Mauro Ferrari

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Frontiers in cancer nanomedicine: directing mass transport through biological barriers
    Mauro Ferrari
    University of Texas Health Science Center at Houston UTHSC H, Department of Nanomedicine and BioMedical Engineering, 1825 Pressler, Suite 537, Houston, TX 77030, USA
    Trends Biotechnol 28:181-8. 2010
  2. doi request reprint The mathematical engines of nanomedicine
    Mauro Ferrari
    The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, 1825 Pressler, Suite 537D, Houston, TX 77031, USA
    Small 4:20-5. 2008
  3. ncbi request reprint Nanoncology
    Mauro Ferrari
    MD Anderson Cancer Center, Houston TX, USA
    Tumori 94:197-9. 2008
  4. pmc Mitotic trafficking of silicon microparticles
    Rita E Serda
    University of Texas Health Science Center, Department of Nanomedicine and BioMedical Engineering, 1825 Pressler, Suite 537, Houston, TX 77030, USA
    Nanoscale 1:250-9. 2009
  5. pmc Polycation-functionalized nanoporous silicon particles for gene silencing on breast cancer cells
    Mingzhen Zhang
    Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA College of Life Information Science and Instrumental Engineering, Hangzhou Dianzi University, Hangzhou, Zhejiang 310018, China
    Biomaterials 35:423-31. 2014
  6. doi request reprint Multistage delivery of chemotherapeutic nanoparticles for breast cancer treatment
    Elvin Blanco
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, United States
    Cancer Lett 334:245-52. 2013
  7. pmc Tailoring the degradation kinetics of mesoporous silicon structures through PEGylation
    Biana Godin
    Department of Nanomedicine and BioMedical Engineering, School of Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Biomed Mater Res A 94:1236-43. 2010
  8. doi request reprint Nanochannel technology for constant delivery of chemotherapeutics: beyond metronomic administration
    Alessandro Grattoni
    Department of NanoMedicine and Biomedical Engineering nBME, The University of Texas Medical School at Houston, Houston, Texas, USA
    Pharm Res 28:292-300. 2011
  9. pmc Tailoring of the nanotexture of mesoporous silica films and their functionalized derivatives for selectively harvesting low molecular weight protein
    Ye Hu
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center at Houston, Texas 77030, USA
    ACS Nano 4:439-51. 2010
  10. pmc Engineering multi-stage nanovectors for controlled degradation and tunable release kinetics
    Jonathan O Martinez
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA
    Biomaterials 34:8469-77. 2013

Collaborators

Detail Information

Publications100

  1. pmc Frontiers in cancer nanomedicine: directing mass transport through biological barriers
    Mauro Ferrari
    University of Texas Health Science Center at Houston UTHSC H, Department of Nanomedicine and BioMedical Engineering, 1825 Pressler, Suite 537, Houston, TX 77030, USA
    Trends Biotechnol 28:181-8. 2010
    ....
  2. doi request reprint The mathematical engines of nanomedicine
    Mauro Ferrari
    The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, 1825 Pressler, Suite 537D, Houston, TX 77031, USA
    Small 4:20-5. 2008
  3. ncbi request reprint Nanoncology
    Mauro Ferrari
    MD Anderson Cancer Center, Houston TX, USA
    Tumori 94:197-9. 2008
  4. pmc Mitotic trafficking of silicon microparticles
    Rita E Serda
    University of Texas Health Science Center, Department of Nanomedicine and BioMedical Engineering, 1825 Pressler, Suite 537, Houston, TX 77030, USA
    Nanoscale 1:250-9. 2009
    ..The finding that mitotic sorting of endosomes is unencumbered by the presence of nanoporous silicon microparticles advocates the use of silicon microparticles for biomedical applications...
  5. pmc Polycation-functionalized nanoporous silicon particles for gene silencing on breast cancer cells
    Mingzhen Zhang
    Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA College of Life Information Science and Instrumental Engineering, Hangzhou Dianzi University, Hangzhou, Zhejiang 310018, China
    Biomaterials 35:423-31. 2014
    ..As a consequence, PEI-modified porous silicon particles may have substantial potential as safe and effective siRNA delivery systems...
  6. doi request reprint Multistage delivery of chemotherapeutic nanoparticles for breast cancer treatment
    Elvin Blanco
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, United States
    Cancer Lett 334:245-52. 2013
    ..Results highlight effective chemotherapeutic shuttling and site-specific controlled release afforded by MSVs, potentially translating towards improvements in patient outcomes and morbidity...
  7. pmc Tailoring the degradation kinetics of mesoporous silicon structures through PEGylation
    Biana Godin
    Department of Nanomedicine and BioMedical Engineering, School of Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Biomed Mater Res A 94:1236-43. 2010
    ....
  8. doi request reprint Nanochannel technology for constant delivery of chemotherapeutics: beyond metronomic administration
    Alessandro Grattoni
    Department of NanoMedicine and Biomedical Engineering nBME, The University of Texas Medical School at Houston, Houston, Texas, USA
    Pharm Res 28:292-300. 2011
    ....
