Pramod Dash

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Serum IL-6: a candidate biomarker for intracranial pressure elevation following isolated traumatic brain injury
    Georgene W Hergenroeder
    The Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas, USA
    J Neuroinflammation 7:19. 2010
  2. pmc Inhibition of prefrontal protein synthesis following recall does not disrupt memory for trace fear conditioning
    Sonja Blum
    The Vivian L Smith Center for Neurologic Research and Department of Neurobiology and Anatomy, The University of Texas, Houston, Texas 77225, USA
    BMC Neurosci 7:67. 2006
  3. ncbi request reprint A molecular description of brain trauma pathophysiology using microarray technology: an overview
    Pramod K Dash
    Department of Neurobiology and Anatomy, and The Vivian L Smith Center for Neurologic Research, The University of Texas Medical School, Houston, Texas 77225, USA
    Neurochem Res 29:1275-86. 2004
  4. ncbi request reprint Performance in long-term memory tasks is augmented by a phosphorylated growth factor receptor fragment
    P K Dash
    The Vivian L Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77225, USA
    J Neurosci Res 77:205-16. 2004
  5. ncbi request reprint A role for hippocampal Rho-ROCK pathway in long-term spatial memory
    Pramod K Dash
    Department of Neurobiology and Anatomy, The Vivian L Smith Center for Neurologic Research, The University of Texas Medical School, Houston, TX, USA
    Biochem Biophys Res Commun 322:893-8. 2004
  6. ncbi request reprint Post-trauma administration of caffeine plus ethanol reduces contusion volume and improves working memory in rats
    Pramod K Dash
    Vivian L Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77225, USA
    J Neurotrauma 21:1573-83. 2004
  7. ncbi request reprint Sequestration of serum response factor in the hippocampus impairs long-term spatial memory
    Pramod K Dash
    The Vivian L Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
    J Neurochem 93:269-78. 2005
  8. ncbi request reprint Blockade of gamma-secretase activity within the hippocampus enhances long-term memory
    Pramod K Dash
    The Vivian L Smith Center for Neurologic Research and Department of Neurobiology and Anatomy, The University of Texas Medical School, P O Box 20708, Houston, TX 77225, USA
    Biochem Biophys Res Commun 338:777-82. 2005
  9. ncbi request reprint Spatial memory formation and memory-enhancing effect of glucose involves activation of the tuberous sclerosis complex-Mammalian target of rapamycin pathway
    Pramod K Dash
    The Vivian L Smith Center for Neurologic Research and Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
    J Neurosci 26:8048-56. 2006
  10. pmc Valproate administered after traumatic brain injury provides neuroprotection and improves cognitive function in rats
    Pramod K Dash
    Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
    PLoS ONE 5:e11383. 2010

Research Grants

  1. Tuberous sclerosis complex in memory formation
    Pramod Dash; Fiscal Year: 2007
  2. MECHANISMS OF MEMORY DEFICITS FOLLOWING BRAIN INJURY
    Pramod Dash; Fiscal Year: 2006
  3. Prefrontal cortex and memory storage
    Pramod Dash; Fiscal Year: 2007
  4. Prefrontal cortex and memory storage
    Pramod K Dash; Fiscal Year: 2010
  5. Working memory deficits following brain trauma
    Pramod Dash; Fiscal Year: 2009
  6. LONG TERM HIPPOCAMPAL MEMORY
    Pramod Dash; Fiscal Year: 2001
  7. MECHANISMS OF MEMORY DEFICITS FOLLOWING BRAIN INJURY
    Pramod Dash; Fiscal Year: 2001
  8. Tuberous sclerosis complex in memory formation
    Pramod K Dash; Fiscal Year: 2010

Collaborators

Detail Information

Publications59

  1. pmc Serum IL-6: a candidate biomarker for intracranial pressure elevation following isolated traumatic brain injury
    Georgene W Hergenroeder
    The Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas, USA
    J Neuroinflammation 7:19. 2010
    ..While pressure catheters can be implanted to monitor ICP, there is no clinically proven method for determining a patient's risk for developing this pathology...
