George P Cobb

Summary

Affiliation: Texas Tech University
Country: USA

Publications

  1. ncbi request reprint Polychlorinated biphenyl occurrence in American alligators (Alligator mississippiensis) from Louisiana and South Carolina
    George P Cobb
    Texas Tech University, Lubbock 79416, USA
    Environ Pollut 118:1-4. 2002
  2. ncbi request reprint Determination of N-nitroso derivatives of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in soils by pressurized liquid extraction and liquid chromatography-electrospray ionization mass spectrometry
    Xiaoping Pan
    The Institute of Environmental and Human Health, Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409 1163, USA
    J Chromatogr A 1107:2-8. 2006
  3. ncbi request reprint Assessment of pathogens and toxicants in New Orleans, LA following Hurricane Katrina
    Steven M Presley
    Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock 79409 1163, USA
    Environ Sci Technol 40:468-74. 2006
  4. ncbi request reprint Influence of land use on metal concentrations in playa sediments and amphibians in the Southern High Plains
    Louise S Venne
    Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, MS 1163, Lubbock, TX 79409, USA
    Environ Pollut 144:112-8. 2006
  5. ncbi request reprint Reproductive effects of hexahydro-1,3,5-trinitroso-1,3,5-triazine in deer mice (Peromyscus maniculatus) during a controlled exposure study
    Jordan N Smith
    The Institute of Environmental and Human Health TIEHH, Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409 1163, USA
    Environ Toxicol Chem 25:446-51. 2006
  6. doi request reprint Tandem capillary column gas chromatography-mass spectrometric determination of the organophosphonate nerve agent surrogate dimethyl methylphosphonate in gaseous phase
    Les N McDaniel
    Texas Tech University, Department of Environmental Toxicology, The Institute of Environmental and Human Health, Lubbock, TX 79409 1163, USA
    Talanta 81:1568-71. 2010
  7. ncbi request reprint Examination of the mutagenicity of RDX and its N-nitroso metabolites using the Salmonella reverse mutation assay
    Xiaoping Pan
    The Institute of Environmental and Human Health TIEHH, Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409 1163, USA
    Mutat Res 629:64-9. 2007
  8. ncbi request reprint Age dependent acute oral toxicity of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and two anaerobic N-nitroso metabolites in deer mice (Peromyscus maniculatus)
    Jordan N Smith
    The Institute of Environmental and Human Health, The Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409, USA
    Chemosphere 67:2267-73. 2007
  9. ncbi request reprint Metal distributions in New Orleans following hurricanes Katrina and Rita: A continuation study
    George P Cobb
    Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, P O Box 41163, Lubbock, Texas, 79409 1163, USA
    Environ Sci Technol 40:4571-7. 2006
  10. ncbi request reprint microRNAs as oncogenes and tumor suppressors
    Baohong Zhang
    Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX 79409 1163, USA
    Dev Biol 302:1-12. 2007

Detail Information

Publications41

  1. ncbi request reprint Polychlorinated biphenyl occurrence in American alligators (Alligator mississippiensis) from Louisiana and South Carolina
    George P Cobb
    Texas Tech University, Lubbock 79416, USA
    Environ Pollut 118:1-4. 2002
    ..However, eggs from Winyah Bay contained 3176 ng/g PCBs which is higher (P < 0.008) than concentrations from the other two sites. These data indicate the ubiquitous nature of PCBs and their bioaccumulation even in remote habitats...
  2. ncbi request reprint Determination of N-nitroso derivatives of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in soils by pressurized liquid extraction and liquid chromatography-electrospray ionization mass spectrometry
    Xiaoping Pan
    The Institute of Environmental and Human Health, Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409 1163, USA
    J Chromatogr A 1107:2-8. 2006
    ..1-108.3%), good precision (RSD: 3.2-12.4%), and reproducibility were achieved. This method proved effective and was applied to monitor the reductive biotransformation of MNX in soils with the presence of earthworms (Eisenia fetida)...
  3. ncbi request reprint Assessment of pathogens and toxicants in New Orleans, LA following Hurricane Katrina
    Steven M Presley
    Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock 79409 1163, USA
    Environ Sci Technol 40:468-74. 2006
    ..Initial findings suggest numerous environmental contaminants are present in New Orleans and support the need for further evaluation of the extent of those threats...
