S M Fischer

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice
    Susan M Fischer
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, PO Box 389, Park Road 1C, Smithville 78957, USA
    Carcinogenesis 24:945-52. 2003
  2. ncbi request reprint Prostaglandins and cancer
    S M Fischer
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, TX 78957, USA
    Front Biosci 2:d482-500. 1997
  3. ncbi request reprint Difluoromethylornithine is effective as both a preventive and therapeutic agent against the development of UV carcinogenesis in SKH hairless mice
    S M Fischer
    The University of Texas MD Anderson Cancer Center, Science Park Research Division, PO Box 389, Park Road 1C, Smithville, TX 78957, USA
    Carcinogenesis 22:83-8. 2001
  4. ncbi request reprint Phorbol ester induction of 8-lipoxygenase in inbred SENCAR (SSIN) but not C57BL/6J mice correlated with hyperplasia, edema, and oxidant generation but not ornithine decarboxylase induction
    S M Fischer
    University of Texas System Cancer Center, Science Park Research Division, Smithville 78957
    Cancer Res 48:658-64. 1988
  5. ncbi request reprint Role of intracellular interleukin-1 receptor antagonist in skin carcinogenesis
    E La
    Department of Carcinogenesis, The University of Texas M. D. Anderson Cancer Center Science Park-Research Division, Smithville 78957, USA
    Mol Carcinog 30:218-23. 2001
  6. pmc IKKα represses a network of inflammation and proliferation pathways and elevates c-Myc antagonists and differentiation in a dose-dependent manner in the skin
    B Liu
    Department of Carcinogenesis, The University of Texas, MD Anderson Cancer Center, Smithville, TX 78957, USA
    Cell Death Differ 18:1854-64. 2011
  7. ncbi request reprint Mechanism-based cancer prevention approaches: targets, examples, and the use of transgenic mice
    S D Hursting
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Natl Cancer Inst 91:215-25. 1999
  8. pmc The role of the EP receptors for prostaglandin E2 in skin and skin cancer
    J E Rundhaug
    The Department of Molecular Carcinogenesis, Science Park, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
    Cancer Metastasis Rev 30:465-80. 2011
  9. ncbi request reprint 8S-lipoxygenase products activate peroxisome proliferator-activated receptor alpha and induce differentiation in murine keratinocytes
    S J Muga
    University of Texas, M D Anderson Cancer Center, Science Park Research Division, Smithville 78957, USA
    Cell Growth Differ 11:447-54. 2000
  10. ncbi request reprint Overexpression of the prostaglandin E2 receptor EP2 results in enhanced skin tumor development
    Y M Sung
    Science Park Research Division, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
    Oncogene 25:5507-16. 2006

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice
    Susan M Fischer
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, PO Box 389, Park Road 1C, Smithville 78957, USA
    Carcinogenesis 24:945-52. 2003
    ..It is concluded that the combination of celecoxib and DFMO are potent therapeutic agents for skin cancer, although the benefits are lost with the cessation of treatment...
  2. ncbi request reprint Prostaglandins and cancer
    S M Fischer
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, TX 78957, USA
    Front Biosci 2:d482-500. 1997
    ..However, the apoptosis caused by these inhibitors as well as other drugs has raised some question concerning the relative importance of PGs. This is an issue that remains to be resolved...
  3. ncbi request reprint Difluoromethylornithine is effective as both a preventive and therapeutic agent against the development of UV carcinogenesis in SKH hairless mice
    S M Fischer
    The University of Texas MD Anderson Cancer Center, Science Park Research Division, PO Box 389, Park Road 1C, Smithville, TX 78957, USA
    Carcinogenesis 22:83-8. 2001
    ..The final tumor number at 30 weeks was 3.0 (96% incidence). Thus, DFMO has strong chemopreventive efficacy, as well as therapeutic activity, against UV-induced skin tumors. Histological and proliferative markers support this conclusion...
