Miguel Cruz

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint C1qTNF-related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen
    Gerald Lasser
    ZymoGenetics, Cardiovascular Biology, Seattle, WA 98102, USA
    Blood 107:423-30. 2006
  2. ncbi request reprint The platelet glycoprotein Ib-von Willebrand factor interaction activates the collagen receptor alpha2beta1 to bind collagen: activation-dependent conformational change of the alpha2-I domain
    Miguel A Cruz
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, N1319, Houston, TX 77030, USA
    Blood 105:1986-91. 2005
  3. ncbi request reprint Evaluation of ADAMTS-13 activity in plasma using recombinant von Willebrand Factor A2 domain polypeptide as substrate
    Miguel A Cruz
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, N1319, Houston, Texas 77030, USA
    Thromb Haemost 90:1204-9. 2003
  4. ncbi request reprint Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex: studies using optical tweezers
    Maneesh Arya
    Department of Bioengineering, Rice University, Houston, TX, USA
    Blood 99:3971-7. 2002
  5. pmc Dynamic force spectroscopy of glycoprotein Ib-IX and von Willebrand factor
    Maneesh Arya
    Department of Bioengineering, Rice University, Houston, TX 77251, USA
    Biophys J 88:4391-401. 2005
  6. pmc Kinetics of GPIbalpha-vWF-A1 tether bond under flow: effect of GPIbalpha mutations on the association and dissociation rates
    R Anand Kumar
    Department of Bioengineering, Rice University, Houston, Texas, USA
    Biophys J 85:4099-109. 2003
  7. pmc The mechanism of VWF-mediated platelet GPIbalpha binding
    Matthew Auton
    Cardiovascular Research, Baylor College of Medicine, Houston, Texas, USA
    Biophys J 99:1192-201. 2010
  8. pmc Destabilization of the A1 domain in von Willebrand factor dissociates the A1A2A3 tri-domain and provokes spontaneous binding to glycoprotein Ibalpha and platelet activation under shear stress
    Matthew Auton
    Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 285:22831-9. 2010
  9. pmc Changes in thermodynamic stability of von Willebrand factor differentially affect the force-dependent binding to platelet GPIbalpha
    Matthew Auton
    Department of Bioengineering, Rice University, Houston, Texas, USA
    Biophys J 97:618-27. 2009
  10. doi request reprint Magnesium maintains endothelial integrity, up-regulates proteolysis of ultra-large von Willebrand factor, and reduces platelet aggregation under flow conditions
    Jing Fei Dong
    Section of Thrombosis Research, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Thromb Haemost 99:586-93. 2008