  9. pmc Tailoring of the nanotexture of mesoporous silica films and their functionalized derivatives for selectively harvesting low molecular weight protein
    Ye Hu
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center at Houston, Texas 77030, USA
    ACS Nano 4:439-51. 2010
    ....
  10. pmc Engineering multi-stage nanovectors for controlled degradation and tunable release kinetics
    Jonathan O Martinez
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA
    Biomaterials 34:8469-77. 2013
    ..Empirical loading and release studies of nanoparticles along with diffusion modeling revealed that this prolonged release was modulated by the penetration within the porous core of the vectors regulated by their pore size. ..
  11. pmc Near-infrared imaging method for the in vivo assessment of the biodistribution of nanoporous silicon particles
    Ennio Tasciotti
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Mol Imaging 10:56-68. 2011
    ....
  12. pmc Thioaptamer conjugated liposomes for tumor vasculature targeting
    Aman P Mann
    Department of Nanomedicine, University of Texas Health Science Center at Houston, 1825 Hermann Pressler, Houston, Texas 77030, USA
    Oncotarget 2:298-304. 2011
    ....
  13. ncbi request reprint Validated RP-HPLC method for the simultaneous analysis of gemcitabine and LY-364947 in liposomal formulations
    Shyam S Bansal
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA
    Curr Drug Targets 14:1061-9. 2013
    ..The method specificity was evaluated in presence of liposomal components in fetal bovine serum (FBS). Finally, the method was demonstrated by quantifying Gem/LY liposomal encapsulation efficiency and concentration liposomes-spiked FBS. ..
  14. doi request reprint Characterization of a nanogland for the autotransplantation of human pancreatic islets
    Omaima M Sabek
    Department of Surgery, The Methodist Hospital, 6565 Fannin Street, Houston, TX 77030, USA
    Lab Chip 13:3675-88. 2013
    ..In this context, mouse endothelial cell infiltration suggesting neovascularization from the host were identified in the retrieved grafts. The NanoGland represents a novel, promising approach for the autotransplantation of human islets. ..
  15. pmc Multistage vectored siRNA targeting ataxia-telangiectasia mutated for breast cancer therapy
    Rong Xu
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Avenue, Houston, Texas 77030, USA
    Small 9:1799-808. 2013
    ..These results indicate that MSV/ATM is biocompatible and efficacious in inhibiting tumor growth, and that further preclinical evaluation is warranted for the development of MSV/ATM as a potential therapeutic agent...
  16. pmc Enhancing chemotherapy response with sustained EphA2 silencing using multistage vector delivery
    Haifa Shen
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Clin Cancer Res 19:1806-15. 2013
    ....
  17. pmc Short and long term, in vitro and in vivo correlations of cellular and tissue responses to mesoporous silicon nanovectors
    Jonathan O Martinez
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave MS R7 414 Houston, TX 77030, USA
    Small 9:1722-33. 2013
    ..It is proposed that future endeavors aimed at understanding the toxicology of naked drug carriers should be designed to address their impact using in vitro and in vivo short- and long-term evaluations of systemic response...
  18. pmc Silicon micro- and nanofabrication for medicine
    Daniel Fine
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Adv Healthc Mater 2:632-66. 2013
    ....
  19. ncbi request reprint Nanotechnologies and regenerative medical approaches for space and terrestrial medicine
    Alessandro Grattoni
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA
    Aviat Space Environ Med 83:1025-36. 2012
    ..These studies target significant areas of human disease such as osteoporosis, diabetes, radiation injury, and many others...
  20. pmc Live-cell single-molecule imaging reveals clathrin and caveolin-1 dependent docking of SMAD4 at the cell membrane
    Yong Yang
    Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA Electronic address
    FEBS Lett 587:3912-20. 2013
    ..The notion that membrane-docking behaviors of downstream molecules could predict the cellular response to growth factors may revolutionize the way we view cell signaling...
  21. pmc Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells
    Yong Yang
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX, USA
    Cell Biochem Funct 31:374-9. 2013
    ..Hesperetin also decreased cellular proliferation, which is likely due to the inhibition of glucose uptake. Cancer cells are highly dependent on glucose and hesperetin may, therefore, have potential application as an anticancer agent...
  22. pmc Porous silicon nanocarriers for dual targeting tumor associated endothelial cells and macrophages in stroma of orthotopic human pancreatic cancers
    Kenji Yokoi
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner St, Houston, TX 77030, USA
    Cancer Lett 334:319-27. 2013
    ..5±1.8% with non-targeted nanocarriers. These results suggest that Ly6C (or CD59) can serve as a novel dual target to deliver therapeutic agents to the stroma of pancreatic tumors...
  23. pmc Rapid tumoritropic accumulation of systemically injected plateloid particles and their biodistribution
    Anne L van de Ven
    Department of Translational Imaging and Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA
    J Control Release 158:148-55. 2012
    ..Plateloid particles appeared well-suited for taking advantage of hydrodynamic forces and interfacial interactions required for efficient tumoritropic accumulation, even without using specific targeting ligands...
