Gail Cornwall

Summary

Affiliation: Texas Tech University Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Oligomerization and transglutaminase cross-linking of the cystatin CRES in the mouse epididymal lumen: potential mechanism of extracellular quality control
    Hans H von Horsten
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA
    J Biol Chem 282:32912-23. 2007
  2. pmc Cystatin-related epididymal spermatogenic aggregates in the epididymis
    Gail A Cornwall
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA
    J Androl 32:679-85. 2011
  3. ncbi request reprint Role of posttranslational protein modifications in epididymal sperm maturation and extracellular quality control
    Gail A Cornwall
    Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX, 79430, USA
    Adv Exp Med Biol 759:159-80. 2014
  4. pmc Nonpathological extracellular amyloid is present during normal epididymal sperm maturation
    Sandra Whelly
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    PLoS ONE 7:e36394. 2012
  5. ncbi request reprint The cystatin-related epididymal spermatogenic protein inhibits the serine protease prohormone convertase 2
    Gail A Cornwall
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Endocrinology 144:901-8. 2003
  6. ncbi request reprint A new subgroup of the family 2 cystatins
    Gail A Cornwall
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock 79430, USA
    Mol Cell Endocrinol 200:1-8. 2003
  7. ncbi request reprint [Cres (cystatin-related epididymal spermatogenic) gene regulation and function]
    Gail A Cornwall
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Zhonghua Nan Ke Xue 8:313-8. 2002
  8. pmc New insights into epididymal biology and function
    Gail A Cornwall
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, 79430, USA
    Hum Reprod Update 15:213-27. 2009
  9. ncbi request reprint Extracellular quality control in the epididymis
    Gail A Cornwall
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA
    Asian J Androl 9:500-7. 2007
  10. ncbi request reprint Recapitulation of germ cell- and pituitary-specific expression with 1.6 kb of the cystatin-related epididymal spermatogenic (Cres) gene promoter in transgenic mice
    Nelson Hsia
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, 3601 4th St, Lubbock, TX 79430, USA
    J Androl 26:249-57. 2005

Research Grants

  1. THE CRES GENE IN REPRODUCTION
    Gail Cornwall; Fiscal Year: 2001
  2. THE CRES GENE IN REPRODUCTION
    Gail Cornwall; Fiscal Year: 2002
  3. THE CRES GENE IN REPRODUCTION
    Gail Cornwall; Fiscal Year: 2003
  4. THE CRES GENE IN REPRODUCTION
    Gail Cornwall; Fiscal Year: 2004
  5. THE CRES GENE IN REPRODUCTION
    Gail Cornwall; Fiscal Year: 2005
  6. THE CRES GENE IN REPRODUCTION
    Gail Cornwall; Fiscal Year: 2007
  7. Protein Amyloidogenesis in the Epididymis: Mechanisms and Biological Significance
    Gail Cornwall; Fiscal Year: 2009
  8. Protein Amyloidogenesis in the Epididymis: Mechanisms and Biological Significance
    Gail Cornwall; Fiscal Year: 2010
  9. Protein Amyloidogenesis in the Epididymis: Mechanisms and Biological Significance
    Gail Cornwall; Fiscal Year: 2011

Collaborators

  • Jonathan Powell
  • Ching Hei Yeung
  • Eberhard Nieschlag
  • R John Lye
  • Trevor G Cooper
  • Nelson Hsia
  • Sandra Whelly
  • H G Sutton-Walsh
  • Adam D Parent
  • Mary Catherine Hastert
  • Qing Yuan
  • Hans H von Horsten
  • Jennifer L Kirby
  • Michael Wassler
  • Seethal Johnson
  • Clinton Borchardt
  • Lauren Y Liu
  • Louis Hermo
  • Charles E Smith
  • Qiang Su Guo
  • Seethal S Johnson
  • Chen Xu
  • Susan K SanFrancisco
  • Yi Fei Wang
  • Sandra M Whelly
  • Stephen R Hann
  • Jeffrey P Brousal
  • Ling Yang
  • Richard Day
  • Jacquelyn C Labus
  • Barry T Hinton
  • Patrick Syntin
  • Daniel M Hardy

