M D Delp

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. ncbi request reprint Effects of aging on cardiac output, regional blood flow, and body composition in Fischer-344 rats
    M D Delp
    Departments of Health and Kinesiology and of Medical Physiology, Texas A and M University, College Station, Texas 77843, USA
    J Appl Physiol 85:1813-22. 1998
  2. ncbi request reprint Rat hindlimb muscle blood flow during level and downhill locomotion
    M D Delp
    Departments of Health and Kinesiology and Medical Physiology, Texas A and M University, College Station, Texas 77843, USA
    J Appl Physiol 86:564-8. 1999
  3. ncbi request reprint Myogenic and vasoconstrictor responsiveness of skeletal muscle arterioles is diminished by hindlimb unloading
    M D Delp
    Departments of Health and Kinesiology and of Medical Physiology, Texas A and M University, College Station, Texas 77843, USA
    J Appl Physiol 86:1178-84. 1999
  4. ncbi request reprint Control of skeletal muscle perfusion at the onset of dynamic exercise
    M D Delp
    Department of Health and Kinesiology, Texas A and M University, College Station 77843, USA
    Med Sci Sports Exerc 31:1011-8. 1999
  5. ncbi request reprint Structural and functional remodeling of skeletal muscle microvasculature is induced by simulated microgravity
    M D Delp
    Department of Health and Kinesiology, Texas A and M University, College Station 77843, USA
    Am J Physiol Heart Circ Physiol 278:H1866-73. 2000
  6. pmc Exercise increases blood flow to locomotor, vestibular, cardiorespiratory and visual regions of the brain in miniature swine
    M D Delp
    Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843, USA
    J Physiol 533:849-59. 2001
  7. ncbi request reprint Integrative control of the skeletal muscle microcirculation in the maintenance of arterial pressure during exercise
    Michael D Delp
    Department of Health and Kinesiology, Texas A and M University and Texas A and M Health Science Center, College Station, Texas 77843 4243, USA
    J Appl Physiol 97:1112-8. 2004
  8. ncbi request reprint Exercise training enhances flow-induced vasodilation in skeletal muscle resistance arteries of aged rats: role of PGI2 and nitric oxide
    Scott A Spier
    Department of Health and Kinesiology, University of Texas at Tyler, Tyler, TX, USA
    Am J Physiol Heart Circ Physiol 292:H3119-27. 2007
  9. ncbi request reprint Effects of aging on vasoconstrictor and mechanical properties of rat skeletal muscle arterioles
    Judy Muller-Delp
    Department of Health and Kinesiology, Texas A and M University, College Station, Texas 77843, USA
    Am J Physiol Heart Circ Physiol 282:H1843-54. 2002
  10. pmc Ageing and exercise training alter adrenergic vasomotor responses of rat skeletal muscle arterioles
    Anthony J Donato
    Department of Health and Kinisiology, Texas A and M University, College Station, TX 77843, USA
    J Physiol 579:115-25. 2007

Detail Information

Publications45

  1. ncbi request reprint Effects of aging on cardiac output, regional blood flow, and body composition in Fischer-344 rats
    M D Delp
    Departments of Health and Kinesiology and of Medical Physiology, Texas A and M University, College Station, Texas 77843, USA
    J Appl Physiol 85:1813-22. 1998
    ....
  2. ncbi request reprint Rat hindlimb muscle blood flow during level and downhill locomotion
    M D Delp
    Departments of Health and Kinesiology and Medical Physiology, Texas A and M University, College Station, Texas 77843, USA
    J Appl Physiol 86:564-8. 1999
    ..e., flows are equivalent in several ankle extensor muscles and higher in ankle flexor muscles...
  3. ncbi request reprint Myogenic and vasoconstrictor responsiveness of skeletal muscle arterioles is diminished by hindlimb unloading
    M D Delp
    Departments of Health and Kinesiology and of Medical Physiology, Texas A and M University, College Station, Texas 77843, USA
    J Appl Physiol 86:1178-84. 1999
    ..In addition, hindlimb unloading appears to induce vascular remodeling of arterioles from muscle composed of type I fibers, as indicated by the decrease in maximal diameter of arterioles from Sol muscle...
