Jing Fei Dong

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Synthesis, assembly, and intracellular transport of the platelet glycoprotein Ib-IX-V complex
    J F Dong
    Division of Hematology Oncology, Departments of Internal Medicine, Baylor College of Medicine and Veterans Affairs Medical Center, Houston, Texas 77030, USA
    J Biol Chem 273:31449-54. 1998
  2. doi request reprint Magnesium maintains endothelial integrity, up-regulates proteolysis of ultra-large von Willebrand factor, and reduces platelet aggregation under flow conditions
    Jing Fei Dong
    Section of Thrombosis Research, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Thromb Haemost 99:586-93. 2008
  3. ncbi request reprint ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor
    Jing Fei Dong
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:29633-9. 2003
  4. ncbi request reprint ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions
    Jing Fei Dong
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Blood 100:4033-9. 2002
  5. ncbi request reprint Structural and functional correlation of ADAMTS13
    Jing Fei Dong
    Thrombosis Research Section, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Opin Hematol 14:270-6. 2007
  6. ncbi request reprint Ristocetin-dependent, but not botrocetin-dependent, binding of von Willebrand factor to the platelet glycoprotein Ib-IX-V complex correlates with shear-dependent interactions
    J F Dong
    Departments of Medicine and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Blood 97:162-8. 2001
  7. ncbi request reprint Cleavage of ultra-large von Willebrand factor by ADAMTS-13 under flow conditions
    J F Dong
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Thromb Haemost 3:1710-6. 2005
  8. ncbi request reprint Mutation in the leucine-rich repeat of platelet glycoprotein Ib alpha results in defects in its interaction with immobilized von Willebrand factor under flow
    J Dong
    Division of Hematology Oncology, Department of Internal Medicine, Baylor College of Medicine, Veterans Affairs Medical Center, Houston, TX, USA
    Chin Med J (Engl) 113:693-8. 2000
  9. ncbi request reprint Potential role of activated platelets in homing of human endothelial progenitor cells to subendothelial matrix
    Eli I Lev
    The Methodist Hospital Research Institute and The Methodist DeBakey Heart Center, Houston, TX, USA
    Thromb Haemost 96:498-504. 2006
  10. ncbi request reprint Measurement of the binding forces between von Willebrand factor and variants of platelet glycoprotein Ibalpha using optical tweezers
    Maneesh Arya
    Department of Bioengineering, Rice University, Houston, Texas 77005, USA
    Lasers Surg Med 30:306-12. 2002

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Synthesis, assembly, and intracellular transport of the platelet glycoprotein Ib-IX-V complex
    J F Dong
    Division of Hematology Oncology, Departments of Internal Medicine, Baylor College of Medicine and Veterans Affairs Medical Center, Houston, Texas 77030, USA
    J Biol Chem 273:31449-54. 1998
    ....
  2. doi request reprint Magnesium maintains endothelial integrity, up-regulates proteolysis of ultra-large von Willebrand factor, and reduces platelet aggregation under flow conditions
    Jing Fei Dong
    Section of Thrombosis Research, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Thromb Haemost 99:586-93. 2008
    ..MgSO(4) is critical for maintaining endothelial integrity and regulates ULVWF proteolysis and aggregation under flow conditions. These results provide a new insight into additional mechanisms involved with magnesium therapy...
  3. ncbi request reprint ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor
    Jing Fei Dong
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:29633-9. 2003
    ..Once released, these cleaved VWF fragments become inaccessible for the metalloprotease to prevent further cleavage...
  4. ncbi request reprint ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions
    Jing Fei Dong
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Blood 100:4033-9. 2002
    ..These results suggest that cleavage of EC-derived ULVWF multimers by ADAMTS-13 is a rapid physiologic process that occurs on endothelial cell surfaces...
  5. ncbi request reprint Structural and functional correlation of ADAMTS13
    Jing Fei Dong
    Thrombosis Research Section, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Opin Hematol 14:270-6. 2007
    ..Thrombotic thrombocytopenic purpura exemplifies how von Willebrand factor can be responsible for life-threatening thrombosis. This review summarizes recent progress on ADAMTS13, which prevents this deadly event...
