Herbert L DuPont

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc A single-nucleotide polymorphism in the gene encoding osteoprotegerin, an anti-inflammatory protein produced in response to infection with diarrheagenic Escherichia coli, is associated with an increased risk of nonsecretory bacterial diarrhea in North Ame
    Jamal A Mohamed
    Division of Infectious Diseases, The University of Texas Medical School, Center for Infectious Diseases, Baylor College of Medicine, Houston, TX, USA
    J Infect Dis 199:477-85. 2009
  2. ncbi request reprint Escherichia coli Pyomyositis: an emerging infectious disease among patients with hematologic malignancies
    Karen J Vigil
    The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1460, Houston, TX 77030, USA
    Clin Infect Dis 50:374-80. 2010
  3. doi request reprint Approach to the patient with infectious colitis
    Herbert L DuPont
    The University of Texas School of Public Health, St Luke s Episcopal Hospital, Baylor College of Medicine and Kelsey Research Foundation, Houston, Texas, USA
    Curr Opin Gastroenterol 28:39-46. 2012
  4. doi request reprint Diagnosis and management of Clostridium difficile infection
    Herbert L DuPont
    Center for Infectious Diseases, University of Texas School of Public Health Department of Medicine, Baylor College of Medicine and Internal Medicine Service, St Luke s Episcopal Hospital, Houston, Texas Electronic address
    Clin Gastroenterol Hepatol 11:1216-23; quiz e73. 2013
  5. pmc Giardia: both a harmless commensal and a devastating pathogen
    Herbert L DuPont
    University of Texas School of Public Health and Medical School, St Luke s Episcopal Hospital, Baylor College of Medicine, and Kelsey Research Foundation, Houston, Texas, USA
    J Clin Invest 123:2352-4. 2013
  6. doi request reprint Biologic properties and clinical uses of rifaximin
    Herbert L DuPont
    The University of Texas School of Public Health, Baylor College of Medicine, St Luke s Episcopal Hospital, Kelsey Research Foundation, 1200 Herman Pressler, Houston, TX 77030, USA
    Expert Opin Pharmacother 12:293-302. 2011
  7. doi request reprint Expert review of the evidence base for prevention of travelers' diarrhea
    Herbert L DuPont
    Center for Infectious Disease, University of Texas School of Public Health at Houston, Houston, TX 77030, USA
    J Travel Med 16:149-60. 2009
  8. ncbi request reprint New advances in Clostridium difficile infection: changing epidemiology, diagnosis, treatment and control
    Herbert L DuPont
    The University of Texas School of Public Health, Houston, Texas 77030, USA
    Curr Opin Infect Dis 21:500-7. 2008
  9. ncbi request reprint Systematic review: the epidemiology and clinical features of travellers' diarrhoea
    H L DuPont
    The University of Texas School of Public Health, St Luke s Episcopal Hospital, Baylor College of Medicine, Houston, TX, USA
    Aliment Pharmacol Ther 30:187-96. 2009
  10. doi request reprint Gastrointestinal infections and the development of irritable bowel syndrome
    Herbert L DuPont
    University of Texas Health Science Center at Houston School of Public Health and Medical School, St Luke s Episcopal Hospital, Baylor College of Medicine and Kelsey Research Foundation, Houston, Texas, USA
    Curr Opin Infect Dis 24:503-8. 2011

Detail Information

Publications122 found, 100 shown here

  1. pmc A single-nucleotide polymorphism in the gene encoding osteoprotegerin, an anti-inflammatory protein produced in response to infection with diarrheagenic Escherichia coli, is associated with an increased risk of nonsecretory bacterial diarrhea in North Ame
    Jamal A Mohamed
    Division of Infectious Diseases, The University of Texas Medical School, Center for Infectious Diseases, Baylor College of Medicine, Houston, TX, USA
    J Infect Dis 199:477-85. 2009
    ....
  2. ncbi request reprint Escherichia coli Pyomyositis: an emerging infectious disease among patients with hematologic malignancies
    Karen J Vigil
    The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1460, Houston, TX 77030, USA
    Clin Infect Dis 50:374-80. 2010
    ..Pyomyositis is typically caused by gram-positive bacteria, especially Staphylococcus aureus. Few cases of Escherichia coli pyomyositis have been reported, including only 1 involving a patient with a hematologic malignancy...
  3. doi request reprint Approach to the patient with infectious colitis
    Herbert L DuPont
    The University of Texas School of Public Health, St Luke s Episcopal Hospital, Baylor College of Medicine and Kelsey Research Foundation, Houston, Texas, USA
    Curr Opin Gastroenterol 28:39-46. 2012
    ....
  4. doi request reprint Diagnosis and management of Clostridium difficile infection
    Herbert L DuPont
    Center for Infectious Diseases, University of Texas School of Public Health Department of Medicine, Baylor College of Medicine and Internal Medicine Service, St Luke s Episcopal Hospital, Houston, Texas Electronic address
    Clin Gastroenterol Hepatol 11:1216-23; quiz e73. 2013
    ..Humanized monoclonal antitoxin antibodies and active immunization with vaccines against C difficile or its toxins are both in development and appear to be of potential value. ..
  5. pmc Giardia: both a harmless commensal and a devastating pathogen
    Herbert L DuPont
    University of Texas School of Public Health and Medical School, St Luke s Episcopal Hospital, Baylor College of Medicine, and Kelsey Research Foundation, Houston, Texas, USA
    J Clin Invest 123:2352-4. 2013
    ..This work in part explains how Giardia infection can lead to growth retardation, and may offer insights that guide future therapeutic strategies...