  2. pmc Inhibition of prefrontal protein synthesis following recall does not disrupt memory for trace fear conditioning
    Sonja Blum
    The Vivian L Smith Center for Neurologic Research and Department of Neurobiology and Anatomy, The University of Texas, Houston, Texas 77225, USA
    BMC Neurosci 7:67. 2006
    ..In the present study, we examine whether protein synthesis inhibition in the mPFC following recall similarly results in the observation of reconsolidation of trace fear memory...
  3. ncbi request reprint A molecular description of brain trauma pathophysiology using microarray technology: an overview
    Pramod K Dash
    Department of Neurobiology and Anatomy, and The Vivian L Smith Center for Neurologic Research, The University of Texas Medical School, Houston, Texas 77225, USA
    Neurochem Res 29:1275-86. 2004
    ..Furthermore, we offer future directions for the continued evaluation of microarray results and discuss the usefulness of microarray techniques as a testing format for determining the efficacy of mechanism-based therapies...
  4. ncbi request reprint Performance in long-term memory tasks is augmented by a phosphorylated growth factor receptor fragment
    P K Dash
    The Vivian L Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77225, USA
    J Neurosci Res 77:205-16. 2004
    ..These findings suggest that stimulation of PI3-kinase activity by phosphorylated receptor fragments containing the YMDM motif augments long-term memory...
  5. ncbi request reprint A role for hippocampal Rho-ROCK pathway in long-term spatial memory
    Pramod K Dash
    Department of Neurobiology and Anatomy, The Vivian L Smith Center for Neurologic Research, The University of Texas Medical School, Houston, TX, USA
    Biochem Biophys Res Commun 322:893-8. 2004
    ..Our results demonstrate a role for the Rho-ROCK pathway in hippocampus-dependent spatial memory...
  6. ncbi request reprint Post-trauma administration of caffeine plus ethanol reduces contusion volume and improves working memory in rats
    Pramod K Dash
    Vivian L Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77225, USA
    J Neurotrauma 21:1573-83. 2004
    ..These results indicate that early administration of caffeinol may be beneficial in lessening some of the deficits and cortical tissue loss associated with brain trauma...
  7. ncbi request reprint Sequestration of serum response factor in the hippocampus impairs long-term spatial memory
    Pramod K Dash
    The Vivian L Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
    J Neurochem 93:269-78. 2005
    ..These findings suggest that SRF-mediated gene expression is required for long-term spatial memory...
  8. ncbi request reprint Blockade of gamma-secretase activity within the hippocampus enhances long-term memory
    Pramod K Dash
    The Vivian L Smith Center for Neurologic Research and Department of Neurobiology and Anatomy, The University of Texas Medical School, P O Box 20708, Houston, TX 77225, USA
    Biochem Biophys Res Commun 338:777-82. 2005
    ..This suggests that a signaling molecule(s) generated by gamma-secretase activity may have a negative influence on long-term memory formation...
  9. ncbi request reprint Spatial memory formation and memory-enhancing effect of glucose involves activation of the tuberous sclerosis complex-Mammalian target of rapamycin pathway
    Pramod K Dash
    The Vivian L Smith Center for Neurologic Research and Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
    J Neurosci 26:8048-56. 2006
    ..Together, these findings suggest that memory formation requires the mTOR cascade and that the memory-enhancing effect of glucose involves its ability to activate this pathway...
  10. pmc Valproate administered after traumatic brain injury provides neuroprotection and improves cognitive function in rats
    Pramod K Dash
    Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
    PLoS ONE 5:e11383. 2010
    ....
  11. pmc Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcome
    Pramod K Dash
    Department of Neurobiology and Anatomy, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
    PLoS ONE 6:e24648. 2011
    ..Growth factors activate Akt, which in turn inhibits GSK-3 activity by direct phosphorylation, leading to a reduction in apoptosis...
  12. ncbi request reprint Acutely increased cyclophilin a expression after brain injury: a role in blood-brain barrier function and tissue preservation
    John B Redell
    Department of Neurobiology, University of Texas Medical School, Houston, Texass 77225, USA
    J Neurosci Res 85:1980-8. 2007
    ..These findings suggest that increased expression of cyclophilin A may play a protective role after TBI, whereas other cyclophilin isoforms may be detrimental...
