ROBERT STEPHEN CHAPKIN

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. pmc Mechanistic insights into the role of microRNAs in cancer: influence of nutrient crosstalk
    Manasvi S Shah
    Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station TX, USA Intercollegiate Faculty of Genetics, Texas A and M University, College Station TX, USA
    Front Genet 3:305. 2012
  2. pmc Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis
    Jennifer M Monk
    Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, Texas, USA
    PLoS ONE 7:e49739. 2012
  3. pmc Alteration of EGFR spatiotemporal dynamics suppresses signal transduction
    Harmony F Turk
    Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 7:e39682. 2012
  4. pmc A metagenomic study of diet-dependent interaction between gut microbiota and host in infants reveals differences in immune response
    Scott Schwartz
    Training Program in Biostatistics, Bioinformatics, Nutrition and Cancer, Texas A and M University, 155 Ireland Street, College Station, TX 77843, USA
    Genome Biol 13:r32. 2012
  5. pmc Evaluation of fecal mRNA reproducibility via a marginal transformed mixture modeling approach
    Nysia I George
    Department of Statistics, University of Michigan, Ann Arbor, MI 48109 1107, USA
    BMC Bioinformatics 11:13. 2010
  6. pmc Use of a novel genetic mouse model to investigate the role of folate in colitis-associated colon cancer
    Robert S Chapkin
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843 2253, USA
    J Nutr Biochem 20:649-55. 2009
  7. pmc Bioactive dietary long-chain fatty acids: emerging mechanisms of action
    Robert S Chapkin
    Faculty of Nutrition, Texas A and M University, College Station, TX, USA
    Br J Nutr 100:1152-7. 2008
  8. pmc Mechanisms by which docosahexaenoic acid and related fatty acids reduce colon cancer risk and inflammatory disorders of the intestine
    Robert S Chapkin
    Center for Environmental and Rural Health, Texas A and M University, College Station, TX 77843 2553, United States
    Chem Phys Lipids 153:14-23. 2008
  9. pmc Docosahexaenoic acid alters the size and distribution of cell surface microdomains
    Robert S Chapkin
    Center for Environmental and Rural Health, Texas A and M University, College Station, Texas, USA
    Biochim Biophys Acta 1778:466-71. 2008
  10. ncbi request reprint Colon cancer, fatty acids and anti-inflammatory compounds
    Robert S Chapkin
    Faculty of Nutrition, Texas A and M University System Health Science Center, College Station, Texas 77843, USA
    Curr Opin Gastroenterol 23:48-54. 2007

Collaborators

Detail Information

Publications65

  1. pmc Mechanistic insights into the role of microRNAs in cancer: influence of nutrient crosstalk
    Manasvi S Shah
    Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station TX, USA Intercollegiate Faculty of Genetics, Texas A and M University, College Station TX, USA
    Front Genet 3:305. 2012
    ..For the purpose of elucidating the epigenetic landscape of cancer, this review will summarize the key findings from recent studies detailing the effect of bioactive dietary agents on miRNA regulation in cancer...
  2. pmc Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis
    Jennifer M Monk
    Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, Texas, USA
    PLoS ONE 7:e49739. 2012
    ....
  3. pmc Alteration of EGFR spatiotemporal dynamics suppresses signal transduction
    Harmony F Turk
    Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 7:e39682. 2012
    ....
  4. pmc A metagenomic study of diet-dependent interaction between gut microbiota and host in infants reveals differences in immune response
    Scott Schwartz
    Training Program in Biostatistics, Bioinformatics, Nutrition and Cancer, Texas A and M University, 155 Ireland Street, College Station, TX 77843, USA
    Genome Biol 13:r32. 2012
    ..Here we report the results from a simultaneous study of the gut microbiome and host epithelial transcriptome of three-month-old exclusively breast- and formula-fed infants...
  5. pmc Evaluation of fecal mRNA reproducibility via a marginal transformed mixture modeling approach
    Nysia I George
    Department of Statistics, University of Michigan, Ann Arbor, MI 48109 1107, USA
    BMC Bioinformatics 11:13. 2010
    ..We used outcomes from bootstrapped goodness-of-fit tests to determine which approach is less sensitive toward potential violation of distributional assumptions...