  6. doi request reprint Biologic properties and clinical uses of rifaximin
    Herbert L DuPont
    The University of Texas School of Public Health, Baylor College of Medicine, St Luke s Episcopal Hospital, Kelsey Research Foundation, 1200 Herman Pressler, Houston, TX 77030, USA
    Expert Opin Pharmacother 12:293-302. 2011
    ..Rifaximin is increasingly being used to treat acute and chronic gastrointestinal infections and disorders. The drug exerts its beneficial effect through a variety of gut-selective mechanisms involving the host intestinal microbiota...
  7. doi request reprint Expert review of the evidence base for prevention of travelers' diarrhea
    Herbert L DuPont
    Center for Infectious Disease, University of Texas School of Public Health at Houston, Houston, TX 77030, USA
    J Travel Med 16:149-60. 2009
    ..In the following document, the authors used an evidence base when available to determine strength and quality of evidence and when data were lacking, the panel experts provided consensus opinion...
  8. ncbi request reprint New advances in Clostridium difficile infection: changing epidemiology, diagnosis, treatment and control
    Herbert L DuPont
    The University of Texas School of Public Health, Houston, Texas 77030, USA
    Curr Opin Infect Dis 21:500-7. 2008
    ..The present review focuses on scientific papers published in the past 18 months in an attempt to provide the latest information on the topic...
  9. ncbi request reprint Systematic review: the epidemiology and clinical features of travellers' diarrhoea
    H L DuPont
    The University of Texas School of Public Health, St Luke s Episcopal Hospital, Baylor College of Medicine, Houston, TX, USA
    Aliment Pharmacol Ther 30:187-96. 2009
    ..Travellers' diarrhoea is the most common medical complaint among persons venturing into developing areas from industrialized regions...
  10. doi request reprint Gastrointestinal infections and the development of irritable bowel syndrome
    Herbert L DuPont
    University of Texas Health Science Center at Houston School of Public Health and Medical School, St Luke s Episcopal Hospital, Baylor College of Medicine and Kelsey Research Foundation, Houston, Texas, USA
    Curr Opin Infect Dis 24:503-8. 2011
    ..Recent studies have helped to identify the pathogenesis and natural history of these disorders...
  11. pmc President's address: travel medicine and principles of safe travel
    Herbert L DuPont
    Houston, Texas, USA
    Trans Am Clin Climatol Assoc 119:1-27. 2008
    ..All persons need to have an idea of how and where they may find medical care if they develop illness while abroad. This article summarizes essential elements in travel medicine and offers 10 recommendations for safe travel...
  12. doi request reprint Systematic review: prevention of travellers' diarrhoea
    H L DuPont
    Houston School of Public Health and School of Medicine, The University of Texas, St Luke s Episcopal Hospital, Houston, TX 77030, USA
    Aliment Pharmacol Ther 27:741-51. 2008
    ..4%) rifaximin, and with evidence that a subgroup of travellers with diarrhoea have progression of their illnesses to postinfectious irritable bowel syndrome...
  13. ncbi request reprint The growing threat of foodborne bacterial enteropathogens of animal origin
    Herbert L DuPont
    University of Texas Houston School of Public Health, St Luke s Episcopal Hospital, and Baylor College of Medicine, Houston, TX, USA
    Clin Infect Dis 45:1353-61. 2007
    ....
  14. pmc Novel one-step method for detection and isolation of active-toxin-producing Clostridium difficile strains directly from stool samples
    Charles Darkoh
    The University of Texas Graduate School of Biomedical Sciences, Houston, TX, USA
    J Clin Microbiol 49:4219-24. 2011
    ..This new method reduces the time and effort required to isolate and confirm toxin-producing C. difficile strains...
  15. doi request reprint Enterotoxigenic Escherichia coli heat-labile toxin seroconversion in US travelers to Mexico
    Jose Flores
    Division of Infectious Diseases, University of Texas Medical School at Houston, Houston, TX 77030, USA
    J Travel Med 15:156-61. 2008
    ..However, the role of LT-producing ETEC (LT-ETEC) as a cause of diarrhea is controversial. We conducted a cohort study in US students traveling to Mexico to assess the ETEC-LT seroconversion rate after natural exposure...
  16. ncbi request reprint Treatment of travelers' diarrhea: randomized trial comparing rifaximin, rifaximin plus loperamide, and loperamide alone
    Herbert L DuPont
    Center for Infectious Diseases, University of Texas School of Public Health, Houston, Texas, USA
    Clin Gastroenterol Hepatol 5:451-6. 2007
    ..This study evaluated the efficacy and safety of rifaximin-loperamide in the treatment of travelers' diarrhea...
  17. ncbi request reprint Association of interleukin-8 polymorphism and immunoglobulin G anti-toxin A in patients with Clostridium difficile-associated diarrhea
    Zhi Dong Jiang
    Center for Infectious Diseases, 1200 Herman Pressler, Room 739, University of Texas School of Public Health, Houston, Texas 77030, USA
    Clin Gastroenterol Hepatol 5:964-8. 2007
    ..This study examined the relationship between serum immunoglobulin G antibodies to CD toxin A and the presence of IL-8 AA genotype in hospitalized patients with CDAD...
  18. ncbi request reprint Virulence characteristics and the molecular epidemiology of enteroaggregative Escherichia coli isolates from travellers to developing countries
    David B Huang
    Baylor College of Medicine, Division of Infectious Diseases, Houston, TX, USA
    J Med Microbiol 56:1386-92. 2007
    ....
  19. ncbi request reprint A review of an emerging enteric pathogen: enteroaggregative Escherichia coli
    David B Huang
    Infectious Diseases Section, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, 535EE, Houston, TX 77030, USA
    J Med Microbiol 55:1303-11. 2006
    ..Ciprofloxacin and rifaximin continue to be an effective treatment in persons infected with EAEC. This review is intended to provide an updated review for healthcare workers on EAEC, an emerging enteric pathogen...
  20. pmc Noroviruses as a cause of diarrhea in travelers to Guatemala, India, and Mexico
    Hoonmo L Koo
    Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Clin Microbiol 48:1673-6. 2010
    ..Significant variation in the prevalence of NoV diarrhea and in the predominant genogroup infecting travelers was demonstrated, dependent upon the specific geographic location and over time...