  4. ncbi request reprint Control of skeletal muscle perfusion at the onset of dynamic exercise
    M D Delp
    Department of Health and Kinesiology, Texas A and M University, College Station 77843, USA
    Med Sci Sports Exerc 31:1011-8. 1999
    ....
  5. ncbi request reprint Structural and functional remodeling of skeletal muscle microvasculature is induced by simulated microgravity
    M D Delp
    Department of Health and Kinesiology, Texas A and M University, College Station 77843, USA
    Am J Physiol Heart Circ Physiol 278:H1866-73. 2000
    ....
  6. pmc Exercise increases blood flow to locomotor, vestibular, cardiorespiratory and visual regions of the brain in miniature swine
    M D Delp
    Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843, USA
    J Physiol 533:849-59. 2001
    ..Additionally, there was an intensity-dependent decrease of vascular resistance in the dorsal cerebellar vermis...
  7. ncbi request reprint Integrative control of the skeletal muscle microcirculation in the maintenance of arterial pressure during exercise
    Michael D Delp
    Department of Health and Kinesiology, Texas A and M University and Texas A and M Health Science Center, College Station, Texas 77843 4243, USA
    J Appl Physiol 97:1112-8. 2004
    ....
  8. ncbi request reprint Exercise training enhances flow-induced vasodilation in skeletal muscle resistance arteries of aged rats: role of PGI2 and nitric oxide
    Scott A Spier
    Department of Health and Kinesiology, University of Texas at Tyler, Tyler, TX, USA
    Am J Physiol Heart Circ Physiol 292:H3119-27. 2007
    ..In arterioles from both old and young rats, the exercise training-induced enhancement of flow-induced dilation occurs primarily through a NOS mechanism...
  9. ncbi request reprint Effects of aging on vasoconstrictor and mechanical properties of rat skeletal muscle arterioles
    Judy Muller-Delp
    Department of Health and Kinesiology, Texas A and M University, College Station, Texas 77843, USA
    Am J Physiol Heart Circ Physiol 282:H1843-54. 2002
    ..Rather, aging-induced adaptations of vasoreactivity of resistance arterioles appear to be limited to mechanisms that are uniquely involved in the signaling of the myogenic response...
  10. pmc Ageing and exercise training alter adrenergic vasomotor responses of rat skeletal muscle arterioles
    Anthony J Donato
    Department of Health and Kinisiology, Texas A and M University, College Station, TX 77843, USA
    J Physiol 579:115-25. 2007
    ....
  11. ncbi request reprint Effects of hindlimb unweighting on the mechanical and structure properties of the rat abdominal aorta
    Anthony Papadopoulos
    Department of Biomedical Engineering, Texas A and M University, College Station 77845, USA
    J Appl Physiol 94:439-45. 2003
    ..However, the significantly lower active Cauchy stress of aortas from HU rats demonstrates a true contractile deficit in these arteries...
  12. pmc Effects of ageing and exercise training on endothelium-dependent vasodilatation and structure of rat skeletal muscle arterioles
    Scott A Spier
    Department of Health and Kinesiology, Texas A and M University College Station, TX 77843, USA
    J Physiol 556:947-58. 2004
    ....
  13. pmc Decreased NO signaling leads to enhanced vasoconstrictor responsiveness in skeletal muscle arterioles of the ZDF rat prior to overt diabetes and hypertension
    Lisa A Lesniewski
    Dept of Health and Kinesiology, Texas A and M University, College Station, Texas, USA
    Am J Physiol Heart Circ Physiol 294:H1840-50. 2008
    ..Collectively, these results indicate that increases in vasoconstrictor responsiveness resulting from diminished NO signaling in skeletal muscle arterioles precede the development of diabetes and hypertension in ZDF rats...
  14. ncbi request reprint Regional variations of contractile activity in isolated rat lymphatics
    Anatoliy A Gashev
    Department of Medical Physiology, College of Medicine, Cardiovascular Research Institute Division of Lymphatic Biology, Texas A and M University System Health Science Center, College Station, Texas, USA
    Microcirculation 11:477-92. 2004
    ..To evaluate lymphatic contractile activity in different regions of the lymphatic system in a single animal model (the rat thoracic duct, mesenteric, cervical, and femoral lymphatics) in response to changes in lymph pressure and flow...
