Ronald Davis

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc The GABAergic anterior paired lateral neuron suppresses and is suppressed by olfactory learning
    Xu Liu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Neurosci 12:53-9. 2009
  2. pmc Isolation of mRNA from specific tissues of Drosophila by mRNA tagging
    Zhiyong Yang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Nucleic Acids Res 33:e148. 2005
  3. pmc Eight different types of dopaminergic neurons innervate the Drosophila mushroom body neuropil: anatomical and physiological heterogeneity
    Zhengmei Mao
    Department of Molecular and Cellular Biology, Baylor College of Medicine Houston, TX, USA
    Front Neural Circuits 3:5. 2009
  4. ncbi request reprint Mushroom bodies, Ca(2+) oscillations, and the memory gene amnesiac
    R L Davis
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 30:653-6. 2001
  5. ncbi request reprint Olfactory memory formation in Drosophila: from molecular to systems neuroscience
    Ronald L Davis
    Department of Molecular and Cellular Biology, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Annu Rev Neurosci 28:275-302. 2005
  6. ncbi request reprint Olfactory learning
    Ronald L Davis
    Department of Molecular and Cellular Biology, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 44:31-48. 2004
  7. ncbi request reprint The scent of Drosophila sex
    Ronald L Davis
    Department of Molecular and Cellular Biology, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030 USA
    Neuron 54:14-6. 2007
  8. pmc A distinct set of Drosophila brain neurons required for neurofibromatosis type 1-dependent learning and memory
    Monica E Buchanan
    Department of Molecular and Human Genetics and Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Neurosci 30:10135-43. 2010
  9. ncbi request reprint Spatiotemporal rescue of memory dysfunction in Drosophila
    Sean E McGuire
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 302:1765-8. 2003
  10. ncbi request reprint The dachshund gene is required for the proper guidance and branching of mushroom body axons in Drosophila melanogaster
    Sharyl R Martini
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurobiol 64:133-44. 2005

Research Grants

  1. Regulated Gene Expression and Drosophila Behavior
    Ronald Davis; Fiscal Year: 2003
  2. INTEGRIN FUNCTION IN MEMORY
    Ronald Davis; Fiscal Year: 2000
  3. MOLECULAR BIOLOGY OF DROSOPHILA LEARNING AND MEMORY
    Ronald Davis; Fiscal Year: 2000
  4. Olfactory memory trace formation in Drosophila
    Ronald Davis; Fiscal Year: 2006
  5. NEUROBIOLOGICALLY IMPORTANT GENES II
    Ronald Davis; Fiscal Year: 1990
  6. MOLECULAR BIOLOGY OF DROSOPHILA LEARNING AND MEMORY
    Ronald Davis; Fiscal Year: 2009
  7. INTEGRIN FUNCTION IN MEMORY
    Ronald Davis; Fiscal Year: 2009
  8. MOLECULAR BIOLOGY OF DROSOPHILA LEARNING AND MEMORY
    Ronald Davis; Fiscal Year: 2005
  9. MOLECULAR BIOLOGY OF DROSOPHILA LEARNING AND MEMORY
    Ronald Davis; Fiscal Year: 2004
  10. INTEGRIN FUNCTION IN MEMORY
    Ronald Davis; Fiscal Year: 2007

