Myriam Fornage

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Genetics of coronary artery calcification among African Americans, a meta-analysis
    Mary K Wojczynski
    Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA
    BMC Med Genet 14:75. 2013
  2. pmc Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology study
    Kira C Taylor
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    BMC Genet 14:33. 2013
  3. pmc Ranking analysis of F-statistics for microarray data
    Yuan De Tan
    College of Life Sciences, Hunan Normal University, Changsha, 410081, China
    BMC Bioinformatics 9:142. 2008
  4. ncbi request reprint Family-based association study of matrix metalloproteinase-3 and -9 haplotypes with susceptibility to ischemic white matter injury
    Myriam Fornage
    Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1825 Pressler St, Room 530 G, Houston, TX 77030, USA
    Hum Genet 120:671-80. 2007
  5. ncbi request reprint Genomics and epigenomics of hypertension
    Myriam Fornage
    Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 2121 WHolcombe Boulevard, Houston, TX 77030, USA
    Curr Opin Mol Ther 8:206-14. 2006
  6. pmc Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain: The Cardiovascular Health Study
    Myriam Fornage
    Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Stroke 39:1952-9. 2008
  7. pmc Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium
    Myriam Fornage
    Brown Foundation Institute of Molecular Medicine, Division of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA
    Ann Neurol 69:928-39. 2011
  8. ncbi request reprint Genetics of stroke
    Myriam Fornage
    Brown Foundation Institute of Molecular Medicine, 1825 Pressler Street, Houston, TX 77030, USA
    Curr Atheroscler Rep 11:167-74. 2009
  9. ncbi request reprint Inverse effects of the PPAR(gamma)2 Pro12Ala polymorphism on measures of adiposity over 15 years in African Americans and whites. The CARDIA study
    Myriam Fornage
    Institute of Molecular Science, University of Texas Health Science Center at Houston, Houston TX 77030, USA
    Metabolism 54:910-7. 2005
  10. ncbi request reprint Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: The Coronary Artery Risk Development in Young Adults (CARDIA) study
    Myriam Fornage
    Institute of Molecular Medicine, University of Texas Health Science Center, Houston, 2121 W Holcombe Blvd, Houston, TX 77030, USA
    Circulation 109:335-9. 2004

Detail Information

Publications48

  1. pmc Genetics of coronary artery calcification among African Americans, a meta-analysis
    Mary K Wojczynski
    Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA
    BMC Med Genet 14:75. 2013
    ..African Americans (AA) have higher rates of CHD but are less well-studied in genomic studies. We assembled the largest AA data resource currently available with measured CAC to identify associated genetic variants...
  2. pmc Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology study
    Kira C Taylor
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    BMC Genet 14:33. 2013
    ..Here, we investigated whether GWAS-identified SNPs for lipid traits exhibited heterogeneity by sex in the Population Architecture using Genomics and Epidemiology (PAGE) study...
  3. pmc Ranking analysis of F-statistics for microarray data
    Yuan De Tan
    College of Life Sciences, Hunan Normal University, Changsha, 410081, China
    BMC Bioinformatics 9:142. 2008
    ..Methods for large-scale statistical analyses have been developed but most of them are applicable to two-sample or two-condition data...
  4. ncbi request reprint Family-based association study of matrix metalloproteinase-3 and -9 haplotypes with susceptibility to ischemic white matter injury
    Myriam Fornage
    Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1825 Pressler St, Room 530 G, Houston, TX 77030, USA
    Hum Genet 120:671-80. 2007
    ..They provide the basis for further investigation of the role of these genes in susceptibility and/or progression to clinical disease...
  5. ncbi request reprint Genomics and epigenomics of hypertension
    Myriam Fornage
    Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 2121 WHolcombe Boulevard, Houston, TX 77030, USA
    Curr Opin Mol Ther 8:206-14. 2006
    ..This review provides an overview of the current progress of and future prospects for the application of genomic and epigenomic sciences to hypertension research...
  6. pmc Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain: The Cardiovascular Health Study
    Myriam Fornage
    Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Stroke 39:1952-9. 2008
    ....