  6. pmc Use of a novel genetic mouse model to investigate the role of folate in colitis-associated colon cancer
    Robert S Chapkin
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843 2253, USA
    J Nutr Biochem 20:649-55. 2009
    ..9+/-0.3) and wild-type control mice (1.1+/-0.1). These data demonstrate that the ablation of two receptor/carrier-mediated pathways for folate transport increases the risk for developing inflammation-associated colon cancer...
  7. pmc Bioactive dietary long-chain fatty acids: emerging mechanisms of action
    Robert S Chapkin
    Faculty of Nutrition, Texas A and M University, College Station, TX, USA
    Br J Nutr 100:1152-7. 2008
    ....
  8. pmc Mechanisms by which docosahexaenoic acid and related fatty acids reduce colon cancer risk and inflammatory disorders of the intestine
    Robert S Chapkin
    Center for Environmental and Rural Health, Texas A and M University, College Station, TX 77843 2553, United States
    Chem Phys Lipids 153:14-23. 2008
    ..Ultimately, this may allow organ systems such as the colon to optimally decode, respond, and adapt to the vagaries of an ever-changing extracellular environment...
  9. pmc Docosahexaenoic acid alters the size and distribution of cell surface microdomains
    Robert S Chapkin
    Center for Environmental and Rural Health, Texas A and M University, College Station, Texas, USA
    Biochim Biophys Acta 1778:466-71. 2008
    ..We speculate that our findings may help define a new paradigm to better understand the complexity of n-3 PUFA modulation of signaling networks...
  10. ncbi request reprint Colon cancer, fatty acids and anti-inflammatory compounds
    Robert S Chapkin
    Faculty of Nutrition, Texas A and M University System Health Science Center, College Station, Texas 77843, USA
    Curr Opin Gastroenterol 23:48-54. 2007
    ..To outline recent findings on the efficacy of n-3 polyunsaturated fatty acids in the prevention/treatment of inflammatory bowel disease and colorectal cancer...
  11. ncbi request reprint Dietary n-3 PUFA alter colonocyte mitochondrial membrane composition and function
    Robert S Chapkin
    Department of Veterinary Anatomy and Public Health, Center for Environmental and Rural Health, Texas A and M University, College Station 77843 2471, USA
    Lipids 37:193-9. 2002
    ..026) were positively correlated with caspase 3 activity. These data provide evidence in vivo indicating that dietary EPA and DHA induce compositional changes in colonic mitochondrial membrane phospholipids that facilitate apoptosis...
  12. pmc Dietary docosahexaenoic and eicosapentaenoic acid: emerging mediators of inflammation
    Robert S Chapkin
    Department of Nutrition and Food Science, Faculty of Nutrition, Kleberg Biotechnology Center, MS 2253, Texas A and M University, College Station, TX 77843 2253, USA
    Prostaglandins Leukot Essent Fatty Acids 81:187-91. 2009
    ..We propose that lipid rafts may be targets for the development of n-3 PUFA-containing dietary bioactive agents to down-modulate inflammatory and immune responses and for the treatment of autoimmune and chronic inflammatory diseases...
  13. pmc Immunomodulatory action of dietary fish oil and targeted deletion of intestinal epithelial cell PPARĪ“ in inflammation-induced colon carcinogenesis
    Jennifer M Monk
    Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, Texas 77843 2253, USA
    Am J Physiol Gastrointest Liver Physiol 302:G153-67. 2012
    ..Moreover, we provide new evidence that dietary n-3 PUFAs attenuate intestinal inflammation in an intestinal epithelial cell PPARĪ“-independent manner...
  14. ncbi request reprint Immunomodulatory effects of (n-3) fatty acids: putative link to inflammation and colon cancer
    Robert S Chapkin
    Faculty of Nutrition, Center for Environmental and Rural Health, Texas A and M University, College Station, TX 77843, USA
    J Nutr 137:200S-204S. 2007
    ..Precisely how the immunomodulatory effects of (n-3) PUFAs influence inflammation-associated colonic tumor development is the subject of an ongoing investigation...