  4. ncbi request reprint Phorbol ester induction of 8-lipoxygenase in inbred SENCAR (SSIN) but not C57BL/6J mice correlated with hyperplasia, edema, and oxidant generation but not ornithine decarboxylase induction
    S M Fischer
    University of Texas System Cancer Center, Science Park Research Division, Smithville 78957
    Cancer Res 48:658-64. 1988
    ..This suggests that oxidant generation or possibly 8-lipoxygenase activity may be the basis for the sensitivity or resistance to TPA as a hyperplasiogen and as a tumor promoter...
  5. ncbi request reprint Role of intracellular interleukin-1 receptor antagonist in skin carcinogenesis
    E La
    Department of Carcinogenesis, The University of Texas M. D. Anderson Cancer Center Science Park-Research Division, Smithville 78957, USA
    Mol Carcinog 30:218-23. 2001
    ..IcIL-1Ra appeared to significantly slow the growth of tumors in vivo. Collectively these observations suggest that IL-1Ra has antiproliferative effects in murine skin carcinoma cells...
  6. pmc IKKα represses a network of inflammation and proliferation pathways and elevates c-Myc antagonists and differentiation in a dose-dependent manner in the skin
    B Liu
    Department of Carcinogenesis, The University of Texas, MD Anderson Cancer Center, Smithville, TX 78957, USA
    Cell Death Differ 18:1854-64. 2011
    ..Thus, IKKα maintains skin homeostasis through a broad range of signaling pathways...
  7. ncbi request reprint Mechanism-based cancer prevention approaches: targets, examples, and the use of transgenic mice
    S D Hursting
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Natl Cancer Inst 91:215-25. 1999
    ..In addition, the utility for mechanism-based cancer prevention research of new animal models that are based on the overexpression or inactivation of specific cancer-related genes is examined...
  8. pmc The role of the EP receptors for prostaglandin E2 in skin and skin cancer
    J E Rundhaug
    The Department of Molecular Carcinogenesis, Science Park, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
    Cancer Metastasis Rev 30:465-80. 2011
    ..Understanding the role and mechanisms of action of the EP receptors potentially offers new targets for the prevention or therapy of NMSCs...
  9. ncbi request reprint 8S-lipoxygenase products activate peroxisome proliferator-activated receptor alpha and induce differentiation in murine keratinocytes
    S J Muga
    University of Texas, M D Anderson Cancer Center, Science Park Research Division, Smithville 78957, USA
    Cell Growth Differ 11:447-54. 2000
    ..From these studies, it is concluded that 8S-HETE plays an important role in keratinocyte differentiation and that at least some of its effects are mediated by PPARalpha...
  10. ncbi request reprint Overexpression of the prostaglandin E2 receptor EP2 results in enhanced skin tumor development
    Y M Sung
    Science Park Research Division, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
    Oncogene 25:5507-16. 2006
    ..Together, our results suggest that the overexpression of the EP2 receptor plays a significant role in the protumorigenic action of PGE2 in mouse skin...
  11. ncbi request reprint Altered expression of transforming growth factor-beta 1 mRNA and protein in mouse skin carcinogenesis
    B Patamalai
    University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville 78957
    Mol Carcinog 9:220-9. 1994
    ..Overall, 28 +/- 6% of the tissue of the 12 analyzed carcinomas stained for the intracellular form and 18 +/- 5% for the extracellular form of TGF-beta 1...
  12. ncbi request reprint Transcriptional regulation of intracellular IL-1 receptor antagonist gene by IL-1 alpha in primary mouse keratinocytes
    E La
    Department of Carcinogenesis, University of Texas M. D. Anderson Cancer Center, Science Park-Research Division, Smithville, TX 78957, USA
    J Immunol 166:6149-55. 2001
    ..Finally, mutational analysis confirmed that these elements were both essential for maximal transcription induced by IL-1alpha...
  13. ncbi request reprint Chemoprevention of skin carcinogenesis by phenylretinamides: retinoid receptor-independent tumor suppression
    Hui Xu
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center Shreveport and the Feist Weiller Cancer Center, Shreveport, Louisiana 17730, USA
    Clin Cancer Res 12:969-79. 2006
    ....