  7. pmc Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium
    Myriam Fornage
    Brown Foundation Institute of Molecular Medicine, Division of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA
    Ann Neurol 69:928-39. 2011
    ..WMHs are associated with an increased risk of cognitive and motor dysfunction, dementia, depression, and stroke. Despite a significant heritability, few genetic loci influencing WMH burden have been identified...
  8. ncbi request reprint Genetics of stroke
    Myriam Fornage
    Brown Foundation Institute of Molecular Medicine, 1825 Pressler Street, Houston, TX 77030, USA
    Curr Atheroscler Rep 11:167-74. 2009
    ..This review provides an overview of the current progress and future prospects of the application of genomic sciences to stroke research...
  9. ncbi request reprint Inverse effects of the PPAR(gamma)2 Pro12Ala polymorphism on measures of adiposity over 15 years in African Americans and whites. The CARDIA study
    Myriam Fornage
    Institute of Molecular Science, University of Texas Health Science Center at Houston, Houston TX 77030, USA
    Metabolism 54:910-7. 2005
    ..01) in African Americans but not in whites. Important roles of BMI and ethnic background in influencing the complex relationships among PPAR gamma gene variation, adiposity, and insulin resistance are suggested...
  10. ncbi request reprint Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: The Coronary Artery Risk Development in Young Adults (CARDIA) study
    Myriam Fornage
    Institute of Molecular Medicine, University of Texas Health Science Center, Houston, 2121 W Holcombe Blvd, Houston, TX 77030, USA
    Circulation 109:335-9. 2004
    ..We examined the relationship between a common, functional polymorphism of the human sEH gene and coronary artery calcification (CAC) in young, largely asymptomatic African-American and non-Hispanic white subjects...
  11. ncbi request reprint Gene expression profiling and functional proteomic analysis reveal perturbed kinase-mediated signaling in genetic stroke susceptibility
    Myriam Fornage
    Houston Institute of Molecular Medicine, University of Texas, Houston, USA
    Physiol Genomics 15:75-83. 2003
    ..Altered gene and protein expression patterns in SHRSP are consistent with increased vulnerability of this strain to cerebrovascular injury...
  12. ncbi request reprint Parental history of stroke and myocardial infarction predicts coronary artery calcification: The Coronary Artery Risk Development in Young Adults (CARDIA) study
    Myriam Fornage
    Institute of Molecular Medicine, University of Texas Health Science Center Houston, Houston, TX 77030, USA
    Eur J Cardiovasc Prev Rehabil 11:421-6. 2004
    ..This study investigates the association between coronary artery calcification (CAC) and parental history of stroke and MI in African-Americans and Caucasians from the CARDIA study...
  13. pmc Common INSIG2 polymorphisms are associated with age-related changes in body size and high-density lipoprotein cholesterol from young adulthood to middle age
    Myriam Fornage
    Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, TX, USA
    Metabolism 59:1084-91. 2010
    ..A similar trend was observed in blacks who consistently maintained a body mass index less than 25 kg/m(2) over the study period. These data support a role of INSIG2 sequence variation in the regulation of cholesterol metabolism...
  14. ncbi request reprint Patterns of association between PPARgamma genetic variation and indices of adiposity and insulin action in African-Americans and whites: the CARDIA Study
    Qi Wei
    Institute of Molecular Medicine, The University of Texas Health Science Center Houston, 1825 Pressler St, Houston, TX 77030, USA
    J Mol Med (Berl) 84:955-65. 2006
    ..It underscores the role of genetic and environmental contexts in shaping the patterns of associations of PPARgamma sequence variants with metabolic traits in human populations...
  15. ncbi request reprint Sequence variation in the soluble epoxide hydrolase gene and subclinical coronary atherosclerosis: interaction with cigarette smoking
    Qi Wei
    Institute of Molecular Medicine, University of Texas Health Science Center Houston, Houston, TX 77030, United States
    Atherosclerosis 190:26-34. 2007
    ..This detailed investigation of the association of EPHX2 genetic variation with CAC supports EPHX2's emerging role as a risk factor for atherosclerosis, whose effects are influenced by smoking...
