C S Cox

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Intravenous multipotent adult progenitor cell therapy after traumatic brain injury: modulation of the resident microglia population
    Peter A Walker
    Department of Surgery, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 5 236, Houston, TX 77030, USA
    J Neuroinflammation 9:228. 2012
  2. pmc Strategies for modulating the inflammatory response after decompression from abdominal compartment syndrome
    Shinil K Shah
    Department of Pediatric Surgery, University of Texas Medical School at Houston, Houston, Texas, USA
    Scand J Trauma Resusc Emerg Med 20:25. 2012
  3. doi request reprint Hypertonic saline modulation of intestinal tissue stress and fluid balance
    Charles S Cox
    Center for Microvascular and Lymphatic Studies, Department of Surgery, Division of Pediatric Surgery, University of Texas Houston Medical School, Houston, TX 77030, USA
    Shock 29:598-602. 2008
  4. ncbi request reprint Myocardial performance after cardiopulmonary bypass and cardioplegic arrest: impact of na+/h+ exchanger inhibition
    Charles S Cox
    Department of Surgery, University of Texas Houston, Medical School, USA
    J Invest Surg 15:219-26. 2002
  5. ncbi request reprint Improved myocardial function using a Na+/H+ exchanger inhibitor during cardioplegic arrest and cardiopulmonary bypass
    Charles S Cox
    Department of Surgery, Center for Microvascular and Lymphatic Studies at the University of Texas Houston, Medical School, Houston, TX, USA
    Chest 123:187-94. 2003
  6. doi request reprint Autologous bone marrow mononuclear cell therapy for severe traumatic brain injury in children
    Charles S Cox
    Department of Pediatric Surgery, University of Texas Medical School at Houston, and Children s Memorial Hermann Hospital, University of Texas, Houston, Texas 77030, USA
    Neurosurgery 68:588-600. 2011
  7. ncbi request reprint Sodium/hydrogen-exchanger inhibition during cardioplegic arrest and cardiopulmonary bypass: an experimental study
    Charles S Cox
    Department of Surgery and Anesthesiology Center for Microvascular and Lymphatic Studies, University of Texas Houston, Medical School, USA
    J Thorac Cardiovasc Surg 123:959-66. 2002
  8. pmc A murine model for the study of edema induced intestinal contractile dysfunction
    S K Shah
    Department of Pediatric Surgery, University of Texas Medical School at Houston, Houston, TX 77030, USA
    Neurogastroenterol Motil 22:1132-e290. 2010
  9. ncbi request reprint Analysis of intestinal microvascular permeability associated with cardiopulmonary bypass
    C S Cox
    Division of Pediatric Surgery, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Surg Res 83:19-26. 1999
  10. pmc Decreased myosin phosphatase target subunit 1(MYPT1) phosphorylation via attenuated rho kinase and zipper-interacting kinase activities in edematous intestinal smooth muscle
    J Chu
    Department of Pediatric Surgery, University of Texas Medical School at Houston, Houston, TX, USA
    Neurogastroenterol Motil 24:257-66, e109. 2012

Research Grants

Collaborators

Detail Information

Publications68

  1. pmc Intravenous multipotent adult progenitor cell therapy after traumatic brain injury: modulation of the resident microglia population
    Peter A Walker
    Department of Surgery, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 5 236, Houston, TX 77030, USA
    J Neuroinflammation 9:228. 2012
    ..We hypothesize that the observed modulation of the systemic inflammatory milieu is related to T regulatory cells and a subsequent increase in the locoregional neuroprotective M2 macrophage population...
  2. pmc Strategies for modulating the inflammatory response after decompression from abdominal compartment syndrome
    Shinil K Shah
    Department of Pediatric Surgery, University of Texas Medical School at Houston, Houston, Texas, USA
    Scand J Trauma Resusc Emerg Med 20:25. 2012
    ....
  3. doi request reprint Hypertonic saline modulation of intestinal tissue stress and fluid balance
    Charles S Cox
    Center for Microvascular and Lymphatic Studies, Department of Surgery, Division of Pediatric Surgery, University of Texas Houston Medical School, Houston, TX 77030, USA
    Shock 29:598-602. 2008
    ..Intestinal edema causes an early increase in interstitial pressure that is prevented by HS. Prevention of the edema-induced increase in interstitial pressure serves to blunt the mechanotransductive signal of sigmaravi-muscularis...