  21. pmc Association of putative enteroaggregative Escherichia coli virulence genes and biofilm production in isolates from travelers to developing countries
    Jamal A Mohamed
    Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical School, Houston, TX 77030, USA
    J Clin Microbiol 45:121-6. 2007
    ..This study suggests that biofilm formation is a common phenomenon among EAEC isolates derived from travelers with or without diarrhea and that multiple genes associated with biofilm formation are regulated by aggR...
  22. pmc Influence of host interleukin-10 polymorphisms on development of traveler's diarrhea due to heat-labile enterotoxin-producing Escherichia coli in travelers from the United States who are visiting Mexico
    Jose Flores
    Division of Infectious Diseases, The University of Texas Medical School, 6431 Fannin Street, Houston, TX 77030, USA
    Clin Vaccine Immunol 15:1194-8. 2008
    ..002). Travelers genetically predisposed to produce high levels of IL-10 were more likely to experience symptomatic ETEC TD...
  23. ncbi request reprint Loperamide plus azithromycin more effectively treats travelers' diarrhea in Mexico than azithromycin alone
    Charles D Ericsson
    Department of Medicine, Division of Infectious Diseases, University of Texas Medical School at Houston, and St Luke s Episcopal Hospital, Houston, TX 77030, USA
    J Travel Med 14:312-9. 2007
    ....
  24. pmc Campylobacter jejuni is not an important pathogen as a cause of diarrhea in US travelers to Mexico
    Nicolas A Villa
    Baylor College of Medicine, Houston, TX, USA
    J Travel Med 18:56-8. 2011
    ..Serum IgG, IgA, and IgM antibodies to Campylobacter seroconverted in only 2 of 353 participants (0.6%). These data further support that C jejuni infection is an unusual cause of travelers' diarrhea in US visitors to Mexico...
  25. doi request reprint Seroprevalence of the enteroaggregative Escherichia coli virulence factor dispersin among USA travellers to Cuernavaca, Mexico: a pilot study
    David B Huang
    Department of Medicine, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    J Med Microbiol 57:476-9. 2008
    ..Further studies are needed to characterize in more detail the host clinical and immunological responses to the dispersin protein...
  26. ncbi request reprint Biochemical and genetic diversity of enterotoxigenic Escherichia coli associated with diarrhea in United States students in Cuernavaca and Guadalajara, Mexico, 2004-2007
    Jeannette Ouyang-Latimer
    Baylor College of Medicine, 2University of Texas School of Public Health, 3University of Texas Medical School, and 4St Luke s Episcopal Hospital, Houston, Texas
    J Infect Dis 201:1831-8. 2010
    ..Molecular characterization of Escherichia coli with use of the random amplified polymorphic DNA (RAPD) assay allows the determination of clonal origin and geographic clustering...
  27. pmc Epidemiology of cryptosporidiosis in North American travelers to Mexico
    Parvathy Nair
    The University of Texas Health Science Center at Houston Medical School and School of Public Health, Houston, Texas, USA
    Am J Trop Med Hyg 79:210-4. 2008
    ..Speciation by 18SrRNA sequencing showed that 13 cases were caused by C. parvum and only 1 case was caused by C. hominis. ELISA showed a sensitivity of 50% and specificity of 100% compared with PCR...
  28. ncbi request reprint A randomized, double-blind, placebo-controlled trial of rifaximin to prevent travelers' diarrhea
    Herbert L DuPont
    University of Texas Houston, Baylor College of Medicine, St Luke s Episcopal Hospital, and M D Anderson Cancer Center, Houston, Texas 77030, USA
    Ann Intern Med 142:805-12. 2005
    ..Travelers' diarrhea causes substantial morbidity and postinfectious irritable bowel syndrome...
  29. pmc Seasonality of diarrheagenic Escherichia coli pathotypes in the US students acquiring diarrhea in Mexico
    Mercedes Paredes-Paredes
    Medical School, The University of Texas at Houston, Houston, TX 77030, USA
    J Travel Med 18:121-5. 2011
    ..In Mexico, rates of diarrhea have been associated with the rainy season and increase in ambient temperature. However, the seasonality of the various diarrheagenic Escherichia coli pathotypes in travelers has not been well described...
  30. ncbi request reprint A novel single-nucleotide polymorphism in the lactoferrin gene is associated with susceptibility to diarrhea in North American travelers to Mexico
    Jamal A Mohamed
    Division of Infectious Diseases, The University of Texas Medical School, Houston, TX 77030, USA
    Clin Infect Dis 44:945-52. 2007
    ..We investigated the impact that selected single-nucleotide polymorphisms (SNPs) in the human lactoferrin gene have on susceptibility to traveler's diarrhea...
  31. pmc Single nucleotide polymorphisms in the promoter of the gene encoding the lipopolysaccharide receptor CD14 are associated with bacterial diarrhea in US and Canadian travelers to Mexico
    Jamal A Mohamed
    Department of Internal Medicine, Division of Infectious Diseases University of Texas Medical School at Houston, Houston, TX 77030, USA
    Clin Infect Dis 52:1332-41. 2011
    ....
  32. ncbi request reprint Coliform contamination of vegetables obtained from popular restaurants in Guadalajara, Mexico, and Houston, Texas
    Hoonmo L Koo
    Baylor College of Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA
    Clin Infect Dis 47:218-21. 2008
    ..Contamination of vegetables in Guadalajara restaurants was widespread. Prevention of traveler's diarrhea by avoidance of "high-risk" foods may be unsuccessful, because contamination of foods may occur regardless of how they are prepared...