  4. ncbi request reprint Influence of land use on metal concentrations in playa sediments and amphibians in the Southern High Plains
    Louise S Venne
    Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, MS 1163, Lubbock, TX 79409, USA
    Environ Pollut 144:112-8. 2006
    ..No correlations between sediment and tissue concentrations were found. Land use appeared to have little influence on metal concentrations and levels were below those known to cause effects in amphibians...
  5. ncbi request reprint Reproductive effects of hexahydro-1,3,5-trinitroso-1,3,5-triazine in deer mice (Peromyscus maniculatus) during a controlled exposure study
    Jordan N Smith
    The Institute of Environmental and Human Health TIEHH, Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409 1163, USA
    Environ Toxicol Chem 25:446-51. 2006
    ..Data from the present study indicate that TNX bioaccumulates in the liver and is associated with postpartum mortality, dose-dependent decrease in body weight from birth to weaning, and decrease in kidney weight of deer mice offspring...
  6. doi request reprint Tandem capillary column gas chromatography-mass spectrometric determination of the organophosphonate nerve agent surrogate dimethyl methylphosphonate in gaseous phase
    Les N McDaniel
    Texas Tech University, Department of Environmental Toxicology, The Institute of Environmental and Human Health, Lubbock, TX 79409 1163, USA
    Talanta 81:1568-71. 2010
    ..168. This method demonstrated high linearity across a wide range of concentrations, as well as excellent sensitivity and repeatability, and proved applicable to other lower alkyl-phosphonates...
  7. ncbi request reprint Examination of the mutagenicity of RDX and its N-nitroso metabolites using the Salmonella reverse mutation assay
    Xiaoping Pan
    The Institute of Environmental and Human Health TIEHH, Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409 1163, USA
    Mutat Res 629:64-9. 2007
    ..Strain TA97a was found to be the most sensitive strain among these four strains. No cytotoxicity of RDX, MNX, and TNX was observed at the concentrations used in this study. Doses were verified by HPLC...
  8. ncbi request reprint Age dependent acute oral toxicity of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and two anaerobic N-nitroso metabolites in deer mice (Peromyscus maniculatus)
    Jordan N Smith
    The Institute of Environmental and Human Health, The Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409, USA
    Chemosphere 67:2267-73. 2007
    ....
  9. ncbi request reprint Metal distributions in New Orleans following hurricanes Katrina and Rita: A continuation study
    George P Cobb
    Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, P O Box 41163, Lubbock, Texas, 79409 1163, USA
    Environ Sci Technol 40:4571-7. 2006
    ..Toxicant concentrations did not exceed soil screening criteria values for lead within any flood sediments or for 32 of 37 soil samples, but arsenic concentrations in 40 of 43 samples exceeded screening criteria...
  10. ncbi request reprint microRNAs as oncogenes and tumor suppressors
    Baohong Zhang
    Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX 79409 1163, USA
    Dev Biol 302:1-12. 2007
    ..miRNA expression profiles may become useful biomarkers for cancer diagnostics. In addition, miRNA therapy could be a powerful tool for cancer prevention and therapeutics...
  11. ncbi request reprint Computational identification of microRNAs and their targets
    Baohong Zhang
    The Institute of Environmental and Human Health, Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409 1163, USA
    Comput Biol Chem 30:395-407. 2006
    ..A majority of known miRNAs and their targets were identified by computational approaches. Several web-based or non-web-based computer software programs are publicly available for predicting miRNAs and their targets...
  12. ncbi request reprint N-Nitroso compounds produced in deer mouse (Peromyscus maniculatus) GI tracts following hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) exposure
    Xiaoping Pan
    The Institute of Environmental and Human Health, Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409 1163, USA
    Chemosphere 67:1164-70. 2007
    ..DNX in stomach were 217 microg/kg for the 10mg/kg dose group and 498 microg/kg for the 100mg/kg dose group. Changes in other toxic endpoints including body weight gain, food consumption, organ weight, and behavior were also reported...