  4. ncbi request reprint Myocardial performance after cardiopulmonary bypass and cardioplegic arrest: impact of na+/h+ exchanger inhibition
    Charles S Cox
    Department of Surgery, University of Texas Houston, Medical School, USA
    J Invest Surg 15:219-26. 2002
    ..Na(+)/H(+) exchanger inhibition during cardiac procedures using CPB/CPA may be a useful adjunct to improve immediate post-CPB/CPA myocardial performance...
  5. ncbi request reprint Improved myocardial function using a Na+/H+ exchanger inhibitor during cardioplegic arrest and cardiopulmonary bypass
    Charles S Cox
    Department of Surgery, Center for Microvascular and Lymphatic Studies at the University of Texas Houston, Medical School, Houston, TX, USA
    Chest 123:187-94. 2003
    ..We hypothesized that Na(+)/H(+) exchanger inhibition with a selective inhibitor (EMD 87580) would decrease myocardial edema and improve myocardial performance after CPB/CPA...
  6. doi request reprint Autologous bone marrow mononuclear cell therapy for severe traumatic brain injury in children
    Charles S Cox
    Department of Pediatric Surgery, University of Texas Medical School at Houston, and Children s Memorial Hermann Hospital, University of Texas, Houston, Texas 77030, USA
    Neurosurgery 68:588-600. 2011
    ..Numerous preclinical studies suggest that bone marrow-derived mononuclear cells (BMMNCs), their derivative cells (marrow stromal cells), or similar cells (umbilical cord blood cells) offer neuroprotection...
  7. ncbi request reprint Sodium/hydrogen-exchanger inhibition during cardioplegic arrest and cardiopulmonary bypass: an experimental study
    Charles S Cox
    Department of Surgery and Anesthesiology Center for Microvascular and Lymphatic Studies, University of Texas Houston, Medical School, USA
    J Thorac Cardiovasc Surg 123:959-66. 2002
    ..We sought to determine whether pretreatment with a sodium/hydrogen-exchange inhibitor (EMD 96 785) improves myocardial performance and reduces myocardial edema after cardioplegic arrest and cardiopulmonary bypass...
  8. pmc A murine model for the study of edema induced intestinal contractile dysfunction
    S K Shah
    Department of Pediatric Surgery, University of Texas Medical School at Houston, Houston, TX 77030, USA
    Neurogastroenterol Motil 22:1132-e290. 2010
    ..To that end, we have developed and validated a hydrostatic intestinal edema model in mice...
  9. ncbi request reprint Analysis of intestinal microvascular permeability associated with cardiopulmonary bypass
    C S Cox
    Division of Pediatric Surgery, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Surg Res 83:19-26. 1999
    ..The purpose of this study was to measure the forces determining fluid flux induced by CPB across the intestinal microvascular barrier...
  10. pmc Decreased myosin phosphatase target subunit 1(MYPT1) phosphorylation via attenuated rho kinase and zipper-interacting kinase activities in edematous intestinal smooth muscle
    J Chu
    Department of Pediatric Surgery, University of Texas Medical School at Houston, Houston, TX, USA
    Neurogastroenterol Motil 24:257-66, e109. 2012
    ..The purpose of the present study was to investigate the mechanism of edema-induced decreases in MLC in a rodent model of intestinal edema...
  11. ncbi request reprint The antioxidant N-acetylcysteine preserves myocardial function and diminishes oxidative stress after cardioplegic arrest
    Uwe M Fischer
    Center for Microvascular and Lymphatic Studies, Department of Surgery and Anesthesiology, The University of Texas Houston Medical School, USA
    J Thorac Cardiovasc Surg 126:1483-8. 2003
    ..We hypothesized that administration of the antioxidant N-acetylcysteine would have beneficial effects on myocardial function after cardiopulmonary bypass and cardioplegic arrest...
