Alan R Davis

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Primitive adult hematopoietic stem cells can function as osteoblast precursors
    Elizabeth A Olmsted-Davis
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:15877-82. 2003
  2. ncbi request reprint Adenovirus BMP2-induced osteogenesis in combination with collagen carriers
    Zbigniew Gugala
    Department of Orthopaedic Surgery, Baylor College of Medicine, Houston, TX, USA
    Biomaterials 28:4469-79. 2007
  3. ncbi request reprint Efficient and rapid osteoinduction in an immune-competent host
    Christine M Fouletier-Dilling
    Center for Cell and Gene Therapy, Department of Orthopedic Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Gene Ther 18:733-45. 2007
  4. pmc An injectable method for noninvasive spine fusion
    Ronke M Olabisi
    Department of Bioengineering, Rice University, MS 142, 6100 Main St, Houston, TX 77005, USA
    Spine J 11:545-56. 2011
  5. pmc Cell-based gene therapy for repair of critical size defects in the rat fibula
    Zawaunyka W Lazard
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    J Cell Biochem 112:1563-71. 2011
  6. ncbi request reprint Oxygen tension directs chondrogenic differentiation of myelo-monocytic progenitors during endochondral bone formation
    Jessica Shafer
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    Tissue Eng 13:2011-9. 2007
  7. doi request reprint Rapid healing of femoral defects in rats with low dose sustained BMP2 expression from PEGDA hydrogel microspheres
    Corinne Sonnet
    Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, ALKEK Building, Room N1010, Houston, Texas 77030, USA
    J Orthop Res 31:1597-604. 2013
  8. pmc Transient brown adipocyte-like cells derive from peripheral nerve progenitors in response to bone morphogenetic protein 2
    Elizabeth A Salisbury
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA
    Stem Cells Transl Med 1:874-85. 2012
  9. ncbi request reprint Large-scale expansion of dendritic cell-primed polyclonal human cytotoxic T-lymphocyte lines using lymphoblastoid cell lines for adoptive immunotherapy
    Uluhan Sili
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Immunother 26:241-56. 2003
  10. pmc Hypoxic adipocytes pattern early heterotopic bone formation
    Elizabeth Olmsted-Davis
    Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Am J Pathol 170:620-32. 2007

