R Fan

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. ncbi request reprint Models and tests of linkage and association studies of quantitative trait locus for multi-allele marker Loci
    R Fan
    Department of Statistics, Texas A and M University, College Station, Tex 77843, USA
    Hum Hered 53:130-45. 2002
  2. pmc A genome-wide association scan for rheumatoid arthritis data by Hotelling's T2 tests
    Lianfu Chen
    Department of Statistics, Texas A and M University, 447 Blocker Building, College Station, TX 77843, USA
    BMC Proc 3:S6. 2009
  3. doi request reprint Combined linkage and association mapping of quantitative trait Loci with missing completely at random genotype data
    Ruzong Fan
    Department of Statistics, Texas A and M University, 447 Blocker Building, 3143 TAMUS, College Station, TX 77843, USA
    Behav Genet 38:316-36. 2008
  4. pmc High-resolution association mapping of quantitative trait loci: a population-based approach
    Ruzong Fan
    Department of Statistics, Texas A and M University, College Station, Texas 77843, USA
    Genetics 172:663-86. 2006
  5. pmc Sibship T2 association tests of complex diseases for tightly linked markers
    Ruzong Fan
    Department of Statistics, The Texas A and M University, College Station, Texas 77843 3143, USA
    Hum Genomics 2:90-112. 2005
  6. ncbi request reprint High resolution T association tests of complex diseases based on family data
    Ruzong Fan
    The Texas A and M University, 447 Blocker Building, College Station, TX 77843 3143, USA
    Ann Hum Genet 69:187-208. 2005
  7. ncbi request reprint Pedigree linkage disequilibrium mapping of quantitative trait loci
    Ruzong Fan
    Department of Statistics, Texas A and M University, 447 Blocker Building, 3143 TAMUS, College Station, TX 77843, USA
    Eur J Hum Genet 13:216-31. 2005
  8. ncbi request reprint High-resolution joint linkage disequilibrium and linkage mapping of quantitative trait loci based on sibship data
    Ruzong Fan
    Department of Statistics, Texas A and M University, College Station, TX 77843, USA
    Hum Hered 56:166-87. 2003
  9. ncbi request reprint High resolution mapping of quantitative trait loci by linkage disequilibrium analysis
    Ruzong Fan
    Department of Statistics, The Texas A and M University, 447 Blocker Building, College Station, Texas, TX 77843 3143, USA
    Eur J Hum Genet 10:607-15. 2002
  10. ncbi request reprint Association studies of QTL for multi-allele markers by mixed models
    Ruzong Fan
    Department of Statistics, Texas A and M University, College Station, TX 77843 3143, USA
    Hum Hered 54:132-50. 2002

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Models and tests of linkage and association studies of quantitative trait locus for multi-allele marker Loci
    R Fan
    Department of Statistics, Texas A and M University, College Station, Tex 77843, USA
    Hum Hered 53:130-45. 2002
    ..To illustrate the usefulness and the power of the methods proposed in this paper, we analyze the chromosome 6 data of the Oxford asthma data, Genetic Analysis Workshop 12...
  2. pmc A genome-wide association scan for rheumatoid arthritis data by Hotelling's T2 tests
    Lianfu Chen
    Department of Statistics, Texas A and M University, 447 Blocker Building, College Station, TX 77843, USA
    BMC Proc 3:S6. 2009
    ..In addition, SNPs with the largest TH score on each chromosome were identified. These SNPs may be located in the regions of genes that have modest effects on rheumatoid arthritis. These regions deserve further investigation...
  3. doi request reprint Combined linkage and association mapping of quantitative trait Loci with missing completely at random genotype data
    Ruzong Fan
    Department of Statistics, Texas A and M University, 447 Blocker Building, 3143 TAMUS, College Station, TX 77843, USA
    Behav Genet 38:316-36. 2008
    ..Hence, the proposed method can help to get correct type I error rates although it does not improve power. As a practical example, the method is applied to analyze the angiotensin-1 converting enzyme (ACE) data...
  4. pmc High-resolution association mapping of quantitative trait loci: a population-based approach
    Ruzong Fan
    Department of Statistics, Texas A and M University, College Station, Texas 77843, USA
    Genetics 172:663-86. 2006
    ..In addition, a simulation study is performed to make a comparison on the basis of the haplotype frequencies of 10 SNPs of angiotensin-1 converting enzyme (ACE) genes...
  5. pmc Sibship T2 association tests of complex diseases for tightly linked markers
    Ruzong Fan
    Department of Statistics, The Texas A and M University, College Station, Texas 77843 3143, USA
    Hum Genomics 2:90-112. 2005
    ..An SAS macro, Hotel_sibs.sas, is written to implement the method for data analysis...
  6. ncbi request reprint High resolution T association tests of complex diseases based on family data
    Ruzong Fan
    The Texas A and M University, 447 Blocker Building, College Station, TX 77843 3143, USA
    Ann Hum Genet 69:187-208. 2005
    ..The proposed paired Hotelling's T(2) statistic tests are potentially powerful in mapping complex diseases. A SAS Macro, Hotel_fam.sas, has been written to implement the method for data analysis...