  13. ncbi request reprint Plant microRNA: a small regulatory molecule with big impact
    Baohong Zhang
    The Institute of Environmental and Human Health TIEHH, and Department of Environmental Toxicology, Texas Tech University, Lubbock, 79409 1163, USA
    Dev Biol 289:3-16. 2006
    ..miRNAs regulate the expression of many important genes; a majority of these genes are transcriptional factors...
  14. ncbi request reprint Toxicity of hexahydro-1,3,5-trinitro-1,3,5-triazine to larval zebrafish (Danio rerio)
    Sandeep Mukhi
    Department of Environmental Toxicology and Texas Cooperative Fish and Wildlife Research Unit, Texas Tech University, Box 41163, Lubbock, TX 79409 1160, USA
    Chemosphere 61:178-85. 2005
    ..The chronic effects of RDX in aquatic vertebrates need to be determined for an adequate assessment of the ecological risk of environmental RDX...
  15. ncbi request reprint Comparison of white-footed mice and rice rats as biomonitors of polychlorinated biphenyl and metal contamination
    Philip N Smith
    The Institute of Environmental and Human Health, Texas Tech University Texas Tech Health Sciences Center, Lubbock 79409 1163, USA
    Environ Pollut 119:261-8. 2002
    ..0335), and aluminum (P = 0.0006) than rice rats at all five sampling areas. Species-specific differences in accumulation of PCBs and metals were observed and attributed to differences in habitat use and foraging strategies...
  16. ncbi request reprint Mercury occurrence in prothonotary warblers (Protonotaria citrea) inhabiting a National Priorities List site and reference areas in southern Alabama
    Blakely M Adair
    The Institute of Environmental and Human Health, The Texas Tech University Health Sciences Center, Texas Tech University, Box 41163, Lubbock, TX 79409, USA
    Arch Environ Contam Toxicol 44:265-71. 2003
    ..Mercury distributions in matrices provide useful information of uptake that can be integrated with risk assessment endpoints...
  17. doi request reprint Metal concentrations in schoolyard soils from New Orleans, Louisiana before and after Hurricanes Katrina and Rita
    Steven M Presley
    Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, 79409 1163, USA
    Chemosphere 80:67-73. 2010
    ....
  18. ncbi request reprint Using chorioallantoic membranes for non-lethal assessment of persistent organic pollutant exposure and effect in oviparous wildlife
    George P Cobb
    The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX 79416, USA
    Ecotoxicology 12:31-45. 2003
    ..Controlled dose-response studies have been completed in chickens. The following manuscript presents the foundations for the CAM approach and a review of research findings involving this technique...
  19. ncbi request reprint Liquid chromatography/electrospray ionization tandem mass spectrometry analysis of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX)
    Xiaoping Pan
    The Institute of Environmental and Human Health TIEHH, and Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409 1163, USA
    Rapid Commun Mass Spectrom 20:2222-6. 2006
    ..Using this quantification technique, the method detection limit was 1.57 microg/L and good linearity was achieved in the range 5-500 microg/L. This method will help to unambiguously analyze environmentally relevant concentrations of HMX...
  20. doi request reprint Spatial distribution of lead concentrations in urban surface soils of New Orleans, Louisiana USA
    Michael T Abel
    Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX 79409 1163, USA
    Environ Geochem Health 32:379-89. 2010
    ..Pb concentrations found throughout New Orleans in this study were then incorporated into a geographic information system to create a spatial distribution model that can be further used to predict Pb exposure to humans in the city...
  21. ncbi request reprint Development of an extraction and cleanup procedure for a liquid chromatographic-mass spectrometric method to analyze octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine in eggs
    Jun Liu
    The Institute of Environmental and Human Health, Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409 1163, USA
    Talanta 71:627-31. 2007
    ..Overall recoveries from eggs containing 10, 50, 250 and 1000ng/g of HMX were 84.0%, 88.0%, 90.6% and 87.4%. A method detection limit (MDL) of 0.15ng/g was achieved...
  22. ncbi request reprint Identification and characterization of new plant microRNAs using EST analysis
    Bao Hong Zhang
    The Institute of Environmental and Human Health, and Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409 1163, USA
    Cell Res 15:336-60. 2005
    ..Environmental stresses and developmental switching may be the signals for synthesis and regulation of miRNAs in plants. A model for miRNA induction and expression, and gene regulation by miRNA is hypothesized...