  15. pmc Noninvasive stool-based detection of infant gastrointestinal development using gene expression profiles from exfoliated epithelial cells
    Robert S Chapkin
    Texas A and M Univ, College Station, TX 77843 2253, USA
    Am J Physiol Gastrointest Liver Physiol 298:G582-9. 2010
    ..As larger data sets become available, this methodology can be extended to validation and, ultimately, identification of the main nutritional components that modulate intestinal maturation and function...
  16. pmc Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis
    David W L Ma
    Molecular and Cell Biology Section, Faculty of Nutrition, Texas A and M University, Kleberg Center, College Station, TX 77843 2471, USA
    Cancer Res 65:887-97. 2005
    ..In conclusion, Folbp1 and RFC1 genetically modified mice exhibit distinct changes in colonocyte phenotype and therefore have utility as models to examine the role of folate homeostasis in colon cancer development...
  17. ncbi request reprint Chemopreventive n-3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the rat
    Laurie A Davidson
    Faculty of Nutrition, Texas A and M University, College Station, Texas 77843 2471, USA
    Cancer Res 64:6797-804. 2004
    ....
  18. pmc n-3 Polyunsaturated fatty acids modulate carcinogen-directed non-coding microRNA signatures in rat colon
    Laurie A Davidson
    Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, TX 77843 2253, USA
    Carcinogenesis 30:2077-84. 2009
    ..32-fold) in adenocarcinomas. These results demonstrate for the first time the utility of the rat AOM model and the novel role of fish oil in protecting the colon from carcinogen-induced miRNA dysregulation...
  19. ncbi request reprint Dietary eicosapentaenoic acid modulates CTLA-4 expression in murine CD4+ T-cells
    Lan H Ly
    Department of Nutrition and Food Science, Texas A and M University System Health Science Center, College Station, TX, USA
    Prostaglandins Leukot Essent Fatty Acids 74:29-37. 2006
    ..01). Therefore, we conclude that dietary EPA may suppress CD4(+) T-cell activation by enhancing the downregulatory co-receptor CTLA-4, while not altering the levels of CD28...
  20. pmc Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats
    Tety Leonardi
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843 3143, USA
    Exp Biol Med (Maywood) 235:710-7. 2010
    ..However, these effects were not due to mitigation of iNOS and COX-2 protein levels at the ACF stage of colon cancer...
  21. pmc Identification of actively translated mRNA transcripts in a rat model of early-stage colon carcinogenesis
    Laurie A Davidson
    Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, Texas 77843 2253, USA
    Cancer Prev Res (Phila) 2:984-94. 2009
    ..Therefore, during early stage colonic neoplasia, diet and carcinogen seem to predominantly regulate gene expression at multiple levels via unique mechanisms...
  22. pmc Upregulation of p21Waf1/Cip1 expression in vivo by butyrate administration can be chemoprotective or chemopromotive depending on the lipid component of the diet
    Kristy Covert Crim
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843 2253, USA
    Carcinogenesis 29:1415-20. 2008
    ....
  23. ncbi request reprint Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca(2+) accumulation in colonocytes
    Satya Sree N Kolar
    Department of Nutrition and Food Science, Kleberg Biotechnology Center, MS 2253, Texas A and M University, College Station, TX 77843 2253, USA
    Am J Physiol Gastrointest Liver Physiol 293:G935-43. 2007
    ....
  24. ncbi request reprint Dietary docosahexaenoic acid suppresses T cell protein kinase C theta lipid raft recruitment and IL-2 production
    Yang Yi Fan
    Molecular and Cell Biology Section, Faculty of Nutrition, Texas A and M University Health Science Center, College Station, TX 77843 2471, USA
    J Immunol 173:6151-60. 2004
    ..Similar results were obtained when purified DHA was fed. These data demonstrate for the first time that dietary DHA alters T cell membrane microdomain composition and suppresses the PKCtheta; signaling axis...
  25. ncbi request reprint n-3 PUFA alter caveolae lipid composition and resident protein localization in mouse colon
    David W L Ma
    Faculty of Nutrition, Texas A and M University, College Station, Texas 77843 2471, USA
    FASEB J 18:1040-2. 2004
    ..These findings reveal a novel modality by which n-3 PUFA remodel membrane microdomains in vivo and thereby alter caveolae protein localization and functionality...