  6. ncbi request reprint Ristocetin-dependent, but not botrocetin-dependent, binding of von Willebrand factor to the platelet glycoprotein Ib-IX-V complex correlates with shear-dependent interactions
    J F Dong
    Departments of Medicine and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Blood 97:162-8. 2001
    ....
  7. ncbi request reprint Cleavage of ultra-large von Willebrand factor by ADAMTS-13 under flow conditions
    J F Dong
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Thromb Haemost 3:1710-6. 2005
    ..Dissecting the process of ULVWF proteolysis is important for not only understanding the pathophysiology of thrombotic microangiopathies, but also developing more effective means to treat these deadly diseases...
  8. ncbi request reprint Mutation in the leucine-rich repeat of platelet glycoprotein Ib alpha results in defects in its interaction with immobilized von Willebrand factor under flow
    J Dong
    Division of Hematology Oncology, Department of Internal Medicine, Baylor College of Medicine, Veterans Affairs Medical Center, Houston, TX, USA
    Chin Med J (Engl) 113:693-8. 2000
    ..To characterize effects of the GP Ib alpha mutation (A156V) on its interaction with von Willebrand factor (vWf) under high fluid shear stress...
  9. ncbi request reprint Potential role of activated platelets in homing of human endothelial progenitor cells to subendothelial matrix
    Eli I Lev
    The Methodist Hospital Research Institute and The Methodist DeBakey Heart Center, Houston, TX, USA
    Thromb Haemost 96:498-504. 2006
    ..This interaction may be a central mechanism for homing of EPCs to vascular injury sites...
  10. ncbi request reprint Measurement of the binding forces between von Willebrand factor and variants of platelet glycoprotein Ibalpha using optical tweezers
    Maneesh Arya
    Department of Bioengineering, Rice University, Houston, Texas 77005, USA
    Lasers Surg Med 30:306-12. 2002
    ..The adhesion of different leucine-rich repeats was studied using optical tweezers in order to determine which ones were critical for the vWf/GP Ibalpha interaction...
  11. ncbi request reprint Effects of low temperature on shear-induced platelet aggregation and activation
    Jian ning Zhang
    Section of Thrombosis Research, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Trauma 57:216-23. 2004
    ....
  12. ncbi request reprint Cytoplasmic truncation of glycoprotein Ib alpha weakens its interaction with von Willebrand factor and impairs cell adhesion
    Alicia J Schade
    Cox Laboratory for Biomedical Engineering, Rice University, Houston, Texas 77030, USA
    Biochemistry 42:2245-51. 2003
    ..Studies measuring the GP Ibalpha-VWF bond strength of three of the mutants using laser tweezers showed that progressive deletion of the cytoplasmic domain led to progressive weakening of the strength of individual GP Ibalpha-VWF bonds...
  13. ncbi request reprint Enhanced platelet adhesion and aggregation by endothelial cell-derived unusually large multimers of von Willebrand factor
    R Anand Kumar
    Department of Bioengineering, Rice University, Houston, TX, USA
    Biorheology 43:681-91. 2006
    ..ULVWF is also significantly more potent than P-VWF in mediating both shear-induced platelet aggregation and ristocetin-mediated platelet agglutination...
  14. ncbi request reprint Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex: studies using optical tweezers
    Maneesh Arya
    Department of Bioengineering, Rice University, Houston, TX, USA
    Blood 99:3971-7. 2002
    ..Therefore, we suggest that the conformational state of ULVWF multimers is more critical than their size for interaction with platelets...
  15. ncbi request reprint The mucin-like macroglycopeptide region of glycoprotein Ibalpha is required for cell adhesion to immobilized von Willebrand factor (VWF) under flow but not for static VWF binding
    Chester Q Li
    Division of Thrombosis Research Section, Department of Medicine, BCM 286, N1319, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Thromb Haemost 88:673-7. 2002
    ....
