Research Topics
| M D DelpSummaryAffiliation: Texas A and M University Country: USA Publications
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Detail Information
Publications
Effects of aging on cardiac output, regional blood flow, and body composition in Fischer-344 ratsM D Delp
Departments of Health and Kinesiology and of Medical Physiology, Texas A and M University, College Station, Texas 77843, USA
J Appl Physiol 85:1813-22. 1998....- Rat hindlimb muscle blood flow during level and downhill locomotionM D Delp
Departments of Health and Kinesiology and Medical Physiology, Texas A and M University, College Station, Texas 77843, USA
J Appl Physiol 86:564-8. 1999..e., flows are equivalent in several ankle extensor muscles and higher in ankle flexor muscles... - Myogenic and vasoconstrictor responsiveness of skeletal muscle arterioles is diminished by hindlimb unloadingM D Delp
Departments of Health and Kinesiology and of Medical Physiology, Texas A and M University, College Station, Texas 77843, USA
J Appl Physiol 86:1178-84. 1999..In addition, hindlimb unloading appears to induce vascular remodeling of arterioles from muscle composed of type I fibers, as indicated by the decrease in maximal diameter of arterioles from Sol muscle... - Control of skeletal muscle perfusion at the onset of dynamic exerciseM D Delp
Department of Health and Kinesiology, Texas A and M University, College Station 77843, USA
Med Sci Sports Exerc 31:1011-8. 1999.... - Structural and functional remodeling of skeletal muscle microvasculature is induced by simulated microgravityM D Delp
Department of Health and Kinesiology, Texas A and M University, College Station 77843, USA
Am J Physiol Heart Circ Physiol 278:H1866-73. 2000.... 
Exercise increases blood flow to locomotor, vestibular, cardiorespiratory and visual regions of the brain in miniature swineM D Delp
Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843, USA
J Physiol 533:849-59. 2001..Additionally, there was an intensity-dependent decrease of vascular resistance in the dorsal cerebellar vermis...- Integrative control of the skeletal muscle microcirculation in the maintenance of arterial pressure during exerciseMichael D Delp
Department of Health and Kinesiology, Texas A and M University and Texas A and M Health Science Center, College Station, Texas 77843 4243, USA
J Appl Physiol 97:1112-8. 2004.... - Exercise training enhances flow-induced vasodilation in skeletal muscle resistance arteries of aged rats: role of PGI2 and nitric oxideScott A Spier
Department of Health and Kinesiology, University of Texas at Tyler, Tyler, TX, USA
Am J Physiol Heart Circ Physiol 292:H3119-27. 2007..In arterioles from both old and young rats, the exercise training-induced enhancement of flow-induced dilation occurs primarily through a NOS mechanism... - Effects of aging on vasoconstrictor and mechanical properties of rat skeletal muscle arteriolesJudy Muller-Delp
Department of Health and Kinesiology, Texas A and M University, College Station, Texas 77843, USA
Am J Physiol Heart Circ Physiol 282:H1843-54. 2002..Rather, aging-induced adaptations of vasoreactivity of resistance arterioles appear to be limited to mechanisms that are uniquely involved in the signaling of the myogenic response... - Ageing and exercise training alter adrenergic vasomotor responses of rat skeletal muscle arteriolesAnthony J Donato
Department of Health and Kinisiology, Texas A and M University, College Station, TX 77843, USA
J Physiol 579:115-25. 2007.... - Effects of hindlimb unweighting on the mechanical and structure properties of the rat abdominal aortaAnthony Papadopoulos
Department of Biomedical Engineering, Texas A and M University, College Station 77845, USA
J Appl Physiol 94:439-45. 2003..However, the significantly lower active Cauchy stress of aortas from HU rats demonstrates a true contractile deficit in these arteries... - Effects of ageing and exercise training on endothelium-dependent vasodilatation and structure of rat skeletal muscle arteriolesScott A Spier
Department of Health and Kinesiology, Texas A and M University College Station, TX 77843, USA
J Physiol 556:947-58. 2004.... - Decreased NO signaling leads to enhanced vasoconstrictor responsiveness in skeletal muscle arterioles of the ZDF rat prior to overt diabetes and hypertensionLisa A Lesniewski
Dept of Health and Kinesiology, Texas A and M University, College Station, Texas, USA
Am J Physiol Heart Circ Physiol 294:H1840-50. 2008..Collectively, these results indicate that increases in vasoconstrictor responsiveness resulting from diminished NO signaling in skeletal muscle arterioles precede the development of diabetes and hypertension in ZDF rats... - Regional variations of contractile activity in isolated rat lymphaticsAnatoliy A Gashev
Department of Medical Physiology, College of Medicine, Cardiovascular Research Institute Division of Lymphatic Biology, Texas A and M University System Health Science Center, College Station, Texas, USA
Microcirculation 11:477-92. 2004..To evaluate lymphatic contractile activity in different regions of the lymphatic system in a single animal model (the rat thoracic duct, mesenteric, cervical, and femoral lymphatics) in response to changes in lymph pressure and flow... 