Research Grants

  1. Vector Targeting for Fracture Repair
    Alan Davis; Fiscal Year: 2002

Collaborators

Detail Information

Publications25

  1. pmc Primitive adult hematopoietic stem cells can function as osteoblast precursors
    Elizabeth A Olmsted-Davis
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:15877-82. 2003
    ..This property not only elucidates a previously unrecognized step in osteoblast development, but also has intriguing implications for the use of SP cells in clinical orthopedics and stem cell-based disorders of bone...
  2. ncbi request reprint Adenovirus BMP2-induced osteogenesis in combination with collagen carriers
    Zbigniew Gugala
    Department of Orthopaedic Surgery, Baylor College of Medicine, Houston, TX, USA
    Biomaterials 28:4469-79. 2007
    ..Adenoviral ex vivo BMP2 gene therapy in combination with collagen carriers with distinct physical characteristics offers the prospects of adjusting this approach to optimally match the specific therapeutic requirements...
  3. ncbi request reprint Efficient and rapid osteoinduction in an immune-competent host
    Christine M Fouletier-Dilling
    Center for Cell and Gene Therapy, Department of Orthopedic Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Gene Ther 18:733-45. 2007
    ..The results suggest that the ability of BMP2 to rapidly induce bone formation overrides contributions from either immune status or the nature of delivery cells...
  4. pmc An injectable method for noninvasive spine fusion
    Ronke M Olabisi
    Department of Bioengineering, Rice University, MS 142, 6100 Main St, Houston, TX 77005, USA
    Spine J 11:545-56. 2011
    ..Even in combination with BMPs, clinical spinal fusion has a high failure rate, presumably because of difficulties in localizing sufficient levels of BMP...
  5. pmc Cell-based gene therapy for repair of critical size defects in the rat fibula
    Zawaunyka W Lazard
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    J Cell Biochem 112:1563-71. 2011
    ..The data collectively indicates that the use of BMP2 gene therapy strategies may vary depending on the location and nature of the defect. Therefore, additional parameters should be considered when implementing such strategies...
  6. ncbi request reprint Oxygen tension directs chondrogenic differentiation of myelo-monocytic progenitors during endochondral bone formation
    Jessica Shafer
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    Tissue Eng 13:2011-9. 2007
    ....
  7. doi request reprint Rapid healing of femoral defects in rats with low dose sustained BMP2 expression from PEGDA hydrogel microspheres
    Corinne Sonnet
    Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, ALKEK Building, Room N1010, Houston, Texas 77030, USA
    J Orthop Res 31:1597-604. 2013
    ..We propose that these osteoinductive microspheres offer a more efficacious and safer clinical option over the use of rhBMP2...
  8. pmc Transient brown adipocyte-like cells derive from peripheral nerve progenitors in response to bone morphogenetic protein 2
    Elizabeth A Salisbury
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA
    Stem Cells Transl Med 1:874-85. 2012
    ....
  9. ncbi request reprint Large-scale expansion of dendritic cell-primed polyclonal human cytotoxic T-lymphocyte lines using lymphoblastoid cell lines for adoptive immunotherapy
    Uluhan Sili
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Immunother 26:241-56. 2003
    ..An unlimited source of antigen presenting cells that could present antigen in the appropriate MHC context emerged as a critical point for expansion of polyclonal, antigen-specific CTL lines...
  10. pmc Hypoxic adipocytes pattern early heterotopic bone formation
    Elizabeth Olmsted-Davis
    Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Am J Pathol 170:620-32. 2007
    ..Manipulation of the transcriptional control of adipocyte fate in local soft-tissue environments may offer a means to prevent or treat development of bone in extraskeletal sites...
  11. pmc Hydrogel microsphere encapsulation of a cell-based gene therapy system increases cell survival of injected cells, transgene expression, and bone volume in a model of heterotopic ossification
    Ronke M Olabisi
    Department of Bioengineering, Rice University, Houston, Texas 77005, USA
    Tissue Eng Part A 16:3727-36. 2010
    ..The data suggest that microencapsulation protects cells and prolongs and spatially distributes transgene expression. Thus, incorporation of PEGDA hydrogels significantly advances current gene therapy bone repair approaches...
  12. doi request reprint Matrix metalloproteinase-9 is a diagnostic marker of heterotopic ossification in a murine model
    Eric Rodenberg
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    Tissue Eng Part A 17:2487-96. 2011
    ....
  13. doi request reprint Cathepsin K-sensitive poly(ethylene glycol) hydrogels for degradation in response to bone resorption
    Chih Wei Hsu
    Department of Bioengineering, Rice University, 6100 Main St, Houston, Texas 77005, USA
    J Biomed Mater Res A 98:53-62. 2011