  33. pmc Rate of occurrence and pathogenic effect of enteroaggregative Escherichia coli virulence factors in international travelers
    Zhi Dong Jiang
    The University of Texas Health Science Center School of Public Health, Houston, Texas 77030, USA
    J Clin Microbiol 40:4185-90. 2002
    ..The different patterns of virulence factors of EAEC revealed several clusters demonstrating diversity among the isolates from the various regions...
  34. pmc Clostridium difficile infection: update on emerging antibiotic treatment options and antibiotic resistance
    Dhara Shah
    University of Houston College of Pharmacy, 1441 Moursund Street, Houston, TX 77030, USA
    Expert Rev Anti Infect Ther 8:555-64. 2010
    ..This review will focus primarily on scientific studies published in the last 36 months in order to provide an up-to-date review on the topic...
  35. pmc PCR-based assay using occult blood detection cards for detection of diarrheagenic Escherichia coli in specimens from U.S. travelers to Mexico with acute diarrhea
    Kevin A Grimes
    Division of Infectious Diseases, The University of Texas Medical School, Houston, Texas, USA
    J Clin Microbiol 46:2227-30. 2008
    ..DNA extracted from fecal cards that was used for the detection of occult blood is of use in identifying diarrheagenic E. coli...
  36. ncbi request reprint Improvement in detection of enterotoxigenic Escherichia coli in patients with travelers' diarrhea by increasing the number of E. coli colonies tested
    Thushara Galbadage
    The University of Texas School of Public Health at Houston, Houston, TX 77225, USA
    Am J Trop Med Hyg 80:20-3. 2009
    ..0%), 37 (31.9%), 45 (38.8%) and 46 (39.7%), respectively. Based on our results, we recommend the testing of at least 10 E. coli colonies for optimum detection of ETEC in patients with TD...
  37. doi request reprint A randomized, double-blind, placebo-controlled pilot study to assess the ability of rifaximin to prevent recurrent diarrhoea in patients with Clostridium difficile infection
    Kevin W Garey
    University of Houston College of Pharmacy, Houston, TX 77030, USA
    J Antimicrob Chemother 66:2850-5. 2011
    ..The purpose of this study was to assess rates of recurrent diarrhoea in patients with CDI given rifaximin versus placebo immediately after standard therapy...
  38. doi request reprint Rifaximin-induced alteration of virulence of diarrhoea-producing Escherichia coli and Shigella sonnei
    Zhi Dong Jiang
    Center for Infectious Diseases, The University of Texas School of Public Health, 1200 Herman Pressler, Room 706, Houston, TX 77030, USA
    Int J Antimicrob Agents 35:278-81. 2010
    ..At subinhibitory concentrations, rifaximin alters the virulence of ETEC, EAEC and S. sonnei isolates. These findings help explain the efficacy of rifaximin despite minimal alteration of colonic flora...
  39. doi request reprint Enterotoxigenic Escherichia coli and diffusely adherent E. coli as likely causes of a proportion of pathogen-negative travelers' diarrhea--a PCR-based study
    Ismail M Meraz
    School of Public Health, University of Texas, Houston, TX 77030, USA
    J Travel Med 15:412-8. 2008
    ..Enteropathogens cannot be identified in 40% to 50% of subjects with travelers' diarrhea (TD)...
  40. ncbi request reprint Travellers' diarrhoea: contemporary approaches to therapy and prevention
    Herbert L DuPont
    University of Texas Houston School of Public Health and Medical School, St Luke s Episcopal Hospital and Baylor College of Medicine, Houston, Texas, USA
    Drugs 66:303-14. 2006
    ..Vaccines and immunoprophylactic products may be beneficial for prevention of a subset of individuals otherwise developing diarrhoea...
  41. ncbi request reprint Antibacterial chemoprophylaxis in the prevention of traveler's diarrhea: evaluation of poorly absorbed oral rifaximin
    Herbert L DuPont
    Houston School of Public Health, Houston, TX, USA
    Clin Infect Dis 41:S571-6. 2005
    ....
  42. doi request reprint A randomized, double-blind, pilot study of rifaximin 550 mg versus placebo in the prevention of travelers' diarrhea in Mexico during the dry season
    Jose Flores
    Center for Infectious Diseases, School of Public Health, The University of Texas Health Science Center at Houston, TX, USA
    J Travel Med 18:333-6. 2011
    ..Rifaximin has been shown to be effective in treating and preventing travelers' diarrhea (TD) during the summer season...
  43. ncbi request reprint Rifaximin: a novel nonabsorbed rifamycin for gastrointestinal disorders
    Javier A Adachi
    Department of Infectious Diseases, Infection Control and Employee Health, MD Anderson Cancer Center, Houston, TX 77030, USA
    Clin Infect Dis 42:541-7. 2006
    ..Additional studies should be performed to further define the role of rifaximin in the treatment of gastrointestinal diseases in adults and children...
  44. ncbi request reprint Rifaximin treatment of pathogen-negative travelers' diarrhea
    Herbert L DuPont
    Center for Infectious Diseases, Houston School of Public Health, The University of Texas, Houston, TX, USA
    J Travel Med 14:16-9. 2007
    ..Antibacterial drugs appear to be effective in shortening the illness of a majority of cases of travelers' diarrhea...
  45. ncbi request reprint Enterotoxigenic Escherichia coli as cause of diarrhea among Mexican adults and US travelers in Mexico
    Alain R Bouckenooghe
    Veterans Affairs Medical Center, Baylor College of Medicine, and University of Texas Medical School and School of Public Health, Houston, Texas, USA
    J Travel Med 9:137-40. 2002
    ..There have been few recent studies looking at the etiology of diarrhea in travelers compared with the local resident population...
  46. ncbi request reprint Prevalence of diarrhea at a university hospital and association with modifiable risk factors
    Kevin W Garey
    College of Pharmacy, Department of Clinical Sciences and Administration, University of Houston, and St Luke s Episcopal Hospital, TX 77030, USA
    Ann Pharmacother 40:1030-4. 2006
    ..To assess the prevalence of diarrhea at a university-affiliated medical center and the presence of modifiable risk factors...