  15. doi request reprint Simulated microgravity alters rat mesenteric artery vasoconstrictor dynamics through an intracellular Ca(2+) release mechanism
    Patrick N Colleran
    Department of Health and Kinesiology, Texas A and M University, College Station, TX, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1577-85. 2008
    ....
  16. ncbi request reprint Exercise training enhances vasodilation responses to vascular endothelial growth factor in porcine coronary arterioles exposed to chronic coronary occlusion
    Jennifer A Fogarty
    Cardiovascular Research Institute and Department of Medical Physiology, Texas A and M University System Health Science Center, College Station, Tex 77843 1114, USA
    Circulation 109:664-70. 2004
    ..We hypothesized that EX enhances vasodilation responses to vascular endothelial growth factor (VEGF165), mediated via nitric oxide (NO), in arterioles exposed to CCO...
  17. ncbi request reprint Inhibition of active lymph pump by simulated microgravity in rats
    Anatoliy A Gashev
    Department of Medical Physiology, College of Medicine, Cardiovascular Research Institute Division of Lymphatic Biology, Texas A and M University System Health Science Center, 336 Reynolds Medical Bldg, College Station, TX 77843 1114, USA
    Am J Physiol Heart Circ Physiol 290:H2295-308. 2006
    ..Mesenteric lymphatics were less strongly influenced by HDT, which may support the idea that lymph hydrodynamic conditions in the mesenteric lymphatic during HDT are not dramatically altered...
  18. ncbi request reprint Effects of aging on microvascular oxygen pressures in rat skeletal muscle
    Brad J Behnke
    Department of Health and Kinesiology, Texas A and M University, College Station, TX, USA
    Respir Physiol Neurobiol 146:259-68. 2005
    ....
  19. ncbi request reprint Aging impairs endothelium-dependent vasodilation in rat skeletal muscle arterioles
    Judy M Muller-Delp
    Department of Health and Kinesiology, Texas A and M University, College Station 77843, USA
    Am J Physiol Heart Circ Physiol 283:H1662-72. 2002
    ..Additionally, ACh-induced vasodilation was altered by age only in soleus muscle arterioles, suggesting that the mechanism of age-related endothelial impairment differs in arterioles from soleus and gastrocnemius muscles...
  20. ncbi request reprint Site- and compartment-specific changes in bone with hindlimb unloading in mature adult rats
    S A Bloomfield
    Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    Bone 31:149-57. 2002
    ..Given the sharp decline in BFR for midshaft cortical bone, it appears likely that deficits in BMD, area, or mechanical properties would develop with longer duration unloading...
  21. ncbi request reprint Effects of chronic heart failure on microvascular oxygen exchange dynamics in muscles of contrasting fiber type
    B J Behnke
    Department of Health and Kinesiology, Texas A and M University, College Station, TX, USA
    Cardiovasc Res 61:325-32. 2004
    ..Res. 56 (2002) 479]. Due to the mosaic nature of this muscle, the effect of CHF on microvascular pO2 dynamics in different fiber types remains unclear...
  22. ncbi request reprint Hindlimb unloading induces a collagen isoform shift in the soleus muscle of the rat
    T A Miller
    Department of Health and Kinesiology, Texas A and M University, College Station, Texas 77843, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1710-7. 2001
    ..The data demonstrate that HU induces a shift in the relative proportion of collagen isoform (type I to III) in the antigravity soleus muscle, which occurs concomitantly with a slow-to-fast myofiber transformation...
  23. ncbi request reprint Mares with delayed uterine clearance have an intrinsic defect in myometrial function
    S L Rigby
    Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4475, USA
    Biol Reprod 65:740-7. 2001
    ..In summary, for mares with delayed uterine clearance, an intrinsic contractile defect of the myometrium may contribute to reduced uterine contractility following breeding...