  12. pmc Intestinal edema: effect of enteral feeding on motility and gene expression
    Stacey D Moore-Olufemi
    Department of Surgery, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Surg Res 155:283-92. 2009
    ..We hypothesized that early enteral feeding would improve intestinal transit. We also wanted to study the impact of early enteral feeding on global gene expression in the intestine...
  13. doi request reprint Nuclear factor-kappaB activation by edema inhibits intestinal contractile activity
    Karen S Uray
    Department of Pediatric Surgery, University of Texas Medical School at Houston, Houston, TX, USA
    Crit Care Med 38:861-70. 2010
    ..Thus, the mechanism(s) by which intestinal edema development causes intestinal dysfunction are likely to be multifactorial...
  14. ncbi request reprint Effects of primary and secondary intra-abdominal hypertension on mesenteric lymph flow: implications for the abdominal compartment syndrome
    Stacey D Moore-Olufemi
    Department of Surgery, University of Texas Houston Medical School, Houston, Texas 77030, USA
    Shock 23:571-5. 2005
    ..Modest elevations in IAP significantly affect mesenteric QL and the development of gut edema. The principle of early abdominal decompression to reduce mesenteric/IVC venous hypertension and capillary pressure is supported by these data...
  15. ncbi request reprint Impact of hetastarch on the intestinal microvascular barrier during ECLS
    C S Cox
    Department of Surgery, Department of Anesthesiology, and Center for Microvascular and Lymphatic Studies, Medical School, University of Texas Houston, Houston, Texas 77030, USA
    J Appl Physiol (1985) 88:1374-80. 2000
    ..Hetastarch decreases the edema associated with ECLS. The reduction in edema is due to the maintenance of the plasma-to-interstitial colloid osmotic pressure gradient and the reduction in the microvascular permeability to protein...
  16. doi request reprint Myocardial function after gut ischemia/reperfusion: does NF kappaB play a role?
    Uwe M Fischer
    Department of Pediatric Surgery, University of Texas Medical School at Houston, Houston, Texas 77030, USA
    J Surg Res 152:264-70. 2009
    ..Thus, we sought to investigate the effect of NF kappaB inhibition on mesenteric I/R-associated myocardial dysfunction in a large animal model (dog)...
  17. ncbi request reprint Resuscitation-induced gut edema and intestinal dysfunction
    Stacey D Moore-Olufemi
    Department of Surgery, University of Texas Houston Medical School, Houston, and The Michael E DeBakey Institute, Texas A and M University, College Station, TX 77030, USA
    J Trauma 58:264-70. 2005
    ..The purpose of this study was to create a model of acute hydrostatic gut edema and to evaluate its effect on gut motility and barrier function...
  18. ncbi request reprint Lymphatic diversion prevents myocardial edema following mesenteric ischemia/reperfusion
    Charles S Cox
    Center for Microvascular and Lymphatic Studies, Department of Surgery, University of Texas Houston Medical School, Houston, Texas, USA
    Microcirculation 11:1-8. 2004
    ..We hypothesized that mesenteric I/R causes myocardial edema resulting in myocardial dysfunction, and that diverting mesenteric lymph would preserve myocardial function...
  19. pmc Effects of traumatic brain injury on intestinal contractility
    A B Olsen
    Department of Pediatric Surgery, University of Texas Medical School at Houston, Houston, TX 77030, USA
    Neurogastroenterol Motil 25:593-e463. 2013
    ..However, it is unclear how TBI affects small intestinal contractile activity. The purpose of this study was to determine if TBI affects intestinal smooth muscle function...
  20. ncbi request reprint Edema-induced intestinal dysfunction is mediated by STAT3 activation
    Karen S Uray
    Division of Pediatric Surgery, Department of Surgery, University of Texas Medical School at Houston, 6431 Fannin, Houston, TX 77030, USA
    Shock 28:239-44. 2007
    ..We conclude from these data that edema-induced decreases in intestinal contractile activity are mediated, at least in part, by STAT3 activation...
