Elizabeth Dial

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Endotoxin-induced changes in phospholipid dynamics of the stomach
    Elizabeth J Dial
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston Medical School, Houston, TX 77030, USA
    J Surg Res 180:140-6. 2013
  2. doi request reprint Oral phosphatidylcholine preserves the gastrointestinal mucosal barrier during LPS-induced inflammation
    Elizabeth J Dial
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston Medical School, Houston, TX 77030, USA
    Shock 30:729-33. 2008
  3. ncbi request reprint Importance of biliary excretion of indomethacin in gastrointestinal and hepatic injury
    Elizabeth J Dial
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Medical School, Houston, Texas 77030, USA
    J Gastroenterol Hepatol 23:e384-9. 2008
  4. ncbi request reprint Role of phosphatidylcholine saturation in preventing bile salt toxicity to gastrointestinal epithelia and membranes
    Elizabeth J Dial
    Department of Integrative Biology and Pharmacology, Medical School, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Gastroenterol Hepatol 23:430-6. 2008
  5. doi request reprint A report on associations among gastric pH, bleeding, duodenogastric reflux, and outcomes after trauma
    Elizabeth Dial
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston Medical School, Houston, Texas, USA
    J Trauma 64:105-10. 2008
  6. ncbi request reprint Phosphatidylcholine-associated nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit DNA synthesis and the growth of colon cancer cells in vitro
    Elizabeth J Dial
    Department of Integrative Biology and Pharmacology, The University of Texas Medical School, Houston, 77030, USA
    Cancer Chemother Pharmacol 57:295-300. 2006
  7. ncbi request reprint Recombinant human lactoferrin prevents NSAID-induced intestinal bleeding in rodents
    Elizabeth J Dial
    Department of Integrative Biology and Pharmacology, Medical School, University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX 77030 1503, USA
    J Pharm Pharmacol 57:93-9. 2005
  8. ncbi request reprint Effect of lactoferrin on Helicobacter felis induced gastritis
    Elizabeth J Dial
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston Medical School, 77225, USA
    Biochem Cell Biol 80:113-7. 2002
  9. pmc Effect of indomethacin on bile acid-phospholipid interactions: implication for small intestinal injury induced by nonsteroidal anti-inflammatory drugs
    Yong Zhou
    Department of Pediatrics Gastroenterology, Baylor College of Medicine, Houston, TX, USA
    Am J Physiol Gastrointest Liver Physiol 298:G722-31. 2010
  10. ncbi request reprint The effects of aspirin on gastric mucosal integrity, surface hydrophobicity, and prostaglandin metabolism in cyclooxygenase knockout mice
    Rebecca L Darling
    Department of Integrative Biology and Pharmacology, The University of Texas Medical School, Houston, Texas 77030, USA
    Gastroenterology 127:94-104. 2004