  24. pmc Enabling individualized therapy through nanotechnology
    Jason H Sakamoto
    The University of Texas Health Science Center, Department of Nanomedicine and BioMedical Engineering, Houston, TX 77030, USA
    Pharmacol Res 62:57-89. 2010
    ....
  25. ncbi request reprint Drug delivery: Logic-Embedded Vectors for Intracellular Partitioning, Endosomal Escape, and Exocytosis of Nanoparticles (Small 23/2010)
    Rita E Serda
    Department of Nanomedicine and BioMedical Engineering, University of Texas Health Science Center, 1825 Pressler Street, Suite 537, Houston, TX 77030, USA
    Small 6:2690. 2010
    ..Thus, LEVs provide a mechanism for shielded transport of nanoparticles to the lesion, cellular manipulation at multiple levels, and a means for targeting both within and between cells...
  26. doi request reprint Device for rapid and agile measurement of diffusivity in micro- and nanochannels
    Alessandro Grattoni
    The University of Texas Health Science Center at Houston, 1825 Pressler Street Suite 537A, Houston, Texas, 77030, USA
    Anal Chem 83:3096-103. 2011
    ..Our design thus is ready for rapid translation into a standard analytical tool--useful for multiple applications...
  27. pmc An integrated approach for the rational design of nanovectors for biomedical imaging and therapy
    Biana Godin
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center, Houston, Texas, USA
    Adv Genet 69:31-64. 2010
    ....
  28. doi request reprint Characterization of nanochannel delivery membrane systems for the sustained release of resveratrol and atorvastatin: new perspectives on promoting heart health
    Juliana Sih
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Anal Bioanal Chem 405:1547-57. 2013
    ....
  29. pmc Preparation, characterization, and cellular associations of silicon logic-embedded vectors
    Anne L van de Ven
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, Texas, USA
    Methods Enzymol 508:1-16. 2012
    ..A specific example of LEV fabrication from start to finish, along with optimization and troubleshooting information, is presented to serve as a template for future designs...
  30. doi request reprint Molecular-targeted nanotherapies in cancer: enabling treatment specificity
    Elvin Blanco
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Mol Oncol 5:492-503. 2011
    ..We will also summarize work regarding the development of a multistage drug delivery strategy, a robust carrier platform designed to overcome several biological barriers while en route to tumors...
  31. pmc Multistage nanovectors: from concept to novel imaging contrast agents and therapeutics
    Biana Godin
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, Texas 77030, USA
    Acc Chem Res 44:979-89. 2011
    ..We envision that the versatility of the MSV platform and its emerging properties will enable the creation of personalized solutions with broad clinical implications within and beyond the realm of cancer theranostics...
  32. pmc Intracellular trafficking of silicon particles and logic-embedded vectors
    Silvia Ferrati
    University of Texas Health Science Center, Department of Nanomedicine and BioMedical Engineering, 1825 Pressler Street, Suite 537, Houston, TX 77030, USA
    Nanoscale 2:1512-20. 2010
    ..These results reinforce the concept of multi-functional nanocarriers, in which different particles are able to perform specific tasks, in order to deliver single- or multi-component payloads to specific sub-cellular compartments...
  33. pmc Cellular association and assembly of a multistage delivery system
    Rita E Serda
    Department of Nanomedicine and BioMedical Engineering, University of Texas Health Science Center UTHSC, Houston, TX 77030, USA
    Small 6:1329-40. 2010
    ..This study demonstrates the assembly and cellular association of a multiparticle delivery system that is biomolecularly targeted and has potential for applications in biological imaging...
  34. pmc Multi-stage delivery nano-particle systems for therapeutic applications
    Rita E Serda
    University of Texas Health Science Center, Department of Nanomedicine and BioMedical Engineering, 1825 Pressler, Suite 537, Houston, TX 77030, USA
    Biochim Biophys Acta 1810:317-29. 2011
    ..The progressive evolution of nanovectors has led to the development of multi-stage delivery systems aimed at overcoming the numerous obstacles encountered by nanovectors on their journey to the target site...
  35. pmc Surface engineering on mesoporous silica chips for enriching low molecular weight phosphorylated proteins
    Ye Hu
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center at Houston, Houston, TX, USA
    Nanoscale 3:421-8. 2011
    ..The novel technology reported provides a platform capable of efficiently profiling the serum proteome for biomarker discovery, forensic sampling, and routine diagnostic applications...
  36. doi request reprint Nanomedicine in cancer therapy: innovative trends and prospects
    Elvin Blanco
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, Texas, USA
    Cancer Sci 102:1247-52. 2011
    ....
