platelet-derived growth factor signaling in healing myocardial infarcts
    Pawel Zymek
    Section of Cardiovascular Sciences, The DeBakey Heart Center, Baylor College of Medicine, and The Methodist Hospital, Houston, Texas 77030, USA
    J Am Coll Cardiol 48:2315-23. 2006
    ..This study sought to examine the role of platelet-derived growth factor (PDGF) signaling in healing myocardial infarcts...
  23. pmc Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling
    Marcin Bujak
    Section of Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Pathol 173:57-67. 2008
    ..Thus, interventional therapeutics targeting the IL-1 system may have great benefits in myocardial infarction...
  24. ncbi request reprint The role of the thrombospondins in healing myocardial infarcts
    Khaled Chatila
    Section of Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Cardiovasc Hematol Agents Med Chem 5:21-7. 2007
    ..Understanding the specific mechanisms responsible for the protective effects of TSP-1 and TSP-2 in healing infarcts may lead to novel therapeutic interventions aiming at attenuating adverse left ventricular remodeling...
  25. pmc Aging-related defects are associated with adverse cardiac remodeling in a mouse model of reperfused myocardial infarction
    Marcin Bujak
    Section of Cardiovascular Sciences, Baylor College of Medicine, Houston, Texas 77030, USA
    J Am Coll Cardiol 51:1384-92. 2008
    ..The purpose of this study was to study aging-associated alterations in the inflammatory and reparative response after myocardial infarction (MI) and their involvement in adverse post-infarction remodeling of the senescent heart...
  26. ncbi request reprint CD44 is critically involved in infarct healing by regulating the inflammatory and fibrotic response
    Peter Huebener
    Section of Cardiovascular Sciences, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Immunol 180:2625-33. 2008
    ..Our findings suggest that CD44-mediated interactions are critically involved in infarct healing. CD44 signaling is important for resolution of the postinfarction inflammatory reaction and regulates fibroblast function...
  27. ncbi request reprint Integrated multimodal-catheter imaging unveils principal relationships among ventricular electrical activity, anatomy, and function
    Liyun Rao
    Department of Cardiology, Methodist DeBakey Heart Center, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 294:H1002-9. 2008
    ....
  28. ncbi request reprint Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling
    Marcin Bujak
    Section of Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Circulation 116:2127-38. 2007
    ..The transforming growth factor-beta/Smad3 pathway is activated in healing infarcts and may regulate cellular events critical for the inflammatory and the fibrotic responses...
  29. ncbi request reprint MCP-1/CCL2 as a therapeutic target in myocardial infarction and ischemic cardiomyopathy
    Ying Xia
    Section of Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Inflamm Allergy Drug Targets 6:101-7. 2007
    ....
  30. ncbi request reprint Effects of diet-induced obesity on inflammation and remodeling after myocardial infarction
    Geeta D Thakker
    Dept of Medicine, Baylor College of Medicine, 6565 Fannin, M S A 601, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 291:H2504-14. 2006
    ....
  31. ncbi request reprint Morphological characteristics of the microvasculature in healing myocardial infarcts
    Guofeng Ren
    Section of Cardiovascular Sciences, Department of Medicine, Methodist Hospital and DeBakey Heart Center, Baylor College of Medicine, Houston, Texas 77030, USA
    J Histochem Cytochem 50:71-9. 2002
    ..Understanding of the mechanisms underlying the formation and remodeling of the microvasculature after MI may be important in designing therapeutic interventions to optimize cardiac repair...
  32. ncbi request reprint Mast cells and macrophages in normal C57/BL/6 mice
    Christine Gersch
    Section of Cardiovascular Sciences, Baylor College of Medicine, One Baylor Plaza M S F 602, Houston TX 77030, USA
    Histochem Cell Biol 118:41-9. 2002
    ..Constitutive growth factor mRNA expression in murine tissues without significant populations of mast cells and macrophages may suggest an alternative role for these factors in tissue homeostasis...
  33. ncbi request reprint Microvascular structural correlates of myocardial contrast echocardiography in patients with coronary artery disease and left ventricular dysfunction: implications for the assessment of myocardial hibernation
    Sarah Shimoni
    Section of Cardiology, Department of Medicine, Baylor College of Medicine and the DeBakey Heart Center, Houston, Tex 77030, USA
    Circulation 106:950-6. 2002
    ..Myocardial contrast echocardiography (MCE) has been used to evaluate myocardial viability. There are no data, however, on the pathological determinants of myocardial perfusion by MCE in humans and the implications of such determinants...