  16. ncbi request reprint P-selectin anchors newly released ultralarge von Willebrand factor multimers to the endothelial cell surface
    Arnoldo Padilla
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Blood 103:2150-6. 2004
    ..Finally, the strength of the minimal ULVWF-P-selectin bond was measured to be 7.2 pN. We, therefore, conclude that P-selectin may anchor ULVWF strings to endothelial cells and facilitate their cleavage by ADAMTS13...
  17. doi request reprint Increased platelet sensitivity among individuals with aspirin resistance - platelet aggregation to submaximal concentration of arachidonic acid predicts response to antiplatelet therapy
    Sasidhar Guthikonda
    Methodist DeBakey Heart Center, 6565 Fannin, F1090, Houston, TX 77030, USA
    Thromb Haemost 100:83-9. 2008
    ..04). In conclusion, platelets in AR subjects demonstrate increased basal sensitivity to submaximal stimulation, which could predict responses to antiplatelet therapy...
  18. pmc Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions
    Zhenyin Tao
    Thrombosis Research Section, Department of Medicine, BCM286, N1319, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Blood 106:4139-45. 2005
    ..These results suggest that the CUB-1 domain may serve as the docking site for ADAMTS13 to bind ULVWF under flow, a critical step to initiate ULVWF proteolysis...
  19. pmc Kinetics of GPIbalpha-vWF-A1 tether bond under flow: effect of GPIbalpha mutations on the association and dissociation rates
    R Anand Kumar
    Department of Bioengineering, Rice University, Houston, Texas, USA
    Biophys J 85:4099-109. 2003
    ..These findings are in contrast to the functionally similar selectin bonds where some of the mutations have been reported to affect only the dissociation rate...
  20. pmc Variability and persistence of aspirin response in lower extremity peripheral arterial disease patients
    Justin Saunders
    Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, Tex, USA
    J Vasc Surg 53:668-75. 2011
    ....
  21. ncbi request reprint Platelet aggregation and activation under complex patterns of shear stress
    Jian ning Zhang
    The Division of Thrombosis Research, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Thromb Haemost 88:817-21. 2002
    ..This process may function as a protective mechanism to prevent in vivo irreversible platelet activation and aggregation under temporary high shear...
  22. pmc Influence of single nucleotide polymorphisms in factor VIII and von Willebrand factor genes on plasma factor VIII activity: the ARIC Study
    Marco Campos
    Cardiovascular Sciences Section, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Blood 119:1929-34. 2012
    ..These data demonstrate that intronic SNPs could directly or indirectly influence intersubject variation of FVIII activity. Further investigation may reveal novel mechanisms of regulating FVIII expression and activity...
  23. ncbi request reprint Glutathione regulates integrin alpha(IIb)beta(3)-mediated cell adhesion under flow conditions
    Chalmette Ball
    Thrombosis Research Section, Department of Medicine, Medicine Baylor College of Medicine, BCM286, N1319 One Baylor Plaza, Houston, Texas 77030, USA
    Thromb Haemost 100:857-63. 2008
    ..They further suggest that the HPA phenotype may be redox-regulated...
  24. doi request reprint Platelet activation patterns in platelet size sub-populations: differential responses to aspirin in vitro
    Kiran Kumar R Mangalpally
    The Methodist Hospital Research Institute and The Methodist DeBakey Heart and Vascular Center, Houston, TX 77030, USA
    J Thromb Thrombolysis 30:251-62. 2010
    ..In conclusion, large platelets are more active than small platelets and aspirin fails to eliminate these differential activation properties...
  25. pmc Hemolytic uremic syndrome-associated Shiga toxins promote endothelial-cell secretion and impair ADAMTS13 cleavage of unusually large von Willebrand factor multimers
    Leticia H Nolasco
    Hematology Research Section, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Blood 106:4199-209. 2005
    ..These processes may contribute to the evolution of glomerular occlusion by platelet and fibrin thrombi in diarrhea-associated HUS...
