J A Dani

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Potential applications of nicotinic ligands in the laboratory and clinic
    J A Dani
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 3498, USA
    Bioorg Med Chem Lett 14:1837-9. 2004
  2. ncbi request reprint Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system
    John A Dani
    Department of Neuroscience, Program of Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Annu Rev Pharmacol Toxicol 47:699-729. 2007
  3. ncbi request reprint Nicotine addiction and comorbidity with alcohol abuse and mental illness
    John A Dani
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Neurosci 8:1465-70. 2005
  4. ncbi request reprint Complex response to afferent excitatory bursts by nucleus accumbens medium spiny projection neurons
    Remigijus Lape
    Div of Neuroscience, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030 3498, USA
    J Neurophysiol 92:1276-84. 2004
  5. ncbi request reprint Variations in desensitization of nicotinic acetylcholine receptors from hippocampus and midbrain dopamine areas
    J A Dani
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 3498, USA
    Eur J Pharmacol 393:31-8. 2000
  6. ncbi request reprint Timing and location of nicotinic activity enhances or depresses hippocampal synaptic plasticity
    D Ji
    Division of Neuroscience and, Structural and Computational Biology and Molecular Biophysics Program, Baylor College of Medicine, One Baylor Plaza, 77030, Houston, TX, USA
    Neuron 31:131-41. 2001
  7. ncbi request reprint Synaptic plasticity and nicotine addiction
    J A Dani
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 31:349-52. 2001
  8. ncbi request reprint Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum
    F M Zhou
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030-3498, USA
    Nat Neurosci 4:1224-9. 2001
  9. ncbi request reprint Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors
    S Vernino
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030 3498
    Neuron 8:127-34. 1992
  10. ncbi request reprint Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth
    A Orr-Urtreger
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurochem 74:2154-66. 2000

