Research Topics
| R FanSummaryAffiliation: Texas A and M University Country: USA Publications
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Detail Information
Publications
Models and tests of linkage and association studies of quantitative trait locus for multi-allele marker LociR Fan
Department of Statistics, Texas A and M University, College Station, Tex 77843, USA
Hum Hered 53:130-45. 2002..To illustrate the usefulness and the power of the methods proposed in this paper, we analyze the chromosome 6 data of the Oxford asthma data, Genetic Analysis Workshop 12...- A genome-wide association scan for rheumatoid arthritis data by Hotelling's T2 testsLianfu Chen
Department of Statistics, Texas A and M University, 447 Blocker Building, College Station, TX 77843, USA
BMC Proc 3:S6. 2009..In addition, SNPs with the largest TH score on each chromosome were identified. These SNPs may be located in the regions of genes that have modest effects on rheumatoid arthritis. These regions deserve further investigation... - Combined linkage and association mapping of quantitative trait Loci with missing completely at random genotype dataRuzong Fan
Department of Statistics, Texas A and M University, 447 Blocker Building, 3143 TAMUS, College Station, TX 77843, USA
Behav Genet 38:316-36. 2008..Hence, the proposed method can help to get correct type I error rates although it does not improve power. As a practical example, the method is applied to analyze the angiotensin-1 converting enzyme (ACE) data... - High-resolution association mapping of quantitative trait loci: a population-based approachRuzong Fan
Department of Statistics, Texas A and M University, College Station, Texas 77843, USA
Genetics 172:663-86. 2006..In addition, a simulation study is performed to make a comparison on the basis of the haplotype frequencies of 10 SNPs of angiotensin-1 converting enzyme (ACE) genes... - Sibship T2 association tests of complex diseases for tightly linked markersRuzong Fan
Department of Statistics, The Texas A and M University, College Station, Texas 77843 3143, USA
Hum Genomics 2:90-112. 2005..An SAS macro, Hotel_sibs.sas, is written to implement the method for data analysis... - High resolution T association tests of complex diseases based on family dataRuzong Fan
The Texas A and M University, 447 Blocker Building, College Station, TX 77843 3143, USA
Ann Hum Genet 69:187-208. 2005..The proposed paired Hotelling's T(2) statistic tests are potentially powerful in mapping complex diseases. A SAS Macro, Hotel_fam.sas, has been written to implement the method for data analysis... - Pedigree linkage disequilibrium mapping of quantitative trait lociRuzong Fan
Department of Statistics, Texas A and M University, 447 Blocker Building, 3143 TAMUS, College Station, TX 77843, USA
Eur J Hum Genet 13:216-31. 2005..Moreover, two markers I/D and 4656(CT)3/2 can fully interpret association with the trait locus at a 0.01 significance level, which provides a unique result for the ACE data... - High-resolution joint linkage disequilibrium and linkage mapping of quantitative trait loci based on sibship dataRuzong Fan
Department of Statistics, Texas A and M University, College Station, TX 77843, USA
Hum Hered 56:166-87. 2003..Population and pedigree data of any type can be combined to perform a joint analysis of high resolution LD and linkage mapping of QTL by generalizing the method... - High resolution mapping of quantitative trait loci by linkage disequilibrium analysisRuzong Fan
Department of Statistics, The Texas A and M University, 447 Blocker Building, College Station, Texas, TX 77843 3143, USA
Eur J Hum Genet 10:607-15. 2002..For a complex disease with heritability h(2)> or =0.15, a study with sample size of 250 can provide high power for QTL detection under moderate linkage disequilibria... - Association studies of QTL for multi-allele markers by mixed modelsRuzong Fan
Department of Statistics, Texas A and M University, College Station, TX 77843 3143, USA
Hum Hered 54:132-50. 2002..The proposed models are used to analyze chromosomes 4 and chromosome 16 data of the Oxford asthma data, Genetic Analysis Workshop 12... - Entropy-based information gain approaches to detect and to characterize gene-gene and gene-environment interactions/correlations of complex diseasesR Fan
Department of Statistics, Texas A and M University, College Station, Texas 77843, USA
Genet Epidemiol 35:706-21. 2011..The test statistics we develop add to a growing body methodologies that will gradually shed light on the complex architecture of common diseases... - Combined high resolution linkage and association mapping of quantitative trait lociRuzong Fan
Department of Statistics, The Texas A and M University, 447 Blocker Building, College Station, Texas 77843 3143, USA
Eur J Hum Genet 11:125-37. 2003.... - Genome association studies of complex diseases by case-control designsRuzong Fan
Department of Statistics, Texas A and M University, College Station, TX 77843, USA
Am J Hum Genet 72:850-68. 2003..Besides, the feasibility of the methods is shown by sample-size calculation... - Linkage and association studies of QTL for nuclear families by mixed modelsRuzong Fan
Department of Statistics, Texas A and M University, 447 Blocker Building, College Station, TX 77843 3143, USA
Biostatistics 4:75-95. 2003..1999) under moderate disequilibrium for nuclear families. Moreover, it has higher power than the TDT statistic which is constructed by randomly choosing a single offspring from each nuclear family... - Quantitative trait loci for exercise training responses in FVB/NJ and C57BL/6J miceMichael P Massett
Department of Health and Kinesiology, Texas A and M University, College Station, Texas 77845 4243, USA
Physiol Genomics 40:15-22. 2009..56 LOD). These data indicate that one or more QTL determine exercise capacity and training responses in mice. Furthermore, these data suggest that the genes that determine pretraining work and training responses may differ... - Using linkage and association to identify and model genetic effects: summary of GAW15 Group 4Qiong Yang
Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
Genet Epidemiol 31:S34-42. 2007..Finally, modeling the disease using association evidence conditional on linkage may improve understanding of the etiology of disease... - Bivariate combined linkage and association mapping of quantitative trait lociJeeSun Jung
Department of Medical and Molecular Genetics, Indiana University, School of Medicine, Indianapolis, Indiana, USA
Genet Epidemiol 32:396-412. 2008.... - Combined linkage and association mapping of quantitative trait loci by multiple markersJeeSun Jung
Department of Human Genetics, University of Pittsburgh, Graduate School of Public Health, Pennsylvania 15261, USA
Genetics 170:881-98. 2005..The multiple-marker analysis can be more advantageous and has higher power in fine mapping QTL. As an application, the Genetic Analysis Workshop 12 German asthma data are analyzed using the proposed methods... - Haplotypes of the surfactant protein genes A and D as susceptibility factors for the development of respiratory distress syndromeNeal J Thomas
Department of Pediatrics, Penn State Children s Hospita, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Acta Paediatr 96:985-9. 2007.... - Family-based association tests suggest linkage between surfactant protein B (SP-B) (and flanking region) and respiratory distress syndrome (RDS): SP-B haplotypes and alleles from SP-B-linked loci are risk factors for RDSJoanna Floros
Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Pediatr Res 59:616-21. 2006..We conclude that SP-B or SP-B-linked loci are linked to RDS and certain alleles or haplotypes are susceptibility or protective factors for the development of RDS in infants born prematurely...