Simulated microgravity alters rat mesenteric artery vasoconstrictor dynamics through an intracellular Ca(2+) release mechanismPatrick N Colleran
Department of Health and Kinesiology, Texas A and M University, College Station, TX, USA
Am J Physiol Regul Integr Comp Physiol 294:R1577-85. 2008....- Exercise training enhances vasodilation responses to vascular endothelial growth factor in porcine coronary arterioles exposed to chronic coronary occlusionJennifer A Fogarty
Cardiovascular Research Institute and Department of Medical Physiology, Texas A and M University System Health Science Center, College Station, Tex 77843-1114, USA
Circulation 109:664-70. 2004..CONCLUSIONS: EX enhances VEGF165-induced vasodilation in arterioles distal to CCO; EX effects seem to be mediated through increases in NO... - Inhibition of active lymph pump by simulated microgravity in ratsAnatoliy A Gashev
Department of Medical Physiology, College of Medicine, Cardiovascular Research Institute Division of Lymphatic Biology, Texas A and M University System Health Science Center, 336 Reynolds Medical Bldg, College Station, TX 77843 1114, USA
Am J Physiol Heart Circ Physiol 290:H2295-308. 2006..Mesenteric lymphatics were less strongly influenced by HDT, which may support the idea that lymph hydrodynamic conditions in the mesenteric lymphatic during HDT are not dramatically altered... - Effects of aging on microvascular oxygen pressures in rat skeletal muscleBrad J Behnke
Department of Health and Kinesiology, Texas A and M University, College Station, TX, USA
Respir Physiol Neurobiol 146:259-68. 2005.... - Aging impairs endothelium-dependent vasodilation in rat skeletal muscle arteriolesJudy M Muller-Delp
Department of Health and Kinesiology, Texas A and M University, College Station 77843, USA
Am J Physiol Heart Circ Physiol 283:H1662-72. 2002..Additionally, ACh-induced vasodilation was altered by age only in soleus muscle arterioles, suggesting that the mechanism of age-related endothelial impairment differs in arterioles from soleus and gastrocnemius muscles... - Site- and compartment-specific changes in bone with hindlimb unloading in mature adult ratsS A Bloomfield
Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
Bone 31:149-57. 2002..Given the sharp decline in BFR for midshaft cortical bone, it appears likely that deficits in BMD, area, or mechanical properties would develop with longer duration unloading... - Effects of chronic heart failure on microvascular oxygen exchange dynamics in muscles of contrasting fiber typeB J Behnke
Department of Health and Kinesiology, Texas A and M University, College Station, TX, USA
Cardiovasc Res 61:325-32. 2004.... - Hindlimb unloading induces a collagen isoform shift in the soleus muscle of the ratT A Miller
Department of Health and Kinesiology, Texas A and M University, College Station, Texas 77843, USA
Am J Physiol Regul Integr Comp Physiol 281:R1710-7. 2001..The data demonstrate that HU induces a shift in the relative proportion of collagen isoform (type I to III) in the antigravity soleus muscle, which occurs concomitantly with a slow-to-fast myofiber transformation... - Mares with delayed uterine clearance have an intrinsic defect in myometrial functionS L Rigby
Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4475, USA
Biol Reprod 65:740-7. 2001..In summary, for mares with delayed uterine clearance, an intrinsic contractile defect of the myometrium may contribute to reduced uterine contractility following breeding... - Inhibition of the active lymph pump by flow in rat mesenteric lymphatics and thoracic ductAnatoliy A Gashev
Department of Medical Physiology, Cardiovascular Research Institute, College of Medicine, Texas A and M University System Health Science Center, 336 Reynolds Medical Building, College Station, TX 77843 1114, USA
