TIMOTHY CUDD

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. ncbi request reprint Thromboxane A2 does not act at the carotid sinus to mediate cardiovascular, adrenocorticotropin, cortisol, or blood gas responses
    T A Cudd
    Department of Physiology, University of Florida, Gainesville 32610 0274, USA
    Can J Physiol Pharmacol 76:118-24. 1998
  2. ncbi request reprint Fetal and maternal thyroid hormone responses to ethanol exposure during the third trimester equivalent of gestation in sheep
    Timothy A Cudd
    Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A and M University, College Station 77843 4466, USA
    Alcohol Clin Exp Res 26:53-8. 2002
  3. ncbi request reprint Fetal and maternal sheep hypothalamus pituitary adrenal axis responses to chronic binge ethanol exposure during the third trimester equivalent
    T A Cudd
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466, USA
    Alcohol Clin Exp Res 25:1065-71. 2001
  4. ncbi request reprint Third trimester binge ethanol exposure results in fetal hypercapnea and acidemia but not hypoxemia in pregnant sheep
    T A Cudd
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    Alcohol Clin Exp Res 25:269-76. 2001
  5. ncbi request reprint Brain high energy phosphate responses to alcohol exposure in neonatal rats: an in vivo 31P-NMR study
    T A Cudd
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    Alcohol Clin Exp Res 24:865-72. 2000
  6. ncbi request reprint Biomedical device design discovery team approach to teaching physiology to undergraduate bioengineering students
    T A Cudd
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466, USA
    Am J Physiol 277:S29-41. 1999
  7. ncbi request reprint Vagal blockade does not prevent adrenocorticotropin, cortisol, and cardiopulmonary responses to thromboxane A2
    T A Cudd
    Department of Physiology, University of Florida, Gainesville 32610 0274, USA
    Can J Physiol Pharmacol 76:1087-94. 1998
  8. ncbi request reprint Cardiovascular, adrenocorticotropin, and cortisol responses to hypertonic saline in euvolemic sheep are altered by prostaglandin synthase inhibition
    T A Cudd
    Department of Physiology, University of Florida, Gainesville 32610 0274, USA
    Shock 10:32-6. 1998
  9. ncbi request reprint Pharmacokinetics and safety of arginine supplementation in animals
    Guoyao Wu
    Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    J Nutr 137:1673S-1680S. 2007
  10. pmc Eyeblink classical conditioning in the preweanling lamb
    Timothy B Johnson
    Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4466, USA
    Behav Neurosci 122:722-9. 2008

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Thromboxane A2 does not act at the carotid sinus to mediate cardiovascular, adrenocorticotropin, cortisol, or blood gas responses
    T A Cudd
    Department of Physiology, University of Florida, Gainesville 32610 0274, USA
    Can J Physiol Pharmacol 76:118-24. 1998
    ..These findings support a hypothesis that TxA2 acts at the brain to mediate cardiovascular, pituitary, adrenocortical, and blood gas responses...
  2. ncbi request reprint Fetal and maternal thyroid hormone responses to ethanol exposure during the third trimester equivalent of gestation in sheep
    Timothy A Cudd
    Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A and M University, College Station 77843 4466, USA
    Alcohol Clin Exp Res 26:53-8. 2002
    ..We investigated whether a binge pattern of maternal ethanol consumption over the last trimester equivalent of gestation in sheep results in an alteration in fetal or maternal thyroid function...
  3. ncbi request reprint Fetal and maternal sheep hypothalamus pituitary adrenal axis responses to chronic binge ethanol exposure during the third trimester equivalent
    T A Cudd
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466, USA
    Alcohol Clin Exp Res 25:1065-71. 2001
    ..We tested the hypothesis that in utero ethanol exposure results in changes in fetal and maternal adrenocorticotropin (ACTH) and cortisol during the third trimester equivalent, by using a chronically instrumented fetal sheep model...
  4. ncbi request reprint Third trimester binge ethanol exposure results in fetal hypercapnea and acidemia but not hypoxemia in pregnant sheep
    T A Cudd
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    Alcohol Clin Exp Res 25:269-76. 2001
    ....