Collaborators

Detail Information

Publications40

  1. pmc The GABAergic anterior paired lateral neuron suppresses and is suppressed by olfactory learning
    Xu Liu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Neurosci 12:53-9. 2009
    ..These results demonstrate a mutual suppression between the GABAergic APL neuron and olfactory learning, and emphasize the functional neuroplasticity of the GABAergic system as a result of learning...
  2. pmc Isolation of mRNA from specific tissues of Drosophila by mRNA tagging
    Zhiyong Yang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Nucleic Acids Res 33:e148. 2005
    ..Furthermore, at least 11 novel genes have been identified as enriched in photoreceptor cells. mRNA tagging is a powerful general method for profiling gene expression in specific tissues and for identifying tissue-specific genes...
  3. pmc Eight different types of dopaminergic neurons innervate the Drosophila mushroom body neuropil: anatomical and physiological heterogeneity
    Zhengmei Mao
    Department of Molecular and Cellular Biology, Baylor College of Medicine Houston, TX, USA
    Front Neural Circuits 3:5. 2009
    ..Differences in functional response properties of these neurons suggest that they are involved in different behavioral processes...
  4. ncbi request reprint Mushroom bodies, Ca(2+) oscillations, and the memory gene amnesiac
    R L Davis
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 30:653-6. 2001
    ..Slow and spontaneous oscillations of calcium levels are elevated in the mushroom body neurons of amnesiac mutants and may contribute to memory consolidation...
  5. ncbi request reprint Olfactory memory formation in Drosophila: from molecular to systems neuroscience
    Ronald L Davis
    Department of Molecular and Cellular Biology, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Annu Rev Neurosci 28:275-302. 2005
    ..Finally, the genes identified to participate in Drosophila olfactory learning have conserved roles in mammalian organisms, highlighting the value of Drosophila for gene discovery...
  6. ncbi request reprint Olfactory learning
    Ronald L Davis
    Department of Molecular and Cellular Biology, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 44:31-48. 2004
    ..Molecular genetic studies of olfactory learning in Drosophila have revealed numerous molecules that function within the third order olfactory neurons for normal olfactory learning...
  7. ncbi request reprint The scent of Drosophila sex
    Ronald L Davis
    Department of Molecular and Cellular Biology, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030 USA
    Neuron 54:14-6. 2007
  8. pmc A distinct set of Drosophila brain neurons required for neurofibromatosis type 1-dependent learning and memory
    Monica E Buchanan
    Department of Molecular and Human Genetics and Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Neurosci 30:10135-43. 2010
    ....
  9. ncbi request reprint Spatiotemporal rescue of memory dysfunction in Drosophila
    Sean E McGuire
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 302:1765-8. 2003
    ..The TARGET system offers general utility in simultaneously addressing issues of when and where gene products are required...
  10. ncbi request reprint The dachshund gene is required for the proper guidance and branching of mushroom body axons in Drosophila melanogaster
    Sharyl R Martini
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurobiol 64:133-44. 2005
    ..In addition, mushroom body axons exhibit excessive branching in dachshund mutant clones. Thus, dachshund is required in mushroom body neurons for proper axon guidance and branching...
  11. ncbi request reprint Drosophila DPM neurons form a delayed and branch-specific memory trace after olfactory classical conditioning
    Dinghui Yu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 123:945-57. 2005
    ..DPM neurons are therefore "odor generalists" and form a delayed, branch-specific, and amnesiac-dependent memory trace that may guide behavior after acquisition...
  12. pmc Pharmacogenetic rescue in time and space of the rutabaga memory impairment by using Gene-Switch
    Zhengmei Mao
    Departments of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:198-203. 2004
    ..Such combined pharmacogenetic regulation of transgene expression now allows this time and space dissection to be made for other behavioral mutants...
  13. pmc Gilgamesh is required for rutabaga-independent olfactory learning in Drosophila
    Ying Tan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 67:810-20. 2010