  26. ncbi request reprint Gain of von Willebrand factor-binding function by mutagenesis of a species-conserved residue within the leucine-rich repeat region of platelet glycoprotein Ibalpha
    Yuandong Peng
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine N1317, One Baylor Plaza, Houston, TX 77030, USA
    Blood 106:1982-7. 2005
    ..Because His86 is 2 nm away from the region of GP Ibalpha with the largest surface of contact with VWF, the data suggest that the LRRs regulate GP Ibalpha affinity for VWF allosterically...
  27. pmc Cleavage of ultralarge multimers of von Willebrand factor by C-terminal-truncated mutants of ADAMTS-13 under flow
    Zhenyin Tao
    Thrombosis Research Section, Department of Medicine, BCM286, N1319, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Blood 106:141-3. 2005
    ..The wild type and the mutant without the spacer were more active in the presence of plasma, raising the possibility of ADAMTS-13 cofactors in plasma...
  28. ncbi request reprint Effects of inflammatory cytokines on the release and cleavage of the endothelial cell-derived ultralarge von Willebrand factor multimers under flow
    Aubrey Bernardo
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Blood 104:100-6. 2004
    ..The findings describe a potential linkage between inflammation and thrombosis that may be of therapeutic importance...
  29. doi request reprint A G-quartet oligonucleotide blocks glycoprotein Ib-mediated platelet adhesion and aggregation under flow conditions
    Zhou Zhou
    Section of Thrombosis Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Thromb Haemost 102:529-37. 2009
    ..It also blocked shear-induced platelet aggregation and thrombus formation on immobilised VWF under arterial shear stress. These results demonstrate that T30923 may have therapeutic potentials to regulate the GP Ibalpha-VWF interaction...
  30. ncbi request reprint Enhanced activation of mitogen-activated protein kinase and myosin light chain kinase by the Pro33 polymorphism of integrin beta 3
    K Vinod Vijayan
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:3860-7. 2003
    ..Post-integrin occupancy signaling through MAPK and MLCK after alpha(IIb)beta(3) cross-linking may explain in part the increased adhesive properties of the Pro(33) variant of integrin beta(3)...
  31. ncbi request reprint Duration of exposure to high fluid shear stress is critical in shear-induced platelet activation-aggregation
    Jian ning Zhang
    Section of Thrombosis Research, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Thromb Haemost 90:672-8. 2003
    ..In a pathologically relevant timeframe, high shear alone is likely to be insufficient in inducing platelet activation and aggregation, but acts synergistically with other stimuli...
  32. ncbi request reprint Shear-induced disulfide bond formation regulates adhesion activity of von Willebrand factor
    Hiuwan Choi
    Section of Thrombosis Research, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 282:35604-11. 2007
    ..These results suggest that the thiol-disulfide state may serve as an important structural determinant of VWF adhesion activity and can be modified by fluid shear stress...
  33. ncbi request reprint Evaluation of ADAMTS-13 activity in plasma using recombinant von Willebrand Factor A2 domain polypeptide as substrate
    Miguel A Cruz
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, N1319, Houston, Texas 77030, USA
    Thromb Haemost 90:1204-9. 2003
    ..This novel recombinant VWF-A2 protein has potential utility as matrix for a rapid clinical measurement of plasma ADAMTS-13 activity...
  34. ncbi request reprint Cleavage of von Willebrand factor by ADAMTS-13 on endothelial cells
    Jose A Lopez
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Semin Hematol 41:15-23. 2004
    ..We propose that attachment of newly released ULVWF to the endothelial cell surface facilitates its cleavage by ADAMTS-13 by allowing tensile force to be applied to the A2 domain, thereby exposing the ADAMTS-13 cleavage site...