  21. ncbi request reprint Sequelae of recurrent laryngeal nerve injury after patent ductus arteriosus ligation
    Kevin D Pereira
    Department of Otolaryngology Head and Neck Surgery, The University of Texas Health Science Center at Houston, United States
    Int J Pediatr Otorhinolaryngol 70:1609-12. 2006
    ..To prospectively study the clinical course of neonates with vocal cord paralysis (VCP) after patent ductus arteriosus (PDA) ligation...
  22. ncbi request reprint Regional hypothermia reduces mucosal NF-kappaB and PMN priming via gut lymph during canine mesenteric ischemia/reperfusion
    Heitham T Hassoun
    Department of Surgery, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Surg Res 115:121-6. 2003
    ....
  23. ncbi request reprint Outcome after surgical resection of recurrent rhabdomyosarcoma
    Andrea Hayes-Jordan
    Department of Surgery, The Children s Cancer Hospital at the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Pediatr Surg 41:633-8; discussion 633-8. 2006
    ..We reviewed our experience with aggressive surgical resection for recurrent RMS...
  24. pmc Late intellectual and academic outcomes following traumatic brain injury sustained during early childhood
    Linda Ewing-Cobbs
    Department of Pediatrics, University of Texas Health Science Center at Houston, 70030, USA
    J Neurosurg 105:287-96. 2006
    ..The present study characterizes intelligence quotient (IQ) and academic outcomes an average of 5.7 years after injury in children who sustained moderate to severe TBI prior to 6 years of age...
  25. pmc Arrested development and disrupted callosal microstructure following pediatric traumatic brain injury: relation to neurobehavioral outcomes
    Linda Ewing-Cobbs
    Department of Pediatrics, University of Texas Houston Health Science Center at Houston, 77030, USA
    Neuroimage 42:1305-15. 2008
    ..Increased radial diffusivity was the most sensitive DTI-based surrogate marker of the extent of neuronal damage following TBI; FA was most strongly correlated with neuropsychological outcomes...
  26. ncbi request reprint Intestinal ischemic preconditioning after ischemia/reperfusion injury in rat intestine: profiling global gene expression patterns
    Stacey D Moore-Olufemi
    Department of Pediatric Surgery, University of Texas Medical School at Houston, Houston, TX 77030, USA
    Dig Dis Sci 55:1866-77. 2010
    ..In an effort to investigate the molecular mechanisms responsible for the protective effects afforded by IPC, we sought to characterize the global gene expression pattern in rats subjected to IPC in the setting of IR injury...
  27. doi request reprint Hypertonic saline alters hydraulic conductivity and up-regulates mucosal/submucosal aquaporin 4 in resuscitation-induced intestinal edema
    Ravi S Radhakrishnan
    Department of Pediatric Surgery and Trauma Research Center, University of Texas Medical School at Houston, Houston, TX, USA
    Crit Care Med 37:2946-52. 2009
    ..Hypertonic saline decreases intestinal edema and improves transit. Aquaporins are water transport membrane proteins that may be up-regulated with edema and/or hypertonic saline...
  28. pmc Human mesenchymal stem cells inhibit vascular permeability by modulating vascular endothelial cadherin/β-catenin signaling
    Shibani Pati
    Department of Surgery, University of Texas Health Sciences Center, Houston, TX, USA
    Stem Cells Dev 20:89-101. 2011
    ..Further, our results suggest that the mediator(s) of these vascular protective effects is a secreted factor(s) released as a result of direct MSC-EC interaction...
  29. ncbi request reprint Effects of selectin-sialyl Lewis blockade on mesenteric microvascular permeability associated with cardiopulmonary bypass
    C S Cox
    Department of Surgery, Division of Pediatric Surgery, and the Center for Lymphatic and Microvascular Studies at the University of Texas Houston, Medical School, Houston, Texas, USA
    J Thorac Cardiovasc Surg 119:1255-61. 2000
    ..Using a selectin antagonist that prevents interactions with their ligands, we hypothesized that there would be less neutrophil infiltration into the tissue and a reduction in microvascular permeability and edema formation...
  30. doi request reprint Regulation of endothelial nitric oxide synthase (eNOS) in myocardium subjected to cardioplegic arrest
    U M Fischer
    Pediatric Surgery, University of Texas Medical School at Houston, Houston, Texas, United States of America
    Thorac Cardiovasc Surg 57:379-85. 2009
    ..Nitric oxide (NO) production by both coronary endothelial cells and cardiomyocytes is thought to play a significant role in myocardial pathophysiology following ischemia/reperfusion (I/R)...