  37. doi request reprint Agarose surface coating influences intracellular accumulation and enhances payload stability of a nano-delivery system
    Enrica De Rosa
    The Methodist Hospital Research Institute TMHRI, 6670 Bertner Av Suite R7 114, Houston, Texas 77030, USA
    Pharm Res 28:1520-30. 2011
    ..We describe a surface modification of nanoporous silicon particles (NSP) with an agarose hydrogel matrix that enhances their ability to load and release proteins, influencing intracellular delivery and preserving molecular stability...
  38. pmc Serum biomarkers for personalization of nanotherapeutics-based therapy in different tumor and organ microenvironments
    Kenji Yokoi
    Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Street, Houston, TX 77030, USA Department of Cancer Biology, Cancer Metastasis Research Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA Electronic address
    Cancer Lett 345:48-55. 2014
    ....
  39. pmc Porous silicon advances in drug delivery and immunotherapy
    David J Savage
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA MD Anderson Cancer Center, Department of Surgical Oncology, 1515 Holcombe Blvd 444, Houston, TX, USA The University of Texas Medical School at Houston, 6431 Fannin, Houston, TX, USA
    Curr Opin Pharmacol 13:834-41. 2013
    ....
  40. pmc Serum peptidomic biomarkers for pulmonary metastatic melanoma identified by means of a nanopore-based assay
    Jia Fan
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Cancer Lett 334:202-10. 2013
    ..We strongly believe our findings can assist to discover stage-specific peptide signatures and lead to more specific and personalized treatments for patients suffering from pulmonary metastatic melanoma...
  41. pmc The physiology of cardiovascular disease and innovative liposomal platforms for therapy
    Guillermo U Ruiz-Esparza
    Methodist Hospital Research Institute, Houston, TX, USA
    Int J Nanomedicine 8:629-40. 2013
    ..Potential pathological targets for therapy are introduced, and promising advances in nanotherapeutic cardiovascular applications involving liposomal platforms are presented...
  42. pmc Enhanced MRI relaxivity of Gd(3+) -based contrast agents geometrically confined within porous nanoconstructs
    Richa Sethi
    Department of Chemistry, Smalley Institute for Nanoscale Science and Technology, Center for Biological and Environmental Nanotechnology, Rice University, Houston, TX 77251 1892, USA
    Contrast Media Mol Imaging 7:501-8. 2012
    ....
  43. doi request reprint Mesoporous silicon: short and long term, in vitro and in vivo correlations of cellular and tissue responses to mesoporous silicon nanovectors (small 9-10/2013)
    Jonathan O Martinez
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave MS R7 414 Houston, TX 77030, USA Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX USA
    Small 9:1721. 2013
    ..Alternative methods are proposed on page 1722 to effectively study the influences of nanovectors on biological systems...
  44. pmc Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions
    Alessandro Parodi
    Department of Nanomedicine, The Methodist Hospital System Research Institute, Houston, Texas 77030, USA
    Nat Nanotechnol 8:61-8. 2013
    ..Moreover, leukolike vectors retained their functions when injected in vivo, showing enhanced circulation time and improved accumulation in a tumour...
  45. doi request reprint A low-voltage electrokinetic nanochannel drug delivery system
    Daniel Fine
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA
    Lab Chip 11:2526-34. 2011
    ..The membrane's clinically relevant electrophoretic release rate at 2 VDC exceeds the passive release by nearly one order of magnitude, demonstrating the potential to realize the therapeutic paradigm goal...
  46. pmc Logic-embedded vectors for intracellular partitioning, endosomal escape, and exocytosis of nanoparticles
    Rita E Serda
    Department of Nanomedicine and BioMedical Engineering, University of Texas Health Science Center, 1825 Pressler Street, Suite 537, Houston, TX 77030, USA
    Small 6:2691-700. 2010
    ..Thus, LEVs provide a mechanism for shielded transport of nanoparticles to the lesion, cellular manipulation at multiple levels, and a means for targeting both within and between cells...
  47. pmc Shrinkage of pegylated and non-pegylated liposomes in serum
    Joy Wolfram
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA Electronic address
    Colloids Surf B Biointerfaces 114:294-300. 2014
    ..The liposomes with polyethylene glycol expressed different characteristics than their non-polymeric counterparts, suggesting the potential formation of a denser protein corona around the non-pegylated liposomes. ..
  48. pmc Evaluation of cell function upon nanovector internalization
    Jonathan O Martinez
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave MS R7 414 Houston, TX 77030, USA
    Small 9:1696-702. 2013
    ..Electron microscopy images demonstrate internalized nanovectors altering the curvature of the nuclear envelope with minimal effect on viability or biological function...
  49. doi request reprint Inter-endothelial transport of microvectors using cellular shuttles and tunneling nanotubes
    Silvia Ferrati
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Small 8:3151-60. 2012
    ..The opportunity to use microparticles to study cellular transfer events and biological triggers that induce these events may aid in the discovery of therapeutics that limit the spread of disease...
  50. pmc Cooperative, nanoparticle-enabled thermal therapy of breast cancer
    Haifa Shen
    The Methodist Hospital Research Institute, Department of Nanomedicine, 6670 Bertner Ave, Houston, Texas 77030, USA
    Adv Healthc Mater 1:84-9. 2012
    ..Collective electromagnetic coupling of nanoconfined hollow gold nanoshells leads to dramatic enhancement of thermal ablation...