  26. ncbi request reprint Testing for spatial correlation in nonstationary binary data, with application to aberrant crypt foci in colon carcinogenesis
    Tatiyana V Apanasovich
    Department of Statistics, Texas A and M University College Station, Texas, USA
    Biometrics 59:752-61. 2003
    ..When applied to our data, the methods indicate the existence of spatial correlation, and hence indicate localization of damage...
  27. ncbi request reprint Dietary fish oil reduces oxidative DNA damage in rat colonocytes
    Laura K Bancroft
    Molecular and Cell Biology Group, Faculty of Nutrition, Texas A and M University, College Station, TX 77843 2471, USA
    Free Radic Biol Med 35:149-59. 2003
    ..05) and increased apoptosis (p =.04) in the upper crypt region; however, FO had no significant effect on OGG1 mRNA. We conclude that FO protects intestinal cells against oxidative DNA damage in part via deletion mechanisms...
  28. pmc n-3 polyunsaturated fatty acids suppress the localization and activation of signaling proteins at the immunological synapse in murine CD4+ T cells by affecting lipid raft formation
    Wooki Kim
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    J Immunol 181:6236-43. 2008
    ..These data imply that lipid rafts may be targets for the development of dietary agents for the treatment of autoimmune and chronic inflammatory diseases...
  29. ncbi request reprint Dietary n-3 polyunsaturated fatty acids promote activation-induced cell death in Th1-polarized murine CD4+ T-cells
    Kirsten C Switzer
    Molecular and Cell Biology Section, Faculty of Nutrition, Texas A and M University, College Station, TX, USA
    J Lipid Res 45:1482-92. 2004
    ..In conclusion, n-3 PUFAs enhance the polarization and deletion of proinflammatory Th1 cells, possibly as a result of alterations in membrane microdomain fatty acid composition...
  30. pmc Dietary curcumin and limonin suppress CD4+ T-cell proliferation and interleukin-2 production in mice
    Wooki Kim
    Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, TX 77843, USA
    J Nutr 139:1042-8. 2009
    ..05) of Cur or Lim with respect to CD4(+) T-cell proliferation in response to anti-CD3/28 mAb. These results suggest that combination chemotherapy (FO+Cur or Lim) may favorably modulate CD4(+) T-cell-mediated inflammation...
  31. pmc Proapoptotic effects of dietary (n-3) fatty acids are enhanced in colonocytes of manganese-dependent superoxide dismutase knockout mice
    Yang Yi Fan
    Program in Integrative Nutrition and Complex Diseases, Center for Environmental and Rural Health, Texas A and M University, College Station, TX 77843, USA
    J Nutr 139:1328-32. 2009
    ..Thus, (n-3) PUFA appear to promote an oxidation-reduction imbalance in the intestine, which may directly or indirectly trigger apoptosis and thereby reduce colon cancer risk...
  32. pmc Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis
    Cynthia A Warren
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA Vegetable and Fruit Improvement Center, Texas A and M University corrected
    J Nutr 139:101-5. 2009
    ..It is possible the effects on proliferation and apoptosis resulted from the tendency for quercetin to suppress the expression of proinflammatory mediators...
  33. ncbi request reprint Dietary fish oil inhibits antigen-specific murine Th1 cell development by suppression of clonal expansion
    Ping Zhang
    Department of Microbial and Molecular Pathogenesis, Texas A and M University System Health Science Center, College Station, TX, USA
    J Nutr 136:2391-8. 2006
    ..05) the number of cell divisions in vivo. These studies suggest that the attenuated inflammatory response which accompanies FO feeding may be explained, at least in part, by suppression of Th1 clonal expansion...
  34. ncbi request reprint Docosahexaenoic acid selectively inhibits plasma membrane targeting of lipidated proteins
    Jeongmin Seo
    Department of Nutrition and Food Science, Chemistry, and Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843 2253, USA
    FASEB J 20:770-2. 2006
    ....
  35. pmc Linoleic acid and butyrate synergize to increase Bcl-2 levels in colonocytes
    Harmony F Turk
    Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, TX, USA
    Int J Cancer 128:63-71. 2011
    ..In comparison, overexpression of bcl-2 blocked the proapoptotic effect of DHA and butyrate. These data provide new mechanistic insights into the regulation of apoptosis by dietary PUFA and fiber...