  31. pmc Pretreatment with bone morphogenetic protein-7 (BMP-7) mimics ischemia preconditioning following intestinal ischemia/reperfusion injury in the intestine and liver
    Ravi S Radhakrishnan
    Department of Surgery, University of Texas Houston Medical School, Houston, Texas 77030, USA
    Shock 30:532-6. 2008
    ..In conclusion, BMP-7 protected against intestinal I/R-induced intestinal and liver injury. Bone morphogenetic protein 7 may be a more logical surrogate to IPC in the prevention of injury in the setting of intestinal I/R...
  32. ncbi request reprint Ischemic preconditioning protects against gut dysfunction and mucosal injury after ischemia/reperfusion injury
    Stacey D Moore-Olufemi
    Department of Surgery, University of Texas Medical School, Houston, TX 77030, USA
    Shock 23:258-63. 2005
    ..Our results show that IR-induced gut dysfunction can be improved by IPC. Both phases of IPC can potentially be useful in the clinical setting of surgical patient care...
  33. ncbi request reprint Resuscitation-induced intestinal edema decreases the stiffness and residual stress of the intestine
    Ravi S Radhakrishnan
    Department of Surgery, University of Texas, Houston Medical School, 77030, USA
    Shock 24:165-70. 2005
    ..Acute intestinal edema leads to a significant loss in stiffness and residual stress and is a plausible explanation for how acute edema impairs intestinal transit...
  34. ncbi request reprint Mild hypothermia impairs left ventricular diastolic but not systolic function
    Uwe M Fischer
    Center for Microvascular and Lymphatic Studies, Department of Anesthesiology, University of Texas Medical School, Houston, USA
    J Invest Surg 18:291-6. 2005
    ..Thus, even mild hypothermia impairs LV diastolic but not systolic function. Cardiac output is temperature sensitive and therefore rewarming of patients post-CPB has priority...
  35. pmc A novel mechanism for neutrophil priming in trauma: potential role of peritoneal fluid
    Shinil K Shah
    Department of Pediatric Surgery, University of Texas Medical School at Houston, Houston, TX 77030, USA
    Surgery 148:263-70. 2010
    ..We hypothesize that peritoneal fluid is a potential priming and/or activating agent for PMNs/monocytes...
  36. ncbi request reprint Intestinal edema decreases intestinal contractile activity via decreased myosin light chain phosphorylation
    Karen S Uray
    Division of Pediatric Surgery, Department of Surgery, University of Texas Medical School at Houston, TX, USA
    Crit Care Med 34:2630-7. 2006
    ..The purpose of this study was to investigate the effects of interstitial edema on intestinal contractile activity...
  37. ncbi request reprint Induction of cardioplegic arrest immediately activates the myocardial apoptosis signal pathway
    Uwe M Fischer
    Center for Microvascular and Lymphatic Studies, Department of Surgery, The University of Texas Houston Medical School, Houston, TX, USA
    Am J Physiol Heart Circ Physiol 292:H1630-3. 2007
    ..Thus apoptosis signal-pathway inhibition as a potential strategy for improved myocardial preservation would have the greatest effect when applied before CA exposure...
  38. pmc Hydrostatic intestinal edema induced signaling pathways: potential role of mechanical forces
    Shinil K Shah
    Department of Pediatric Surgery, University of Texas Medical School at Houston, Houston, TX, USA
    Surgery 147:772-9. 2010
    ..We sought to examine whether isolated similar magnitude mechanical forces induced the same signal transduction cascades associated with edema...
  39. ncbi request reprint Hypertonic saline resuscitation prevents hydrostatically induced intestinal edema and ileus
    Ravi S Radhakrishnan
    Department of Surgery, University of Texas Houston Medical School, Houston, TX, USA
    Crit Care Med 34:1713-8. 2006
    ..We hypothesized that hypertonic saline (7.5%) would reverse these detrimental effects of acute edema...