  51. pmc Probing the mechanical properties of TNF-α stimulated endothelial cell with atomic force microscopy
    Sei Young Lee
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Medical School at Houston, Houston, TX, USA
    Int J Nanomedicine 6:179-95. 2011
    ....
  52. ncbi request reprint Proteomic analysis of serum opsonins impacting biodistribution and cellular association of porous silicon microparticles
    Rita E Serda
    Department of Nanomedicine and BioMedical Engineering, University of Texas Health Science Center, Houston, TX 77030, USA
    Mol Imaging 10:43-55. 2011
    ..In summary, particle surface chemistry drives selective binding of serum components impacting cellular interactions and biodistribution...
  53. pmc Antibody-free detection of Mycobacterium tuberculosis antigen using customized nanotraps
    Hung Jen Wu
    Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Avenue R8 213, Houston, TX 77030, United States
    Anal Chem 86:1988-96. 2014
    ..This assay can reach a detection limit of 10 fmol and an isolation rate of 90% for the antigen CFP-10. Our strategy has significant potential to fill the conceptual and technical gaps in rapid diagnosis of active TB disease. ..
  54. pmc In silico vascular modeling for personalized nanoparticle delivery
    Shaolie S Hossain
    Department of Translational Imaging, The Methodist Hospital Research Institute, 6670 Bertner Avenue, Room R8 218, Houston, TX 77030, USA
    Nanomedicine (Lond) 8:343-57. 2013
    ..To predict the deposition of nanoparticles in a patient-specific arterial tree as a function of the vascular architecture, flow conditions, receptor surface density and nanoparticle properties...
  55. pmc Monitoring the progression of metastatic breast cancer on nanoporous silica chips
    Jia Fan
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Philos Trans A Math Phys Eng Sci 370:2433-47. 2012
    ..The approach and results reported in this study possess a significant potential for the discovery of proteomic biomarkers that may significantly enhance personalized medicine targeted at metastatic breast cancer...
  56. doi request reprint Shaping nano-/micro-particles for enhanced vascular interaction in laminar flows
    Sei Young Lee
    Department of Nanomedicine and BioMedical Engineering, University of Texas Health Science Center at Houston, Houston, TX, USA
    Nanotechnology 20:495101. 2009
    ....
  57. pmc Mesoporous silica chips for selective enrichment and stabilization of low molecular weight proteome
    Ali Bouamrani
    Department of Nanomedicine and BioMedical Engineering, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Proteomics 10:496-505. 2010
    ..The introduction of this mesoporous material with fine controlled properties will provide a powerful platform for proteomics application offering a rapid and efficient methodology for low molecular weight biomarker discovery...
  58. doi request reprint A robust nanofluidic membrane with tunable zero-order release for implantable dose specific drug delivery
    Daniel Fine
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Lab Chip 10:3074-83. 2010
    ..Finally, an optimal ratio of the molecular hydrodynamic diameter to the nanochannel dimension is determined to assure zero-order release for each tested molecule...
  59. ncbi request reprint Shaping the micromechanical behavior of multi-phase composites for bone tissue engineering
    Shivakumar I Ranganathan
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center, Houston, TX, USA
    Acta Biomater 6:3448-56. 2010
    ....
  60. ncbi request reprint Polyarginine induces an antitumor immune response through binding to toll-like receptor 4
    Yong Yang
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX, 77030, USA
    Small 10:1250-4. 2014
    ..Moreover, polyarginine induced immune activation inhibits tumor growth. These results suggest the potential use of polyarginine for cancer immunotherapy. ..
  61. pmc Hesperetin: an inhibitor of the transforming growth factor-β (TGF-β) signaling pathway
    Yong Yang
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Eur J Med Chem 58:390-5. 2012
    ..In addition we demonstrated that this compound hinders TGF-β1-induced cancer cell migration and invasion. These results suggest a potential future application for hesperetin as a TGF-β inhibitor in cancer therapy...
  62. pmc The preferential targeting of the diseased microvasculature by disk-like particles
    Giulia Adriani
    Department of Mechanical and Management Engineering, Politecnico di Bari, Bari, Italy
    Biomaterials 33:5504-13. 2012
    ..In view of the growing evidence on vascular molecular heterogeneity, the present data suggests that thin disk-like particles could more effectively target the diseased microvasculature as compared to spheres and slender rods...
  63. ncbi request reprint Molecular modeling of glucose diffusivity in silica nanochannels
    Arturas Ziemys
    School of Health Information Sciences, The University of Texas Health Science Center at Houston, 7000 Fannin, Suite 600, Houston, Texas 77030, USA
    J Nanosci Nanotechnol 9:6349-59. 2009
    ..It is also observed that the dynamics on the interface is characterized by adsorption-desorption processes. These results clearly suggest that glucose transport is affected by the interface in 10 nm nano-confinement...
