Research Topics
| TIMOTHY CUDDSummaryAffiliation: Texas A and M University Country: USA Publications
Research Grants
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Detail Information
Publications
Thromboxane A2 does not act at the carotid sinus to mediate cardiovascular, adrenocorticotropin, cortisol, or blood gas responsesT A Cudd
Department of Physiology, University of Florida, Gainesville 32610 0274, USA
Can J Physiol Pharmacol 76:118-24. 1998..These findings support a hypothesis that TxA2 acts at the brain to mediate cardiovascular, pituitary, adrenocortical, and blood gas responses...- Fetal and maternal thyroid hormone responses to ethanol exposure during the third trimester equivalent of gestation in sheepTimothy A Cudd
Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A and M University, College Station 77843 4466, USA
Alcohol Clin Exp Res 26:53-8. 2002..We investigated whether a binge pattern of maternal ethanol consumption over the last trimester equivalent of gestation in sheep results in an alteration in fetal or maternal thyroid function... - Fetal and maternal sheep hypothalamus pituitary adrenal axis responses to chronic binge ethanol exposure during the third trimester equivalentT A Cudd
Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466, USA
Alcohol Clin Exp Res 25:1065-71. 2001..We tested the hypothesis that in utero ethanol exposure results in changes in fetal and maternal adrenocorticotropin (ACTH) and cortisol during the third trimester equivalent, by using a chronically instrumented fetal sheep model... - Third trimester binge ethanol exposure results in fetal hypercapnea and acidemia but not hypoxemia in pregnant sheepT A Cudd
Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
Alcohol Clin Exp Res 25:269-76. 2001.... - Brain high energy phosphate responses to alcohol exposure in neonatal rats: an in vivo 31P-NMR studyT A Cudd
Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
Alcohol Clin Exp Res 24:865-72. 2000..We reasoned that decreases in brain oxygenation sufficient to result in brain injury would also reduce high energy phosphates and pHi... - Biomedical device design discovery team approach to teaching physiology to undergraduate bioengineering studentsT A Cudd
Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466, USA
Am J Physiol 277:S29-41. 1999.... - Vagal blockade does not prevent adrenocorticotropin, cortisol, and cardiopulmonary responses to thromboxane A2T A Cudd
Department of Physiology, University of Florida, Gainesville 32610 0274, USA
Can J Physiol Pharmacol 76:1087-94. 1998.... - Cardiovascular, adrenocorticotropin, and cortisol responses to hypertonic saline in euvolemic sheep are altered by prostaglandin synthase inhibitionT A Cudd
Department of Physiology, University of Florida, Gainesville 32610 0274, USA
Shock 10:32-6. 1998..These responses were not due to increases in circulating concentrations of TxA2 but might involve local formation of TxA2 or some other prostaglandin synthase metabolite... - Pharmacokinetics and safety of arginine supplementation in animalsGuoyao Wu
Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
J Nutr 137:1673S-1680S. 2007.... 
Eyeblink classical conditioning in the preweanling lambTimothy B Johnson
Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4466, USA
Behav Neurosci 122:722-9. 2008....- Maternal adrenocorticotropin, cortisol, and thyroid hormone responses to all three-trimester equivalent repeated binge alcohol exposure: ovine modelJayanth Ramadoss
Department of Veterinary Physiology and Pharmacology and Michael E DeBakey Institute, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
Alcohol 42:199-205. 2008.... - Intravenous administration of L-citrulline to pregnant ewes is more effective than L-arginine for increasing arginine availability in the fetusArantzatzu Lassala
Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
J Nutr 139:660-5. 2009..These novel findings provide support for studies of the clinical use of arginine and citrulline as therapeutic means to prevent or ameliorate fetal growth retardation in mammals... - Binge alcohol exposure during all three trimesters alters bone strength and growth in fetal sheepJayanth Ramadoss
Department of Veterinary Physiology and Pharmacology and Michael E. DeBakey Institute, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843-4466, USA
Alcohol 38:185-92. 2006..The alcohol-exposed fetal bones also tended to exhibit reduced lengths. We conclude that binge alcohol exposure throughout gestation resulted in dose-dependent differences in the maximum stress absorbed by the fetal bones... - Temporal vulnerability of fetal cerebellar Purkinje cells to chronic binge alcohol exposure: ovine modelJayanth Ramadoss
Department of Veterinary Physiology and Pharmacology and Michael E DeBakey Institute, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843 4466, USA