  36. pmc Dietary polyunsaturated fatty acids modulate resistance to Mycobacterium tuberculosis in guinea pigs
    Christine T McFarland
    Department of Microbial and Molecular Pathogenesis, Texas A and M Health Science Center, College Station, TX 77843, USA
    J Nutr 138:2123-8. 2008
    ..The loss of antigen-specific T-cell functions in addition to impaired resistance to mycobacterial disease suggests a susceptible phenotype in (n-3) fatty acid-fed guinea pigs...
  37. ncbi request reprint Quantification of human intestinal gene expression profiles using exfoliated colonocytes: a pilot study
    Laurie A Davidson
    Faculty of Nutrition and the Center for Environmental and Rural Health, Texas A and M University, College Station, TX 77843 2471, USA
    Biomarkers 8:51-61. 2003
    ..This will allow for the development of robust classifiers that can determine critical gene sets for the diagnosis and prediction of colon cancer in animal models and humans...
  38. ncbi request reprint The role of docosahexaenoic acid in mediating mitochondrial membrane lipid oxidation and apoptosis in colonocytes
    Yeevoon Ng
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    Carcinogenesis 26:1914-21. 2005
    ..These data indicate that DHA and butyrate potentiate mitochondrial lipid oxidation and the dissipation of MP which contribute to the induction of apoptosis...
  39. pmc fat-1 transgene expression prevents cell culture-induced loss of membrane n-3 fatty acids in activated CD4+ T-cells
    Yang Yi Fan
    Department of Nutrition and Food Science, Texas A and M University, College Station, TX 77843 2253, USA
    Prostaglandins Leukot Essent Fatty Acids 79:209-14. 2008
    ..05) number of cell divisions. We conclude that fat-1-containing CD4+ T-cells express a physiologically relevant, n-3 PUFA enriched, membrane fatty acid composition which is resistant to conventional cell culture-induced depletion...
  40. ncbi request reprint Fish oil enhances targeted apoptosis during colon tumor initiation in part by downregulating Bcl-2
    Mee Young Hong
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    Nutr Cancer 46:44-51. 2003
    ..05) in the top third of the crypt in the distal colon. In conclusion, one pathway by which fish oil may mediate apoptosis and thus protect against colon tumorigenesis is by downregulation of anti-apoptotic bcl-2...
  41. pmc n-3 polyunsaturated fatty acids--physiological relevance of dose
    Wooki Kim
    Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, TX 77843, USA
    Prostaglandins Leukot Essent Fatty Acids 82:155-8. 2010
    ....
  42. pmc Incorporation of a dietary omega 3 fatty acid impairs murine macrophage responses to Mycobacterium tuberculosis
    Diana L Bonilla
    Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, College Station, Texas, United States of America
    PLoS ONE 5:e10878. 2010
    ..We hypothesized that incorporation of n-3 PUFA suppresses activation of macrophage antimycobacterial responses and favors bacterial growth, in part, by modulating the IFNgamma-mediated signaling pathway...
  43. pmc Noninvasive detection of candidate molecular biomarkers in subjects with a history of insulin resistance and colorectal adenomas
    Chen Zhao
    Department of Electrical Engineering, Texas A and M University, College Station, Texas 77843 2253, USA
    Cancer Prev Res (Phila) 2:590-7. 2009
    ..These results support our premise that gene products (RNA) isolated from stool have diagnostic value in terms of assessing colon cancer risk...
  44. ncbi request reprint Oncogenic ras alters sensitivity of mouse colonocytes to butyrate and fatty acid mediated growth arrest and apoptosis
    Nancy D Turner
    Faculty of Nutrition, Texas A and M University, 2471 TAMU, College Station, TX 77843 2471, USA
    Cancer Lett 186:29-35. 2002
    ..Only non-transformed cells were sensitive to the apoptogenic effects of DHA, indicating that Ras transformation alters sensitivity to dietary chemopreventive agents...
  45. ncbi request reprint Dietary (n-3) polyunsaturated fatty acids modulate murine Th1/Th2 balance toward the Th2 pole by suppression of Th1 development
    Ping Zhang
    Faculty of Nutrition, Texas A and M University, TX, USA
    J Nutr 135:1745-51. 2005
    ....