    ..Therefore, gish participates in a rutabaga-independent pathway for memory formation and accounts for some of the residual learning that occurs in rutabaga mutants...
  14. pmc GABAA receptor RDL inhibits Drosophila olfactory associative learning
    Xu Liu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 56:1090-102. 2007
    ..Together, these data suggest that RDL negatively modulates olfactory associative learning, possibly by gating the input of olfactory information into the MBs...
  15. pmc Drosophila alpha/beta mushroom body neurons form a branch-specific, long-term cellular memory trace after spaced olfactory conditioning
    Dinghui Yu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Neuron 52:845-55. 2006
    ....
  16. ncbi request reprint Drosophila homer is required in a small set of neurons including the ellipsoid body for normal ethanol sensitivity and tolerance
    Nancy L Urizar
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 27:4541-51. 2007
    ..Thus, some of the molecular- and systems-level requirements for these two behavioral responses to ethanol are identical...
  17. ncbi request reprint Altered representation of the spatial code for odors after olfactory classical conditioning; memory trace formation by synaptic recruitment
    Dinghui Yu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030 USA
    Neuron 42:437-49. 2004
    ..The rapid recruitment by conditioning of new synapses into the representation of sensory information may be a general mechanism underlying many forms of short-term memory...
  18. ncbi request reprint Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in Drosophila
    Sean E McGuire
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Sci STKE 2004:pl6. 2004
    ..In this protocol, we provide guidelines for the use of these two novel systems, which should have general utility in studying Drosophila biology and in using the fly as a model for human disease...
  19. ncbi request reprint Thirty years of olfactory learning and memory research in Drosophila melanogaster
    Sean E McGuire
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Prog Neurobiol 76:328-47. 2005
    ....
  20. ncbi request reprint Insect olfactory memory in time and space
    Xu Liu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Opin Neurobiol 16:679-85. 2006
    ....
  21. pmc Roles for Drosophila mushroom body neurons in olfactory learning and memory
    David Benjamin G Akalal
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 13:659-68. 2006
    ....
  22. ncbi request reprint Conditional expression of UAS-transgenes in the adult eye with a new gene-switch vector system
    Gregg Roman
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genesis 34:127-31. 2002
  23. pmc Olfactory memory traces in Drosophila
    Jacob Berry
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Prog Brain Res 169:293-304. 2008
    ..Therefore, it appears that aversive olfactory associations are encoded by multiple cellular memory traces that occur in different regions of the brain with different temporal domains...
  24. pmc The GABAA receptor RDL suppresses the conditioned stimulus pathway for olfactory learning
    Xu Liu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 29:1573-9. 2009
    ..The combined data suggest that RDL suppresses olfactory learning via CS pathway involvement...
  25. ncbi request reprint Detection of calcium transients in Drosophila mushroom body neurons with camgaroo reporters
    Dinghui Yu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 23:64-72. 2003
    ..Fluorescence was observed to increase in all three classes of mushroom body neurons, indicating that all types respond to cholinergic innervation...
  26. pmc Dynamics of learning-related cAMP signaling and stimulus integration in the Drosophila olfactory pathway
    Seth M Tomchik
    Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 64:510-21. 2009
    ..These data suggest that rutabaga functions as a coincidence detector in an intact neuronal circuit, with dopamine and octopamine bidirectionally influencing the generation of cAMP...
  27. ncbi request reprint Gene expression systems in Drosophila: a synthesis of time and space
    Sean E McGuire
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Trends Genet 20:384-91. 2004
    ....
  28. ncbi request reprint The role of cAMP response element-binding protein in Drosophila long-term memory
    Bastianella Perazzona
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 24:8823-8. 2004
    ..Overexpression of the dCREB2-b repressor transgene, in contrast, produced the anticipated block in LTM formation. We discuss the implications of these findings and propose an alternative model for the role of dCREB in Drosophila LTM...