  24. pmc Inhibition of the active lymph pump by flow in rat mesenteric lymphatics and thoracic duct
    Anatoliy A Gashev
    Department of Medical Physiology, Cardiovascular Research Institute, College of Medicine, Texas A and M University System Health Science Center, 336 Reynolds Medical Building, College Station, TX 77843 1114, USA
    J Physiol 540:1023-37. 2002
    ..Exposure to NO mimicked the effects of flow, and inhibition of the NO synthase by N (G)-monomethyl-L-arginine attenuated but did not completely abolish the effects of flow...
  25. doi request reprint Neuropilin-1 is essential for enhanced VEGF(165)-mediated vasodilatation in collateral-dependent coronary arterioles of exercise-trained pigs
    Jennifer A Fogarty
    Department of Systems Biology and Translational Medicine, The Texas A and M University System Health Science Center, College Station, Tex, USA
    J Vasc Res 46:152-61. 2009
    ....
  26. doi request reprint Altered bone mass, geometry and mechanical properties during the development and progression of type 2 diabetes in the Zucker diabetic fatty rat
    Rhonda D Prisby
    Departments of Health and Kinesiology Intercollegiate Faculty of Nutrition Mechanical Engineering, Texas A and M University, College Station, Texas 77843, USA
    J Endocrinol 199:379-88. 2008
    ....
  27. ncbi request reprint The effects of aging and exercise training on endothelin-1 vasoconstrictor responses in rat skeletal muscle arterioles
    Anthony J Donato
    Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    Cardiovasc Res 66:393-401. 2005
    ..We hypothesized that vasoreactivity to ET-1 would be greater in skeletal muscle arterioles from old rats, and that endurance exercise training would abolish differences in ET-1 responsiveness between young and old animals...
  28. ncbi request reprint Aging potentiates the effect of congestive heart failure on muscle microvascular oxygenation
    Bradley J Behnke
    Division of Exercise Physiology, and the Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, West Virginia, USA
    J Appl Physiol 103:1757-63. 2007
    ....
  29. ncbi request reprint Effects of aging on adipose resistance artery vasoconstriction: possible implications for orthostatic blood pressure regulation
    Michael W Ramsey
    Department of Kinesiology, Leisure, and Sport Sciences, East Tennessee State University, Johnson City, Tennessee, USA
    J Appl Physiol 103:1636-43. 2007
    ..These results demonstrate that aging reduces the ability to maintain MAP during orthostatic stress, and this is associated with a diminished vasoconstriction of adipose resistance arteries...
  30. pmc Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles
    Michael D Delp
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    J Physiol 586:1161-8. 2008
    ..Rather, the age-related deficit in flow-mediated vasodilatation appears to be the result, in part, of limited BH(4) bioavailability...
  31. pmc Diminished mesenteric vaso- and venoconstriction and elevated plasma ANP and BNP with simulated microgravity
    Bradley J Behnke
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
    J Appl Physiol 104:1273-80. 2008
    ..Elevated levels of circulating ANP or NT-proBNP could adversely affect the ability of these vascular beds to constrict in vivo and conceivably could alter the intrinsic constrictor properties of these vessels with long-term exposure...
  32. doi request reprint Age, gender, and hormonal status modulate the vascular toxicity of the diesel exhaust extract phenanthraquinone
    Rhonda D Prisby
    Faculte de Medecine, Laboratoire de Biologie du Tissue Osseux, Université Jean Monnet, Saint Etienne, Cedex, France
    J Toxicol Environ Health A 71:464-70. 2008
    ..g., elderly, males, and postmenopausal women) may be more susceptible to the adverse consequences of airborne pollutants...
  33. ncbi request reprint Aging reduces skeletal blood flow, endothelium-dependent vasodilation, and NO bioavailability in rats
    Rhonda D Prisby
    Division of Exercise Physiology, Department of Physiology and Pharmacology, and the Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
    J Bone Miner Res 22:1280-8. 2007
    ..Femoral perfusion was lower in old animals, as well as endothelium-dependent vasodilation and NO bioavailability. These effects could contribute to old age-related bone loss and the increased risk of fracture...