  64. pmc Geometrical confinement of gadolinium-based contrast agents in nanoporous particles enhances T1 contrast
    Jeyarama S Ananta
    Department of Chemistry, Smalley Institute for Nanoscale Science and Technology, Center for Biological and Environmental Nanotechnology, Rice University, Houston, Texas 77251 1892, USA
    Nat Nanotechnol 5:815-21. 2010
    ..Thus, nanoscale confinement offers a new and general strategy for enhancing the contrast of gadolinium-based contrast agents...
  65. doi request reprint Modulating cellular adhesion through nanotopography
    Paolo Decuzzi
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center Houston, Houston, TX, USA
    Biomaterials 31:173-9. 2010
    ..The model proposed supports the notion for rationally designing substrates where topography and physico-chemical properties are tailored to favour cellular proliferation whilst repelling bacterial adhesion...
  66. doi request reprint Intravascular delivery of particulate systems: does geometry really matter?
    Paolo Decuzzi
    School of Health Information Sciences, The University of Texas Health Science Center, Houston, Texas 77030, USA
    Pharm Res 26:235-43. 2009
    ..The integration of mathematical modeling with in-vitro and in-vivo testing provides the tools for establishing a rational design of nanoparticles...
  67. pmc Emerging applications of nanomedicine for the diagnosis and treatment of cardiovascular diseases
    Biana Godin
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center at Houston, 1825 Pressler, Suite 537, Houston, TX 77030, USA
    Trends Pharmacol Sci 31:199-205. 2010
    ..Specifically, we discuss the use of nanoparticles for molecular imaging and advanced therapeutics, specially designed drug eluting stents and in vivo/ex vivo early detection techniques...
  68. pmc Sustained small interfering RNA delivery by mesoporous silicon particles
    Takemi Tanaka
    Department of Nanomedicine and BioMedical Engineering, University of Texas Health Science Center at Houston, Texas, USA
    Cancer Res 70:3687-96. 2010
    ..In summary, we have provided the first in vivo therapeutic validation of a novel, multistage siRNA delivery system for sustained gene silencing with broad applicability to pathologies beyond ovarian neoplasms...
  69. ncbi request reprint Conference Scene: Nanotechnology and medicine: the next big thing is really small
    Ennio Tasciotti
    Division of NanoMedicine, Department of Biomedical Engineering, The University of Texas Health Science Center at Houston, 1825 Pressler St, Suite 537B, 77030 Houston, TX, USA
    Nanomed 4:619-21. 2009
    ....
  70. pmc Quantitative mechanics of endothelial phagocytosis of silicon microparticles
    Rita E Serda
    Division of NanoMedicine, Department of Biomedical Engineering, University of Texas Health Science Center, Houston, Texas 77030, USA
    Cytometry A 75:752-60. 2009
    ..The resulting half-time for microparticle internalization was 15.7 min, with confirmation provided by live confocal imaging as well as transmission electron microscopy...
  71. pmc The margination propensity of spherical particles for vascular targeting in the microcirculation
    Francesco Gentile
    Center of Bio Nanotechnology and Engineering for Medicine University of Magna Graecia at Catanzaro, Viale Europa Loc, Germaneto, 88100, Catanzaro, Italy
    J Nanobiotechnology 6:9. 2008
    ....
  72. pmc Size of the nanovectors determines the transplacental passage in pregnancy: study in rats
    Jerrie S Refuerzo
    Department of Obstetrics, Gynecology, and Reproductive Medicine, University of Texas Health Science Center at Houston, 77030, USA
    Am J Obstet Gynecol 204:546.e5-9. 2011
    ..The objective of the study was to examine whether the size of silicon nanovectors (SNVs) inhibits their entrance into the fetal circulation...
  73. ncbi request reprint Osmotic pressure beyond concentration restrictions
    Alessandro Grattoni
    Dipartimento di Meccanica, Politecnico di Torino, C so Duca degli Abruzzi, 24, 10129, Torino, Italy
    J Phys Chem B 111:11770-5. 2007
    ..In this work, we examine the validity of predictive theories of osmosis, by comparison with our new experimental results, and a meta-analysis of literature data...
  74. doi request reprint Nanotechnology for breast cancer therapy
    Takemi Tanaka
    Brown Institute of Molecular Medicine, Department of Biomedical Engineering, University of Texas Houston Health Science Center, 1825 Herman Pressler Street, Suite 537D, Houston, TX, 77030, USA
    Biomed Microdevices 11:49-63. 2009
    ....
  75. pmc Identification of an inhibitory mechanism of luteolin on the insulin-like growth factor-1 ligand-receptor interaction
    Yong Yang
    Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA
    Chembiochem 14:929-33. 2013
    ..This inhibition mechanism, which was confirmed by flow cytometry and molecular docking, could play a role in cancer therapy...