  40. ncbi request reprint Impact of acute myocardial edema on left ventricular function
    Uwe M Fischer
    Center for Microvascular and Lymphatic Studies, Department of Anesthesiology, University of Texas Medical School, Houston, Texas, USA
    J Invest Surg 19:31-8. 2006
    ..3% to 77.7 +/- 0.3% (p < .05). PRSW and dP/dt(max) did not decrease in either group. Diastolic parameters did not change significantly. We conclude that acute myocardial edema without myocardial injury does not impair LV function...
  41. pmc Direct intrathecal implantation of mesenchymal stromal cells leads to enhanced neuroprotection via an NFkappaB-mediated increase in interleukin-6 production
    Peter A Walker
    Department of Surgery, University of Texas Medical School at Houston, Houston, Texas 77030, USA
    Stem Cells Dev 19:867-76. 2010
    ..In addition, the observed NFkappaB activity depends on direct cell contact...
  42. pmc Intravenous multipotent adult progenitor cell therapy for traumatic brain injury: preserving the blood brain barrier via an interaction with splenocytes
    Peter A Walker
    Department of Surgery, University of Texas Medical School at Houston, Houston, TX, USA
    Exp Neurol 225:341-52. 2010
    ..Furthermore, the co-localization of transplanted MAPC and resident CD4+ splenocytes is associated with a global increase in IL-4 and IL-10 production and stabilization of the cerebral microvasculature tight junction proteins...
  43. ncbi request reprint Hypertonic saline reverses stiffness in a Sprague-Dawley rat model of acute intestinal edema, leading to improved intestinal function
    Ravi S Radhakrishnan
    Department of Surgery, University of Texas Houston Medical School, Houston, TX, USA
    Crit Care Med 35:538-43. 2007
    ..Furthermore, HS administration will abolish these detrimental effects of edema...
  44. ncbi request reprint Inhibition of intestinal transit by resuscitation-induced gut edema is reversed by L-NIL
    S D Moore-Olufemi
    Department of Surgery, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Surg Res 129:1-5. 2005
    ..We hypothesized that gut edema increases expression of inducible nitric oxide synthase (iNOS) protein, and that selective iNOS inhibition using L-NIL reverses the delayed intestinal transit associated with gut edema...
  45. ncbi request reprint Current trends in cell therapy for pediatric acquired brain injury
    P A Walker
    Department of Pediatric Surgery, University of Texas Medical School at Houston and Children s Memorial Hermann Hospital, Houston, TX, USA
    Minerva Pediatr 62:91-106. 2010
    ..The optimal therapeutic benefit may be seen using a combination of therapies (controlled hypothermia, hypertonic therapy, and/or cellular therapeutics) to attack the complex pathophysiology of TBI at multiple points...
  46. ncbi request reprint Blunt versus penetrating subclavian artery injury: presentation, injury pattern, and outcome
    C S Cox
    Department of Surgery, University of Texas Houston Medical School and the Hermann Hospital Hermann Children s Hospital, USA
    J Trauma 46:445-9. 1999
    ..The majority of SCA injuries are secondary to penetrating trauma. The purpose of this report is to examine the injury patterns, diagnostic and therapeutic approaches, and outcome of patients with blunt and penetrating SCA injuries...
  47. pmc Evaluating the potential role of nitric oxide as a mediator of hydrostatic edema mediated intestinal contractile dysfunction
    Shinil K Shah
    Department of Pediatric Surgery, University of Texas Medical School at Houston, Houston, Texas 77030, USA
    J Surg Res 163:102-9. 2010
    ..The purpose of this study was to elucidate the iNOS/nitric oxide (NO) signal transduction pathway in intestinal edema...
  48. doi request reprint Portable arteriovenous rewarming for hypothermia: cardiovascular considerations
    Uwe M Fischer
    Department of Pediatric Surgery, University of Texas Medical School at Houston, Houston, Texas 77030, USA
    ASAIO J 54:278-83. 2008
    ..Arteriovenous rewarming, using the tested portable fluid warmer, effectively reversed hypothermia without compromising hemodynamics or regional blood flow...