  7. ncbi request reprint Pedigree linkage disequilibrium mapping of quantitative trait loci
    Ruzong Fan
    Department of Statistics, Texas A and M University, 447 Blocker Building, 3143 TAMUS, College Station, TX 77843, USA
    Eur J Hum Genet 13:216-31. 2005
    ..Moreover, two markers I/D and 4656(CT)3/2 can fully interpret association with the trait locus at a 0.01 significance level, which provides a unique result for the ACE data...
  8. ncbi request reprint High-resolution joint linkage disequilibrium and linkage mapping of quantitative trait loci based on sibship data
    Ruzong Fan
    Department of Statistics, Texas A and M University, College Station, TX 77843, USA
    Hum Hered 56:166-87. 2003
    ..Population and pedigree data of any type can be combined to perform a joint analysis of high resolution LD and linkage mapping of QTL by generalizing the method...
  9. ncbi request reprint High resolution mapping of quantitative trait loci by linkage disequilibrium analysis
    Ruzong Fan
    Department of Statistics, The Texas A and M University, 447 Blocker Building, College Station, Texas, TX 77843 3143, USA
    Eur J Hum Genet 10:607-15. 2002
    ..For a complex disease with heritability h(2)> or =0.15, a study with sample size of 250 can provide high power for QTL detection under moderate linkage disequilibria...
  10. ncbi request reprint Association studies of QTL for multi-allele markers by mixed models
    Ruzong Fan
    Department of Statistics, Texas A and M University, College Station, TX 77843 3143, USA
    Hum Hered 54:132-50. 2002
    ..The proposed models are used to analyze chromosomes 4 and chromosome 16 data of the Oxford asthma data, Genetic Analysis Workshop 12...
  11. pmc Entropy-based information gain approaches to detect and to characterize gene-gene and gene-environment interactions/correlations of complex diseases
    R Fan
    Department of Statistics, Texas A and M University, College Station, Texas 77843, USA
    Genet Epidemiol 35:706-21. 2011
    ..The test statistics we develop add to a growing body methodologies that will gradually shed light on the complex architecture of common diseases...
  12. ncbi request reprint Combined high resolution linkage and association mapping of quantitative trait loci
    Ruzong Fan
    Department of Statistics, The Texas A and M University, 447 Blocker Building, College Station, Texas 77843 3143, USA
    Eur J Hum Genet 11:125-37. 2003
    ....
  13. pmc Genome association studies of complex diseases by case-control designs
    Ruzong Fan
    Department of Statistics, Texas A and M University, College Station, TX 77843, USA
    Am J Hum Genet 72:850-68. 2003
    ..Besides, the feasibility of the methods is shown by sample-size calculation...
  14. ncbi request reprint Linkage and association studies of QTL for nuclear families by mixed models
    Ruzong Fan
    Department of Statistics, Texas A and M University, 447 Blocker Building, College Station, TX 77843 3143, USA
    Biostatistics 4:75-95. 2003
    ..1999) under moderate disequilibrium for nuclear families. Moreover, it has higher power than the TDT statistic which is constructed by randomly choosing a single offspring from each nuclear family...
  15. pmc Quantitative trait loci for exercise training responses in FVB/NJ and C57BL/6J mice
    Michael P Massett
    Department of Health and Kinesiology, Texas A and M University, College Station, Texas 77845 4243, USA
    Physiol Genomics 40:15-22. 2009
    ..56 LOD). These data indicate that one or more QTL determine exercise capacity and training responses in mice. Furthermore, these data suggest that the genes that determine pretraining work and training responses may differ...
  16. ncbi request reprint Using linkage and association to identify and model genetic effects: summary of GAW15 Group 4
    Qiong Yang
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
    Genet Epidemiol 31:S34-42. 2007
    ..Finally, modeling the disease using association evidence conditional on linkage may improve understanding of the etiology of disease...
  17. doi request reprint Bivariate combined linkage and association mapping of quantitative trait loci
    JeeSun Jung
    Department of Medical and Molecular Genetics, Indiana University, School of Medicine, Indianapolis, Indiana, USA
    Genet Epidemiol 32:396-412. 2008
    ....
  18. pmc Combined linkage and association mapping of quantitative trait loci by multiple markers
    JeeSun Jung
    Department of Human Genetics, University of Pittsburgh, Graduate School of Public Health, Pennsylvania 15261, USA
    Genetics 170:881-98. 2005
    ..The multiple-marker analysis can be more advantageous and has higher power in fine mapping QTL. As an application, the Genetic Analysis Workshop 12 German asthma data are analyzed using the proposed methods...
  19. ncbi request reprint Haplotypes of the surfactant protein genes A and D as susceptibility factors for the development of respiratory distress syndrome
    Neal J Thomas
    Department of Pediatrics, Penn State Children s Hospita, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Acta Paediatr 96:985-9. 2007
    ....
  20. ncbi request reprint Family-based association tests suggest linkage between surfactant protein B (SP-B) (and flanking region) and respiratory distress syndrome (RDS): SP-B haplotypes and alleles from SP-B-linked loci are risk factors for RDS
    Joanna Floros
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Pediatr Res 59:616-21. 2006
    ..We conclude that SP-B or SP-B-linked loci are linked to RDS and certain alleles or haplotypes are susceptibility or protective factors for the development of RDS in infants born prematurely...