  16. pmc The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts
    Jan Bressler
    Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    BMC Med Genet 10:56. 2009
    ..The combined study sample is comprised of 24,722 white, African-American, and Mexican-American participants...
  17. pmc Genome-wide identification of allelic expression in hypertensive rats
    Renata I Dmitrieva
    Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center, 2121 Holcombe Blvd, Houston, TX 77030, USA
    Circ Cardiovasc Genet 2:106-15. 2009
    ..Inbred animal models can facilitate genetic studies of disease traits. The spontaneously hypertensive rat (SHR) is an inbred model of hypertension that exists in several closely related but genetically distinct lines...
  18. pmc The soluble epoxide hydrolase gene harbors sequence variation associated with susceptibility to and protection from incident ischemic stroke
    Myriam Fornage
    Institute of Molecular Medicne for the prevention of Human Diseases, University of Texas Health Science Center, Houston, TX 77030, USA
    Hum Mol Genet 14:2829-37. 2005
    ..These findings suggest that multiple variants exist within or near the EPHX2 gene, with greatly contrasting relationships to ischemic stroke incidence; some associated with a higher incidence and others with a lower incidence...
  19. ncbi request reprint Altered soluble epoxide hydrolase gene expression and function and vascular disease risk in the stroke-prone spontaneously hypertensive rat
    Mandi J Corenblum
    Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1825 Pressler St, 530 G, Houston, TX 77030, USA
    Hypertension 51:567-73. 2008
    ..These data support a role for Ephx2 polymorphism on sEH gene expression and function and risk of end-organ injury in the stroke-prone SHR...
  20. ncbi request reprint Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes
    Cruz A Hinojos
    Institute for Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA
    Hypertension 45:698-704. 2005
    ..The present approach identifies a number of genes that may influence blood pressure in SHR by virtue of allelic effects on gene expression...
  21. pmc Hepatocyte nuclear factor 1 and hypertensive nephropathy
    Renata I Dmitrieva
    Institute of Molecular Medicine, University of Texas HSC at Houston, TX 77030, USA
    Hypertension 51:1583-9. 2008
    ..The present experiments uncover a major change in transcriptional control by HNF1 that affects redox and other genes and precedes emergence of hypertensive renal injury...
  22. pmc Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium
    Megan L Grove
    School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, Texas, USA
    PLoS ONE 8:e68095. 2013
    ..The cluster file from this experiment is available at www.chargeconsortium.com/main/exomechip. ..
  23. pmc Fat mass and obesity gene and cognitive decline: the Atherosclerosis Risk in Communities Study
    Jan Bressler
    Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, USA
    Neurology 80:92-9. 2013
    ....
  24. ncbi request reprint Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants
    Kathy L E Klos
    University of Texas Health Science Center at Houston, School of Public Health, Human Genetics Center, P O Box 20186, Houston, Texas 77225, USA
    Arterioscler Thromb Vasc Biol 26:1828-36. 2006
    ..To identify common variations in genes in the reverse cholesterol transport pathway with nongender-specific influence on plasma lipid and apolipoprotein levels...
  25. ncbi request reprint The uncoupling protein 2 Ala55Val polymorphism is associated with diabetes mellitus: the CARDIA study
    Xinhua Yu
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
    Clin Chem 51:1451-6. 2005
    ..Uncoupling proteins (UCPs) reduce ATP generation with concomitant increased release of heat. The activities of UCPs have been related to obesity and energy metabolism...
  26. pmc Ala54Thr polymorphism of the fatty acid binding protein 2 gene and saturated fat intake in relation to lipid levels and insulin resistance: the Coronary Artery Risk Development in Young Adults (CARDIA) study
    Alanna M Chamberlain
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
    Metabolism 58:1222-8. 2009
    ..Lipid levels and log(HOMA-IR) did not vary by genotype with saturated fat intake less than 53.2 g/d. Limiting dietary saturated fat intake may be particularly important among carriers of the A allele of FABP2...
  27. ncbi request reprint The transcribed genome and the heritable basis of essential hypertension
    Peter A Doris
    Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA
    Cardiovasc Toxicol 5:95-108. 2005
    ..This review explores the potential to uncover hypertension genes by exploiting quantitative variation in the heritable control of gene expression...