J Physiol 540:1023-37. 2002..Exposure to NO mimicked the effects of flow, and inhibition of the NO synthase by N (G)-monomethyl-L-arginine attenuated but did not completely abolish the effects of flow... - Neuropilin-1 is essential for enhanced VEGF(165)-mediated vasodilatation in collateral-dependent coronary arterioles of exercise-trained pigsJennifer A Fogarty
Department of Systems Biology and Translational Medicine, The Texas A and M University System Health Science Center, College Station, Tex, USA
J Vasc Res 46:152-61. 2009.... - Altered bone mass, geometry and mechanical properties during the development and progression of type 2 diabetes in the Zucker diabetic fatty ratRhonda D Prisby
Departments of Health and Kinesiology Intercollegiate Faculty of Nutrition Mechanical Engineering, Texas A and M University, College Station, Texas 77843, USA
J Endocrinol 199:379-88. 2008.... - The effects of aging and exercise training on endothelin-1 vasoconstrictor responses in rat skeletal muscle arteriolesAnthony J Donato
TX A and M U, College Station
Cardiovasc Res 66:393-401. 2005..These findings suggest that enhanced vascular ET-1 sensitivity in fast-twitch skeletal muscles may play a role in the vascular dysfunction that is often associated with old age... - Aging potentiates the effect of congestive heart failure on muscle microvascular oxygenationBradley J Behnke
Division of Exercise Physiology, and the Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, West Virginia, USA
J Appl Physiol 103:1757-63. 2007.... - Effects of aging on adipose resistance artery vasoconstriction: possible implications for orthostatic blood pressure regulationMichael W Ramsey
Department of Kinesiology, Leisure, and Sport Sciences, East Tennessee State University, Johnson City, Tennessee, USA
J Appl Physiol 103:1636-43. 2007..These results demonstrate that aging reduces the ability to maintain MAP during orthostatic stress, and this is associated with a diminished vasoconstriction of adipose resistance arteries... - Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arteriolesMichael D Delp
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
J Physiol 586:1161-8. 2008..Rather, the age-related deficit in flow-mediated vasodilatation appears to be the result, in part, of limited BH(4) bioavailability... - Diminished mesenteric vaso- and venoconstriction and elevated plasma ANP and BNP with simulated microgravityBradley J Behnke
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
J Appl Physiol 104:1273-80. 2008..Elevated levels of circulating ANP or NT-proBNP could adversely affect the ability of these vascular beds to constrict in vivo and conceivably could alter the intrinsic constrictor properties of these vessels with long-term exposure... - Age, gender, and hormonal status modulate the vascular toxicity of the diesel exhaust extract phenanthraquinoneRhonda D Prisby
Faculte de Medecine, Laboratoire de Biologie du Tissue Osseux, Université Jean Monnet, Saint Etienne, Cedex, France
J Toxicol Environ Health A 71:464-70. 2008..g., elderly, males, and postmenopausal women) may be more susceptible to the adverse consequences of airborne pollutants... - Aging reduces skeletal blood flow, endothelium-dependent vasodilation, and NO bioavailability in ratsRhonda D Prisby
Division of Exercise Physiology, Department of Physiology and Pharmacology, and the Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
J Bone Miner Res 22:1280-8. 2007..Femoral perfusion was lower in old animals, as well as endothelium-dependent vasodilation and NO bioavailability. These effects could contribute to old age-related bone loss and the increased risk of fracture... - Acute and chronic head-down tail suspension diminishes cerebral perfusion in ratsM Keith Wilkerson
TX A and M U, College Station