  47. doi request reprint Rifaximin: a nonsystemic rifamycin antibiotic for gastrointestinal infections
    Jessica Cottreau
    University of Houston College of Pharmacy, 1441 Moursund Street, Houston, TX 77030, USA
    Expert Rev Anti Infect Ther 8:747-60. 2010
    ..Finally, clinical trials with rifaximin for nonsystemic gastrointestinal indications will be updated...
  48. pmc In vitro antimicrobial susceptibility of bacterial enteropathogens isolated from international travelers to Mexico, Guatemala, and India from 2006 to 2008
    Jeannette Ouyang-Latimer
    Baylor College of Medicine, Houston, Texas, USA
    Antimicrob Agents Chemother 55:874-8. 2011
    ..There were no significant changes in rifaximin MICs. Rising MICs over time imply the need for continuous surveillance of susceptibility patterns worldwide and geographically specific recommendations in TD therapy...
  49. ncbi request reprint A common polymorphism in the interleukin 8 gene promoter is associated with Clostridium difficile diarrhea
    Zhi Dong Jiang
    The University of Texas School of Public Health, USA
    Am J Gastroenterol 101:1112-6. 2006
    ..We hypothesized that like other inflammatory mucosal infections, susceptibility to CDD would relate to genetically determined variations in the production of IL-8...
  50. pmc Harnessing the glucosyltransferase activities of Clostridium difficile for functional studies of toxins A and B
    Charles Darkoh
    The University of Texas School of Public Health, Center for Infectious Diseases, 1200 Herman Pressler, Suite 733, Houston, TX 77030, USA
    J Clin Microbiol 49:2933-41. 2011
    ..Our results demonstrate that this new assay is comparable to the current commercial ELISA for detecting the toxins in the samples tested and has the added advantage of quantitating toxin activity...
  51. pmc A nosocomial outbreak of norovirus infection masquerading as clostridium difficile infection
    Hoonmo L Koo
    Baylor College of Medicine, University of Texas Houston School of Public Health, Houston, Texas, USA
    Clin Infect Dis 48:e75-7. 2009
    ..We describe here the unique challenges of the identification of NoVs as the true etiologic pathogen in an outbreak occurring in a health care setting, where C. difficile infection is endemic, as well as the important lessons learned...
  52. ncbi request reprint Enteroaggregative Escherichia coli diarrhea in travelers: response to rifaximin therapy
    Rosa M Infante
    Center for Infectious Diseases, The University of Texas Houston School of Public Health and Medical School, Houston, Texas, USA
    Clin Gastroenterol Hepatol 2:135-8. 2004
    ..We have recently shown that enteroaggregative Escherichia coli (EAEC) strains commonly cause travelers' diarrhea. The study was designed to determine whether U.S. travelers with EAEC diarrhea responded to rifaximin therapy...
  53. doi request reprint Rifaximin: a unique gastrointestinal-selective antibiotic for enteric diseases
    Hoonmo L Koo
    Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Opin Gastroenterol 26:17-25. 2010
    ..We review the unique pharmaceutical properties of this antibiotic and the published evidence in the literature regarding the use of rifaximin for different gastrointestinal disorders...
  54. pmc Interleukin-8 response in an intestinal HCT-8 cell line infected with enteroaggregative and enterotoxigenic Escherichia coli
    David B Huang
    University of Texas Health Science Center, Houston Medical School, 6431 Fannin, JFB 1 728, Houston, TX 77030, USA
    Clin Diagn Lab Immunol 11:548-51. 2004
    ....
  55. ncbi request reprint Post-diarrhea chronic intestinal symptoms and irritable bowel syndrome in North American travelers to Mexico
    Pablo C Okhuysen
    Division of Infectious Diseases, Medical School, The University of Texas Health Science Center at Houston, 6431 Fannin, JFB 1 728, Houston, TX 77096, USA
    Am J Gastroenterol 99:1774-8. 2004
    ..Because of the frequency of international travel and the common occurrence of bacterial diarrhea, we studied the occurrence of chronic gastrointestinal complaints and post-diarrhea IBS in North U.S. travelers to Mexico...
  56. ncbi request reprint Association of virulence factor-positive and -negative enteroaggregative Escherichia coli and occurrence of clinical illness in travelers from the United States to Mexico
    David B Huang
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Trop Med Hyg 69:506-8. 2003
    ..Our study suggests that clinical illness by EAEC is not explained by presence of a defined EAEC virulence factors, and we provide suggestive evidence that EAEC infection protects against future symptomatic infection...
  57. ncbi request reprint Enteroaggregative Escherichia coli: an emerging enteric pathogen
    David B Huang
    Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Am J Gastroenterol 99:383-9. 2004
    ..The objective of this review is to increase awareness of this important emerging pathogen and to discuss the epidemiology, pathogenesis, and host-pathogen factors associated with EAEC infection...
  58. ncbi request reprint Enteric pathogens in Mexican sauces of popular restaurants in Guadalajara, Mexico, and Houston, Texas
    Javier A Adachi
    University of Texas, St Luke s Episcopal Hospital, and Baylor College of Medicine, Houston, Texas 77030, USA
    Ann Intern Med 136:884-7. 2002
    ..The transmission of traveler's diarrhea is primarily foodborne...
  59. ncbi request reprint Natural history of enteroaggregative and enterotoxigenic Escherichia coli infection among US travelers to Guadalajara, Mexico
    Javier A Adachi
    Center for Infectious Diseases, Medical School and School of Public Health, University of Texas Houston, Houston, TX, USA
    J Infect Dis 185:1681-3. 2002
    ..Symptomatic EAEC infection occurred early after arrival in Guadalajara, Mexico, and was as common as ETEC infection. Asymptomatic EAEC infection was recurrent...