  23. ncbi request reprint Contaminant exposure in terrestrial vertebrates
    Philip N Smith
    The Institute of Environmental and Human Health, Department of Environmental Toxicology, Texas Tech University, Lubbock, TX, USA
    Environ Pollut 150:41-64. 2007
    ..Lastly, we identify areas related to exposure among terrestrial and semi-terrestrial organisms that warrant additional research...
  24. ncbi request reprint Metals and organochlorine pesticides in caudal scutes of crocodiles from Belize and Costa Rica
    Thomas R Rainwater
    The Institute of Environmental and Human Health, Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409, USA
    Sci Total Environ 373:146-56. 2007
    ....
  25. ncbi request reprint Identification of cotton microRNAs and their targets
    Baohong Zhang
    Henan Institute of Science and Technology, Xinxiang, Henna, PR China
    Gene 397:26-37. 2007
    ....
  26. ncbi request reprint Effect of two major N-nitroso hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) metabolites on earthworm reproductive success
    Baohong Zhang
    The Institute of Environmental and Human Health, Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409, USA
    Environ Pollut 153:658-67. 2008
    ..7mg/kg for MNX and TNX, respectively, in soil and 4.5 and 3.1mg/L in the topical test. Both MNX and TNX inhibited cocoon production and hatching, suggesting that they may have a negative affect on soil ecosystems at contaminated sites...
  27. ncbi request reprint Spatial and temporal evaluation of metal concentrations in soils and sediments from New Orleans, Louisiana, USA, following hurricanes Katrina and Rita
    Michael T Abel
    Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Box 41163, Lubbock, Texas 79409 1163, USA
    Environ Toxicol Chem 26:2108-14. 2007
    ..Metal concentrations were evaluated for temporal comparisons using a pair sampled t test. Arsenic concentrations differed significantly over time, but Pb concentrations did not...
  28. ncbi request reprint Characterizing viral microRNAs and its application on identifying new microRNAs in viruses
    Xiaoping Pan
    The Institute of Environmental and Human Health, and Department of Environmental Toxicology, Texas Tech University, Lubbock, Texas, USA
    J Cell Physiol 211:10-8. 2007
    ..A better understanding of viral miRNA functions will be useful to design new approaches for treating viruses, especially those viruses that can induce human, animal, and plant diseases...
  29. ncbi request reprint Chorioallantoic membranes indicate avian exposure and biomarker responses to environmental contaminants: a laboratory study with White Leghorn chickens (Gallus domesticus)
    Timothy A Bargar
    The Institute of Environmental and Human Health, Department of Environmental Toxicology, Texas Tech University, Lubbock, Texas 79409, USA
    Environ Sci Technol 37:256-60. 2003
    ..49, p = 0.0001) and hens (r2 = 0.45, p = 0.014) was also significant but not as strong. This study shows that CAMs can be used to estimate avian exposure to PCBs and resultant biological response...
  30. ncbi request reprint Effects of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) exposure on reproduction and hatchling development in Northern bobwhite quail
    Kristina J Brunjes
    Texas Tech University, The Institute of Environmental and Human Health, Lubbock, Texas, USA
    J Toxicol Environ Health A 70:682-7. 2007
    ..However, results of these studies further suggest that the potential for reproductive toxicity of HMX to birds is low...
  31. ncbi request reprint Conservation and divergence of plant microRNA genes
    Baohong Zhang
    The Institute of Environmental and Human Health TIEHH, and Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409 1163, USA
    Plant J 46:243-59. 2006
    ..Regulation of gene expression by miRNAs appears to have existed at the earliest stages of plant evolution and has been tightly constrained (functionally) for more than 425 million years...
  32. ncbi request reprint Northern pocket gophers (Thomomys talpoides) as biomonitors of environmental metal contamination
    Kevin D Reynolds
    The Institute of Environmental and Human Health, Texas Tech University, P O Box 41163, Lubbock, Texas 79409, USA
    Environ Toxicol Chem 25:458-69. 2006
    ....