  28. ncbi request reprint Polymorphism in soluble epoxide hydrolase and blood pressure in spontaneously hypertensive rats
    Myriam Fornage
    Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, Tex 77030, USA
    Hypertension 40:485-90. 2002
    ..These data indicate that sequence variation determining functional alterations in EPHX2 is not likely to contribute to blood pressure levels in SHR...
  29. doi request reprint Cardiovascular biomarkers and subclinical brain disease in the atherosclerosis risk in communities study
    Razvan T Dadu
    Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Stroke 44:1803-8. 2013
    ....
  30. ncbi request reprint Single-nucleotide polymorphism genotyping for disease association studies
    Myriam Fornage
    The University of Texas, Institute of Molecular Medicine, Research Center for Human Genetics, Houston, USA
    Methods Mol Med 108:159-72. 2005
    ..This chapter focuses on two of them: the 5'-nuclease assay and mass spectrometry genotyping...
  31. ncbi request reprint L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion
    Yasunori Abe
    Section of Atherosclerosis and Lipoprotein Research, Department of Medicine, Baylor College of Medicine, 6565 Fannin, A679B, Houston, TX 77030, United States
    Atherosclerosis 192:56-66. 2007
    ....
  32. pmc Characterization of a human 12/15-lipoxygenase promoter variant associated with atherosclerosis identifies vimentin as a promoter binding protein
    Susmita Samanta
    Research Center for Human Genetics, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
    PLoS ONE 7:e42417. 2012
    ..Sequence variation in the human 12/15 lipoxygenase (ALOX15) has been associated with atherosclerotic disease. We functionally characterized an ALOX15 promoter polymorphism, rs2255888, previously associated with carotid plaque burden...
  33. pmc Complexity in the genetic architecture of leukoaraiosis in hypertensive sibships from the GENOA Study
    Jennifer A Smith
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
    BMC Med Genomics 2:16. 2009
    ....
  34. ncbi request reprint Parent-child pair design for detecting gene-environment interactions in complex diseases
    Yuan De Tan
    Institute of Molecular Medicine, University of Texas Houston, Houston, TX, USA
    Hum Genet 121:745-57. 2007
    ....
  35. pmc Ranking analysis of microarray data: a powerful method for identifying differentially expressed genes
    Yuan De Tan
    Institute of Molecular Medicine, School of Public Health, University of Texas at Houston, Houston, TX 77030, USA
    Genomics 88:846-54. 2006
    ....
  36. ncbi request reprint Hepatic gene expression profiling reveals perturbed calcium signaling in a mouse model lacking both LDL receptor and Apobec1 genes
    Ranjan Dutta
    Research Center for Human Genetics, Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 2121 W Holcombe Blvd, Houston, TX 77030, USA
    Atherosclerosis 169:51-62. 2003
    ..The results of the study provide new insights into the significance of calcification in atherogenesis...
  37. pmc Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study
    Craig R Lee
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health Research, Triangle Park, NC 27709, USA
    Hum Mol Genet 15:1640-9. 2006
    ..315). Genetic variation in EPHX2 was significantly associated with risk of incident CHD in Caucasians, implicating EPHX2 as a potential cardiovascular disease-susceptibility gene...
  38. ncbi request reprint D-dimer, inflammatory markers, and lower extremity functioning in patients with and without peripheral arterial disease
    Mary Mcgrae McDermott
    Department of Medicine, Northwestern University s Feinberg School of Medicine, Chicago, IL, USA
    Circulation 107:3191-8. 2003
    ..We determined whether higher levels of D-dimer, C-reactive protein (CRP), fibrinogen, and serum amyloid A are associated independently with functional impairment in patients with and without peripheral arterial disease (PAD)...
  39. ncbi request reprint Genomic susceptibility loci for brain atrophy in hypertensive sibships from the GENOA study
    Stephen T Turner
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    Hypertension 45:793-8. 2005
    ....