  34. ncbi request reprint Acute and chronic head-down tail suspension diminishes cerebral perfusion in rats
    M Keith Wilkerson
    Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843, USA
    Am J Physiol Heart Circ Physiol 282:H328-34. 2002
    ..These results demonstrate that HDT results in chronic elevations in total and regional cerebral vascular resistance, and this may be the underlying stimulus for the HDT-induced smooth muscle hypertrophy of cerebral resistance arteries...
  35. ncbi request reprint Simulated microgravity enhances cerebral artery vasoconstriction and vascular resistance through endothelial nitric oxide mechanism
    M Keith Wilkerson
    Dept of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    Am J Physiol Heart Circ Physiol 288:H1652-61. 2005
    ..The functional consequence of these vascular alterations with HDT is regional elevations in CVR and corresponding reductions in cerebral perfusion...
  36. pmc Influence of ageing and physical activity on vascular morphology in rat skeletal muscle
    Bradley J Behnke
    Division of Exercise Physiology, Department of Physiology and Pharmacology, and the Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, WV 26506, USA
    J Physiol 575:617-26. 2006
    ....
  37. ncbi request reprint Endothelium-dependent vasodilation of cerebral arteries is altered with simulated microgravity through nitric oxide synthase and EDHF mechanisms
    Rhonda D Prisby
    Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
    J Appl Physiol 101:348-53. 2006
    ....
  38. ncbi request reprint Chronic exercise improves myocardial inotropic reserve capacity through alpha1-adrenergic and protein kinase C-dependent effects in Senescent rats
    Donna H Korzick
    106 Noll Physiological Research Center, The Pennsylvania State University, University Park, PA 16802, USA
    J Gerontol A Biol Sci Med Sci 59:1089-98. 2004
    ..These results further suggest that alterations in PKC levels underlie, at least in part, EX-induced improvements in alpha(1)-AR contraction...
  39. ncbi request reprint Effects of arterial hypotension on microvascular oxygen exchange in contracting skeletal muscle
    Brad J Behnke
    Dept of Kinesiology, Kansas State University, Manhattan, KS 66505 5802, USA
    J Appl Physiol 100:1019-26. 2006
    ..According to Fick's law, this scenario will decrease blood-myocyte O2 flux, thereby slowing Vo2 kinetics and exacerbating the O2 deficit generated at exercise onset...
  40. ncbi request reprint Myocardial heat shock protein 70 expression in young and old rats after identical exercise programs
    Joseph W Starnes
    Department of Kinesiology and Health Education, University of Texas, Austin, TX, USA
    J Gerontol A Biol Sci Med Sci 60:963-9. 2005
    ..Our results indicate an age-related decrease in HSP70 production in heart and liver following chronic exercise. Furthermore, the aged heart does not increase its antioxidant enzyme defenses to compensate for the HSP70 deficit...
  41. ncbi request reprint Vascular function in the metabolic syndrome and the effects on skeletal muscle perfusion: lessons from the obese Zucker rat
    Jefferson C Frisbee
    Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia School of Medicine, Morgantown, USA
    Essays Biochem 42:145-61. 2006
    ....
  42. doi request reprint Unraveling the complex web of impaired wound healing with mechanical unloading and physical deconditioning
    Michael D Delp
    J Appl Physiol 104:1262-3. 2008
  43. ncbi request reprint Arterial adaptations in microgravity contribute to orthostatic tolerance
    Michael D Delp
    J Appl Physiol 102:836. 2007
  44. ncbi request reprint Fiber composition and oxidative capacity of hamster skeletal muscle
    John P Mattson
    Department of Exercise and Sport Science, University of Utah, Salt Lake City 84112, USA
    J Histochem Cytochem 50:1685-92. 2002
    ..68, p<0.0001) and was in the rank order of type IIA > I > IIX > IIB. These data demonstrate that hamster skeletal muscle is predominantly composed of type IIB and IIX fibers...
  45. ncbi request reprint Chronic ethanol increases fetal cerebral blood flow specific to the ethanol-sensitive cerebellum under normoxaemic, hypercapnic and acidaemic conditions: ovine model
    Scott E Parnell
    Bowles Center for Alcohol Studies and Department of Cell and Developmental Biology, The University of North Carolina, Chapel Hill, NC, USA
    Exp Physiol 92:933-43. 2007
    ....