  13. ncbi request reprint Molecular activity underlying working memory
    Pramod K Dash
    The Vivian L Smith Center for Neurologic Research, and Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
    Learn Mem 14:554-63. 2007
    ..Finally, we will discuss considerations for the development of clinical treatments for working memory disorders...
  14. pmc Sulforaphane improves cognitive function administered following traumatic brain injury
    Pramod K Dash
    Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, United States
    Neurosci Lett 460:103-7. 2009
    ..These studies support the use of sulforaphane in the treatment of TBI, and extend the previously observed protective effects to include enhanced cognition...
  15. doi request reprint Serum ceruloplasmin and copper are early biomarkers for traumatic brain injury-associated elevated intracranial pressure
    Pramod K Dash
    Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, TX 77225, USA
    J Neurosci Res 88:1719-26. 2010
    ..These results suggest that initial serum ceruloplasmin/copper levels may have diagnostic value in predicting patients at risk for developing high intracranial pressure...
  16. doi request reprint Biomarkers for the diagnosis, prognosis, and evaluation of treatment efficacy for traumatic brain injury
    Pramod K Dash
    Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
    Neurotherapeutics 7:100-14. 2010
    ..This need is punctuated in mild injuries that cannot be readily detected using current techniques, as well as in defining patient risk for developing TBI-associated secondary injuries...
  17. ncbi request reprint A unified theory for systems and cellular memory consolidation
    Pramod K Dash
    The Vivian L Smith Center for Neurologic Research and the Department of Neurobiology and Anatomy, The University of Texas Medical School, P O Box 20708, Houston, TX 77225, USA
    Brain Res Brain Res Rev 45:30-7. 2004
    ....
  18. ncbi request reprint The role of extracellular signal-regulated kinase in cognitive and motor deficits following experimental traumatic brain injury
    P K Dash
    Vivian L Smith Center for Neurologic Research and Department of Neurobiology and Anatomy, The University of Texas Medical School, PO Box 20708, Houston, TX 77225, USA
    Neuroscience 114:755-67. 2002
    ..These findings suggest that the Erk cascade plays an essential role for the maintenance of neuronal function and plasticity following TBI...
  19. pmc Intrahippocampal wortmannin infusion enhances long-term spatial and contextual memories
    Pramod K Dash
    Department of Neurobiology and Anatomy, The Vivian L Smith Center for Neurologic Research, The University of Texas Medical School, Houston, Texas 77225, USA
    Learn Mem 9:167-77. 2002
    ..These results are consistent with the hypothesis that memory consolidation involves competing processes, and that blockade of an inhibitory constraint facilitates the consolidation process...
  20. doi request reprint Histone deactylase inhibition combined with behavioral therapy enhances learning and memory following traumatic brain injury
    P K Dash
    Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, TX 77225, USA
    Neuroscience 163:1-8. 2009
    ....
  21. ncbi request reprint Enhanced neurogenesis in the rodent hippocampus following traumatic brain injury
    P K Dash
    The Vivian L Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
    J Neurosci Res 63:313-9. 2001
    ..These findings show that traumatic brain injury increases neurogenesis in the granule cell layer and suggests that these new cells may contribute to the function of the hippocampus...
  22. ncbi request reprint Altered expression of novel genes in the cerebral cortex following experimental brain injury
    Nobuhide Kobori
    The Vivian L Smith Center for Neurological Research, Department of Neurobiology and Anatomy, The University of Texas Medical School, PO Box 20708, Houston, TX 77255, USA
    Brain Res Mol Brain Res 104:148-58. 2002
    ..The functional significance of these genes in neurite outgrowth, neuronal regeneration, and plasticity following injury are discussed...
  23. ncbi request reprint Comparative analysis of mRNA levels in the frontal cortex and the hippocampus in the basal state and in response to experimental brain injury
    J M Rall
    The Vivian L Smith Center for Neurologic Research, Department of Neurobiology, The University of Texas Medical School, Houston, TX 77225, USA
    Neuropathol Appl Neurobiol 29:118-31. 2003
    ..In addition to genes previously reported in the literature, this study found several genes that have not been associated with TBI. The functional implications of changes in the expression of some of these genes are discussed...