  60. ncbi request reprint Genetic susceptibility to enteroaggregative Escherichia coli diarrhea: polymorphism in the interleukin-8 promotor region
    Zhi Dong Jiang
    University of Texas School of Public Health, Houston, Texas, USA
    J Infect Dis 188:506-11. 2003
    ..0053). In the present study, the AA genotype at the -251 position was associated with the occurrence of EAEC-associated diarrhea and increased levels of fecal IL-8...
  61. ncbi request reprint The role of diet in the treatment of travelers' diarrhea: a pilot study
    David B Huang
    Center for Infectious Diseases, School of Public Health, University of Texas at Houston, Houston, TX 77030, USA
    Clin Infect Dis 39:468-71. 2004
    ..However, a much higher number of subjects would need to be studied to prove this point statistically...
  62. ncbi request reprint Azithromycin found to be comparable to levofloxacin for the treatment of US travelers with acute diarrhea acquired in Mexico
    Javier A Adachi
    Center for Infectious Diseases, University of Texas Houston School of Public Health and Medical School, Houston, Texas, USA
    Clin Infect Dis 37:1165-71. 2003
    ..Azithromycin was found to be a safe and effective alternative to levofloxacin for the treatment of acute travelers' diarrhea in US adult travelers to Mexico...
  63. ncbi request reprint United States male students who heavily consume alcohol in Mexico are at greater risk of travelers' diarrhea than their female counterparts
    David B Huang
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    J Travel Med 11:143-5. 2004
    ..The relationship between alcohol consumption and travelers' diarrhea has not been well studied...
  64. doi request reprint Rifamycin antibiotics for treatment of Clostridium difficile-associated diarrhea
    Kevin W Garey
    Department of Clinical Sciences and Administration, College of Pharmacy, University of Houston, Houston, TX 77030, USA
    Ann Pharmacother 42:827-35. 2008
    ..To review the existing data on use of the rifamycin class of antibiotics as therapy for Clostridium difficile-associated diarrhea (CDAD)...
  65. ncbi request reprint Peripartum Clostridium difficile infection: case series and review of the literature
    Kevin W Garey
    Texas Medical Center, University of Houston College of Pharmacy, Houston, TX 77030, USA
    Am J Obstet Gynecol 199:332-7. 2008
    ..Further research into the scope and risk factors for peripartum CDI is warranted...
  66. doi request reprint The intestinal microbiota and chronic disorders of the gut
    Andrew W Dupont
    University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77030, USA andrew dupont uth tmc edu
    Nat Rev Gastroenterol Hepatol 8:523-31. 2011
    ..This Review provides a broad overview of the importance of the intestinal microbiota in chronic disorders of the gut...
  67. ncbi request reprint Current and future developments in travelers' diarrhea therapy
    Hoonmo L Koo
    Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Expert Rev Anti Infect Ther 4:417-27. 2006
    ..Antibacterial drugs will continue to be the optimal treatment for travelers' diarrhea subjects for the most part caused by bacterial enteropathogens and shorten the duration of diarrhea by 1-2 days compared with no active drug treatment...
  68. pmc Pilot study of whole-blood gamma interferon response to the Vibrio cholerae toxin B subunit and resistance to enterotoxigenic Escherichia coli-associated diarrhea
    Jose Flores
    Center for Infectious Diseases, School of Public Health, University of Texas at Houston, Houston, Texas, USA
    Clin Vaccine Immunol 17:879-81. 2010
    ..Markers of the cellular immune response to ETEC LT could help in identifying individuals immune to ETEC LT, and these markers deserve additional study...
  69. pmc Future novel therapeutic agents for Clostridium difficile infection
    Hoonmo L Koo
    Baylor College of Medicine, Internal Medicine, Houston, TX 77030, USA
    Expert Opin Investig Drugs 19:825-36. 2010
    ....
  70. pmc Noroviruses: The leading cause of gastroenteritis worldwide
    Hoonmo L Koo
    Baylor College of Medicine, Houston, Texas, USA
    Discov Med 10:61-70. 2010
    ..However, vaccines based on norovirus capsid protein virus-like particles are promising and may one day become widely available through transgenic expression in plants...
  71. ncbi request reprint Therapy for and prevention of traveler's diarrhea
    Herbert L DuPont
    Center for Infectious Diseases, University of Texas Houston School of Public Health, Houston, TX, USA
    Clin Infect Dis 45:S78-84. 2007
    ..Further study is needed to determine whether it is possible to avoid important morbidity associated with diarrhea and the development of postinfectious irritable bowel syndrome with chemoprophylaxis and/or early effective treatment...
  72. ncbi request reprint Rifaximin--a novel antimicrobial for enteric infections
    David B Huang
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    J Infect 50:97-106. 2005
    ....
  73. ncbi request reprint Markers of inflammation in bacterial diarrhea among travelers, with a focus on enteroaggregative Escherichia coli pathogenicity
    David E Greenberg
    Baylor College of Medicine, Houston, Texas, USA
    J Infect Dis 185:944-9. 2002
    ..Bacterial pathogens causing traveler's diarrhea commonly produce intestinal inflammation, although a subset of patients with EAEC-associated diarrhea fail to develop an inflammatory response...
  74. ncbi request reprint Epidemiology and incidence of Clostridium difficile-associated diarrhoea diagnosed upon admission to a university hospital
    M F Price
    St Luke s Episcopal Hospital, Houston, TX, USA
    J Hosp Infect 65:42-6. 2007
    ..Admitting physicians should consider C. difficile in the differential diagnosis of patients admitted with diarrhoea, with or without a history of admission to healthcare facilities...
  75. pmc Characterization of norovirus-associated traveler's diarrhea
    N Ajami
    Department of Molecular Virology and Microbiology and Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Clin Infect Dis 51:123-30. 2010
    ..Sequences were compared using multiple sequence alignment, and phylogenetic trees were generated to evaluate the evolutionary relatedness of the viral strains associated with cases of traveler's diarrhea...
