Kelly T Dineley

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease
    K T Dineley
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 21:4125-33. 2001
  2. ncbi request reprint beta -Amyloid peptide activates alpha 7 nicotinic acetylcholine receptors expressed in Xenopus oocytes
    Kelly T Dineley
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:25056-61. 2002
  3. ncbi request reprint MAPK recruitment by beta-amyloid in organotypic hippocampal slice cultures depends on physical state and exposure time
    Karen A Bell
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas, USA
    J Neurochem 91:349-61. 2004
  4. ncbi request reprint Postsynaptic contributions to hippocampal network hyperexcitability induced by chronic activity blockade in vivo
    Cynthia D Galvan
    The Cain Foundation Laboratories, Department of Pediatrics and Division of Neuroscience, Baylor College of Medicine, 6621 Fannim St, MC 3 6365, Houston, TX 77030, USA
    Eur J Neurosci 18:1861-72. 2003
  5. ncbi request reprint Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins
    Kelly T Dineley
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:22768-80. 2002
  6. ncbi request reprint Amino acid determinants of alpha 7 nicotinic acetylcholine receptor surface expression
    K T Dineley
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 275:13974-85. 2000
  7. ncbi request reprint Leitmotifs in the biochemistry of LTP induction: amplification, integration and coordination
    K T Dineley
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas, USA
    J Neurochem 77:961-71. 2001
  8. ncbi request reprint Beta-amyloid peptide--nicotinic acetylcholine receptor interaction: the two faces of health and disease
    Kelly T Dineley
    Department of Neurology, George and Cynthia Mitchell Research Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, TX 77555 0874, USA
    Front Biosci 12:5030-8. 2007
  9. pmc Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice
    Kelly T Dineley
    Department of Neurology, The University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX 77555 1043, USA
    Neurobiol Learn Mem 88:217-24. 2007
  10. ncbi request reprint Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression
    Adam R Cole
    Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital, Dundee, Scotland, UK
    J Neurochem 103:1132-44. 2007

Collaborators

  • Hui Zheng
  • J D Sweatt
  • J W Patrick
  • KAREN A ASHE
  • A E Anderson
  • Adam R Cole
  • Karen A Bell
  • Cynthia D Galvan
  • Frank LaFerla
  • Frank Gunn-Moore
  • Diane P Hanger
  • Lidy van Aalten
  • K Peter Giese
  • Dale Hogan
  • Wendy Noble
  • Salvatore Oddo
  • Stuart M Allan
  • Calum Sutherland
  • Alex Verkhratsky
  • John LaFrancois
  • Karen Duff
  • Rena Meimaridou
  • Margaret Taylor
  • Jill C Richardson
  • Shi Du Yan
  • Florian Plattner
  • Kenneth J O'Riordan
  • Trang T Lam
  • Philip A Schwartzkroin
  • Jurgen H Wenzel
  • John W Swann

Detail Information

Publications10

  1. ncbi request reprint Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease
    K T Dineley
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 21:4125-33. 2001
    ....
  2. ncbi request reprint beta -Amyloid peptide activates alpha 7 nicotinic acetylcholine receptors expressed in Xenopus oocytes
    Kelly T Dineley
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:25056-61. 2002
    ..Thus, when beta-amyloid peptide activation of alpha7 receptors occurs, these currents are comprised, at least in part, of Ca(2+)...
  3. ncbi request reprint MAPK recruitment by beta-amyloid in organotypic hippocampal slice cultures depends on physical state and exposure time
    Karen A Bell
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas, USA
    J Neurochem 91:349-61. 2004
    ..These data indicate the existence of differential coupling of alpha7 to downstream targets depending on the type of ligand that leads to receptor activation...
  4. ncbi request reprint Postsynaptic contributions to hippocampal network hyperexcitability induced by chronic activity blockade in vivo
    Cynthia D Galvan
    The Cain Foundation Laboratories, Department of Pediatrics and Division of Neuroscience, Baylor College of Medicine, 6621 Fannim St, MC 3 6365, Houston, TX 77030, USA
    Eur J Neurosci 18:1861-72. 2003
    ..Postsynaptic changes are likely to be the major contributors to the hippocampal network hyperexcitability and should enhance both excitatory synaptic efficacy and plasticity...
  5. ncbi request reprint Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins
    Kelly T Dineley
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:22768-80. 2002
    ..These findings provide two robust and rapid assays for beta-amyloid-associated effects that can be performed on young animals: impaired contextual fear learning and up-regulation of alpha 7 nicotinic receptors...
  6. ncbi request reprint Amino acid determinants of alpha 7 nicotinic acetylcholine receptor surface expression
    K T Dineley
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 275:13974-85. 2000
    ..How these surface expression determinants in the alpha7 nicotinic acetylcholine receptor might influence synaptic efficacy is discussed...
  7. ncbi request reprint Leitmotifs in the biochemistry of LTP induction: amplification, integration and coordination
    K T Dineley
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas, USA
    J Neurochem 77:961-71. 2001
    ..Among these themes are signal amplification, signal integration and signal coordination. Here we use these themes as an organizing context for reviewing the profusion of signaling mechanisms involved in the induction of LTP...
  8. ncbi request reprint Beta-amyloid peptide--nicotinic acetylcholine receptor interaction: the two faces of health and disease
    Kelly T Dineley
    Department of Neurology, George and Cynthia Mitchell Research Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, TX 77555 0874, USA
    Front Biosci 12:5030-8. 2007
    ..This review will discuss the extant literature on the subject in terms of clarifying this apparent dichotomy regarding the consequences of Abeta-nAChR interaction during health and disease...
  9. pmc Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice
    Kelly T Dineley
    Department of Neurology, The University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX 77555 1043, USA
    Neurobiol Learn Mem 88:217-24. 2007
    ..These results indicate that calcineurin may mediate some of the cognitive effects of excess Abeta such that inhibition of calcineurin shall be further explored as a potential treatment to reverse cognitive impairments in AD...
  10. ncbi request reprint Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression
    Adam R Cole
    Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital, Dundee, Scotland, UK
    J Neurochem 103:1132-44. 2007
    ..These observations implicate hyperphosphorylation of CRMP2 as an early event in the development of AD and suggest that it can be induced by a severe APP over-expression and/or processing defect...