Research Grants

  1. THERAPY FOR GASTROINTESTINAL DISORDERS
    Elizabeth Dial; Fiscal Year: 2002

Collaborators

Detail Information

Publications16

  1. pmc Endotoxin-induced changes in phospholipid dynamics of the stomach
    Elizabeth J Dial
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston Medical School, Houston, TX 77030, USA
    J Surg Res 180:140-6. 2013
    ..The current studies compared PC and lyso-PC levels in mucus and gastric mucosa before and after LPS treatment, and examined potential mechanisms for surface phospholipid changes...
  2. doi request reprint Oral phosphatidylcholine preserves the gastrointestinal mucosal barrier during LPS-induced inflammation
    Elizabeth J Dial
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston Medical School, Houston, TX 77030, USA
    Shock 30:729-33. 2008
    ..Under the conditions studied, oral PC does not block systemic effects of LPS. However, enteral formulations containing PC may be useful adjuncts in the prevention of GI injury from endotoxemia...
  3. ncbi request reprint Importance of biliary excretion of indomethacin in gastrointestinal and hepatic injury
    Elizabeth J Dial
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Medical School, Houston, Texas 77030, USA
    J Gastroenterol Hepatol 23:e384-9. 2008
    ..We investigated the role of bile acids and PC in the mechanism of indomethacin-induced epithelial injury...
  4. ncbi request reprint Role of phosphatidylcholine saturation in preventing bile salt toxicity to gastrointestinal epithelia and membranes
    Elizabeth J Dial
    Department of Integrative Biology and Pharmacology, Medical School, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Gastroenterol Hepatol 23:430-6. 2008
    ....
  5. doi request reprint A report on associations among gastric pH, bleeding, duodenogastric reflux, and outcomes after trauma
    Elizabeth Dial
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston Medical School, Houston, Texas, USA
    J Trauma 64:105-10. 2008
    ..In a prospective study, the gastric fluid of major torso trauma patients was examined for evidence of duodenogastric reflux and potential gastric injury, and was compared with patient outcomes regarding MOF...
  6. ncbi request reprint Phosphatidylcholine-associated nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit DNA synthesis and the growth of colon cancer cells in vitro
    Elizabeth J Dial
    Department of Integrative Biology and Pharmacology, The University of Texas Medical School, Houston, 77030, USA
    Cancer Chemother Pharmacol 57:295-300. 2006
    ..Due to its greater efficacy in this model system, IBU-PC should be further evaluated as a chemopreventive agent that is safer for the GI tract than unmodified NSAID...
  7. ncbi request reprint Recombinant human lactoferrin prevents NSAID-induced intestinal bleeding in rodents
    Elizabeth J Dial
    Department of Integrative Biology and Pharmacology, Medical School, University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX 77030 1503, USA
    J Pharm Pharmacol 57:93-9. 2005
    ..We conclude that orally administered RHLF is effective at preventing NSAID-induced intestinal injury in rodents and should be investigated for this potential therapeutic use in man...
  8. ncbi request reprint Effect of lactoferrin on Helicobacter felis induced gastritis
    Elizabeth J Dial
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston Medical School, 77225, USA
    Biochem Cell Biol 80:113-7. 2002
    ....
  9. pmc Effect of indomethacin on bile acid-phospholipid interactions: implication for small intestinal injury induced by nonsteroidal anti-inflammatory drugs
    Yong Zhou
    Department of Pediatrics Gastroenterology, Baylor College of Medicine, Houston, TX, USA
    Am J Physiol Gastrointest Liver Physiol 298:G722-31. 2010
    ..This mechanism potentially contributes to the NSAID-induced injury in the small bowel...
  10. ncbi request reprint The effects of aspirin on gastric mucosal integrity, surface hydrophobicity, and prostaglandin metabolism in cyclooxygenase knockout mice
    Rebecca L Darling
    Department of Integrative Biology and Pharmacology, The University of Texas Medical School, Houston, Texas 77030, USA
    Gastroenterology 127:94-104. 2004
    ....
  11. doi request reprint Pathophysiology of LPS-induced gastrointestinal injury in the rat: role of secretory phospholipase A2
    Mayssa Zayat
    Department of Pediatric Gastroenterology, Baylor College of Medicine, Houston, TX, USA
    Shock 30:206-11. 2008
    ....
  12. ncbi request reprint NSAID injury to the gastrointestinal tract: evidence that NSAIDs interact with phospholipids to weaken the hydrophobic surface barrier and induce the formation of unstable pores in membranes
    Lenard M Lichtenberger
    The Department of Integrative Biology and Pharmacology, The University of Texas Medical School, Houston, TX 77030, USA
    J Pharm Pharmacol 58:1421-8. 2006
    ..This understanding of the interaction of NSAIDs with membrane phospholipids may prove valuable in the design of novel NSAID formulations with reduced gastrointestinal side-effects...
  13. pmc A direct role for secretory phospholipase A2 and lysophosphatidylcholine in the mediation of LPS-induced gastric injury
    Elizabeth J Dial
    Department of Integrative Biology and Pharmacology, University of Texas Medical School at Houston, Texas, USA
    Shock 33:634-8. 2010
    ..An LPS-induced increase in sPLA2 activity in the gastric lumen and its product, lyso-PC, are capable of directly disrupting the gastric hydrophobic layer and may contribute to gastric barrier disruption and subsequent inflammation...
  14. pmc Aggregation behavior of ibuprofen, cholic acid and dodecylphosphocholine micelles
    Priyanka Prakash
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin St, Houston, TX 77030, USA
    Biochim Biophys Acta 1818:3040-7. 2012
    ....
  15. ncbi request reprint Lipopolysaccharide-induced gastrointestinal injury in rats: role of surface hydrophobicity and bile salts
    Elizabeth J Dial
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center, Houston Medical School, 77225, USA
    Shock 17:77-80. 2002
    ..We conclude that LPS disrupts gastrointestinal barrier integrity, in part by mechanisms involving bile constituents and an attenuation in the mucosa's hydrophobic characteristics...
  16. pmc Bile acids improve the antimicrobial effect of rifaximin
    Charles Darkoh
    University of Texas Graduate School of Biomedical Sciences, Houston, TX, USA
    Antimicrob Agents Chemother 54:3618-24. 2010
    ..The water insolubility of rifaximin is the likely explanation for the drug's minimal effects on colonic flora and fecal pathogens, despite in vitro susceptibility...

Research Grants1

  1. THERAPY FOR GASTROINTESTINAL DISORDERS
    Elizabeth Dial; Fiscal Year: 2002
    ..Development of this therapeutic potential for rhLF will fulfill a crucial need for a way to safely administer NSAIDs. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..