Research Topics
Species | S DattaSummaryAffiliation: Texas A and M University Country: USA Publications
Research Grants
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Detail Information
Publications
Drosophila perlecan modulates FGF and hedgehog signals to activate neural stem cell divisionYoungji Park
Department of Biochemistry and Biophysics, Texas A and M University, TAMU 2128, College Station, TX 77843 2128, USA
Dev Biol 253:247-57. 2003..These results indicate that Trol can mediate signaling through both of the FGF and Hedgehog pathways to control the onset of stem cell proliferation in the developing nervous system...
Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathwayMilton W Datta
Department of Pathology, Emory University, Atlanta, GA 30322, USA
Mol Cancer 5:9. 2006..Previously we have linked Perlecan to Hedgehog signaling in Drosophila. More recently, we have demonstrated the importance of Hedgehog signaling in humans for advanced prostate cancer...- The Drosophila Perlecan gene trol regulates multiple signaling pathways in different developmental contextsJonathan R Lindner
Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas, 77843 2128, USA
BMC Dev Biol 7:121. 2007..Here we extend analysis of trol mutant phenotypes to show that trol is required for a variety of developmental events and modulates signaling by multiple growth factors in different situations... - Activation of neuroblast proliferation in explant culture of the Drosophila larval CNSS Datta
Department of Biochemistry, Center for Advanced Invertebrate Molecular Sciences, Texas A and M University, College Station, TX 77843 2128, USA
Brain Res 818:77-83. 1999.... - Perlecan signaling: helping hedgehog stimulate prostate cancer growthSumana Datta
Department of Biochemistry and Biophysics, MS 2128, Texas A and M University, College Station, TX 77843 2128, United States
Int J Biochem Cell Biol 38:1855-61. 2006..Inhibitors of Perlecan function at either the protein or glycan level would be ideal drug candidates for anti-cancer therapies... - Sonic Hedgehog signaling in advanced prostate cancerS Datta
Department of Biochemistry and Biophysics, MS 2128, Texas A and M University, College Station, Texas 77843 2128, USA
Cell Mol Life Sci 63:435-48. 2006..Thus, Hedgehog signaling represents a novel pathway in prostate cancer that offers opportunities for prognostic biomarker development, drug targeting and therapeutic response monitoring... - even skipped is required to produce a trans-acting signal for larval neuroblast proliferation that can be mimicked by ecdysoneY Park
Department of Biochemistry and Biophysics, Texas A and M University, College Station, TX 77843 2128, USA
Development 128:1899-909. 2001..Furthermore, the effect of an eve mutation can be rescued both in vivo and in culture by the hormone ecdysone. These results suggest that eve is required to produce a trans-acting factor that stimulates cell division in the larval brain... - Drosophila homeobox gene eve enhances trol, an activator of neuroblast proliferation in the larval CNSY Park
Dept of Biochemistry and Biophysics, Texas A and M University, College Station 77843 2128, USA
Dev Genet 23:247-57. 1998..Finally, activation of neuroblast proliferation is normal in eve4 heterozygotes, suggesting that the proliferation defect observed in trolb22;eve/+ animals is due to a synergistic interaction... - Expression of cyclin E or DP/E2F rescues the G1 arrest of trol mutant neuroblasts in the Drosophila larval central nervous systemM C Caldwell
Department of Biochemistry and Biophysics, Texas A and M University, College Station 77843 2128, USA
Mech Dev 79:121-30. 1998..Neither cyclin E nor E2F expression can phenocopy ana mutations, indicating that arrest caused by lack of Trol is different from Ana-mediated arrest... - Mutation of the central nervous system neuroblast proliferation repressor ana leads to defects in larval olfactory behaviorY Park
Department of Biochemistry and Biophysics and Center for Advanced Invertebrate Molecular Sciences, Texas A and M University, College Station 77843 2128, USA
J Neurobiol 33:199-211. 1997..This is consistent with proliferation analysis in the early larval AMC region which uncovered a significantly higher number of S-phase cells in ana9 mutants... - Control of proliferation activation in quiescent neuroblasts of the Drosophila central nervous systemS Datta
Department of Biochemistry and Biophysics, Texas A and M University, College Station 77843 2128, USA
Development 121:1173-82. 1995..These results suggest that trol and ana are components of a novel developmental pathway for the control of cell cycle activation in quiescent neuroblasts... 
Proline metabolism in the conceptus: implications for fetal growth and developmentG Wu
Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
Amino Acids 35:691-702. 2008....- Branchless and Hedgehog operate in a positive feedback loop to regulate the initiation of neuroblast division in the Drosophila larval brainA L Barrett
Department of Biochemistry and Biophysics, MS 2128, Texas A and M University, College Station, TX 77843 2128, USA
Dev Biol 317:234-45. 2008..These studies establish the molecular mechanism through which Branchless and Hedgehog signaling interface to regulate the activation of neural stem cell division... - Induction of string rescues the neuroblast proliferation defect in trol mutant animalsYoungji Park
Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843, USA
Genesis 36:187-95. 2003..These results suggest that Drosophila Cdc25 may directly or indirectly increase the kinase activity of Cyclin E-Cdk2 complexes in vivo, thus driving arrested neuroblasts into cell division... - Curable genetic instability of a gal4 transgene in DrosophilaAndrea Barrett
Department of Biochemistry and Biophysics, MS 2128, Texas A and M University, College Station, Texas 77843 2128, USA
Fly (Austin) 2:67-73. 2008..Our data indicate that other tetracycline-sensitive agents can cause genetic instability of transgenes, and also provides a potential solution to the problem... - Arabidopsis vegetative storage protein is an anti-insect acid phosphataseYilin Liu
Department of Entomology, Texas A and M University, College Station, TX 77843, USA
Plant Physiol 139:1545-56. 2005..Collectively, we conclude that AtVSP2 is an anti-insect protein and that its defense function is correlated with its acid phosphatase activity... - Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signalingPilar Sanchez
Skirball Institute and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Proc Natl Acad Sci U S A 101:12561-6. 2004..Our data demonstrate the dependence of prostate cancer on SHH-GLI function and suggest a novel therapeutic approach...
Research Grants
- CONTROL OF NEUROBLAST PROLIFERATION IN DROSOPHILASumana Datta; Fiscal Year: 2001..These studies will provide important insights into the mechanism by which proliferation of stem cells is controlled by developmental cues, and will generate new tools and reagents to probe further into these mechanisms. ..
- Perlecan-Mediated Control of Prostate Cancer ProgressionSumana Datta; Fiscal Year: 2005..These studies will link proteoglycan expression, signaling function and sugar structure to cancer progression. ..
- CONTROL OF NEUROBLAST PROLIFERATION IN DROSOPHILASumana Datta; Fiscal Year: 2006..These studies will provide important insights into the mechanism(s) by which stem cell division is controlled by developmental cues--a process of fundamental importance in all animals, including humans. ..