  29. pmc A Drosophila nonvisual arrestin is required for the maintenance of olfactory sensitivity
    Hong Ge
    Department of Biology and Biochemistry, University of Houston, 4800 Calhoun Road, Houston, TX 77204, USA
    Chem Senses 31:49-62. 2006
    ..The reduced receptor potentials in krz(1) antenna indicate that nonvisual arrestins are required for the early odor-induced signaling events within the ORNs...
  30. ncbi request reprint Cyclic AMP imaging sheds light on PDF signaling in circadian clock neurons
    Seth M Tomchik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 58:161-3. 2008
    ..Thus, PDF apparently exerts more widespread effects on the circadian clock network than suggested by previous studies of PDF receptor expression...
  31. ncbi request reprint An adjustable-threshold algorithm for the identification of objects in three-dimensional images
    Artem L Ponomarev
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Bioinformatics 19:1431-5. 2003
    ..To test the algorithm on images of the Drosophila brain, and identify, count and determine the locations of neurons in the images...
  32. ncbi request reprint Remote control of fruit fly behavior
    Ronald L Davis
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Cell 121:6-7. 2005
    ..In this issue of Cell, Lima and Miesenböck (Lima and Miesenböck, 2005) dump the stimulating electrode in favor of a new remote control system to excite specific neurons--light activation of transgenically supplied ion channels...
  33. ncbi request reprint SRC-1 null mice exhibit moderate motor dysfunction and delayed development of cerebellar Purkinje cells
    Eijun Nishihara
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 23:213-22. 2003
    ..Disruption of SRC-1 specifically delays the PC development and maturation in early stages and results in moderate motor dysfunction in adulthood...
  34. pmc Exploratory activity in Drosophila requires the kurtz nonvisual arrestin
    Lingzhi Liu
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204, USA
    Genetics 175:1197-212. 2007
    ..Therefore, the exploratory phase of open field activity requires kurtz in the nervous system, but is independent of dopamine's stimulation of activity...
  35. ncbi request reprint Integrin requirement for hippocampal synaptic plasticity and spatial memory
    Chi Shing Chan
    Department of Molecular and Cellular Biology, Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 23:7107-16. 2003
    ..These results demonstrate that several different integrins are involved in physiological plasticity and provide the first evidence of their requirement for behavioral plasticity in vertebrates...
  36. pmc Alpha3-integrins are required for hippocampal long-term potentiation and working memory
    Chi Shing Chan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 14:606-15. 2007
    ..The impairment in LTP and working memory is similar to that observed in beta1-integrin conditional knockout mice, suggesting that alpha3-integrin is the functional binding partner for beta1 for these processes in the forebrain...
  37. pmc Beta 1-integrins are required for hippocampal AMPA receptor-dependent synaptic transmission, synaptic plasticity, and working memory
    Chi Shing Chan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 26:223-32. 2006
    ..These observations suggest a new function of beta1-integrins as regulators of synaptic glutamate receptor function and working memory...
  38. pmc Spatial and temporal control of gene expression in Drosophila using the inducible GeneSwitch GAL4 system. I. Screen for larval nervous system drivers
    Louise Nicholson
    MCDB Department, Yale University, New Haven, CT 06520 8103, USA
    Genetics 178:215-34. 2008
    ..However, >90% of the neuron-specific driver lines showed little or no background activity, making them particularly useful for inducible expression studies...
  39. doi request reprint Behavioural neuroscience: Out of sight, but not out of mind
    Seth M Tomchik
    Nature 453:1192-4. 2008
  40. ncbi request reprint Octopamine receptor OAMB is required for ovulation in Drosophila melanogaster
    Hyun Gwan Lee
    Department of Biobehavioral Health and The Huck Institute of Life Sciences, 315 Health and Human Development East, Pennsylvania State University, University Park, PA 16802, USA
    Dev Biol 264:179-90. 2003
    ..The novel expression pattern of OAMB and its genetic resource described in this study will help advance our understanding on how the neuromodulatory or endocrine system controls reproductive physiology and behavior...