Research Grants

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Potential applications of nicotinic ligands in the laboratory and clinic
    J A Dani
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 3498, USA
    Bioorg Med Chem Lett 14:1837-9. 2004
    ..For example, boosting the release from cholinergic neurons would help patients with Alzheimer's disease, and boosting the release from dopaminergic neurons would help patients with Parkinson's disease...
  2. ncbi request reprint Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system
    John A Dani
    Department of Neuroscience, Program of Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Annu Rev Pharmacol Toxicol 47:699-729. 2007
    ..Decline, disruption, or alterations of nicotinic cholinergic mechanisms contribute to dysfunctions such as epilepsy, schizophrenia, Parkinson's disease, autism, dementia with Lewy bodies, Alzheimer's disease, and addiction...
  3. ncbi request reprint Nicotine addiction and comorbidity with alcohol abuse and mental illness
    John A Dani
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Neurosci 8:1465-70. 2005
    ..Nicotine addiction progresses rapidly in adolescents and is most highly expressed in vulnerable people who have psychiatric illness or other substance abuse problems...
  4. ncbi request reprint Complex response to afferent excitatory bursts by nucleus accumbens medium spiny projection neurons
    Remigijus Lape
    Div of Neuroscience, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030 3498, USA
    J Neurophysiol 92:1276-84. 2004
    ..That convergent excitation is further integrated by the postsynaptic neuron into a prolonged depolarization that may contribute to the depolarized "up state" observed in vivo...
  5. ncbi request reprint Variations in desensitization of nicotinic acetylcholine receptors from hippocampus and midbrain dopamine areas
    J A Dani
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 3498, USA
    Eur J Pharmacol 393:31-8. 2000
    ..The prevailing conditions and the rate of agonist application and removal will control the degree of activation vs. desensitization. These and other factors regulate the efficacy of nicotinic agonists experimentally and physiologically...
  6. ncbi request reprint Timing and location of nicotinic activity enhances or depresses hippocampal synaptic plasticity
    D Ji
    Division of Neuroscience and, Structural and Computational Biology and Molecular Biophysics Program, Baylor College of Medicine, One Baylor Plaza, 77030, Houston, TX, USA
    Neuron 31:131-41. 2001
    ..Loss of these synaptic mechanisms may contribute to the cognitive deficits experienced during Alzheimer's diseases, which is associated with a loss of cholinergic projections and with a decrease in the number of nicotinic receptors...
  7. ncbi request reprint Synaptic plasticity and nicotine addiction
    J A Dani
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 31:349-52. 2001
    ..This influence has particular importance in the mesocorticolimbic dopamine system, which serves during the reinforcement of rewarding behaviors...
  8. ncbi request reprint Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum
    F M Zhou
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030-3498, USA
    Nat Neurosci 4:1224-9. 2001
    ..The results offer new perspectives when considering nicotine addiction and the high prevalence of smoking in schizophrenics...
  9. ncbi request reprint Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors
    S Vernino
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030 3498
    Neuron 8:127-34. 1992
    ..Also, activation of neuronal nAChRs produces a significant influx of Ca2+ that could be an important intracellular signal...
  10. ncbi request reprint Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth
    A Orr-Urtreger
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurochem 74:2154-66. 2000
    ..These findings indicate that neurons in the developing brain expressing only alpha7 L250T mutant nAChRs are susceptible to abnormal apoptosis, possibly due to increased Ca2+ influx...
  11. ncbi request reprint Cellular mechanisms of nicotine addiction
    J A Dani
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030-3498, USA
    Pharmacol Biochem Behav 70:439-46. 2001
    ..As obtained from tobacco, nicotine activates and desensitizes nAChRs, and both processes contribute to the cellular events that underlie nicotine addiction...
  12. ncbi request reprint Overview of nicotinic receptors and their roles in the central nervous system
    J A Dani
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030-3498, USA
    Biol Psychiatry 49:166-74. 2001
    ....
  13. ncbi request reprint Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents
    A Orr-Urtreger
    Department of Molecular and Human Genetics, Houston, Texas 77030, USA
    J Neurosci 17:9165-71. 1997
    ....
  14. ncbi request reprint Quantitative measurement of calcium flux through muscle and neuronal nicotinic acetylcholine receptors
    S Vernino
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030 3498
    J Neurosci 14:5514-24. 1994
    ..At both muscle and neuronal cholinergic synapses, activity-dependent Ca2+ influx through nicotinic receptors produces intracellular signals that may have important roles in synaptic development, maintenance, and plasticity...
  15. pmc Route of nicotine administration influences in vivo dopamine neuron activity: habituation, needle injection, and cannula infusion
    Yu Dong
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030 3498, USA
    J Mol Neurosci 40:164-71. 2010
    ..microdialysis results after habituation, our in vivo tetrode unit recordings showed no significant difference in midbrain DA neuron activity in response to nicotine delivered by needle or cannula as long as predictive cues were avoided..
  16. pmc Controls of tonic and phasic dopamine transmission in the dorsal and ventral striatum
    Lifen Zhang
    Department of Neuroscience, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030 3498, USA
    Mol Pharmacol 76:396-404. 2009
    ..A combination of mechanisms provides specific local control of DA release that underlies pathway-specific information associated with motor and reward-related functions...
  17. ncbi request reprint Altered anxiety-related responses in mutant mice lacking the beta4 subunit of the nicotinic receptor
    Ramiro Salas
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 23:6255-63. 2003
    ..Through their influence on anxiety-related behavior, beta4* nAChRs might influence both tobacco consumption and smoking relapse...
  18. pmc Nicotinic cholinergic synaptic mechanisms in the ventral tegmental area contribute to nicotine addiction
    Volodymyr I Pidoplichko
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 11:60-9. 2004
    ..Consistent with other summarized studies, this work indicates that the synaptic changes normally associated with learning and memory can be influenced and commandeered during the nicotine addiction process...
  19. ncbi request reprint Nicotinic acetylcholine receptors at glutamate synapses facilitate long-term depression or potentiation
    Shaoyu Ge
    Department of Neuroscience, Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    J Neurosci 25:6084-91. 2005
    ..Disruption of events such as those described here may contribute to the deficits associated with the decline of nicotinic cholinergic functions during degenerative diseases such as Alzheimer's dementia...
  20. pmc Dopamine signaling differences in the nucleus accumbens and dorsal striatum exploited by nicotine
    Tianxiang Zhang