  76. doi request reprint Adult and umbilical cord blood-derived platelet-rich plasma for mesenchymal stem cell proliferation, chemotaxis, and cryo-preservation
    Matthew B Murphy
    Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77025, USA
    Biomaterials 33:5308-16. 2012
    ..Lastly, we successfully demonstrated that PRP and PPP represented a viable alternative to FBS containing media for the cryo-preservation of MSC from human and rat BM...
  77. ncbi request reprint Antibiological barrier nanovector technology for cancer applications
    Jason Sakamoto
    Alliance for NanoHealth, 1825 Herman Pressler Street, Suite 537A, Houston, Texas 77030, USA
    Expert Opin Drug Deliv 4:359-69. 2007
    ..This novel, multi-stage strategy enables efficient localised delivery of chemotoxic drugs that may lead to significant improvements in therapy efficacy, reduced systemic toxicity and decreased total amount of injected drugs...
  78. ncbi request reprint The association of silicon microparticles with endothelial cells in drug delivery to the vasculature
    Rita E Serda
    Brown Institute of Molecular Medicine, University of Texas Health Science Center, Nanomedicine Division, 1825 Pressler, Suite 537, Houston, TX 77030, USA
    Biomaterials 30:2440-8. 2009
    ..These findings suggest that it may be possible to bioengineer silicon microparticles to favor opsonization with proteins that enhance uptake by endothelial cells, without a concurrent enhanced uptake by macrophages...
  79. pmc Prediction of drug response in breast cancer using integrative experimental/computational modeling
    Hermann B Frieboes
    School of Health Information Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 69:4484-92. 2009
    ....
  80. ncbi request reprint Nanotechnology and tumor imaging: seizing an opportunity
    Daniel C Sullivan
    Division of Cancer Treatment and Diagnosis, National Cancer Institute, EPN Room 6052, 6130 Executive Boulevard, Rockville, MD 20892 7412, USA
    Mol Imaging 3:364-9. 2004
    ..Appropriately labeled and targeted nanoparticles could lead to a paradigm change in which cancer detection, diagnosis, and therapy are combined in a single molecular complex...
  81. ncbi request reprint Interstitial stress and fluid pressure within a growing tumor
    Malisa Sarntinoranont
    University of California at Berkeley, Department of Mechanical Engineering, Berkeley, CA, USA
    Ann Biomed Eng 31:327-35. 2003
    ..An application of this model includes a solid stress-based framework for predicting regions of vascular collapse within the tumor interior...
  82. ncbi request reprint Cancer nanotechnology: opportunities and challenges
    Mauro Ferrari
    Division of Haematology and Oncology, 110U Davis Heart and Lung Research Institute, The Ohio State University, 473 West 12th Avenue, Columbus OH 43210 1002, USA
    Nat Rev Cancer 5:161-71. 2005
    ..These and other nanodevices can provide essential breakthroughs in the fight against cancer...
  83. ncbi request reprint Tailoring width of microfabricated nanochannels to solute size can be used to control diffusion kinetics
    Frank Martin
    iMEDD Inc, Columbus, OH, USA
    J Control Release 102:123-33. 2005
    ..Such a nonmechanical device offers important advantages in drug delivery applications, including zero-order release and high loading capacity...
  84. ncbi request reprint Opportunities for nanotechnology-based innovation in tissue proteomics
    David H Geho
    FDA NCI Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Biomed Microdevices 6:231-9. 2004
    ....
  85. ncbi request reprint Object-oriented design tools for supramolecular devices and biomedical nanotechnology
    Stephen C Lee
    Biomedical Engineering Center, The Ohio State University, Columbus, Ohio 43210, USA
    Ann N Y Acad Sci 1013:110-23. 2004
    ..The nested, hierarchical nature of object-oriented approaches allows treatment of devices as objects in higher-order structures, and so will facilitate concatenation of multiple devices into higher-order, higher-function nanosystems...
  86. ncbi request reprint Recommendations of the National Heart, Lung, and Blood Institute Nanotechnology Working Group
    Denis B Buxton
    Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Circulation 108:2737-42. 2003
    ..Finally, encouragement of small businesses to develop nanotechnology-based approaches to clinical problems was considered important...
  87. ncbi request reprint Prospects for microtechnology and nanotechnology in bioengineering of replacement microvessels
    Nicanor I Moldovan
    Biomedical Engineering Center and Dorothy M Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    Arch Pathol Lab Med 126:320-4. 2002
    ..Due to its anticipated curative potential, therapeutic angiogenesis recently became a major preoccupation for the biomedical research community. Most of the related work reported to date employs either biochemical or genetic tools...
  88. pmc Mechanical spectral signatures of malignant disease? A small-sample, comparative study of continuum vs. nano-biomechanical data analyses
    Jun Liu
    Biomedical Engineering Center, The Ohio State University, 1080 Carmack Road, Columbus, OH 43210, USA
    Dis Markers 18:175-83. 2002
    ..In this paper, the validity of the nanomechanical approach to tissue characterization is discussed, and its potential extensions to biomolecular marker-based cancer diagnostics and therapeutics are considered...