  33. ncbi request reprint Use of pressurized liquid extraction (PLE)/gas chromatography-electron capture detection (GC-ECD) for the determination of biodegradation intermediates of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in soils
    Baohong Zhang
    The Institute of Environmental and Human Health TIEHH, and Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409 1163, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 824:277-82. 2005
    ..243, 0.095, 0.138, and 0.057 ng/g for RDX, MNX, DNX, and TNX, respectively. The method gave high recovery (98-102%), good precision (0.22-5.14%), and reproducibility, and proved to be suitable for real world sample analysis...
  34. ncbi request reprint Uptake of perchlorate in terrestrial plants
    Lu Yu
    Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University and Texas Tech University Health Sciences Center, Box 41163, Lubbock, TX 79409 1163, USA
    Ecotoxicol Environ Saf 58:44-9. 2004
    ..The potential for trophic transfer of perchlorate from soil to higher organisms through plants exists...
  35. ncbi request reprint Organochlorine pesticides and mercury in cottonmouths (Agkistrodon piscivorus) from northeastern Texas, USA
    Thomas R Rainwater
    The Institute of Environmental and Human Health, Department of Environmental Toxicology, Texas Tech University, Box 41163, Lubbock, Texas 79409 1163, USA
    Environ Toxicol Chem 24:665-73. 2005
    ..Both long-term field studies and controlled laboratory investigations are needed to adequately assess the response of cottonmouths to chronic contaminant exposure...
  36. doi request reprint Development of a method for the determination of 9 currently used cotton pesticides by gas chromatography with electron capture detection
    Baohong Zhang
    Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX 79409 1163, United States
    Talanta 75:1055-60. 2008
    ..After 10 days storage at room temperature, 30-40% degradation of lambda-cyhalothrin was observed. It is recommended that acephate, acetamiprid, and lambda-cyhalothrin be stored at -20 degrees C or analyzed immediately after extraction...
  37. ncbi request reprint The effect of flight, fasting and p,p'-DDT on thyroid hormones and corticosterone in Gambel's white-crowned sparrow, Zonotrichia leucophrys gambelli
    Edward J Scollon
    The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX 79409, USA
    Comp Biochem Physiol C Toxicol Pharmacol 137:179-89. 2004
    ..001) and triiodothyronine decreased in fasted birds dosed with DDT (P = 0.004). The increased rate of hormone diminution may be a result of the ability of DDT to induce microsomal enzyme production...
  38. ncbi request reprint Vapor-phase analysis of isobutyl acetate, isopropyl acetate, n-propyl acetate and their respective alcohols using solid-phase microextraction-gas chromatography with a mass selective detector
    Corey W Radtke
    Biotechnology Department, Idaho National Engineering and Environmental Laboratory, Idaho Falls, ID 83415, USA
    J Chromatogr A 1066:225-30. 2005
    ..1 +/- 6.1% at 1 ppmv, becoming most precise at 50 ppmv at 1.01 +/- 0.45%, then increasing at 100 ppmv to 4.12 +/- 1.88%. The contributors to error trended as: concentration > daily effects > operator...
  39. ncbi request reprint Effects of perchlorate on earthworm (Eisenia fetida) survival and reproductive success
    Mindy Landrum
    The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX, United States
    Sci Total Environ 363:237-44. 2006
    ..In addition, preliminary data suggest that cocoons produced under perchlorate contamination did not hatch as well as cocoons produced in control soil despite incubation of both sets of cocoons in clean soil or sand...
  40. ncbi request reprint Uptake, accumulation and depuration of sodium perchlorate and sodium arsenate in zebrafish (Danio rerio)
    Fu Jun Liu
    The Institute of Environmental and Human Health and Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409 1163, USA
    Chemosphere 65:1679-89. 2006
    ..This study represents the first examination of the interaction of two anions-perchlorate and arsenate with respect to toxicokinetics...
  41. doi request reprint Effects of HMX exposure upon metabolic rate of northern bobwhite quail (Colinus virginianus) in ovo
    Jun Liu
    The Institute of Environmental and Human Health, Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409 1163, USA
    Chemosphere 71:1945-9. 2008
    ..0001). Oxygen consumption rates did not vary as a function of HMX in embryos (p=0.18). No evidence was observed for alterations of in ovo metabolic rates associated with HMX exposure...