Research Grants39

  1. Regulated Gene Expression and Drosophila Behavior
    Ronald Davis; Fiscal Year: 2003
    ..The techniques proposed here offer a general method for turning on gene activity both spatially and temporally in Drosophila. ..
  2. INTEGRIN FUNCTION IN MEMORY
    Ronald Davis; Fiscal Year: 2000
    ..In addition, the research may highlight possible points of molecular dysfunction underlying cognitive diseases. ..
  3. MOLECULAR BIOLOGY OF DROSOPHILA LEARNING AND MEMORY
    Ronald Davis; Fiscal Year: 2000
    ....
  4. Olfactory memory trace formation in Drosophila
    Ronald Davis; Fiscal Year: 2006
    ..These experiments will significantly increase our understanding of how memories form and the events that can potentially perturb normal memory formation. This will aid in our understanding of the diseases that affect memory formation. ..
  5. NEUROBIOLOGICALLY IMPORTANT GENES II
    Ronald Davis; Fiscal Year: 1990
    ....
  6. MOLECULAR BIOLOGY OF DROSOPHILA LEARNING AND MEMORY
    Ronald Davis; Fiscal Year: 2009
    ....
  7. INTEGRIN FUNCTION IN MEMORY
    Ronald Davis; Fiscal Year: 2009
    ..Insights for the improvement of the diagnosis and treatment of diseases of working memory may be gathered from these studies. ..
  8. MOLECULAR BIOLOGY OF DROSOPHILA LEARNING AND MEMORY
    Ronald Davis; Fiscal Year: 2005
    ..This basic information is expected to be of general significance to learning in other species and of relevance to diseases that affect cognition. ..
  9. MOLECULAR BIOLOGY OF DROSOPHILA LEARNING AND MEMORY
    Ronald Davis; Fiscal Year: 2004
    ..This basic information is expected to be of general significance to learning in other species and of relevance to diseases that affect cognition. ..
  10. INTEGRIN FUNCTION IN MEMORY
    Ronald Davis; Fiscal Year: 2007
    ..Insights for the improvement of the diagnosis and treatment of diseases of working memory may be gathered from these studies. ..
  11. Olfactory memory trace formation in Drosophila
    Ronald Davis; Fiscal Year: 2007
    ..These experiments will significantly increase our understanding of how memories form and the events that can potentially perturb normal memory formation. This will aid in our understanding of the diseases that affect memory formation. ..
  12. Cyclic AMP Signaling and Bipolar Disorder
    Ronald Davis; Fiscal Year: 2007
    ..Public Health Relevance: Bipolar Disorder is a prevalent brain disorder. The studies proposed here will help to elucidate the genetic basis for the disease. ..
  13. Generation and validation of inducible Cre driver lines by enhancer trapping
    Ronald Davis; Fiscal Year: 2007
    ..This is the lesson learned from Drosophila genetics and there is every reason to expect it to hold in the mouse. ..
  14. Neuroadaptations to Ethanol in Drosophila
    Therese Kosten; Fiscal Year: 2007
    ..These studies will further our understanding of the genetic basis for ethanol sensitivity and tolerance, important parameters for susceptibility to alcoholism. ..
  15. Olfactory memory trace formation in Drosophila
    Ronald Davis; Fiscal Year: 2009
    ..This will aid in our understanding of the diseases that affect memory formation. ..
  16. INTEGRIN FUNCTION IN MEMORY
    Ronald Davis; Fiscal Year: 2003
    ..In addition, the research may highlight possible points of molecular dysfunction underlying cognitive diseases. ..
  17. MOLECULAR BIOLOGY OF DROSOPHILA LEARNING AND MEMORY
    Ronald Davis; Fiscal Year: 2003
    ..This basic information is expected to be of general significance to learning in other species and of relevance to diseases that affect cognition. ..
  18. MOLECULAR BIOLOGY OF DROSOPHILA LEARNING AND MEMORY
    Ronald Davis; Fiscal Year: 1999
    ....
  19. NEUROBIOLOGICALLY IMPORTANT GENES II
    Ronald Davis; Fiscal Year: 1991
    ....
  20. Regulated Gene Expression and Drosophila Behavior
    Ronald Davis; Fiscal Year: 2001
    ..The techniques proposed here offer a general method for turning on gene activity both spatially and temporally in Drosophila. ..
  21. INTEGRIN FUNCTION IN MEMORY
    Ronald Davis; Fiscal Year: 2001
    ..In addition, the research may highlight possible points of molecular dysfunction underlying cognitive diseases. ..
  22. MOLECULAR BIOLOGY OF DROSOPHILA LEARNING AND MEMORY
    Ronald Davis; Fiscal Year: 2001
    ..This basic information is expected to be of general significance to learning in other species and of relevance to diseases that affect cognition. ..
  23. Regulated Gene Expression and Drosophila Behavior
    Ronald Davis; Fiscal Year: 2002
    ..The techniques proposed here offer a general method for turning on gene activity both spatially and temporally in Drosophila. ..
  24. INTEGRIN FUNCTION IN MEMORY
    Ronald Davis; Fiscal Year: 2002
    ..In addition, the research may highlight possible points of molecular dysfunction underlying cognitive diseases. ..
  25. MOLECULAR BIOLOGY OF DROSOPHILA LEARNING AND MEMORY
    Ronald Davis; Fiscal Year: 2002
    ..This basic information is expected to be of general significance to learning in other species and of relevance to diseases that affect cognition. ..