Detail Information

Publications18

  1. ncbi request reprint Oligomerization and transglutaminase cross-linking of the cystatin CRES in the mouse epididymal lumen: potential mechanism of extracellular quality control
    Hans H von Horsten
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA
    J Biol Chem 282:32912-23. 2007
    ..We propose that transglutaminase activity in the epididymal lumen may function as a mechanism of extracellular quality control by diverting proteins such as CRES from the amyloidogenic pathway...
  2. pmc Cystatin-related epididymal spermatogenic aggregates in the epididymis
    Gail A Cornwall
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA
    J Androl 32:679-85. 2011
    ....
  3. ncbi request reprint Role of posttranslational protein modifications in epididymal sperm maturation and extracellular quality control
    Gail A Cornwall
    Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX, 79430, USA
    Adv Exp Med Biol 759:159-80. 2014
    ....
  4. pmc Nonpathological extracellular amyloid is present during normal epididymal sperm maturation
    Sandra Whelly
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    PLoS ONE 7:e36394. 2012
    ..The presence of an extracellular and nonpathological amyloid in the epididymis suggests that similar amyloid structures may be present in other organ systems and may carry out distinctive tissue-specific functions...
  5. ncbi request reprint The cystatin-related epididymal spermatogenic protein inhibits the serine protease prohormone convertase 2
    Gail A Cornwall
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Endocrinology 144:901-8. 2003
    ..These studies suggest that CRES is a cross-class inhibitor that may regulate proprotein processing within the reproductive and neuroendocrine systems...
  6. ncbi request reprint A new subgroup of the family 2 cystatins
    Gail A Cornwall
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock 79430, USA
    Mol Cell Endocrinol 200:1-8. 2003
    ..This review describes the CRES subgroup within the family 2 cystatins including potential new members and their putative functions in the reproductive tract...
  7. ncbi request reprint [Cres (cystatin-related epididymal spermatogenic) gene regulation and function]
    Gail A Cornwall
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Zhonghua Nan Ke Xue 8:313-8. 2002
    ..Therefore, CRES is a new cross-class inhibitor that may regulate PC2 of PC2-like proteases and suggests a role for CRES in the regulation of prohormone and proprotein processing...
  8. pmc New insights into epididymal biology and function
    Gail A Cornwall
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, 79430, USA
    Hum Reprod Update 15:213-27. 2009
    ....
  9. ncbi request reprint Extracellular quality control in the epididymis
    Gail A Cornwall
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA
    Asian J Androl 9:500-7. 2007
    ....
  10. ncbi request reprint Recapitulation of germ cell- and pituitary-specific expression with 1.6 kb of the cystatin-related epididymal spermatogenic (Cres) gene promoter in transgenic mice
    Nelson Hsia
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, 3601 4th St, Lubbock, TX 79430, USA
    J Androl 26:249-57. 2005
    ..These studies demonstrate that 1.6 kb of Cres promoter contains the DNA elements necessary for germ cell and pituitary gland-specific expression but lacks critical sequences necessary for expression in the epididymis and ovary...
  11. ncbi request reprint Cres2 and Cres3: new members of the cystatin-related epididymal spermatogenic subgroup of family 2 cystatins
    Nelson Hsia
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Endocrinology 144:909-15. 2003
    ..Taken together, CRES2 and CRES3 represent new members of a subgroup of cystatin family 2 proteins that likely carry out tissue-specific functions distinct from that of typical cystatins...
  12. ncbi request reprint Identification and characterization of cystatin-related epididymal spermatogenic protein in human spermatozoa: localization in the equatorial segment
    Michael Wassler
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Biol Reprod 67:795-803. 2002
    ..Taken together, these studies show that CRES protein is present in the sperm equatorial segment and becomes accessible to the extracellular environment during fertilization...
  13. ncbi request reprint DNA microarray analysis of region-specific gene expression in the mouse epididymis
    Nelson Hsia
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Biol Reprod 70:448-57. 2004
    ..The studies presented here show a global survey of region-specific gene expression in the epididymis, identifying 15287 sequences, the majority of which have not previously been shown to be expressed in this organ...
  14. ncbi request reprint Differential effects of GnRH and androgens on Cres mRNA and protein in male mouse anterior pituitary gonadotropes
    H G Sutton-Walsh
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    J Androl 27:802-15. 2006
    ..Together, our studies suggest that Cres mRNA and protein are low at peak gonadotrope secretory activity, possibly as a means to allow proprotein processing events to occur that are integral to gonadotrope function...
  15. pmc Alterations in the testis and epididymis associated with loss of function of the cystatin-related epididymal spermatogenic (CRES) protein
    Adam D Parent
    Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
    J Androl 32:444-63. 2011
    ..These findings suggest that the altered testicular and epididymal histology reflects a cumulative effect of the loss of CRES and support a role for CRES in maintaining the normal integrity and function of the testis and epididymis...
  16. ncbi request reprint Age-dependent expression of the cystatin-related epididymal spermatogenic (Cres) gene in mouse testis and epididymis
    Qing Yuan
    Department of Histology and Embryology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Asian J Androl 9:305-11. 2007
    ..To investigate the spatial and temporal expression of the cystatin-related epididymal spermatogenic (Cres) gene in mouse testis and epididymis during postnatal development...
  17. ncbi request reprint Characterization of epididymal epithelial cell-specific gene promoters by in vivo electroporation
    Jennifer L Kirby
    Department of Cell Biology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Biol Reprod 71:613-9. 2004
    ..These studies demonstrate the utility of in vivo electroporation for elucidating promoter elements that may not be identified when traditional in vitro methods are used...
  18. ncbi request reprint Gene and protein expression in the epididymis of infertile c-ros receptor tyrosine kinase-deficient mice
    Trevor G Cooper
    Institute of Reproductive Medicine of the University, D 48129 Munster, Germany
    Biol Reprod 69:1750-62. 2003
    ..The changes in these genes could affect sperm function by modifying the composition of epididymal fluid and explain the infertility of the KO males. These genes may be targets for a posttesticular contraceptive...