  34. ncbi request reprint Identification of hibernating myocardium with quantitative intravenous myocardial contrast echocardiography: comparison with dobutamine echocardiography and thallium-201 scintigraphy
    Sarah Shimoni
    Section of Cardiology, Department of Medicine, Baylor College of Medicine and The Methodist DeBakey Heart Center, Houston, Tex 77030, USA
    Circulation 107:538-44. 2003
    ....
  35. pmc Development of murine ischemic cardiomyopathy is associated with a transient inflammatory reaction and depends on reactive oxygen species
    Oliver Dewald
    Cardiovascular Sciences and DeBakey Heart Center, Baylor College of Medicine, and The Methodist Hospital, One Baylor Plaza, M S F 602, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:2700-5. 2003
    ..The reduction of the cellular and functional response in EC-SOD mice suggests a role for reactive O(2) in the pathogenesis of ischemic cardiomyopathy...
  36. ncbi request reprint Inflammatory mechanisms in myocardial infarction
    Guofeng Ren
    Section of Cardiovascular Sciences, Department of Medicine, The Methodist Hospital, Houston TX, USA
    Curr Drug Targets Inflamm Allergy 2:242-56. 2003
    ..Understanding the cellular and molecular steps involved in regulating infarct healing may lead to specific interventions aimed at optimizing cardiac repair...
  37. pmc Of mice and dogs: species-specific differences in the inflammatory response following myocardial infarction
    Oliver Dewald
    Section of Cardiovascular Sciences, Baylor College of Medicine, The Methodist Hospital, and The DeBakey Heart Center, Houston, Texas 77030, USA
    Am J Pathol 164:665-77. 2004
    ..These important species-specific differences should be considered when interpreting findings derived from studies using genetically altered mice...
  38. ncbi request reprint Vascular mural cells in healing canine myocardial infarcts
    Marcin Dobaczewski
    Section of Cardiovascular Sciences, One Baylor Plaza M S F 602, Baylor College of Medicine, Houston, TX 77030, USA
    J Histochem Cytochem 52:1019-29. 2004
    ..Recruitment of a muscular coat and formation of neoarterioles in mature scars may inhibit endothelial cell proliferation and vascular sprouting, stabilizing the infarct vasculature...
  39. ncbi request reprint Targeting the chemokines in myocardial inflammation
    Nikolaos G Frangogiannis
    Circulation 110:1341-2. 2004
  40. pmc Mast cell tryptase may modulate endothelial cell phenotype in healing myocardial infarcts
    Porur Somasundaram
    Section of Cardiovascular Sciences, DeBakey Heart Center, Baylor College of Medicine, and The Methodist Hospital, Houston, Texas 77030, USA
    J Pathol 205:102-11. 2005
    ..Endothelial PAR-2 stimulation with the agonist peptide SLIGKV induced a similar chemokine expression profile. Mast cell tryptase may exert its angiogenic effects in part through selective stimulation of angiogenic chemokines...
  41. ncbi request reprint CCL2/Monocyte Chemoattractant Protein-1 regulates inflammatory responses critical to healing myocardial infarcts
    Oliver Dewald
    Section of Cardiovascular Sciences, DeBakey Heart Center, Baylor College of Medicine, and The Methodist Hospital, Houston, Tex 77030, USA
    Circ Res 96:881-9. 2005
    ..Absence of MCP-1 results in attenuated post-infarction left ventricular remodeling, at the expense of a prolonged inflammatory phase and delayed replacement of injured cardiomyocytes with granulation tissue...
  42. ncbi request reprint Identification of mast cells in the cellular response to myocardial infarction
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Methods Mol Biol 315:91-101. 2006
    ..These techniques are useful tools for pathological studies in canine models...
  43. ncbi request reprint Impact of myocardial structure and function postinfarction on diastolic strain measurements: implications for assessment of myocardial viability
    Tae Ho Park
    Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Am J Physiol Heart Circ Physiol 290:H724-31. 2006
    ..86, P < 0.01). In an animal model of healing canine infarcts, diastolic strain rate by Doppler echocardiography appears to be a promising novel index of myocardial viability...

Research Grants7

  1. Resolution of inflammation in healing myocardial infarcts
    Nikolaos Frangogiannis; Fiscal Year: 2009
    ..These studies may lead to therapeutic interventions aimed at optimizing cardiac repair by preventing prolongation and extension of the inflammatory injury. ..
  2. Chemokines in Healing Myocardial Infarcts
    Nikolaos Frangogiannis; Fiscal Year: 2009
    ..Understanding the role of chemokines in infarct healing may identify novel therapeutic targets aiming at optimizing cardiac repair and decreasing adverse remodeling. ..