Am J Physiol Heart Circ Physiol 282:H328-34. 2002..These results demonstrate that HDT results in chronic elevations in total and regional cerebral vascular resistance, and this may be the underlying stimulus for the HDT-induced smooth muscle hypertrophy of cerebral resistance arteries... - Simulated microgravity enhances cerebral artery vasoconstriction and vascular resistance through endothelial nitric oxide mechanismM Keith Wilkerson
TX A and M U, College Station
Am J Physiol Heart Circ Physiol 288:H1652-61. 2005..The functional consequence of these vascular alterations with HDT is regional elevations in CVR and corresponding reductions in cerebral perfusion... - Influence of ageing and physical activity on vascular morphology in rat skeletal muscleBradley J Behnke
Division of Exercise Physiology, Department of Physiology and Pharmacology, and the Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, WV 26506, USA
J Physiol 575:617-26. 2006.... - Endothelium-dependent vasodilation of cerebral arteries is altered with simulated microgravity through nitric oxide synthase and EDHF mechanismsRhonda D Prisby
Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
J Appl Physiol 101:348-53. 2006.... - Chronic exercise improves myocardial inotropic reserve capacity through alpha1-adrenergic and protein kinase C-dependent effects in Senescent ratsDonna H Korzick
106 Noll Physiological Research Center, The Pennsylvania State University, University Park, PA 16802, USA
J Gerontol A Biol Sci Med Sci 59:1089-98. 2004..These results further suggest that alterations in PKC levels underlie, at least in part, EX-induced improvements in alpha(1)-AR contraction... - Effects of arterial hypotension on microvascular oxygen exchange in contracting skeletal muscleBrad J Behnke
Dept. of Kinesiology, Kansas State University, Manhattan, KS 66505-5802, USA
J Appl Physiol 100:1019-26. 2006..According to Fick's law, this scenario will decrease blood-myocyte O2 flux, thereby slowing Vo2 kinetics and exacerbating the O2 deficit generated at exercise onset... - Myocardial heat shock protein 70 expression in young and old rats after identical exercise programsJoseph W Starnes
Department of Kinesiology and Health Education, University of Texas, Austin, TX, USA
J Gerontol A Biol Sci Med Sci 60:963-9. 2005..Our results indicate an age-related decrease in HSP70 production in heart and liver following chronic exercise. Furthermore, the aged heart does not increase its antioxidant enzyme defenses to compensate for the HSP70 deficit... - Vascular function in the metabolic syndrome and the effects on skeletal muscle perfusion: lessons from the obese Zucker ratJefferson C Frisbee
Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia School of Medicine, Morgantown, USA
Essays Biochem 42:145-61. 2006.... - Unraveling the complex web of impaired wound healing with mechanical unloading and physical deconditioningMichael D Delp
J Appl Physiol 104:1262-3. 2008 - Arterial adaptations in microgravity contribute to orthostatic toleranceMichael D Delp
J Appl Physiol 102:836. 2007 - Fiber composition and oxidative capacity of hamster skeletal muscleJohn P Mattson
Department of Exercise and Sport Science, University of Utah, Salt Lake City 84112, USA
J Histochem Cytochem 50:1685-92. 2002..68, p<0.0001) and was in the rank order of type IIA > I > IIX > IIB. These data demonstrate that hamster skeletal muscle is predominantly composed of type IIB and IIX fibers... - Chronic ethanol increases fetal cerebral blood flow specific to the ethanol-sensitive cerebellum under normoxaemic, hypercapnic and acidaemic conditions: ovine modelScott E Parnell
Bowles Center for Alcohol Studies and Department of Cell and Developmental Biology, The University of North Carolina, Chapel Hill, NC, USA
Exp Physiol 92:933-43. 2007....