  5. ncbi request reprint Brain high energy phosphate responses to alcohol exposure in neonatal rats: an in vivo 31P-NMR study
    T A Cudd
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    Alcohol Clin Exp Res 24:865-72. 2000
    ..We reasoned that decreases in brain oxygenation sufficient to result in brain injury would also reduce high energy phosphates and pHi...
  6. ncbi request reprint Biomedical device design discovery team approach to teaching physiology to undergraduate bioengineering students
    T A Cudd
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466, USA
    Am J Physiol 277:S29-41. 1999
    ....
  7. ncbi request reprint Vagal blockade does not prevent adrenocorticotropin, cortisol, and cardiopulmonary responses to thromboxane A2
    T A Cudd
    Department of Physiology, University of Florida, Gainesville 32610 0274, USA
    Can J Physiol Pharmacol 76:1087-94. 1998
    ....
  8. ncbi request reprint Cardiovascular, adrenocorticotropin, and cortisol responses to hypertonic saline in euvolemic sheep are altered by prostaglandin synthase inhibition
    T A Cudd
    Department of Physiology, University of Florida, Gainesville 32610 0274, USA
    Shock 10:32-6. 1998
    ..These responses were not due to increases in circulating concentrations of TxA2 but might involve local formation of TxA2 or some other prostaglandin synthase metabolite...
  9. ncbi request reprint Pharmacokinetics and safety of arginine supplementation in animals
    Guoyao Wu
    Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    J Nutr 137:1673S-1680S. 2007
    ....
  10. pmc Eyeblink classical conditioning in the preweanling lamb
    Timothy B Johnson
    Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4466, USA
    Behav Neurosci 122:722-9. 2008
    ....
  11. pmc Maternal adrenocorticotropin, cortisol, and thyroid hormone responses to all three-trimester equivalent repeated binge alcohol exposure: ovine model
    Jayanth Ramadoss
    Department of Veterinary Physiology and Pharmacology and Michael E DeBakey Institute, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Alcohol 42:199-205. 2008
    ....
  12. pmc Intravenous administration of L-citrulline to pregnant ewes is more effective than L-arginine for increasing arginine availability in the fetus
    Arantzatzu Lassala
    Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    J Nutr 139:660-5. 2009
    ..These novel findings provide support for studies of the clinical use of arginine and citrulline as therapeutic means to prevent or ameliorate fetal growth retardation in mammals...
  13. ncbi request reprint Binge alcohol exposure during all three trimesters alters bone strength and growth in fetal sheep
    Jayanth Ramadoss
    Department of Veterinary Physiology and Pharmacology and Michael E DeBakey Institute, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4466, USA
    Alcohol 38:185-92. 2006
    ..The alcohol-exposed fetal bones also tended to exhibit reduced lengths. We conclude that binge alcohol exposure throughout gestation resulted in dose-dependent differences in the maximum stress absorbed by the fetal bones...
  14. ncbi request reprint Temporal vulnerability of fetal cerebellar Purkinje cells to chronic binge alcohol exposure: ovine model
    Jayanth Ramadoss
    Department of Veterinary Physiology and Pharmacology and Michael E DeBakey Institute, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843 4466, USA
    Alcohol Clin Exp Res 31:1738-45. 2007
    ..In this study, we utilized the ovine model, where all 3 trimester-equivalents occur in utero, to determine the critical window of vulnerability of fetal cerebellar Purkinje cells...
  15. pmc Chronic binge ethanol-mediated acidemia reduces availability of glutamine and related amino acids in maternal plasma of pregnant sheep
    Jayanth Ramadoss
    Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Alcohol 42:657-66. 2008
    ..We also speculate that the consequent increase in fetal glutamate during critical periods of brain development may contribute to the pathogenesis of FAS...
  16. pmc Acid-sensitive channel inhibition prevents fetal alcohol spectrum disorders cerebellar Purkinje cell loss
    Jayanth Ramadoss
    Department of Veterinary Physiology and Pharmacology, Hwy 60, Bldg VMA, Rm 332, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4466, USA
    Am J Physiol Regul Integr Comp Physiol 295:R596-603. 2008
    ..These results demonstrate for the first time functional significance of fetal cerebellar two-pore domain pH-sensitive channels and establishes them as a potential therapeutic target for prevention of ethanol teratogenesis...