  89. ncbi request reprint Release of biologically functional interferon-alpha from a nanochannel delivery system
    Gregory B Lesinski
    Department of Human Cancer Genetics, Division of Hematology and Oncology, Arthur G James Cancer Hospital and Richard J Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA
    Biomed Microdevices 7:71-9. 2005
    ..This drug delivery platform could be used to develop alternative strategies for the treatment of unresectable tumors...
  90. doi request reprint nan'o.tech.nol'o.gy n
    Thomas Theis
    IBM Watson Research Center, USA
    Nat Nanotechnol 1:8-10. 2006
  91. ncbi request reprint Biomedical nanotechnology for cancer
    Amy Pope-Harman
    Dorothy M Davis Heart and Lung Research Institute, Department of Internal Medicine, The Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA
    Med Clin North Am 91:899-927. 2007
    ....
  92. ncbi request reprint Multiscale modeling of protein transport in silicon membrane nanochannels. Part 1. Derivation of molecular parameters from computer simulations
    Sabrina Pricl
    Molecular Simulation Engineering MOSE Laboratory, Department of Chemical Engineering, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy
    Biomed Microdevices 8:277-90. 2006
    ....
  93. ncbi request reprint Multiscale modeling of protein transport in silicon membrane nanochannels. Part 2. From molecular parameters to a predictive continuum diffusion model
    Francesco Amato
    Department of Experimental and Clinical Medicine, Universita degli Studi Magna Graecia, Via T Campanella 115, 88100 Catanzaro, Italy
    Biomed Microdevices 8:291-8. 2006
    ....
  94. ncbi request reprint Dynamic model of biomolecular diffusion through two-dimensional nanochannels
    Carlo Cosentino
    Department of Experimental and Clinical Medicine, Università degli Studi Magna Graecia di Catanzaro, Via T Campanella 115, 88100 Catanzaro, Italy
    J Phys Chem B 109:7358-64. 2005
    ..Moreover, a physical description, derived from van der Waals equation of state, is presented, and it is compared with the results obtained by the mathematical model...
  95. ncbi request reprint Mathematical modeling of cancer progression and response to chemotherapy
    Sandeep Sanga
    University of California, Department of Biomedical Engineering, Irvine, 3120, CA 92697 2715, USA
    Expert Rev Anticancer Ther 6:1361-76. 2006
    ....
  96. ncbi request reprint Nanoporous surfaces as harvesting agents for mass spectrometric analysis of peptides in human plasma
    Marco Gaspari
    Department of Clinical and Experimental Medicine, Magna Graecia University, 88100 Catanzaro, Italy
    J Proteome Res 5:1261-6. 2006
    ..The same molecular cutoff effect was observed for mixtures of standard proteins and peptides incubated with silicon-based nanoporous surfaces...
  97. ncbi request reprint Controlled-release microchips
    Sadhana Sharma
    Davis Heart and Lung Research Institute, Ohio State University, 473 West 12th Avenue, Columbus, OH 43210, USA
    Expert Opin Drug Deliv 3:379-94. 2006
    ....
  98. ncbi request reprint Morphologic instability and cancer invasion
    Vittorio Cristini
    Department of Biomedical Engineering, University of California, Irvine, California 92697 2715, USA
    Clin Cancer Res 11:6772-9. 2005
    ....
  99. ncbi request reprint Medical nanotechnology: shortening clinical trials and regulatory pathways?
    Mauro Ferrari
    National Cancer Institute, Bethesda, Maryland, USAThe Ohio State University, Columbus, Ohio, USA
    BioDrugs 19:203-10. 2005
    ..These advances could be utilized to shave time and expense from multiple stages of the drug discovery and development effort...
  100. ncbi request reprint Nanotechnologies for biomolecular detection and medical diagnostics
    Mark Ming Cheng Cheng
    Division of Hematology and Oncology, Internal Medicine, The Ohio State University, 473 West 12 Avenue, Columbus OH 43210 1002, USA
    Curr Opin Chem Biol 10:11-9. 2006
    ....

Research Grants7

  1. Nanomechanical Method for Molecular Analysis of Cancer
    Mauro Ferrari; Fiscal Year: 2004
    ..In the R33 phase, the objectives of the proposed program would be to optimize the system's performance and create an actual prototype for clinical testing in the context of breast malignancies. ..
  2. Nanoparticles for Harvesting and Targeting Angiogenic Proteins
    Mauro Ferrari; Fiscal Year: 2006
    ..These studies may also provide strategies to selectively target tumor vessels for destruction using nanotechnology approaches. ..
  3. Nanovectors for Characterization and Destruction of Breast Tumor Vasculature
    Mauro Ferrari; Fiscal Year: 2007
    ....
  4. Nanovectors for Characterization and Destruction of Breast Tumor Vasculature
    Mauro Ferrari; Fiscal Year: 2009
    ....
  5. Nanovectors for Characterization and Destruction of Breast Tumor Vasculature
    Mauro Ferrari; Fiscal Year: 2009
    ....