  35. ncbi request reprint Haemoglobin blocks von Willebrand factor proteolysis by ADAMTS-13: a mechanism associated with sickle cell disease
    Zhou Zhou
    Thrombosis Research Section, Dept of Medicine, One Baylor Plaza, BCM286, N1319, Houston, Texas 77030, USA
    Thromb Haemost 101:1070-7. 2009
    ..Therefore, the Hb-VWF interaction may be considered as a therapeutic target for treating thrombotic and vaso-occlusive complications in patients with severe intravascular haemolysis such as those with SCD...
  36. ncbi request reprint Endotoxin enhances microvascular thrombosis in mouse cremaster venules via a TLR4-dependent, neutrophil-independent mechanism
    Rolando E Rumbaut
    Medical Care Line, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 290:H1671-9. 2006
    ..These findings support the notion that endotoxemia promotes platelet thrombus formation independent of neutrophils and without enhancement of platelet aggregation, via a TLR4-dependent mechanism...
  37. ncbi request reprint Acquired ADAMTS-13 deficiency in pediatric patients with severe sepsis
    Trung C Nguyen
    Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA
    Haematologica 92:121-4. 2007
    ..The deficiency may contribute to the development of thrombocytopenia and ischemic organ failure associated with sepsis...
  38. ncbi request reprint Platelet reactivity among Asian Indians and Caucasians
    Rajnikant T Patel
    Division of Cardiology, Baylor College of Medicine, Houston, TX, USA
    Platelets 18:261-5. 2007
    ..These differences indicate an increase in measures of platelet reactivity among Asian Indians and may help elucidate the reported disparity in cardiovascular disease rates between the two ethnic groups...
  39. doi request reprint Cysteine residues in CUB-1 domain are critical for ADAMTS13 secretion and stability
    Zhou Zhou
    Section of Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Thromb Haemost 105:21-30. 2011
    ..They also identify an ADAMTS-13 mutant that is resistant to proteolytic degradation, while maintaining a normal VWF-cleaving activity...
  40. pmc Localization of the adhesion receptor glycoprotein Ib-IX-V complex to lipid rafts is required for platelet adhesion and activation
    Corie N Shrimpton
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Exp Med 196:1057-66. 2002
    ..Thus, localization of the GP Ib-IX-V complex within rafts is crucial for both platelet adhesion and postadhesion signaling...
  41. ncbi request reprint Shear stress and the role of high molecular weight von Willebrand factor multimers in thrombus formation
    Jose A Lopez
    Baylor College of Medicine, Thrombosis Research Section, Houston, TX 77030, USA
    Blood Coagul Fibrinolysis 16:S11-6. 2005
    ..These studies have important implications in bleeding and thrombotic disorders, including von Willebrand disease and TTP...
  42. doi request reprint Flow cytometric measurement of microparticles: pitfalls and protocol modifications
    Mona D Shah
    Baylor College opf Medicine, Texas Children s Cancer Center and Hematology Service, Texas Children s Hospital, Houston, Texas 77030, USA
    Platelets 19:365-72. 2008
    ..These results illustrate the need to standardize assay protocols in order to obtain consistent measurements. Our studies further optimize sample preparation for microparticle detection...
  43. pmc Aggregometry detects platelet hyperreactivity in healthy individuals
    Donald L Yee
    Thrombosis Research Section, Baylor College of Medicine, One Baylor Plaza, BCM 286, N1319, Houston, TX 77030
    Blood 106:2723-9. 2005
    ..These include clinical studies to improve risk assessment for arterial thrombosis, as well as genetic studies to establish determinants of the hyperreactive platelet phenotype...
  44. pmc Mechanical activation of a multimeric adhesive protein through domain conformational change
    Sithara S Wijeratne
    Department of Physics and Astronomy, Rice University, Houston, Texas 77005, USA
    Phys Rev Lett 110:108102. 2013
    ..These results provide insight into the mechanism of shear-induced activation of PVWF multimers...
  45. ncbi request reprint Association of hypercoagulable states and increased platelet adhesion and aggregation with bacterial colonization of intravenous catheters
    Daniel Musher
    Medical Service, Veterans Affairs Medical Center, and Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    J Infect Dis 186:769-73. 2002
    ....