    ..In summary, we have demonstrated that by incorporating a cathepsin K-sensitive peptide into a synthetic polymer structure, we can generate biomaterials that specifically respond to cues from the natural process of bone remodeling...
  14. pmc Histologic identification of brown adipose and peripheral nerve involvement in human atherosclerotic vessels
    Elizabeth Salisbury
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Pathol 43:2213-22. 2012
    ....
  15. pmc Sensory nerve induced inflammation contributes to heterotopic ossification
    Elizabeth Salisbury
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    J Cell Biochem 112:2748-58. 2011
    ..Further, blocking this process significantly reduces HO, suggesting that the stem cell population contributes to bone formation...
  16. ncbi request reprint Novel compound enables high-level adenovirus transduction in the absence of an adenovirus-specific receptor
    Christine M Fouletier-Dilling
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Gene Ther 16:1287-97. 2005
    ..The results suggest a novel and versatile method for achieving high-level transduction using adenovirus...
  17. ncbi request reprint Endochondral bone formation from hydrogel carriers loaded with BMP2-transduced cells
    Malavosklish Bikram
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, 1441 Moursund Street, Houston, TX 77030, USA
    Ann Biomed Eng 35:796-807. 2007
    ..5 +/- 25.0 mm3 mineralized tissue and 31.8 +/- 7.8 mm3 for the cell-injected mice, and the bone was localized to the hydrogel surfaces. Histology revealed bone as well as cartilage for both hydrogel implanted and cell-injected animals...
  18. ncbi request reprint Use of a chimeric adenovirus vector enhances BMP2 production and bone formation
    Elizabeth A Olmsted-Davis
    Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Gene Ther 13:1337-47. 2002
    ..Mineralized bone was radiologically identified only in muscle that received the Ad5F35BMP2 transduced hBM-MSCs. In summary, Ad5F35BMP2 can efficiently transduce hBM-MSCs leading to enhanced bone formation in vivo...
  19. pmc Multiple treatment cycles of liposome-encapsulated adenoviral RIP-TK gene therapy effectively ablate human pancreatic cancer cells in SCID mice
    Shi He Liu
    Michael E DeBakey Department of Surgery, Elkins Pancreas Center, Baylor College of Medicine, Houston, TX 77030, USA
    Surgery 149:484-95. 2011
    ....
  20. pmc Characterization of chemical, radiochemical and optical properties of a dual-labeled MMP-9 targeting peptide
    Ali Azhdarinia
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX 77030, USA
    Bioorg Med Chem 19:3769-76. 2011
    ..This attests to the feasibility of using (68)Ga/NIR for dual-labeling of other peptides or small molecules for multimodality molecular imaging...
  21. ncbi request reprint Heterotopic ossification has some nerve
    Elizabeth Salisbury
    Center for Cell and Gene Therapy and Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Crit Rev Eukaryot Gene Expr 20:313-24. 2010
    ..We concentrate on the manner in which local changes in bone morphogenetic protein (BMP) expression contribute to a cascade of events within the peripheral nerves, both sensory and sympathetic, in the immediate area of HO formation...
  22. pmc Vessel formation is induced prior to the appearance of cartilage in BMP-2-mediated heterotopic ossification
    Christine Fouletier Dilling
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    J Bone Miner Res 25:1147-56. 2010
    ..The data collectively suggest that vascular remodeling and growth may be essential to modify the microenvironment and enable engraftment of the necessary progenitors to form endochondral bone...
  23. pmc Assessing mechanical integrity of spinal fusion by in situ endochondral osteoinduction in the murine model
    Ashvin K Dewan
    Spine Research Lab, Baylor College of Medicine, Houston, TX USA
    J Orthop Surg Res 5:58. 2010
    ..abstract:..
  24. ncbi request reprint Generating CTLs against the subdominant Epstein-Barr virus LMP1 antigen for the adoptive immunotherapy of EBV-associated malignancies
    Stephen Gottschalk
    Center for Cell and Gene Therapy, Texas Children s Cancer Center, Departments of Pediatrics, Medicine, and Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Blood 101:1905-12. 2003
    ..Targeting LMP1 in these malignancies may improve the efficacy of current adoptive immunotherapy approaches...
  25. pmc Differential proteoglycan and hyaluronan distribution in calcified aortic valves
    Elizabeth H Stephens
    Department of Bioengineering, Rice University, Houston, TX 77005, USA
    Cardiovasc Pathol 20:334-42. 2011
    ..Proteoglycans and the glycosaminoglycan hyaluronan are involved in calcification in arteriosclerosis and their characterization in calcified aortic valves may lend insight into the pathogenesis of the disease...

Research Grants1

  1. Vector Targeting for Fracture Repair
    Alan Davis; Fiscal Year: 2002
    ..Given the applicant's experience in adenoviral vector design and translational research in university and pharmaceutical settings, the prospects for a successful outcome of this project appear high. ..