Alcohol Clin Exp Res 31:1738-45. 2007..In this study, we utilized the ovine model, where all 3 trimester-equivalents occur in utero, to determine the critical window of vulnerability of fetal cerebellar Purkinje cells... - Chronic binge ethanol-mediated acidemia reduces availability of glutamine and related amino acids in maternal plasma of pregnant sheepJayanth Ramadoss
Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
Alcohol 42:657-66. 2008..We also speculate that the consequent increase in fetal glutamate during critical periods of brain development may contribute to the pathogenesis of FAS... - Acid-sensitive channel inhibition prevents fetal alcohol spectrum disorders cerebellar Purkinje cell lossJayanth Ramadoss
Department of Veterinary Physiology and Pharmacology, Hwy 60, Bldg VMA, Rm 332, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4466, USA
Am J Physiol Regul Integr Comp Physiol 295:R596-603. 2008..These results demonstrate for the first time functional significance of fetal cerebellar two-pore domain pH-sensitive channels and establishes them as a potential therapeutic target for prevention of ethanol teratogenesis... - All three trimester binge alcohol exposure causes fetal cerebellar purkinje cell loss in the presence of maternal hypercapnea, acidemia, and normoxemia: ovine modelJayanth Ramadoss
Department of Veterinary Physiology and Pharmacology and Michael E DeBakey Institute, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4466, USA
Alcohol Clin Exp Res 31:1252-8. 2007..We also wished to correlate cerebellar Purkinje cell loss to alcohol-mediated alterations in maternal arterial pH and blood gases as these responses might be important mechanistically in mediating the damage... - Animal model systems for the study of alcohol teratologyTimothy A Cudd
Department of Veterinary Physiology and Pharmacology and Michael E DeBakey Institute, Texas A and M University, Highway 60, Building VMA, Room 332, College Station, Texas 77843 4466, USA
Exp Biol Med (Maywood) 230:389-93. 2005..Substantial progress in this field will require the judicious use of multiple scientific approaches that use different animal model systems... - Maternal nutrition and fetal developmentGuoyao Wu
Department of Animal Science, Texas A and M University, Health Science Center, College Station, TX 77843, USA
J Nutr 134:2169-72. 2004..Promoting optimal nutrition will not only ensure optimal fetal development, but will also reduce the risk of chronic diseases in adults... - Parenteral administration of L-arginine prevents fetal growth restriction in undernourished ewesArantzatzu Lassala
Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
J Nutr 140:1242-8. 2010..The findings also lay a new framework for studying cellular and molecular mechanisms responsible for the beneficial effects of Arg in regulating conceptus growth and development... - Chronic ethanol increases fetal cerebral blood flow specific to the ethanol-sensitive cerebellum under normoxaemic, hypercapnic and acidaemic conditions: ovine modelScott E Parnell
Bowles Center for Alcohol Studies and Department of Cell and Developmental Biology, The University of North Carolina, Chapel Hill, NC, USA
Exp Physiol 92:933-43. 2007.... - Elevated fatty acid ethyl esters in meconium of sheep fetuses exposed in utero to ethanol--a new animal modelYoav Littner
Department of Pediatrics, Case Western Reserve University and Rainbow Babies and Children s Hospital, Cleveland, Ohio 44106, USA
Pediatr Res 63:164-8. 2008..In conclusion, pregnant ewes are a feasible model for validating biomarkers of prenatal ethanol exposure. Ethyl oleate, ethyl linoleate, and ethyl arachidonate may be useful biomarkers of prenatal alcohol exposure...
Research Grants
- OVINE MODEL SYSTEM FOR ALCOHOL RELATED BIRTH DEFECTSTIMOTHY CUDD; Fiscal Year: 2009..This research addresses a stated goal in the National Institute on Alcoholism and Alcohol Abuse strategic plan. ..
- Translational Studies of FASD Using a Sheep Model-U01TIMOTHY CUDD; Fiscal Year: 2007..This sheep model provides a unique opportunity to bridge the basic and clinical arms of the consortium more closely than has been achieved in the past. ..
- OVINE MODEL SYSTEM FOR ALCOHOL RELATED BIRTH DEFECTSTIMOTHY CUDD; Fiscal Year: 2006..abstract_text> ..
- Functional measure of 3rd trimester FASD: neonatal sheepTIMOTHY CUDD; Fiscal Year: 2006....
- OVINE MODEL SYSTEM FOR ALCOHOL RELATED BIRTH DEFECTSTIMOTHY CUDD; Fiscal Year: 2000..Together, these studies will provide new, important data related to fetal alcohol exposure and brain damage that have not been addressed adequately with other animal model systems. ..
- OVINE MODEL SYSTEM FOR ALCOHOL RELATED BIRTH DEFECTSTimothy A Cudd; Fiscal Year: 2010..This research addresses a stated goal in the National Institute on Alcoholism and Alcohol Abuse strategic plan. ..