  14. ncbi request reprint Troglitazone induction of COX-2 expression is dependent on ERK activation in keratinocytes
    Guobin He
    Department of Carcinogenesis, Science Park Research Division, University of Texas M D Anderson Cancer Center, 1808 Park Road 1C, P O Box 389, Smithville, TX 78957, USA
    Prostaglandins Leukot Essent Fatty Acids 74:193-7. 2006
    ..These data suggest that troglitazone is capable of inducing COX-2 expression through an ERK-dependent mechanism in mouse skin keratinocytes...
  15. ncbi request reprint Selective cyclooxygenase-2 inhibitors inhibit growth and induce apoptosis of bladder cancer
    Jason Gee
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Oncol Rep 15:471-7. 2006
    ..Induction of apoptosis in all three cell lines by celecoxib was associated with downregulation of Bcl-2. These changes occur independently of COX-2 expression levels suggesting the presence of a COX-2 independent pathway...
  16. ncbi request reprint Lack of expression of the EP2 but not EP3 receptor for prostaglandin E2 results in suppression of skin tumor development
    You Me Sung
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, TX 78957, USA
    Cancer Res 65:9304-11. 2005
    ..Our data suggest that the EP2 receptor plays a significant role in the protumorigenic action of PGE2 in skin tumor development...
  17. ncbi request reprint The effect of PPARgamma ligands on UV- or chemically-induced carcinogenesis in mouse skin
    Guobin He
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Mol Carcinog 43:198-206. 2005
    ..Collectively, our data suggest that PPARgamma ligands may not be useful in the prevention of chemically or UV-induced skin tumors...
  18. ncbi request reprint Thiazolidinediones inhibit insulin-like growth factor-i-induced activation of p70S6 kinase and suppress insulin-like growth factor-I tumor-promoting activity
    Guobin He
    Department of Carcinogenesis, University of Texas M D Anderson Cancer Center, Science Park Research Division, 1808 Park Road 1C, Smithville, TX 78957, USA
    Cancer Res 66:1873-8. 2006
    ..Collectively, these data suggest that thiazolidinediones specifically inhibit IGF-I tumor-promoting activity in mouse skin through activation of AMPK and subsequent inhibition of p70S6K...
  19. pmc Cyclooxygenase-2 expression is critical for chronic UV-induced murine skin carcinogenesis
    Susan M Fischer
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Mol Carcinog 46:363-71. 2007
    ..UV-induced apoptosis, however, was greater in COX-2 heterozygous mice. Collectively, these results clearly establish the requirement for COX-2 in the development of skin tumors...
  20. ncbi request reprint A role for cyclooxygenase-2 in ultraviolet light-induced skin carcinogenesis
    Joyce E Rundhaug
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Mol Carcinog 46:692-8. 2007
    ..Together these studies demonstrate that COX-2 expression/activity is critical to the development of UV-related nonmelanoma skin cancers...
  21. doi request reprint Vitamin E analog, alpha-tocopherol ether-linked acetic acid analog, alone and in combination with celecoxib, reduces multiplicity of ultraviolet-induced skin cancers in mice
    Shelley B Riedel
    Section of Molecular Genetics and Microbiology, The University of Texas, Austin, TX 78712, USA
    Anticancer Drugs 19:175-81. 2008
    ..In conclusion alpha-TEA is an effective late-stage chemopreventive agent for nonmelanoma skin cancer that exhibits lasting benefits...
  22. doi request reprint Cyclo-oxygenase-2 plays a critical role in UV-induced skin carcinogenesis
    Joyce E Rundhaug
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, TX, USA
    Photochem Photobiol 84:322-9. 2008
    ..A combination of signaling from the PGE2 EP1, EP2 and/or EP4 receptors mediates the effects of COX-2 overexpression. These studies demonstrate the crucial role of COX-2 in the development of UV-related nonmelanoma skin cancers...