  40. ncbi request reprint Matrix Gla protein and osteopontin genetic associations with coronary artery calcification and bone density: the CARDIA study
    Brent C Taylor
    Center for Chronic Disease Outcomes Research, VA Medical Center 152 2E, One Veterans Drive, Minneapolis, MN 55417, USA
    Hum Genet 116:525-8. 2005
    ..Given the significant role of both MGP and SPP1 in arteriosclerosis, further research in higher risk, older populations are needed to determine fully the way in which MGP and SPP1 polymorphisms are associated with disease...
  41. pmc Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels
    Christopher S Carlson
    Department of Genome Sciences, University of Washington, Seattle, WA, USA
    Am J Hum Genet 77:64-77. 2005
    ..We also demonstrate the functional importance of these SNPs in vitro...
  42. doi request reprint A whole-genome scan for stroke or myocardial infarction in family blood pressure program families
    Richard Sherva
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, USA
    Stroke 39:1115-20. 2008
    ..Using data from the Family Blood Pressure Program, we tested for chromosomal regions linked to the composite phenotype of stroke or myocardial infarction in a large set of hypertensive families...
  43. ncbi request reprint Genome-wide linkage analysis for loci affecting pulse pressure: the Family Blood Pressure Program
    Suzette J Bielinski
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, USA
    Hypertension 46:1286-93. 2005
    ..The identification of these loci for pulse pressure and the apparent congruence with other blood pressure phenotypes provide increased support that these regions contain genes influencing blood pressure phenotypes...
  44. ncbi request reprint Heritability of leukoaraiosis in hypertensive sibships
    Stephen T Turner
    Division of Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    Hypertension 43:483-7. 2004
    ..671+/-0.110 (P<0.0001). This evidence of strong genetic influence on the susceptibility to leukoaraiosis justifies efforts to localize the responsible genes and characterize the predisposing genetic polymorphisms...
  45. ncbi request reprint Family history of stroke among Mexican-American and non-Hispanic white patients with stroke and TIA: implications for the feasibility and design of stroke genetics research
    Lynda D Lisabeth
    Stroke Program, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Neuroepidemiology 24:96-102. 2005
    ..9%; 95% CI: 0.1-3.8). Since MAs are more likely to have living siblings with stroke compared with NHWs, MAs may be a more feasible population for family stroke studies than predominantly white populations...
  46. pmc Changes over 14 years in androgenicity and body mass index in a biracial cohort of reproductive-age women
    Barbara Sternfeld
    Division of Research, Kaiser Permanente, 2000 Broadway, Oakland, CA 94612, USA
    J Clin Endocrinol Metab 93:2158-65. 2008
    ..Body mass index (BMI) is directly related to testosterone (total T and free T) and inversely to SHBG cross-sectionally, but little is known about how changes in body fat and androgen markers affect each other over time...
  47. ncbi request reprint Mapping functions
    Yuan De Tan
    College of Life Science, Hunan Normal University, Changsha, Hunan 410081, China
    Genetica 133:235-46. 2008
    ..Therefore, they can provide much more precise estimates of map distances than the two conventional mapping functions. Furthermore, our mapping functions produced almost linear (additive) map distances...
  48. ncbi request reprint Unraveling hypertension: epigenomics comes of age
    Myriam Fornage
    Pharmacogenomics 8:125-8. 2007

Research Grants15

  1. Genes of the CYP450-Derived Eicosanoids Pathway in Subclinical Atherosclerosis
    Myriam Fornage; Fiscal Year: 2010
    ....
  2. Genes of the CYP450-Derived Eicosanoids Pathway in Subclinical Atherosclerosis
    Myriam Fornage; Fiscal Year: 2007
    ....
  3. Gene-Environment Interactions and Stroke Susceptibility
    Myriam Fornage; Fiscal Year: 2004
    ..We will also identify and characterize DNA variation in a panel of selected stroke-candidate human genes and test whether variation in these genes is associated with risk of developing a stroke in the ARIC sample. ..
  4. FUNCTIONAL GENOMICS OF ARTERIAL THROMBOSIS
    Myriam Fornage; Fiscal Year: 2004
    ..This collaborative effort is novel for its ability to translate unique animal model research findings to the human condition. ..
  5. A Genome-Wide Association Study of Ischemic Brain Vascular Injury
    Myriam Fornage; Fiscal Year: 2010
    ....