  49. ncbi request reprint Acute hemodynamic decompensation following patent ductus arteriosus ligation in premature infants
    Matthew T Harting
    University of Texas Medical School at Houston, Houston, TX, USA
    J Invest Surg 21:133-8. 2008
    ..The purpose of this study was to prospectively determine the incidence, predictors, and clinical impact of hemodynamic decompensation after PDA ligation in preterm infants...
  50. doi request reprint Effects of poloxamer 188 on human PMN cells
    Matthew T Harting
    Department of Pediatric Surgery, University of Texas Medical School, Houston, TX 77030, USA
    Surgery 144:198-203. 2008
    ..We studied human PMN oxidative burst and adhesion molecule expression when exposed to P188...
  51. ncbi request reprint Measurement of intestinal edema using an impedance analyzer circuit
    Ravi S Radhakrishnan
    Department of Surgery, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Surg Res 138:106-10. 2007
    ..However, there is no simple method to measure intestinal tissue water without biopsy. We sought to develop a tissue impedance analyzer to measure tissue edema, without the need for invasive biopsy...
  52. ncbi request reprint Patients with impending abdominal compartment syndrome do not respond to early volume loading
    Zsolt Balogh
    Department of Surgery, Division of General Surgery, University of Texas at Houston Medical School, Houston, TX 77030, USA
    Am J Surg 186:602-7; discussion 607-8. 2003
    ..We evaluated our prospective resuscitation database to determine how patients who developed ACS differ from non-ACS patients in response to early volume loading...
  53. pmc Acute, regional inflammatory response after traumatic brain injury: Implications for cellular therapy
    Matthew T Harting
    Department of Pediatric Surgery, University of Texas Medical School at Houston and Children s Memorial Hermann Hospital, Houston, Texas 77030, USA
    Surgery 144:803-13. 2008
    ..We sought to characterize the acute, regional inflammatory response after TBI...
  54. pmc Modern approaches to pediatric brain injury therapy
    Peter A Walker
    Department of Pediatric Surgery, University of Texas Medical School at Houston, Texas 77030, USA
    J Trauma 67:S120-7. 2009
    ....
  55. pmc Cell therapies for traumatic brain injury
    Matthew T Harting
    Department of Pediatric Surgery, University of Texas Medical School at Houston, Texas 77030, USA
    Neurosurg Focus 24:E18. 2008
    ..In this report the authors discuss the current status of using adult stem cells to treat traumatic brain injury, including the basic cell types and potential mechanisms of action, preclinical data, and the initiation of clinical trials...
  56. doi request reprint A novel physiologic model for the study of abdominal compartment syndrome (ACS)
    Shinil K Shah
    Departments of Pediatric Surgery, University of Texas Medical School at Houston, Houston, Texas, USA
    J Trauma 68:682-9. 2010
    ..Although this allows for the study of the effects of increased abdominal pressure, it poorly mimics its pathogenesis. We have developed the first reported large animal model of ACS incorporating hemorrhagic shock/resuscitation...
  57. pmc Regional differences in cerebral edema after traumatic brain injury identified by impedance analysis
    Matthew T Harting
    Department of Surgery, Division of Pediatric Surgery, The Center for Microvascular and Lymphatic Studies, University of Texas Medical School at Houston, Houston, Texas 77030, USA
    J Surg Res 159:557-64. 2010
    ..Cerebral edema is a common and potentially devastating sequel of traumatic brain injury. We developed and validated a system capable of tissue impedance analysis, which was found to correlate with cerebral edema...
  58. pmc Progenitor cell therapies for traumatic brain injury: barriers and opportunities in translation
    Peter A Walker
    Department of Pediatric Surgery, University of Texas Medical School at Houston, Houston, TX 77030, USA
    Dis Model Mech 2:23-38. 2009
    ..Here, we review the preclinical evidence that is currently guiding the translation of adult stem cell therapy for TBI...
  59. ncbi request reprint Delayed institution of extracorporeal membrane oxygenation is associated with increased mortality rate and prolonged hospital stay
    Brijesh S Gill
    Department of Surgery and Pediatrics, The University of Texas Houston Medical School, Houston, Texas, USA
    J Pediatr Surg 37:7-10. 2002
    ..The authors hypothesized that those infants with severe MAS who are treated with ECMO early will have a lower mortality rate and a shorter hospital course than those who receive delayed ECMO...