  76. ncbi request reprint Markers of enteric inflammation in enteroaggregative Escherichia coli diarrhea in travelers
    A R Bouckenooghe
    Division of Infectious Disease, Baylor College of Medicine, Houston, Texas, USA
    Am J Trop Med Hyg 62:711-3. 2000
    ..The study provides evidence that EAEC infection is associated with an intestinal inflammatory response...
  77. ncbi request reprint Enteroaggregative Escherichia coli as a major etiologic agent in traveler's diarrhea in 3 regions of the world
    J A Adachi
    Center for Infectious Diseases, University of Texas-Houston Medical School and School of Public Health, Houston, TX, USA
    Clin Infect Dis 32:1706-9. 2001
    ..EAEC was a major cause of traveler's diarrhea in 3 geographically distinct study areas...
  78. ncbi request reprint Intestinal immunoglobulin a response to naturally acquired enterotoxigenic Escherichia coli in US travelers to an endemic area of Mexico
    M T Estrada-Garcia
    Center of Infectious Diseases, The University of Texas School of Public Health, Houston, Texas, USA
    J Travel Med 9:247-50. 2002
    ..Simple methods for detecting secretory immunoglobulin A (sIgA) immune responses following natural enteric infection and oral immunization are needed...
  79. doi request reprint Patterns of illness in travelers visiting Mexico and Central America: the GeoSentinel experience
    Jose Flores-Figueroa
    Center for Infectious Diseases, School of Public Health, Houston, Texas, USA
    Clin Infect Dis 53:523-31. 2011
    ..Mexico and Central America are important travel destinations for North American and European travelers. There is limited information on regional differences in travel related morbidity...
  80. doi request reprint Antimotility agents for the treatment of Clostridium difficile diarrhea and colitis
    Hoonmo L Koo
    Department of Medicine, Division of Infectious Diseases, Baylor College of Medicine, Houston, TX 77030, USA
    Clin Infect Dis 48:598-605. 2009
    ..Further study of the role of antimotility agents in providing symptomatic relief and reducing environmental contamination with infectious stool may be warranted...
  81. pmc Microbial etiology of travelers' diarrhea in Mexico, Guatemala, and India: importance of enterotoxigenic Bacteroides fragilis and Arcobacter species
    Zhi Dong Jiang
    Center for Infectious Diseases, University of Texas School of Public Health, 1200 Herman Pressler Room 741, Houston, TX 77030, USA
    J Clin Microbiol 48:1417-9. 2010
    ..S. and European travelers with acute diarrhea acquired in Mexico, Guatemala, and India. Arcobacter butzleri and ETBF were detected in 8% and 7% of diarrhea cases, respectively...
  82. doi request reprint Strongyloides hyperinfection syndrome: an emerging global infectious disease
    Luis A Marcos
    Internal Medicine Department, University of Texas Health Science, 6431 Fannin Street, Suite 1 150, Houston, TX 77030, USA
    Trans R Soc Trop Med Hyg 102:314-8. 2008
    ..HS is an example of an emerging tropical infection migrating to developed countries and requiring greater clinician awareness...
  83. ncbi request reprint Rifaximin in the treatment of infectious diarrhea
    Charles D Ericsson
    Department of Internal Medicine and Division of Infectious Diseases, University of Texas Houston Medical School, Houston, TX 77030, USA
    Chemotherapy 51:73-80. 2005
    ..Uses limited to enteric indications and its inherently low propensity to induce sustainable resistance among Gram-negative flora favor the sustained usefulness of rifaximin in the treatment of enteric infectious syndromes...
  84. ncbi request reprint Travelers' diarrhea: antimicrobial therapy and chemoprevention
    Herbert L DuPont
    St Luke s Episcopal Hospital, Houston, Texas, USA
    Nat Clin Pract Gastroenterol Hepatol 2:191-8; quiz 1 p following 198. 2005
    ..In the future, the ability to evaluate the genetic risk of illness acquisition might allow person-specific recommendations to be made...
  85. ncbi request reprint Rifaximin: a nonabsorbable rifamycin antibiotic for use in nonsystemic gastrointestinal infections
    Laura Gerard
    University of Houston College of Pharmacy, TX 77030, USA
    Expert Rev Anti Infect Ther 3:201-11. 2005
    ..Importantly, rifaximin does not appear to lead to bacterial resistance. Rifaximin has an excellent safety profile and adverse drug reactions have been comparable to those associated with the placebo control agent...
  86. ncbi request reprint Prevalence of enteric pathogens among international travelers with diarrhea acquired in Kenya (Mombasa), India (Goa), or Jamaica (Montego Bay)
    Zhi Dong Jiang
    Center for Infectious Diseases, University of Texas Houston School of Public Health, Houston, TX 77030, USA
    J Infect Dis 185:497-502. 2002
    ..Quinolones were active against the bacterial enteropathogens in the 3 sites...
  87. ncbi request reprint Problem pathogens: extra-intestinal complications of Salmonella enterica serotype Typhi infection
    David B Huang
    Center for Infectious Diseases, Baylor College of Medicine, Houston, Texas 77030, USA
    Lancet Infect Dis 5:341-8. 2005
    ..We describe the epidemiology, clinical manifestations, pathogenesis, and treatment of extra-intestinal S typhi infections...
  88. pmc Pretreatment of epithelial cells with rifaximin alters bacterial attachment and internalization profiles
    Eric L Brown
    The University of Texas School of Public Health, 1200 Herman Pressler, Houston, TX 77030, USA
    Antimicrob Agents Chemother 54:388-96. 2010
    ..The study provides evidence that rifaximin-mediated changes in epithelial cell physiology are associated with changes in bacterial attachment/internalization and reduced inflammatory cytokine release...
