S Datta

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. ncbi request reprint Drosophila perlecan modulates FGF and hedgehog signals to activate neural stem cell division
    Youngji Park
    Department of Biochemistry and Biophysics, Texas A and M University, TAMU 2128, College Station, TX 77843 2128, USA
    Dev Biol 253:247-57. 2003
  2. pmc Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway
    Milton W Datta
    Department of Pathology, Emory University, Atlanta, GA 30322, USA
    Mol Cancer 5:9. 2006
  3. pmc The Drosophila Perlecan gene trol regulates multiple signaling pathways in different developmental contexts
    Jonathan R Lindner
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas, 77843 2128, USA
    BMC Dev Biol 7:121. 2007
  4. ncbi request reprint Perlecan signaling: helping hedgehog stimulate prostate cancer growth
    Sumana Datta
    Department of Biochemistry and Biophysics, MS 2128, Texas A and M University, College Station, TX 77843 2128, United States
    Int J Biochem Cell Biol 38:1855-61. 2006
  5. ncbi request reprint Sonic Hedgehog signaling in advanced prostate cancer
    S Datta
    Department of Biochemistry and Biophysics, MS 2128, Texas A and M University, College Station, Texas 77843 2128, USA
    Cell Mol Life Sci 63:435-48. 2006
  6. ncbi request reprint Activation of neuroblast proliferation in explant culture of the Drosophila larval CNS
    S Datta
    Department of Biochemistry, Center for Advanced Invertebrate Molecular Sciences, Texas A and M University, College Station, TX 77843 2128, USA
    Brain Res 818:77-83. 1999
  7. pmc even skipped is required to produce a trans-acting signal for larval neuroblast proliferation that can be mimicked by ecdysone
    Y Park
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, TX 77843 2128, USA
    Development 128:1899-909. 2001
  8. ncbi request reprint Expression of cyclin E or DP/E2F rescues the G1 arrest of trol mutant neuroblasts in the Drosophila larval central nervous system
    M C Caldwell
    Department of Biochemistry and Biophysics, Texas A and M University, College Station 77843 2128, USA
    Mech Dev 79:121-30. 1998
  9. ncbi request reprint Drosophila homeobox gene eve enhances trol, an activator of neuroblast proliferation in the larval CNS
    Y Park
    Dept of Biochemistry and Biophysics, Texas A and M University, College Station 77843 2128, USA
    Dev Genet 23:247-57. 1998
  10. ncbi request reprint Mutation of the central nervous system neuroblast proliferation repressor ana leads to defects in larval olfactory behavior
    Y Park
    Department of Biochemistry and Biophysics and Center for Advanced Invertebrate Molecular Sciences, Texas A and M University, College Station 77843 2128, USA
    J Neurobiol 33:199-211. 1997