  23. pmc Progressive metaplastic and dysplastic changes in mouse pancreas induced by cyclooxygenase-2 overexpression
    Jennifer Kl Colby
    Science Park Research Division, University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
    Neoplasia 10:782-96. 2008
    ..The progressive nature of the metaplastic/dysplastic changes observed in this model make it a valuable tool for examining the transition from chronic inflammation to neoplasia...
  24. doi request reprint IKKalpha is required to maintain skin homeostasis and prevent skin cancer
    Bigang Liu
    Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
    Cancer Cell 14:212-25. 2008
    ..Thus, IKKalpha serves as an innate surveillant...
  25. ncbi request reprint Troglitazone inhibits cyclin D1 expression and cell cycling independently of PPARgamma in normal mouse skin keratinocytes
    Guobin He
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas, USA
    J Invest Dermatol 123:1110-9. 2004
    ..Given the important role of keratinocyte proliferation in skin carcinogenesis, our data suggest that TZD may be useful tumor preventive agents in skin...
  26. ncbi request reprint Is cyclooxygenase-2 important in skin carcinogenesis?
    Susan M Fischer
    The University of Texas M D Anderson, Department of Carcinogenesis, Smithville 78957, USA
    J Environ Pathol Toxicol Oncol 21:183-91. 2002
    ..Collectively, these studies suggest that prostaglandins play a critical role in skin cancer development...
  27. pmc The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells
    Imad Shureiqi
    Departments of Clinical Cancer Prevention, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:9968-73. 2003
    ..Our findings indicate that the down-regulation of PPAR-delta by 15-LOX-1 through 13-S-HODE is an apoptotic signaling pathway that is activated by NSAIDs...
  28. ncbi request reprint Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development
    David K Bol
    Bristol Myers Squibb Pharmaceutical Research Institute, Department of Oncology Drug Discovery, Princeton, New Jersey 08543, USA
    Cancer Res 62:2516-21. 2002
    ..These results clearly raise questions regarding the role of COX-2 and elevated prostaglandin levels in skin tumor development...
  29. ncbi request reprint Formation and antiproliferative effect of prostaglandin E(3) from eicosapentaenoic acid in human lung cancer cells
    Peiying Yang
    Pharmaceutical Development Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    J Lipid Res 45:1030-9. 2004
    ..These data indicate that exposure of lung cancer cells to EPA results in a decrease in the COX-2-mediated formation of PGE(2), an increase in the level of PGE(3), and PGE(3)-mediated inhibition of tumor cell proliferation...
  30. ncbi request reprint Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells
    Shaohua Tang
    Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    J Biol Chem 277:16189-201. 2002
    ..Taken together, these results suggest that 15-LOX2 could be a suppressor of prostate cancer development, which functions by restricting cell cycle progression...
  31. ncbi request reprint Black tea polyphenols inhibit IGF-I-induced signaling through Akt in normal prostate epithelial cells and Du145 prostate carcinoma cells
    Russell D Klein
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, PO Box 389, Smithville, TX 78957, USA
    Carcinogenesis 23:217-21. 2002
    ....
  32. pmc Multiple signaling pathways are responsible for prostaglandin E2-induced murine keratinocyte proliferation
    Kausar M Ansari
    Science Park Research Division, The University of Texas M D Anderson Cancer Center, PO Box 389, Smithville, TX 78957, USA
    Mol Cancer Res 6:1003-16. 2008
    ..Our findings provide evidence for a link between cyclooxygenase-2 overexpression and EGFR-, ERK-, PI3K-, cAMP-mediated cell proliferation, and the tumor-promoting activity of PGE2 in mouse skin...
  33. ncbi request reprint Prostaglandin receptor EP2 is responsible for cyclooxygenase-2 induction by prostaglandin E2 in mouse skin
    Kausar M Ansari
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, PO Box 389, Smithville, TX 78957, USA
    Carcinogenesis 28:2063-8. 2007
    ..Taken together, EP2 activation of the PKA/CREB-signaling pathway is responsible for keratinocyte proliferation and our findings reveal a positive feedback loop between COX-2 and PGE2 that is mediated by the EP2 receptor...