  89. ncbi request reprint In vitro susceptibility of Clostridium difficile to rifaximin and rifampin in 359 consecutive isolates at a university hospital in Houston, Texas
    Z D Jiang
    Center for Infectious Disease, University of Texas School of Public Health, Houston, Texas 77030, USA
    J Clin Pathol 63:355-8. 2010
    ..This was an in vitro study to analyse the susceptibility of Clostridium difficile isolates to rifampin and rifaximin...
  90. ncbi request reprint Rifaximin: in vitro and in vivo antibacterial activity--a review
    Z D Jiang
    Center for Infectious Diseases, University of Texas Houston School of Public Health, Houston, TX 77030, USA
    Chemotherapy 51:67-72. 2005
    ..The available data suggest that rifaximin is active in vitro and in vivo in the treatment of bacterial infection of adults and children...
  91. ncbi request reprint Influence of rifaximin treatment on the susceptibility of intestinal Gram-negative flora and enterococci
    H L DuPont
    University of Texas, Houston School of Public Health, Houston, TX 77030, USA
    Clin Microbiol Infect 10:1009-11. 2004
    ..Enterococci recovered pre- and post-treatment showed similar susceptibilities. Rifaximin did not select for significant resistance in the Gram-negative and Gram-positive intestinal flora during therapy...
  92. ncbi request reprint Etiology of travelers' diarrhea on a Caribbean island
    P Paredes
    Center for Infectious Diseases, The University of Texas Houston, Houston, Texas, USA
    J Travel Med 7:15-8. 2000
    ..In the Jamaican hotels with all inclusive meal packages most diarrhea cases occurred as small clusters, presumably as the result of foodborne outbreaks...
  93. pmc Susceptibility and serologic response of healthy adults to reinfection with Cryptosporidium parvum
    P C Okhuysen
    Division of Infectious Diseases, The University of Texas Medical School and Center for Infectious Diseases, Houston 77030, USA
    Infect Immun 66:441-3. 1998
    ..62; P < 0.05). The number of anti-Cryptosporidium immunoglobulin G and A seroconversions increased after secondary exposure. However, the C. parvum serum antibody response did not correlate with the presence or absence of infection...
  94. ncbi request reprint Characterization of enterotoxigenic Escherichia coli strains in patients with travelers' diarrhea acquired in Guadalajara, Mexico, 1992-1997
    Z D Jiang
    Center for Infectious Diseases, University of Texas Houston, School of Public Health, Houston, TX 77030, USA
    J Infect Dis 181:779-82. 2000
    ..The finding that differences in the results of ribotyping and plasmid analysis change over time suggests that multiple strains of ETEC were responsible for the illness in the region studied...
  95. ncbi request reprint Interferon-gamma expression in jejunal biopsies in experimental human cryptosporidiosis correlates with prior sensitization and control of oocyst excretion
    A C White
    Infectious Diseases Section, Dept of Medicine, Baylor College of Medicine, Houston, TX 77030
    J Infect Dis 181:701-9. 2000
    ..IFN-gamma production may explain the resistance to infection noted in sensitized persons but may not be involved in control of human primary infection...
  96. ncbi request reprint Virulence of three distinct Cryptosporidium parvum isolates for healthy adults
    P C Okhuysen
    Division of Infectious Diseases, The University of Texas Medical School, Houston, Texas 77030, USA
    J Infect Dis 180:1275-81. 1999
    ..A trend toward a longer duration of diarrhea was seen for the TAMU (94.5 h) versus UCP (81.6 h) and Iowa (64.2 h) isolates. C. parvum isolates of the C genotype differ in their infectivity for humans...
  97. pmc HEp-2 cell-adherent Escherichia coli and intestinal secretory immune response to human immunodeficiency virus (HIV) in outpatients with HIV-associated diarrhea
    J J Mathewson
    Center for Infectious Diseases, The University of Texas School of Public Health and Medical School, Houston 77030, USA
    Clin Diagn Lab Immunol 5:87-90. 1998
    ..4%), Giardia spp. (1.2%), Salmonella spp. (1.2%), and Mycobacterium spp. (1.2%). The role of HEp-2 cell-adherent E. coli and HIV enteric infections in patients with HIV-associated diarrhea deserves further study...
  98. ncbi request reprint Rifaximin: a nonabsorbed antimicrobial in the therapy of travelers' diarrhea
    H L DuPont
    St Luke s Episcopal Hospital, University of Texas Houston, Tex, USA
    Digestion 59:708-14. 1998
    ..Bacterial enteropathogens, the major cause of travelers' diarrhea, are customarily treated with antibacterial drugs. Rifaximin, a nonabsorbed antimicrobial was examined as treatment for travelers' diarrhea...
  99. ncbi request reprint Impact of breast-feeding on Giardia lamblia infections in Bilbeis, Egypt
    M A Mahmud
    University of Texas School of Public Health, Houston, USA
    Am J Trop Med Hyg 65:257-60. 2001
    ..9%, P < 0.05) compared with infants who were not exclusively breast-fed. Breast-feeding should be considered as an effective means to prevent Giardia infections and should be encouraged in regions where G. lambia is highly endemic...
  100. doi request reprint Meta-analysis to assess risk factors for recurrent Clostridium difficile infection
    K W Garey
    University of Houston College of Pharmacy, Houston, TX 77030, USA
    J Hosp Infect 70:298-304. 2008
    ..Significant prognostic risk factors were identified as risk factors for CDI recurrence. Additional or novel interventions may be required for these patients to prevent CDI recurrence...
  101. ncbi request reprint Automated system to identify Clostridium difficile infection among hospitalised patients
    Y Yadav
    University of Texas School of Public Health, Houston, Texas, USA
    J Hosp Infect 72:337-41. 2009
    ..Using an electronic data capture technique, number of days of diarrhoea and maximum number of diarrhoea stools in a 24h time period were able to identify a patient population at high risk for CDI...