  46. ncbi request reprint Docosahexaenoic acid and butyrate synergistically induce colonocyte apoptosis by enhancing mitochondrial Ca2+ accumulation
    Satya Sree N Kolar
    Faculty of Nutrition, Texas A and M University, College Station, Texas 77843 2253, USA
    Cancer Res 67:5561-8. 2007
    ..Collectively, these data show that the combination of DHA and butyrate, compared with butyrate alone, further enhances apoptosis by additionally recruiting a Ca2+ -mediated intrinsic mitochondrial pathway...
  47. ncbi request reprint Fish oil decreases oxidative DNA damage by enhancing apoptosis in rat colon
    Mee Young Hong
    Department of Nutrition and Food Science and the Center for Environmental and Rural Health, Texas A and M University, College Station, TX 77843, USA
    Nutr Cancer 52:166-75. 2005
    ..corn oil on these variables may account, in part, for the observed protective effect of fish oil against oxidatively induced colon cancer...
  48. ncbi request reprint Suppression of colon carcinogenesis by bioactive compounds in grapefruit
    Jairam Vanamala
    Department of Nutrition and Food Science, Texas A and M University, College Station, TX 77843, USA
    Carcinogenesis 27:1257-65. 2006
    ..These results suggest that consumption of grapefruit or limonin may help to suppress colon cancer development...
  49. ncbi request reprint Effects of dietary n-3 polyunsaturated fatty acids on T-cell membrane composition and function
    Kirsten C Switzer
    Molecular and Cell Biology Section, Faculty of Nutrition, Texas A and M University Health Science Center, College Station, Texas 77843 2471, USA
    Lipids 39:1163-70. 2004
    ....
  50. ncbi request reprint (n-3) Polyunsaturated fatty acids promote activation-induced cell death in murine T lymphocytes
    Kirsten C Switzer
    Molecular and Cell Biology Section, Faculty of Nutrition, Texas A and M University, College Station, TX, USA
    J Nutr 133:496-503. 2003
    ..In conclusion, we have identified a novel mechanism by which (n-3) PUFA modulate T cell-mediated immunity by selective deletion of Th1-like cells while maintaining or enhancing the Th2-mediated humoral immune response...
  51. pmc Reduced colitis-associated colon cancer in Fat-1 (n-3 fatty acid desaturase) transgenic mice
    Qian Jia
    Department of Nutrition and Food Science, Intercollegiate Faculty of Nutrition, Texas A and M University, Houston, USA
    Cancer Res 68:3985-91. 2008
    ..05) CD3(+), CD4(+) T helper, and macrophage cell numbers per colon as compared with wt mice. These results suggest that the antitumorigenic effect of n-3 PUFA may be mediated, in part, via its anti-inflammatory properties...
  52. ncbi request reprint n-3 PUFA and membrane microdomains: a new frontier in bioactive lipid research
    David W L Ma
    Molecular and Cell Biology Section, Faculty of Nutrition, Texas A and M University, College Station, TX 77843 2471, USA
    J Nutr Biochem 15:700-6. 2004
    ..This review examines the role of n-3 PUFA in modulating the lipid composition and functionality of lipid microdomains and its potential significance to human health...
  53. doi request reprint Transgenic mice enriched in omega-3 fatty acids are more susceptible to pulmonary tuberculosis: impaired resistance to tuberculosis in fat-1 mice
    Diana L Bonilla
    Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, Texas A and M University, College Station, Texas, USA
    J Infect Dis 201:399-408. 2010
    ..These data suggest that n-3 PUFA-supplemented diets might have a detrimental effect on immunity to M. tuberculosis and raise concerns regarding the safety of omega-3 dietary supplementation in humans...
  54. ncbi request reprint Chemopreventive n-3 fatty acids activate RXRalpha in colonocytes
    Yang Yi Fan
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    Carcinogenesis 24:1541-8. 2003
    ..These data indicate that, RXRalpha, an obligatory component of various nuclear receptors, preferentially binds n-3 PUFA in colonocytes, and that the nuclear receptor targets for PUFA in the colon are modulated by dietary lipid exposure...