  24. pmc Altered adrenergic receptor signaling following traumatic brain injury contributes to working memory dysfunction
    N Kobori
    The Vivian L Smith Department of Neurosurgery, The University of Texas Medical School at Houston, Houston, TX 77225, USA
    Neuroscience 172:293-302. 2011
    ....
  25. ncbi request reprint Regional expression and role of cyclooxygenase-2 following experimental traumatic brain injury
    P K Dash
    Department of Neurobiology and Anatomy, University of Texas Medical School, Houston 77225, USA
    J Neurotrauma 17:69-81. 2000
    ....
  26. doi request reprint Persistent working memory dysfunction following traumatic brain injury: evidence for a time-dependent mechanism
    M M Hoskison
    Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, The University of Texas Medical School, Houston, TX 77225, USA
    Neuroscience 159:483-91. 2009
    ..Taken together, the present findings, along with previously published reports, suggest that temporal considerations must be taken into account when designing mechanism-based therapies to improve working memory function in TBI patients...
  27. ncbi request reprint Characterization and phosphorylation of CREB-like proteins in Aplysia central nervous system
    P K Dash
    Department of Neurobiology and Anatomy, University of Texas Houston Health Science Center 77225, USA
    Brain Res Mol Brain Res 39:43-51. 1996
    ..This biochemical data further supports the involvement of CREB-like proteins in memory storage...
  28. pmc Sequestration of cAMP response element-binding proteins by transcription factor decoys causes collateral elaboration of regenerating Aplysia motor neuron axons
    P K Dash
    Department of Neurobiology and Anatomy, University of Texas Houston Health Science Center, Houston, TX 77225, USA
    Proc Natl Acad Sci U S A 95:8339-44. 1998
    ..These findings show that Ca2+/cAMP-mediated gene expression via CRE-binding transcription factors participates in the regeneration of motor neuron axons...
  29. ncbi request reprint Requirement for DARPP-32 in progesterone-facilitated sexual receptivity in female rats and mice
    S K Mani
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 287:1053-6. 2000
    ..P also enhanced phosphorylation of DARPP-32 on threonine 34 in the hypothalamus of mice. DARPP-32 activation is thus an obligatory step in progestin receptor regulation of sexual receptivity in rats and mice...
  30. pmc Elevated albumin in retinas of monkeys with experimental glaucoma
    Louvenia Carter-Dawson
    Richard S Ruiz Department of Ophthalmology and Visual Science, University of Texas Medical School at Houston, Houston, Texas 77030, USA
    Invest Ophthalmol Vis Sci 51:952-9. 2010
    ....
  31. ncbi request reprint Expression of cytochromes P450 4F4 and 4F5 in infection and injury models of inflammation
    X Cui
    Department of Biochemistry and Molecular Biology, The University of Texas Houston Medical School, P O Box 20708, 6431 Fannin Street, Houston, TX 77225, USA
    Biochim Biophys Acta 1619:325-31. 2003
    ..As time after injury increases those conditions reverse. Increased CYP 4F expression leads to diminished concentrations of leukotriene and prostaglandin mediators and then to recovery and repair...
  32. pmc Extracellular signal-regulated kinase activity in the entorhinal cortex is necessary for long-term spatial memory
    April E Hebert
    Department of Neurobiology and Anatomy, The Vivian L Smith Center for Neurologic Research, The University of Texas Medical School, Houston, Texas 77225, USA
    Learn Mem 9:156-66. 2002
    ..The findings presented in this article are consistent with the idea that the EC is involved in spatial memory and indicate that Erk activity is necessary for memory consolidation in this structure...
  33. ncbi request reprint GDNF abates serum deprivation-induced tyrosine hydroxylase Ser19 phosphorylation and activity
    Nobuhide Kobori
    Department of Neurobiology and Anatomy, The Vivian L Smith Center for Neurological Research, The University of Texas Medical School, PO Box 20708, Houston, 77255, USA
    Brain Res 1086:142-51. 2006
    ..Taken together, these findings suggest that GDNF may reduce dopamine synthesis in pathological conditions...