Research Grants

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Drosophila perlecan modulates FGF and hedgehog signals to activate neural stem cell division
    Youngji Park
    Department of Biochemistry and Biophysics, Texas A and M University, TAMU 2128, College Station, TX 77843 2128, USA
    Dev Biol 253:247-57. 2003
    ..These results indicate that Trol can mediate signaling through both of the FGF and Hedgehog pathways to control the onset of stem cell proliferation in the developing nervous system...
  2. pmc Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway
    Milton W Datta
    Department of Pathology, Emory University, Atlanta, GA 30322, USA
    Mol Cancer 5:9. 2006
    ..Previously we have linked Perlecan to Hedgehog signaling in Drosophila. More recently, we have demonstrated the importance of Hedgehog signaling in humans for advanced prostate cancer...
  3. pmc The Drosophila Perlecan gene trol regulates multiple signaling pathways in different developmental contexts
    Jonathan R Lindner
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas, 77843 2128, USA
    BMC Dev Biol 7:121. 2007
    ..Here we extend analysis of trol mutant phenotypes to show that trol is required for a variety of developmental events and modulates signaling by multiple growth factors in different situations...
  4. ncbi request reprint Perlecan signaling: helping hedgehog stimulate prostate cancer growth
    Sumana Datta
    Department of Biochemistry and Biophysics, MS 2128, Texas A and M University, College Station, TX 77843 2128, United States
    Int J Biochem Cell Biol 38:1855-61. 2006
    ..Inhibitors of Perlecan function at either the protein or glycan level would be ideal drug candidates for anti-cancer therapies...
  5. ncbi request reprint Sonic Hedgehog signaling in advanced prostate cancer
    S Datta
    Department of Biochemistry and Biophysics, MS 2128, Texas A and M University, College Station, Texas 77843 2128, USA
    Cell Mol Life Sci 63:435-48. 2006
    ..Thus, Hedgehog signaling represents a novel pathway in prostate cancer that offers opportunities for prognostic biomarker development, drug targeting and therapeutic response monitoring...
  6. ncbi request reprint Activation of neuroblast proliferation in explant culture of the Drosophila larval CNS
    S Datta
    Department of Biochemistry, Center for Advanced Invertebrate Molecular Sciences, Texas A and M University, College Station, TX 77843 2128, USA
    Brain Res 818:77-83. 1999
    ....
  7. pmc even skipped is required to produce a trans-acting signal for larval neuroblast proliferation that can be mimicked by ecdysone
    Y Park
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, TX 77843 2128, USA
    Development 128:1899-909. 2001
    ..Furthermore, the effect of an eve mutation can be rescued both in vivo and in culture by the hormone ecdysone. These results suggest that eve is required to produce a trans-acting factor that stimulates cell division in the larval brain...
  8. ncbi request reprint Expression of cyclin E or DP/E2F rescues the G1 arrest of trol mutant neuroblasts in the Drosophila larval central nervous system
    M C Caldwell
    Department of Biochemistry and Biophysics, Texas A and M University, College Station 77843 2128, USA
    Mech Dev 79:121-30. 1998
    ..Neither cyclin E nor E2F expression can phenocopy ana mutations, indicating that arrest caused by lack of Trol is different from Ana-mediated arrest...
  9. ncbi request reprint Drosophila homeobox gene eve enhances trol, an activator of neuroblast proliferation in the larval CNS
    Y Park
    Dept of Biochemistry and Biophysics, Texas A and M University, College Station 77843 2128, USA
    Dev Genet 23:247-57. 1998
    ..Finally, activation of neuroblast proliferation is normal in eve4 heterozygotes, suggesting that the proliferation defect observed in trolb22;eve/+ animals is due to a synergistic interaction...
  10. ncbi request reprint Mutation of the central nervous system neuroblast proliferation repressor ana leads to defects in larval olfactory behavior
    Y Park
    Department of Biochemistry and Biophysics and Center for Advanced Invertebrate Molecular Sciences, Texas A and M University, College Station 77843 2128, USA
    J Neurobiol 33:199-211. 1997
    ..This is consistent with proliferation analysis in the early larval AMC region which uncovered a significantly higher number of S-phase cells in ana9 mutants...
  11. pmc Branchless and Hedgehog operate in a positive feedback loop to regulate the initiation of neuroblast division in the Drosophila larval brain
    A L Barrett
    Department of Biochemistry and Biophysics, MS 2128, Texas A and M University, College Station, TX 77843 2128, USA
    Dev Biol 317:234-45. 2008
    ..These studies establish the molecular mechanism through which Branchless and Hedgehog signaling interface to regulate the activation of neural stem cell division...
  12. ncbi request reprint Control of proliferation activation in quiescent neuroblasts of the Drosophila central nervous system
    S Datta
    Department of Biochemistry and Biophysics, Texas A and M University, College Station 77843 2128, USA
    Development 121:1173-82. 1995
    ..These results suggest that trol and ana are components of a novel developmental pathway for the control of cell cycle activation in quiescent neuroblasts...
  13. doi request reprint Proline metabolism in the conceptus: implications for fetal growth and development
    G Wu
    Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    Amino Acids 35:691-702. 2008
    ....
  14. ncbi request reprint Induction of string rescues the neuroblast proliferation defect in trol mutant animals
    Youngji Park
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843, USA
    Genesis 36:187-95. 2003
    ..These results suggest that Drosophila Cdc25 may directly or indirectly increase the kinase activity of Cyclin E-Cdk2 complexes in vivo, thus driving arrested neuroblasts into cell division...
  15. ncbi request reprint Curable genetic instability of a gal4 transgene in Drosophila
    Andrea Barrett
    Department of Biochemistry and Biophysics, MS 2128, Texas A and M University, College Station, Texas 77843 2128, USA
    Fly (Austin) 2:67-73. 2008
    ..Our data indicate that other tetracycline-sensitive agents can cause genetic instability of transgenes, and also provides a potential solution to the problem...
  16. pmc Arabidopsis vegetative storage protein is an anti-insect acid phosphatase
    Yilin Liu
    Department of Entomology, Texas A and M University, College Station, TX 77843, USA
    Plant Physiol 139:1545-56. 2005
    ..Collectively, we conclude that AtVSP2 is an anti-insect protein and that its defense function is correlated with its acid phosphatase activity...
  17. pmc Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling
    Pilar Sanchez
    Skirball Institute and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 101:12561-6. 2004
    ..Our data demonstrate the dependence of prostate cancer on SHH-GLI function and suggest a novel therapeutic approach...

Research Grants7

  1. CONTROL OF NEUROBLAST PROLIFERATION IN DROSOPHILA
    Sumana Datta; Fiscal Year: 2001
    ..These studies will provide important insights into the mechanism by which proliferation of stem cells is controlled by developmental cues, and will generate new tools and reagents to probe further into these mechanisms. ..
  2. Perlecan-Mediated Control of Prostate Cancer Progression
    Sumana Datta; Fiscal Year: 2005
    ..These studies will link proteoglycan expression, signaling function and sugar structure to cancer progression. ..
  3. CONTROL OF NEUROBLAST PROLIFERATION IN DROSOPHILA
    Sumana Datta; Fiscal Year: 2006
    ..These studies will provide important insights into the mechanism(s) by which stem cell division is controlled by developmental cues--a process of fundamental importance in all animals, including humans. ..