  60. pmc Advances in progenitor cell therapy using scaffolding constructs for central nervous system injury
    Peter A Walker
    Department of Surgery, University of Texas Medical School at Houston, Houston, TX 77030, USA
    Stem Cell Rev 5:283-300. 2009
    ..The focus of this review is to explore the current state of the art as it relates to current and novel progenitor cell delivery methods...
  61. pmc Autologous bone marrow mononuclear cells enhance recovery after acute ischemic stroke in young and middle-aged rats
    Miranda Brenneman
    Department ofNeurology, University of Texas, Houston Medical School, Houston, Texas 77030, USA
    J Cereb Blood Flow Metab 30:140-9. 2010
    ..Autologous bone marrow MNCs can be safely harvested from rodents after stroke, migrate to the peri-infarct area, enhance recovery, and modulate the post-ischemic inflammatory response...
  62. pmc Subacute neural stem cell therapy for traumatic brain injury
    Matthew T Harting
    University of Texas Medical School at Houston, Department of Pediatric Surgery, Houston, TX 77030, USA
    J Surg Res 153:188-94. 2009
    ..Unfortunately, recent study has revealed potential limitations of acute and intravenous stem cell therapy. We studied subacute, direct intracerebral neural stem and progenitor cell (NSC) therapy for TBI...
  63. pmc Progenitor cell therapy for traumatic brain injury: effect of serum osmolarity on cell viability and cytokine production
    Peter A Walker
    Department of Pediatric Surgery, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 5 234, Houston, TX 77030, USA
    Regen Med 5:65-71. 2010
    ..Optimization of MSC therapy requires delivery to the target area without significant loss of cellular function or viability. No model evaluating the potential efficacy of MSC therapy at varying osmolarities currently exists...
  64. pmc Intravenous mesenchymal stem cell therapy for traumatic brain injury
    Matthew T Harting
    Departments of Pediatric Surgery, University of Texas Medical School at Houston, Texas, USA
    J Neurosurg 110:1189-97. 2009
    ....
  65. doi request reprint Mechanics of the left ventricular myocardial interstitium: effects of acute and chronic myocardial edema
    Ketaki V Desai
    Michael E DeBakey Institute, Texas A and M University, College Station, Texas 77843 4466, USA
    Am J Physiol Heart Circ Physiol 294:H2428-34. 2008
    ....
  66. ncbi request reprint Effect of venous air embolization on pulmonary microvascular protein permeability
    Randolph H Stewart
    Michael E DeBakey Institute, Texas A and M University, College Station, Texas 77843 4466, USA
    Microcirculation 11:409-14. 2004
    ....
  67. ncbi request reprint Pulmonary air embolization inhibits lung lymph flow by increasing lymphatic outflow pressure
    Randolph H Stewart
    Michael E DeBakey Institute, Texas A and M University, College Station, 77843 4466, USA
    Lymphat Res Biol 4:18-22. 2006
    ..We hypothesized that pulmonary air embolization would lead to systemic venous hypertension and that this increase in lymphatic outflow pressure would prevent an increase in pulmonary lymph flow...
  68. doi request reprint Myocardial fluid balance in dogs with naturally acquired heartworm infection
    Randolph H Stewart
    Michael E DeBakey Institute, Texas A and M University, College Station, TX 77843, USA
    Am J Vet Res 69:356-61. 2008
    ..To determine the effect of naturally acquired heartworm (Dirofilaria immitis) infection on myocardial fluid balance as indicated by myocardial water content and the dynamics of transepicardial fluid flow...

Research Grants2

  1. Hypothermia for Acute Brain Injury in Children
    Charles Cox; Fiscal Year: 2004
    ..abstract_text> ..
  2. MICROVASCULAR INJURY DURING EXTRACORPOREAL LIFE SUPPORT
    Charles Cox; Fiscal Year: 2004
    ..Dr. McIntire's expertise in PMN/endothelial/blood flow interactions will provide an important addition to the candidate's training. ..