Research Grants9

  1. THE CRES GENE IN REPRODUCTION
    Gail Cornwall; Fiscal Year: 2001
    ..abstract_text> ..
  2. THE CRES GENE IN REPRODUCTION
    Gail Cornwall; Fiscal Year: 2002
    ..abstract_text> ..
  3. THE CRES GENE IN REPRODUCTION
    Gail Cornwall; Fiscal Year: 2003
    ..abstract_text> ..
  4. THE CRES GENE IN REPRODUCTION
    Gail Cornwall; Fiscal Year: 2004
    ..abstract_text> ..
  5. THE CRES GENE IN REPRODUCTION
    Gail Cornwall; Fiscal Year: 2005
    ..abstract_text> ..
  6. THE CRES GENE IN REPRODUCTION
    Gail Cornwall; Fiscal Year: 2007
    ..Also, the newly purchased mass spec will enable on site protein analysis for the studies described above. In short, the environment at TTUHSC is exceptional and will fully support my proposed studies. ..
  7. Protein Amyloidogenesis in the Epididymis: Mechanisms and Biological Significance
    Gail Cornwall; Fiscal Year: 2009
    ....
  8. Protein Amyloidogenesis in the Epididymis: Mechanisms and Biological Significance
    Gail Cornwall; Fiscal Year: 2010
    ....
  9. Protein Amyloidogenesis in the Epididymis: Mechanisms and Biological Significance
    Gail Cornwall; Fiscal Year: 2011
    ....