  55. ncbi request reprint Dietary (n-3) polyunsaturated fatty acids remodel mouse T-cell lipid rafts
    Yang Yi Fan
    Faculty of Nutrition, Center for Environmental and Rural Health, Texas A and M University System, Health Science Center, College Station, TX, USA
    J Nutr 133:1913-20. 2003
    ..These data indicate for the first time that dietary (n-3) PUFA differentially modulate T-cell raft and soluble membrane phospholipid and fatty acyl composition...
  56. pmc Dietary fish oil promotes colonic apoptosis and mitochondrial proton leak in oxidatively stressed mice
    Yang Yi Fan
    Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, TX, USA
    Cancer Prev Res (Phila) 4:1267-74. 2011
    ....
  57. ncbi request reprint An increase in reactive oxygen species by dietary fish oil coupled with the attenuation of antioxidant defenses by dietary pectin enhances rat colonocyte apoptosis
    Lisa M Sanders
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    J Nutr 134:3233-8. 2004
    ..These results suggest that the enhancement of apoptosis associated with fish oil and pectin feeding may be due to a modulation of the redox environment that promotes ROS-mediated apoptosis...
  58. ncbi request reprint Understanding the relationship between carcinogen-induced DNA adduct levels in distal and proximal regions of the colon
    Jeffrey S Morris
    Department of Biostatistics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Adv Exp Med Biol 537:105-16. 2003
  59. ncbi request reprint Fish oil increases mitochondrial phospholipid unsaturation, upregulating reactive oxygen species and apoptosis in rat colonocytes
    Mee Young Hong
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843 2471, USA
    Carcinogenesis 23:1919-25. 2002
    ....
  60. ncbi request reprint Tissue-specific attenuation of endogenous DNA I-compounds in rats by carcinogen azoxymethane: possible role of dietary fish oil in colon cancer prevention
    Guo Dong Zhou
    Institute of Biosciences and Technology, Texas Medical Center, Texas A and M University System, 2121 West Holcombe Boulevard, Houston, TX 77030 3303, USA
    Cancer Epidemiol Biomarkers Prev 14:1230-5. 2005
    ....
  61. pmc Aberrant crypt foci and semiparametric modeling of correlated binary data
    Tatiyana V Apanasovich
    School of Operations Research and Industrial Engineering, Cornell University, Ithaca, New York 14853, USA
    Biometrics 64:490-500. 2008
    ..Finally, we apply the methods to the data from our experiment ACF. We discover an unexpected location for peak formation of ACF...
  62. ncbi request reprint A two-stage normalization method for partially degraded mRNA microarray data
    Li Yu D Liu
    Department of Agronomy, Biostatistic Division, National Taiwan University Taipei, Taiwan
    Bioinformatics 21:4000-6. 2005
    ..The difficulties encountered by this procedure are that certain probe information may be compromised due to partially degraded mRNA. Proper normalization is essential to obtaining useful information from these fecal array data...
  63. ncbi request reprint Differential response to DNA damage may explain different cancer susceptibility between small and large intestine
    Mee Young Hong
    Department of Nutrition and Food Science, Texas A and M University, TX 77843 2253, USA
    Exp Biol Med (Maywood) 230:464-71. 2005
    ..These differential responses to oxidative DNA damage may contribute to the difference in cancer susceptibility between these two anatomic sites of the intestine...
  64. pmc Protein kinase C betaII and TGFbetaRII in omega-3 fatty acid-mediated inhibition of colon carcinogenesis
    Nicole R Murray
    Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1048, USA
    J Cell Biol 157:915-20. 2002
    ..These data indicate that dietary omega-3 fatty acids prevent colon cancer, at least in part, through inhibition of colonic PKCbetaII signaling and restoration of TGF-beta responsiveness...
  65. ncbi request reprint Pro-oxidant environment of the colon compared to the small intestine may contribute to greater cancer susceptibility
    Lisa M Sanders
    Faculty of Nutrition, Texas A and M University, 2471 TAMU, College Station, TX 77843 2471, USA
    Cancer Lett 208:155-61. 2004
    ..Thus the colon responds to oxidative stress less effectively than the small intestine, possibly contributing to increased cancer incidence at this site...