  46. doi request reprint Effects of naturally occurring mutations in CUB-1 domain on synthesis, stability, and activity of ADAMTS-13
    Zhou Zhou
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Thromb Res 124:323-7. 2009
    ..ADAMTS-13 fits in the consensus of the ADAMTS family metalloproteases, but also contains two unique C- terminal CUB domains. Studying mutations in CUB domains could provide insights into the functional role of these domains...
  47. doi request reprint Von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura
    Zhou Zhou
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Semin Thromb Hemost 36:71-81. 2010
    ..This review also discusses the potential for ADAMTS-13 as a therapeutic drug for thrombotic conditions other than TTP...
  48. ncbi request reprint Heterogeneous effects of tissue inhibitors of matrix metalloproteinases on cardiac fibroblasts
    Joshua D Lovelock
    Winters Center for Heart Failure Research, Michael E DeBakey Department of Veterans Affairs Medical Center, Houston, Texas 77030, USA
    Am J Physiol Heart Circ Physiol 288:H461-8. 2005
    ....
  49. pmc Differences in responses of platelets to fluid shear stress in patients with peripheral artery disease (PAD) and coronary artery disease (CAD)
    Vijay Nambi
    Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Platelets 20:199-205. 2009
    ..Although the mechanism for these observed differences are not clear, we hypothesize that in vivo platelet activation in PAD patients may contribute to the differences and will need to be further investigated...
  50. doi request reprint Role of reticulated platelets and platelet size heterogeneity on platelet activity after dual antiplatelet therapy with aspirin and clopidogrel in patients with stable coronary artery disease
    Sasidhar Guthikonda
    Department of Cardiology, Methodist DeBakey Heart and Vascular Center and Methodist Hospital Research Institute, Houston, Texas, USA
    J Am Coll Cardiol 52:743-9. 2008
    ..The aim of this study was to evaluate the relationship between reticulated platelets (RPs), platelet size, and platelet function in patients with stable coronary artery disease (CAD) taking aspirin and clopidogrel...
  51. doi request reprint Increased platelet:RBC ratios are associated with improved survival after massive transfusion
    John B Holcomb
    Division of Acute Care Surgery, Center for Translational Injury Research, University of Texas Health Sciences Center, Houston, Texas 77030, USA
    J Trauma 71:S318-28. 2011
    ..However, outcomes associated with platelet transfusions are poorly characterized. We hypothesized that increased platelet:red blood cells (RBC) ratios would decrease hemorrhagic death and improve survival after massive transfusion (MT)...
  52. ncbi request reprint Shear stress augments the enhanced adhesive phenotype of cells expressing the Pro33 isoform of integrin beta3
    K Vinod Vijayan
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, BCM 286, N1319, Houston, TX 77030, USA
    FEBS Lett 540:41-6. 2003
    ..Thus, shear stress enhances the adhesive phenotype of the Pro33 cells to multiple physiologic substrates...
  53. pmc Differential role of von Willebrand factor and P-selectin on microvascular thrombosis in endotoxemia
    Kavita N Patel
    Medical Care Line, Michael E DeBakey VA Medical Center, Houston, TX, USA
    Arterioscler Thromb Vasc Biol 28:2225-30. 2008
    ..Because von Willebrand factor (vWF) and P-selectin are suggested to mediate LPS-induced platelet-microvessel interactions, we determined whether vWF and P-selectin contribute to microvascular thrombosis in endotoxemia...
  54. ncbi request reprint Tyrosine sulfation of glycoprotein I(b)alpha. Role of electrostatic interactions in von Willebrand factor binding
    J Dong
    Division of Thrombosis Research, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 276:16690-4. 2001
    ....
  55. pmc Genetic determinants of plasma von Willebrand factor antigen levels: a target gene SNP and haplotype analysis of ARIC cohort
    Marco Campos
    Section of Cardiology, Baylor College of Medicine, Houston, TX, USA
    Blood 117:5224-30. 2011
    ..In summary, we identified a cluster of intronic VWF SNPs that associate with plasma levels of VWF, individually or additively, in a large cohort of healthy subjects...