  34. ncbi request reprint Brain trauma leads to enhanced lung inflammation and injury: evidence for role of P4504Fs in resolution
    Auinash Kalsotra
    Department of Biochemistry and Molecular Biology, The Vivian L Smith Center for Neurologic Research, The University of Texas, Houston Medical School, Houston, Texas 77225, USA
    J Cereb Blood Flow Metab 27:963-74. 2007
    ....
  35. pmc Traumatic brain injury stimulates hippocampal catechol-O-methyl transferase expression in microglia
    John B Redell
    Departments of Neurobiology and Anatomy, Neurosurgery, and The Vivian L Smith Center for Neurologic Research, The University of Texas Medical School, Houston, TX 77030, United States
    Neurosci Lett 413:36-41. 2007
    ..Since dopamine transporter expression has been reported to be down-regulated after brain injury, COMT-mediated catecholamine metabolism may play a more prominent role in terminating catecholamine signaling in injured areas...
  36. ncbi request reprint High-density microarray analysis of hippocampal gene expression following experimental brain injury
    David A Matzilevich
    The Vivian L Smith Center for Neurologic Research, Departments of Neurobiology and Anatomy, Neurosurgery, The University of Texas Medical School, Houston, Texas 77225, USA
    J Neurosci Res 67:646-63. 2002
    ..The analysis revealed genes whose expression levels have been reported to be altered in response to injury as well as several genes not previously implicated in TBI pathophysiology...
  37. ncbi request reprint Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury
    Jing Zhao
    The Vivian L Smith Center for Neurologic Research and Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
    J Neurosci 27:10240-8. 2007
    ..These findings indicate a potential therapeutic usefulness for Nrf2-activating molecules to improve the function of the neurovascular unit after injury...
  38. ncbi request reprint Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury
    Jing Zhao
    The Vivian L Smith Center for Neurologic Research and Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, 77225, USA
    J Neurosci Res 82:499-506. 2005
    ..These findings suggest that the reduction of brain edema in response to SUL administration could be due, in part, to water clearance by AQP4 from the injured brain...
  39. ncbi request reprint A role for the prefrontal cortex in recall of recent and remote memories
    Sonja Blum
    The Vivian L Smith Center for Neurologic Research, The University of Texas Medical School, Houston, Texas 77225, USA
    Neuroreport 17:341-4. 2006
    ....
  40. ncbi request reprint Rho/ROCK and Cdk5 effects on phosphorylation of a beta-thymosin repeat protein in Hermissenda
    Terry Crow
    Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, TX 77030, USA
    Biochem Biophys Res Commun 323:395-401. 2004
    ..Using a pull-down assay we found that LPA treatments activated Rho and exposure to 5-HT decreased Rho activity. Our results indicate that the Rho/ROCK and Cdk5 signaling pathways contribute to the regulation of Csp24 phosphorylation...
  41. ncbi request reprint Intra-medial prefrontal administration of SCH-23390 attenuates ERK phosphorylation and long-term memory for trace fear conditioning in rats
    Jason D Runyan
    The Vivian L Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, The University of Texas Medical School, P O Box 20708, Houston, TX 77225, USA
    Neurobiol Learn Mem 82:65-70. 2004
    ..These findings implicate mPFC dopamine D1 receptor activity in the storage of long-term memory for higher-cognitive associative tasks...
  42. ncbi request reprint Intrahippocampal infusion of a cyclooxygenase-2 inhibitor attenuates memory acquisition in rats
    Jason M Rall
    Department of Neurobiology and Anatomy, Neurosurgery, Vivian L Smith Center for Neurologic Research, The University of Texas Medical School, P O Box 20708, Houston, TX 77225, USA
    Brain Res 968:273-6. 2003
    ..These findings, along with previously published reports, implicate COX-2 activity in both memory acquisition and retention...