Research Grants

  1. MOLECULAR BASIS OF PLATELET ADHESION
    Miguel Cruz; Fiscal Year: 2007

Collaborators

Detail Information

Publications19

  1. ncbi request reprint C1qTNF-related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen
    Gerald Lasser
    ZymoGenetics, Cardiovascular Biology, Seattle, WA 98102, USA
    Blood 107:423-30. 2006
    ....
  2. ncbi request reprint The platelet glycoprotein Ib-von Willebrand factor interaction activates the collagen receptor alpha2beta1 to bind collagen: activation-dependent conformational change of the alpha2-I domain
    Miguel A Cruz
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, N1319, Houston, TX 77030, USA
    Blood 105:1986-91. 2005
    ..These results strongly suggest that the interaction of platelet GP Ib with VWF mediates the activation of alpha2beta1, increasing its affinity for collagen...
  3. ncbi request reprint Evaluation of ADAMTS-13 activity in plasma using recombinant von Willebrand Factor A2 domain polypeptide as substrate
    Miguel A Cruz
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, N1319, Houston, Texas 77030, USA
    Thromb Haemost 90:1204-9. 2003
    ..This novel recombinant VWF-A2 protein has potential utility as matrix for a rapid clinical measurement of plasma ADAMTS-13 activity...
  4. ncbi request reprint Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex: studies using optical tweezers
    Maneesh Arya
    Department of Bioengineering, Rice University, Houston, TX, USA
    Blood 99:3971-7. 2002
    ..Therefore, we suggest that the conformational state of ULVWF multimers is more critical than their size for interaction with platelets...
  5. pmc Dynamic force spectroscopy of glycoprotein Ib-IX and von Willebrand factor
    Maneesh Arya
    Department of Bioengineering, Rice University, Houston, TX 77251, USA
    Biophys J 88:4391-401. 2005
    ..Our data illustrate the importance of the bond kinetics associated with the VWF/GP Ib-IX interaction in hemostasis and also demonstrate the drastic changes in binding that can occur when only a single amino acid of GP Ibalpha is altered...
  6. pmc Kinetics of GPIbalpha-vWF-A1 tether bond under flow: effect of GPIbalpha mutations on the association and dissociation rates
    R Anand Kumar
    Department of Bioengineering, Rice University, Houston, Texas, USA
    Biophys J 85:4099-109. 2003
    ..These findings are in contrast to the functionally similar selectin bonds where some of the mutations have been reported to affect only the dissociation rate...
  7. pmc The mechanism of VWF-mediated platelet GPIbalpha binding
    Matthew Auton
    Cardiovascular Research, Baylor College of Medicine, Houston, Texas, USA
    Biophys J 99:1192-201. 2010
    ..Our analysis unites thermodynamics of protein unfolding and conformation-specific binding with the force dependence of biological catch bonds and it encompasses the effects of two subtypes of mutations that cause Von Willebrand Disease...
  8. pmc Destabilization of the A1 domain in von Willebrand factor dissociates the A1A2A3 tri-domain and provokes spontaneous binding to glycoprotein Ibalpha and platelet activation under shear stress
    Matthew Auton
    Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 285:22831-9. 2010
    ..Therefore, the termination of A domain association within VWF in solution results in binding to GPIba and platelet activation under high shear stress...
  9. pmc Changes in thermodynamic stability of von Willebrand factor differentially affect the force-dependent binding to platelet GPIbalpha
    Matthew Auton
    Department of Bioengineering, Rice University, Houston, Texas, USA
    Biophys J 97:618-27. 2009
    ....
  10. doi request reprint Magnesium maintains endothelial integrity, up-regulates proteolysis of ultra-large von Willebrand factor, and reduces platelet aggregation under flow conditions
    Jing Fei Dong
    Section of Thrombosis Research, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Thromb Haemost 99:586-93. 2008
    ..MgSO(4) is critical for maintaining endothelial integrity and regulates ULVWF proteolysis and aggregation under flow conditions. These results provide a new insight into additional mechanisms involved with magnesium therapy...
  11. ncbi request reprint ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor
    Jing Fei Dong
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:29633-9. 2003
    ..Once released, these cleaved VWF fragments become inaccessible for the metalloprotease to prevent further cleavage...
  12. ncbi request reprint The alpha1 helix-beta13 strand spanning Leu214 to Val229 of platelet glycoprotein Ibalpha facilitates the interaction with von Willebrand factor: evidence from characterization of the epitope of monoclonal antibody AP1
    Yuandong Peng
    Thrombosis Research Section, Baylor College of Medicine, BCM 286, N1319, 1 Baylor Plaza, Houston, TX 77030, USA
    Blood 104:3971-8. 2004
    ..This region thus appears to be more important for maintaining the regional conformation of GP Ibalpha, thereby facilitating the interaction with VWF...
  13. ncbi request reprint Haemoglobin blocks von Willebrand factor proteolysis by ADAMTS-13: a mechanism associated with sickle cell disease
    Zhou Zhou
    Thrombosis Research Section, Dept of Medicine, One Baylor Plaza, BCM286, N1319, Houston, Texas 77030, USA
    Thromb Haemost 101:1070-7. 2009
    ..Therefore, the Hb-VWF interaction may be considered as a therapeutic target for treating thrombotic and vaso-occlusive complications in patients with severe intravascular haemolysis such as those with SCD...
  14. ncbi request reprint Conformational stability and domain unfolding of the Von Willebrand factor A domains
    Matthew Auton
    Department of Bioengineering, Rice University, Houston, TX 77005, USA
    J Mol Biol 366:986-1000. 2007
    ..The low stability of the A2 domain is likely to be important in regulating the exposure of the A2 domain cleavage site in response to shear stress, ULVWF platelet adherence, and the attachment of ADAMTS-13 to ULVWF...
  15. pmc The catalytic subunit of protein phosphatase 1 gamma regulates thrombin-induced murine platelet alpha(IIb)beta(3) function
    Francisca C Gushiken
    Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    PLoS ONE 4:e8304. 2009
    ..Although the catalytic subunit of protein phosphatase 1 (PP1c) interacts with alpha(IIb)beta(3), the role of PP1c in platelet reactivity is unclear...
  16. pmc Localization of the adhesion receptor glycoprotein Ib-IX-V complex to lipid rafts is required for platelet adhesion and activation
    Corie N Shrimpton
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Exp Med 196:1057-66. 2002
    ..Thus, localization of the GP Ib-IX-V complex within rafts is crucial for both platelet adhesion and postadhesion signaling...
  17. pmc Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF
    Tadayuki Yago
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Clin Invest 118:3195-207. 2008
    ..We conclude that in type 2B vWD, prolonged lifetimes of vWF bonds with GPIbalpha on circulating platelets may allow ADAMTS-13 to deplete large vWF multimers, causing bleeding...
  18. ncbi request reprint Platelet aggregation by membrane-expressed A1 domains of von Willebrand Factor is dependent on residues Asp 560 and Gly 561
    Jan Schulte Am Esch
    Department of Hepatobiliary and Transplantation Surgery, University Hospital, University of Hamburg, Hamburg, Germany
    Biochem Biophys Res Commun 302:873-7. 2003
    ..The experimental system tested here provides a rapid and reproducible approach for the functional analysis of isolated A1-domain interactions with platelet-GPIb...
  19. ncbi request reprint Structural basis of von Willebrand factor activation by the snake toxin botrocetin
    Koichi Fukuda
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Structure 10:943-50. 2002
    ..Functional studies of platelet adhesion under flow further suggest that the activation mechanism is distinct from that of the gain-of-function mutation...

Research Grants5

  1. MOLECULAR BASIS OF PLATELET ADHESION
    Miguel Cruz; Fiscal Year: 2007
    ..It may also contribute to the development of an effective assay to detect the activity of the metalloprotease in plasma. It will provide molecular guidance for the generation of reagents to treat arterial thrombosis. ..