  56. doi request reprint Antihemostatic activity of human granzyme B mediated by cleavage of von Willebrand factor
    Marguerite S Buzza
    Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia
    J Biol Chem 283:22498-504. 2008
    ..GrB also cleaves the matrix form of fibrinogen at several sites. These studies suggest extracellular GrB may help control localized coagulation during inflammation...
  57. ncbi request reprint Site-directed mutagenesis of platelet glycoprotein Ib alpha demonstrating residues involved in the sulfation of tyrosines 276, 278, and 279
    A Sasha Tait
    Department of Haematology, Prince of Wales Hospital, New South Wales, Australia
    Blood 99:4422-7. 2002
    ..The second mutation involves changing the lysine residues at 253, 258, and 262 to alanine. This also led to distinct changes in VWF binding and abolition of sulfation...
  58. pmc Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF
    Tadayuki Yago
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Clin Invest 118:3195-207. 2008
    ..We conclude that in type 2B vWD, prolonged lifetimes of vWF bonds with GPIbalpha on circulating platelets may allow ADAMTS-13 to deplete large vWF multimers, causing bleeding...
  59. ncbi request reprint Changes in circulating human endothelial progenitor cells after brain injury
    Li Liu
    Department of Neurosurgery, Tianjin Medical University, Tianjin Neurological Institute, Tianjin, China
    J Neurotrauma 24:936-43. 2007
    ..These results suggest that EPC mobilization following traumatic brain injury may take a different course compared to that associated with body or vascular injuries...
  60. ncbi request reprint Glycoprotein V: the predominant target antigen in gold-induced autoimmune thrombocytopenia
    Stephen F Garner
    Division of Transfusion Medicine, University of Cambridge and National Blood Service East Anglia Centre, United Kingdom
    Blood 100:344-6. 2002
    ..Autoantibodies recognizing GPV were not seen in the 28 nonthrombocytopenic control RA patients. Thus, GPV seems to be targeted in gold-induced autoimmune thrombocytopenia...

Research Grants11

  1. Proteolysis of ultralarge von Willebrand factor and metabolic syndrome-diabetes
    Jing Fei Dong; Fiscal Year: 2010
    ..Results of the study will help us to understand how defective ULVWF proteolysis contributes to the development of atherothrombosis associated with the syndrome. ..
  2. Ultra-Large von Willebrand Factor and Thrombotic Microangiopathy
    Jing Fei Dong; Fiscal Year: 2009
    ..Results will help us to dissect this novel mechanism of shear-induced VWF activation. New information will be critical for development new strategies to regulate the role of VWF in hemostasis and thrombosis. ..
  3. Ultra-Large VWF and Thrombotic Microangiopathy
    Jing Fei Dong; Fiscal Year: 2007
    ..Finally, they allow us to develop a clinical assay to test the activity of the VWF-cleaving protease. Thus, giving the ability to diagnose TTP. This assay will be fast and more physiologically relevant. ..
  4. Ultra-Large VWF and Thrombotic Microangiopathy
    Jing Fei Dong; Fiscal Year: 2006
    ..Finally, they allow us to develop a clinical assay to test the activity of the VWF-cleaving protease thus giving the ability to diagnose TTP. This assay will be fast and more physiologically relevant. ..
  5. Ultra-Large VWF and Thrombotic Microangiopathy
    Jing Fei Dong; Fiscal Year: 2003
    ..Finally, they allow us to develop a clinical assay to test the activity of the VWF-cleaving protease thus giving the ability to diagnose TTP. This assay will be fast and more physiologically relevant. ..
  6. Ultra-Large von Willebrand Factor and Thrombotic Microangiopathy
    Jing Fei Dong; Fiscal Year: 2010
    ..Results will help us to dissect this novel mechanism of shear-induced VWF activation. New information will be critical for development new strategies to regulate the role of VWF in hemostasis and thrombosis. ..