  43. ncbi request reprint Inhibition of conditioned stimulus pathway phosphoprotein 24 expression blocks the development of intermediate-term memory in Hermissenda
    Terry Crow
    Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77225, USA
    J Neurosci 23:3415-22. 2003
    ..These results demonstrate that the synthesis of Csp24 is required for the development and maintenance of intermediate memory...
  44. ncbi request reprint A cell-permeable phospholipase Cgamma1-binding peptide transduces neurons and impairs long-term spatial memory
    Sonja Blum
    Department of Neurobiology and Anatomy, The Vivian L Smith Center for Neurologic Research, The University of Texas Medical School, Houston, Texas 77225, USA
    Learn Mem 11:239-43. 2004
    ..These results, along with previous studies on extracellular signal-regulated kinase (ERK) and phosphoinositide-3 kinase (PI3K), implicate all three key growth factor receptor-activated intracellular signaling pathways in memory storage...
  45. ncbi request reprint Enhancement of tyrosine hydroxylase phosphorylation and activity by glial cell line-derived neurotrophic factor
    Nobuhide Kobori
    The Vivian L Smith Center for Neurological Research, University of Texas Medical School, Houston, TX 77225, USA
    J Biol Chem 279:2182-91. 2004
    ..Our results indicate that, in addition to its role as a survival factor for dopaminergic neurons, GDNF can directly increase dopamine synthesis...
  46. ncbi request reprint A role for prefrontal cortex in memory storage for trace fear conditioning
    Jason D Runyan
    The Vivian L Smith Center for Neurologic Research and the Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
    J Neurosci 24:1288-95. 2004
    ....
  47. ncbi request reprint Differential effects of traumatic brain injury on the cytochrome p450 system: a perspective into hepatic and renal drug metabolism
    Auinash Kalsotra
    Department of Biochemistry, The Vivian L Smith Center for Neurologic Research, The University of Texas Houston Medical School, Houston, Texas, USA
    J Neurotrauma 20:1339-50. 2003
    ..CYP4F subfamily showed induction in kidney only. Collectively, the data reveal the differential effects of TBI on hepatic and renal drug metabolism...
  48. ncbi request reprint Nonredundant roles for hippocampal and entorhinal cortical plasticity in spatial memory storage
    April E Hebert
    The Vivian L Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, The University of Texas Medical School, P O Box 20708, Houston, TX 77225, USA
    Pharmacol Biochem Behav 79:143-53. 2004
    ....
  49. ncbi request reprint Inhibition of hippocampal protein synthesis following recall disrupts expression of episodic-like memory in trace conditioning
    Jason D Runyan
    The Vivian L Smith Center for Neurologic Research and Department of Neurobiology and Anatomy, University of Texas, Houston, Texas 77225, USA
    Hippocampus 15:333-9. 2005
    ..This and other studies are consistent with the role of the hippocampus in coordinating episodic memory retrieval...
  50. ncbi request reprint Plasticity in the entorhinal cortex suppresses memory for contextual fear
    April E Hebert
    The Vivian L Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
    J Neurosci 24:10111-6. 2004
    ....
  51. pmc Genetic networks controlling retinal injury
    Felix R Vazquez-Chona
    Department of Ophthalmology, The Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Mol Vis 11:958-70. 2005
    ..The present study defines genomic loci underlying coordinate changes in gene expression following retinal injury...
  52. pmc Distinct prefrontal molecular mechanisms for information storage lasting seconds versus minutes
    Jason D Runyan
    The Vivian L Smith Center for Neurological Research, Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
    Learn Mem 12:232-8. 2005
    ....
  53. ncbi request reprint Expression of the prodynorphin gene after experimental brain injury and its role in behavioral dysfunction
    John B Redell
    The Vivian L Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77225, USA
    Exp Biol Med (Maywood) 228:261-9. 2003
    ..These results suggest that dynorphin action may serve a beneficial role after TBI...
  54. pmc A role for prefrontal calcium-sensitive protein phosphatase and kinase activities in working memory
    Jason D Runyan
    The Vivian L Smith Center for Neurological Research, Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
    Learn Mem 12:103-10. 2005
    ..Our findings suggest that the active maintenance of information required for working memory involves transient changes in the balance of these enzymes' activities...