  17. ncbi request reprint All three trimester binge alcohol exposure causes fetal cerebellar purkinje cell loss in the presence of maternal hypercapnea, acidemia, and normoxemia: ovine model
    Jayanth Ramadoss
    Department of Veterinary Physiology and Pharmacology and Michael E DeBakey Institute, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4466, USA
    Alcohol Clin Exp Res 31:1252-8. 2007
    ..We also wished to correlate cerebellar Purkinje cell loss to alcohol-mediated alterations in maternal arterial pH and blood gases as these responses might be important mechanistically in mediating the damage...
  18. ncbi request reprint Animal model systems for the study of alcohol teratology
    Timothy A Cudd
    Department of Veterinary Physiology and Pharmacology and Michael E DeBakey Institute, Texas A and M University, Highway 60, Building VMA, Room 332, College Station, Texas 77843 4466, USA
    Exp Biol Med (Maywood) 230:389-93. 2005
    ..Substantial progress in this field will require the judicious use of multiple scientific approaches that use different animal model systems...
  19. ncbi request reprint Maternal nutrition and fetal development
    Guoyao Wu
    Department of Animal Science, Texas A and M University, Health Science Center, College Station, TX 77843, USA
    J Nutr 134:2169-72. 2004
    ..Promoting optimal nutrition will not only ensure optimal fetal development, but will also reduce the risk of chronic diseases in adults...
  20. pmc Parenteral administration of L-arginine prevents fetal growth restriction in undernourished ewes
    Arantzatzu Lassala
    Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    J Nutr 140:1242-8. 2010
    ..The findings also lay a new framework for studying cellular and molecular mechanisms responsible for the beneficial effects of Arg in regulating conceptus growth and development...
  21. ncbi request reprint Chronic ethanol increases fetal cerebral blood flow specific to the ethanol-sensitive cerebellum under normoxaemic, hypercapnic and acidaemic conditions: ovine model
    Scott E Parnell
    Bowles Center for Alcohol Studies and Department of Cell and Developmental Biology, The University of North Carolina, Chapel Hill, NC, USA
    Exp Physiol 92:933-43. 2007
    ....
  22. ncbi request reprint Elevated fatty acid ethyl esters in meconium of sheep fetuses exposed in utero to ethanol--a new animal model
    Yoav Littner
    Department of Pediatrics, Case Western Reserve University and Rainbow Babies and Children s Hospital, Cleveland, Ohio 44106, USA
    Pediatr Res 63:164-8. 2008
    ..In conclusion, pregnant ewes are a feasible model for validating biomarkers of prenatal ethanol exposure. Ethyl oleate, ethyl linoleate, and ethyl arachidonate may be useful biomarkers of prenatal alcohol exposure...

Research Grants14

  1. OVINE MODEL SYSTEM FOR ALCOHOL RELATED BIRTH DEFECTS
    TIMOTHY CUDD; Fiscal Year: 2009
    ..This research addresses a stated goal in the National Institute on Alcoholism and Alcohol Abuse strategic plan. ..
  2. Translational Studies of FASD Using a Sheep Model-U01
    TIMOTHY CUDD; Fiscal Year: 2007
    ..This sheep model provides a unique opportunity to bridge the basic and clinical arms of the consortium more closely than has been achieved in the past. ..
  3. OVINE MODEL SYSTEM FOR ALCOHOL RELATED BIRTH DEFECTS
    TIMOTHY CUDD; Fiscal Year: 2006
    ..abstract_text> ..
  4. Functional measure of 3rd trimester FASD: neonatal sheep
    TIMOTHY CUDD; Fiscal Year: 2006
    ....
  5. OVINE MODEL SYSTEM FOR ALCOHOL RELATED BIRTH DEFECTS
    TIMOTHY CUDD; Fiscal Year: 2000
    ..Together, these studies will provide new, important data related to fetal alcohol exposure and brain damage that have not been addressed adequately with other animal model systems. ..
  6. OVINE MODEL SYSTEM FOR ALCOHOL RELATED BIRTH DEFECTS
    Timothy A Cudd; Fiscal Year: 2010
    ..This research addresses a stated goal in the National Institute on Alcoholism and Alcohol Abuse strategic plan. ..