  34. pmc Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors
    Philippe Thuillier
    Department of Carcinogenesis, University of Texas M D Anderson Cancer Center, Smithville 78957, USA
    Biochem J 366:901-10. 2002
    ..Ligand-binding studies revealed that the LOX inhibitors bind directly to PPARs and demonstrate a novel mechanism for these inhibitors in altering PPAR-mediated gene expression...
  35. ncbi request reprint The effect of cyclooxygenase-2 overexpression on skin carcinogenesis is context dependent
    Joyce E Rundhaug
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Mol Carcinog 46:981-92. 2007
    ..COX2 mice treated only with DMBA developed approximately 3.5 times more tumors than wild-type mice, suggesting that PGs have intrinsic tumor promoting activity. We conclude that the role of PGs in skin tumorigenesis is context dependent...
  36. ncbi request reprint Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas
    Eunmi Park
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Smithville, Texas 78957, USA
    Cancer Res 67:9158-68. 2007
    ..Our findings provide evidence that a reduction in IKKalpha expression promotes the development of papillomas and carcinomas and that the integrity of the Ikkalpha gene is required for suppressing skin carcinogenesis...
  37. ncbi request reprint The resistance to the tumor suppressive effects of COX inhibitors and COX-2 gene disruption in TRAMP mice is associated with the loss of COX expression in prostate tissue
    Xingya Wang
    Department of Human Nutrition and Molecular Carcinogenesis and Chemoprevention Program, The Ohio State University Comprehensive Cancer Center, The Ohio State University, 325 Campbell Hall, 1787 Neil Avenue, Columbus, OH 43210, USA
    Carcinogenesis 29:120-8. 2008
    ..Collectively, our results suggest that COX-2 may not play a tumorigenic role during prostate carcinogenesis in the TRAMP model...
  38. ncbi request reprint Regulation of transcription of the intracellular interleukin-1 receptor antagonist gene by AP-1 in mouse carcinoma cells
    Eunhye La
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Mol Carcinog 33:237-43. 2002
    ..Moreover, electrophoretic mobility shift assay and cotransfection experiments showed that c-jun and c-fos proteins bound to the AP-1 site and functionally transactivated the icIL-1Ra promoter in mouse carcinoma CH72 cells...
  39. ncbi request reprint GATA-6 transcriptional regulation of 15-lipoxygenase-1 during NSAID-induced apoptosis in colorectal cancer cells
    Imad Shureiqi
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer Res 62:1178-83. 2002
    ..Ectopic GATA-6 expression blocked NSAID induction of 15-LOX-1 and apoptosis. NSAIDs down-regulate GATA-6 to transcriptionally up-regulate 15-LOX-1 and induce apoptosis in colorectal cancer cells...
  40. ncbi request reprint An antitumorigenic role for murine 8S-lipoxygenase in skin carcinogenesis
    Eunjung Kim
    Science Park Research Division, University of Texas MD Anderson Cancer Center, 1808 Park Road 1C, PO Box 389, Smithville, TX 78957, USA
    Oncogene 24:1174-87. 2005
    ..Collectively, these data suggest that 8S-LOX plays a role as a prodifferentiating, antitumorigenic, and tumor suppressing gene in mouse skin carcinogenesis...
  41. ncbi request reprint Quantitative high-performance liquid chromatography/electrospray ionization tandem mass spectrometric analysis of 2- and 3-series prostaglandins in cultured tumor cells
    Peiying Yang
    Department of Experimental Therapeutics, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Anal Biochem 308:168-77. 2002
    ..Concomitantly, EPA increased formation of PGE(3) by 10-fold in A549 cells. This is the first report that unequivocally demonstrates that EPA can be converted to PGE(3) by cyclooxygenase in human cancer cells...