  55. ncbi request reprint Reversal of brain injury-induced prefrontal glutamic acid decarboxylase expression and working memory deficits by D1 receptor antagonism
    Nobuhide Kobori
    The Vivian L Smith Center for Neurological Research, The University of Texas Medical School, Houston, Texas 77225, USA
    J Neurosci 26:4236-46. 2006
    ..These findings indicate that inhibition of prefrontal neuronal activity contributes to WM deficits and that strategies to reduce GAD67 expression can offer prolonged WM improvement in brain-injured patients...
  56. ncbi request reprint Acute ethanol intake attenuates inflammatory cytokines after brain injury in rats: a possible role for corticosterone
    Zehava Gottesfeld
    Vivian L Smith Center for Neurologic Research and Department of Neurobiology and Anatomy, University of Texas, Medical School, Houston 77225, USA
    J Neurotrauma 19:317-26. 2002
    ..Our findings suggest that ethanol-induced decrease in pro-inflammatory cytokine production may be linked to increased circulating corticosterone, both of which may contribute to the outcome of brain injury...
  57. ncbi request reprint Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents
    Jing Zhao
    Vivian L Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, University of Texas Medical School, P O Box 20708, Houston, TX 77225, USA
    Neurosci Lett 393:108-12. 2006
    ..Delayed administration (15 min) of a single dose of SUL significantly decreased cerebral infarct volume following focal ischemia, suggesting a potential therapeutic value for this compound...
  58. ncbi request reprint Enhanced catecholamine synthesis in the prefrontal cortex after traumatic brain injury: implications for prefrontal dysfunction
    Nobuhide Kobori
    Vivian L Smith Center for Neurological Research, Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, 77225, USA
    J Neurotrauma 23:1094-102. 2006
    ....
  59. doi request reprint Identification of serum biomarkers in brain-injured adults: potential for predicting elevated intracranial pressure
    Georgene Hergenroeder
    Vivian L Smith Center for Neurologic Research, University of Texas Medical School, Houston, TX, USA
    J Neurotrauma 25:79-93. 2008
    ..Our results support the use of serum as a source for discovery of TBI biomarkers, and indicate that serum biomarkers may have utility for predicting secondary pathologies (e.g., elevated ICP) associated with TBI...

Research Grants33

  1. Tuberous sclerosis complex in memory formation
    Pramod Dash; Fiscal Year: 2007
    ..The results from these studies will provide a crucial step towards development of pharmacological and/or molecular strategies to treat memory disorders. ..
  2. MECHANISMS OF MEMORY DEFICITS FOLLOWING BRAIN INJURY
    Pramod Dash; Fiscal Year: 2006
    ..Furthermore, this project will broaden our understanding of the pathogenesis of neurodegenerative diseases such as stroke and Alzheimer's disease. ..
  3. Prefrontal cortex and memory storage
    Pramod Dash; Fiscal Year: 2007
    ....
  4. Prefrontal cortex and memory storage
    Pramod K Dash; Fiscal Year: 2010
    ....
  5. Working memory deficits following brain trauma
    Pramod Dash; Fiscal Year: 2009
    ..An understanding of the mechanisms by which TBI alters dopamine signaling is critical for the development of mechanism-based intelligent pharmacological treatments for working memory deficits for brain trauma patients. ..
  6. LONG TERM HIPPOCAMPAL MEMORY
    Pramod Dash; Fiscal Year: 2001
    ..Understanding the molecular basis of memory storage will be of value in the future development of pharmacological agents to treat amnesia associated with neurological disorders and other mental health related problems. ..
  7. MECHANISMS OF MEMORY DEFICITS FOLLOWING BRAIN INJURY
    Pramod Dash; Fiscal Year: 2001
    ..The results obtained from these studies may lead to development of new molecular therapies for memory deficits associated with TBI and other neurological conditions. ..
  8. Tuberous sclerosis complex in memory formation
    Pramod K Dash; Fiscal Year: 2010
    ..The results from these studies will provide a crucial step towards development of pharmacological and/or molecular strategies to treat memory disorders. ..