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    J Neurosci 29:4035-43. 2009
    ..By favoring release from bursts while depressing release from tonic signals, nicotine spreads the range of dopamine signaling and effectively increases the signal-to-noise relationship along dopamine afferents...
  21. pmc Acid-sensitive ionic channels in midbrain dopamine neurons are sensitive to ammonium, which may contribute to hyperammonemia damage
    Volodymyr I Pidoplichko
    Department of Neuroscience, Menninger Department of Psychiatry and Behavioral Science, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:11376-80. 2006
    ..The ammonium sensitivity suggests a role for ASIC1s in hepatic encephalopathy, cirrhosis, and other neuronal disorders that are associated with hyperammonemia...
  22. ncbi request reprint Cholinergic drugs for Alzheimer's disease enhance in vitro dopamine release
    Lifen Zhang
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030 3498, USA
    Mol Pharmacol 66:538-44. 2004
    ..Furthermore, these results suggest that acting via nicotinic receptors, these drugs may serve presently untapped therapeutic roles by altering dopamine release in other disorders involving dopaminergic systems...
  23. pmc Age dependent nicotinic influences over dopamine neuron synaptic plasticity
    Andon N Placzek
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, United States
    Biochem Pharmacol 78:686-92. 2009
    ..Age-related differences in the excitability and the nicotine sensitivity within the midbrain dopamine system may contribute to the greater risk of nicotine addiction in adolescent animals and humans...
  24. pmc UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors
    Khosrow Rezvani
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 29:6883-96. 2009
    ..This effect is achieved by controlling the stability of the alpha3 subunit and, consequently, the number of receptors at the cell surface...
  25. ncbi request reprint Differential desensitization and distribution of nicotinic acetylcholine receptor subtypes in midbrain dopamine areas
    Julian R A Wooltorton
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    J Neurosci 23:3176-85. 2003
    ....
  26. pmc Dopamine enables in vivo synaptic plasticity associated with the addictive drug nicotine
    Jianrong Tang
    Department of Neuroscience, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 63:673-82. 2009
    ..These results suggest that dopaminergic signaling serves as a functional label of salient events by enabling and scaling synaptic plasticity that underlies drug-induced associative memory...
  27. pmc Mouse muscle denervation increases expression of an alpha7 nicotinic receptor with unusual pharmacology
    Hiroshi Tsuneki
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 3498, USA
    J Physiol 547:169-79. 2003
    ..These results indicate that functional alpha7* nAChRs are significantly present on denervated muscle, and that these receptors display unusual functional and pharmacological characteristics...
  28. ncbi request reprint Cholinergic interneuron characteristics and nicotinic properties in the striatum
    Fu Ming Zhou
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurobiol 53:590-605. 2002
    ..The correlated response of these two broad and dense neurotransmitter systems helps to coordinate the output of the striatum, and is likely to be an important process in sensorimotor planning and learning...
  29. ncbi request reprint Increased sensitivity to nicotine-induced seizures in mice expressing the L250T alpha 7 nicotinic acetylcholine receptor mutation
    Ron S Broide
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Pharmacol 61:695-705. 2002
    ..Hence, these present findings suggest that alterations in the properties rather than absence of alpha 7 nAChRs might affect the mechanisms underlying the convulsive properties of nicotine...
  30. ncbi request reprint Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium
    P Seguela
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030
    J Neurosci 13:596-604. 1993
    ..These results imply that alpha 7-containing receptors may play a role in activating calcium-dependent mechanisms in specific neuronal populations of the adult rat limbic system...
  31. pmc Regulation of synaptic transmission and plasticity by neuronal nicotinic acetylcholine receptors
    Bruce E McKay
    Department of Neuroscience, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Biochem Pharmacol 74:1120-33. 2007
    ..Therapeutic activation of nAChRs may prove efficacious in the treatment of neuropathologies where synaptic transmission is compromised, as in Alzheimer's or Parkinson's disease...
  32. ncbi request reprint Functional polymorphisms in the human beta4 subunit of nicotinic acetylcholine receptors
    Yong Liang
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Neurogenetics 6:37-44. 2005
    ....
  33. ncbi request reprint Applying small quantities of multiple compounds to defined locations of in vitro brain slices
    Volodymyr I Pidoplichko
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 3498, USA
    J Neurosci Methods 142:55-66. 2005
    ..The validity of the approach is verified by measuring ligand-gated channel currents activated by glutamate (Glu), acetylcholine (ACh), and gamma-amino butyric acid (GABA)...
  34. ncbi request reprint Muscarinic and nicotinic cholinergic mechanisms in the mesostriatal dopamine systems
    Fu Ming Zhou
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    Neuroscientist 9:23-36. 2003
    ..Evidence indicates that cholinergic and dopaminergic systems work together to produce the coordinated functioning of the striatum. Loss of that cooperative activity contributes to the dysfunction underlying Parkinson's disease...
  35. pmc Addictive nicotine alters local circuit inhibition during the induction of in vivo hippocampal synaptic potentiation
    Tao A Zhang
    Department of Neuroscience, Menninger Department of Psychiatry and Behavioral Science, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 30:6443-53. 2010
    ..Through this learning process, environmental features become cues that motivate conditioned drug-seeking and drug-taking behaviors...
  36. ncbi request reprint Marine alkaloids (-)-pictamine and (-)-lepadin B block neuronal nicotinic acetylcholine receptors
    Hiroshi Tsuneki
    Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, Japan
    Biol Pharm Bull 28:611-4. 2005
    ....
  37. ncbi request reprint Alkaloids indolizidine 235B', quinolizidine 1-epi-207I, and the tricyclic 205B are potent and selective noncompetitive inhibitors of nicotinic acetylcholine receptors
    Hiroshi Tsuneki
    Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930 0194, Japan
    Mol Pharmacol 66:1061-9. 2004
    ....
  38. ncbi request reprint Selective dopamine filter of glutamate striatal afferents
    John A Dani
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030 USA
    Neuron 42:522-4. 2004
    ..In this issue of Neuron, Bamford et al. report that dopamine inhibits glutamate release in a selective manner by activating presynaptic D2 receptors...
  39. ncbi request reprint Stress hormone enhances synaptic NMDA response on dopamine neurons
    Mariella De Biasi
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Neuron 39:387-8. 2003

Research Grants1

  1. NICOTINIC CHOLINERGIC INFLUENCES OVER HIPPOCAMPAL CIRCUITS
    JOHN DANI; Fiscal Year: 2007
    ..The results immediately apply to associative memory of addiction, and more broadly indicate the synaptic mechanisms that likely underlie the nicotinic component of normal memory and memory dysfunction during degenerative diseases. ..