  42. ncbi request reprint SAGE profiling of UV-induced mouse skin squamous cell carcinomas, comparison with acute UV irradiation effects
    Joyce E Rundhaug
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Mol Carcinog 42:40-52. 2005
    ....
  43. ncbi request reprint Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells
    Shaohua Tang
    Department of Carcinogenesis, Science Park Research Division, The University of Texas MD Anderson Cancer Center, 1808 Park Rd 1C, Smithville, TX 78957, USA
    Oncogene 23:6942-53. 2004
    ..The results indicate that androgen does not directly regulate 15-LOX2 gene expression. Together, these observations provide insight on how 15-LOX2 gene expression may be regulated in NHP cells...
  44. ncbi request reprint Mutation frequencies in murine keratinocytes as a function of carcinogenic status
    Laura A Christensen
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas, USA
    Mol Carcinog 40:122-33. 2004
    ..These data suggested that a strong mutator phenotype was not required for progression to an advanced malignant phenotype in our model system...
  45. pmc The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis
    Imad Shureiqi
    Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 65:11486-92. 2005
    ..Therefore, 15-LOX-1 down-regulation rather than a shift in the balance of LOXs is likely the dominant alteration in LOX metabolism which contributes to colorectal tumorigenesis by repressing apoptosis...
  46. ncbi request reprint Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription: critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors
    Stefan Jüttner
    Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Cell Microbiol 5:821-34. 2003
    ..pylori-dependent cox-2 gene expression in gastric epithelial cells, and may thus contribute to a better understanding of mechanisms underlying H. pylori pathogenicity...
  47. ncbi request reprint Evidence for downregulation of calcium signaling proteins in advanced mouse adenocarcinoma
    Viola C Ruddat
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
    Prostate 64:128-38. 2005
    ..Gleason grading is currently the predominant method for prediction, with only few biomarkers available. More biomarkers, especially as they relate to cancer progression are desirable...
  48. ncbi request reprint Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma
    Kevin D Houston
    University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Cancer Res 63:1221-7. 2003
    ..These results suggest that in uterine leiomyomas PPARgamma activation is growth inhibitory and that this inhibition is mediated at least in part by negative cross-talk between ER and PPAR signaling pathways...
  49. pmc A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas
    Bigang Liu
    Department of Carcinogenesis, University of Texas M D Anderson Cancer Center, Smithville, TX 78957, USA
    Proc Natl Acad Sci U S A 103:17202-7. 2006
    ..Thus, overexpression of IKKalpha in the epidermis antagonized chemical carcinogen-induced mitogenic and angiogenic activities, repressing tumor progression and metastases...
  50. ncbi request reprint Modulation of UVB-induced and basal cyclooxygenase-2 (COX-2) expression by apigenin in mouse keratinocytes: role of USF transcription factors
    Rukiyah T van Dross
    Department of Pharmacology and Toxicology, Leo Jenkins Cancer Center, East Carolina University, Greenville, North Carolina 27834, USA
    Mol Carcinog 46:303-14. 2007
    ..These results suggest that one pathway by which apigenin inhibits COX-2 expression is through modulation of USF transcriptional activity...
  51. ncbi request reprint Protein expression profiles in the epidermis of cyclooxygenase-2 transgenic mice by 2-dimensional gel electrophoresis and mass spectrometry
    Jianjun Shen
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    J Proteome Res 6:273-86. 2007
    ..The current data suggest that some of the differentially expressed proteins might increase apoptosis and cell cycle arrest, which, in turn, may provide insight into the role of COX-2 in skin tumorigenesis...
  52. ncbi request reprint Cyclooxygenase-2 deficiency increases epidermal apoptosis and impairs recovery following acute UVB exposure
    Jacqueline K Akunda
    Laboratory of Molecular Carcinogenesis, NIEHS NIH, Research Triangle Park, North Carolina 27709, USA
    Mol Carcinog 46:354-62. 2007
    ..The data indicate that COX-2 induction initially protects against the acute sunburn effects of UVB, but that continuous induction of COX-2 may contribute to skin cancer in chronic UVB exposure...