Research Grants28

  1. N-3 Fatty Acids Alter T Cell Activation and Signaling
    ROBERT CHAPKIN; Fiscal Year: 2007
    ..Findings from the proposed studies could lead to the development of new therapeutic tools to treat T-cell-mediated inflammation and autoimmunity. ..
  2. Colonic Cytokinetics and Cell Signaling: Dietary Effects
    ROBERT CHAPKIN; Fiscal Year: 2004
    ..At present, the molecular basis of the n-3 PUFA effects on colonocyte apoptosis is a complete black box. The proposed experiments represent the first attempt to provide an explanation of EPA and DHA action at the molecular level. ..
  3. Colonic Cytokinetics and Cell Signaling: Dietary Effects
    ROBERT CHAPKIN; Fiscal Year: 2007
    ..At present, the molecular basis of the n-3 PUFA effects on colonocyte apoptosis is a complete black box. The proposed experiments represent the first attempt to provide an explanation of EPA and DHA action at the molecular level. ..
  4. Gene expression analysis of coding and non-coding RNAs in colon cancer prevention
    ROBERT CHAPKIN; Fiscal Year: 2007
    ..This effort will identify new molecular targets for chemotherapeutic tools to both prevent and treat colon cancer. ..
  5. n-3 Fatty Acids Alter T-cell Activation and Signaling
    ROBERT CHAPKIN; Fiscal Year: 2007
    ..Findings from the proposed studies could lead to the development of new therapeutic tools to treat T-cell-mediated inflammation and autoimmunity. ..
  6. n-3 Fatty Acids Alter T-cell Activation and Signaling
    ROBERT CHAPKIN; Fiscal Year: 2009
    ..Findings from the proposed studies could lead to the development of new therapeutic tools to treat T-cell-mediated inflammation and autoimmunity. ..
  7. Colonic Cytokinetics and Cell Signaling: Dietary Effects
    ROBERT CHAPKIN; Fiscal Year: 2009
    ....
  8. Gene expression analysis of coding and non-coding RNAs in colon cancer prevention
    ROBERT CHAPKIN; Fiscal Year: 2009
    ..This effort will identify new molecular targets for chemotherapeutic tools to both prevent and treat colon cancer. ..
  9. n-3 Fatty Acids Alter T-cell Activation and Signaling
    ROBERT STEPHEN CHAPKIN; Fiscal Year: 2010
    ..Findings from the proposed studies could lead to the development of new therapeutic tools to treat T-cell-mediated inflammation and autoimmunity. ..
  10. Colonic Cytokinetics and Cell Signaling: Dietary Effects
    ROBERT STEPHEN CHAPKIN; Fiscal Year: 2010
    ....
  11. Gene expression analysis of coding and non-coding RNAs in colon cancer prevention
    ROBERT STEPHEN CHAPKIN; Fiscal Year: 2010
    ..This effort will identify new molecular targets for chemotherapeutic tools to both prevent and treat colon cancer. ..
  12. Colonic Cytokinetics and Cell Signaling: Dietary Effects
    ROBERT CHAPKIN; Fiscal Year: 2006
    ..At present, the molecular basis of the n-3 PUFA effects on colonocyte apoptosis is a complete black box. The proposed experiments represent the first attempt to provide an explanation of EPA and DHA action at the molecular level. ..
  13. Colonic Cytokinetics and Cell Signaling: Dietary Effects
    ROBERT CHAPKIN; Fiscal Year: 2005
    ..At present, the molecular basis of the n-3 PUFA effects on colonocyte apoptosis is a complete black box. The proposed experiments represent the first attempt to provide an explanation of EPA and DHA action at the molecular level. ..
  14. SUPPRESSION OF T CELL ACTIVATION BY DIETARY FATTY ACIDS
    ROBERT CHAPKIN; Fiscal Year: 1999
    ..g., rheumatoid arthritis), without compromising host defenses. ..
  15. COLONIC CYTOKINETICS AND CELL SIGNALING--DIETARY EFFECT
    ROBERT CHAPKIN; Fiscal Year: 1999
    ..Therefore, chemopreventive dietary strategies must be developed in order to decrease the risk of colon cancer. ..
  16. SUPPRESSION OF T CELL ACTIVATION BY DIETARY FATTY ACIDS
    ROBERT CHAPKIN; Fiscal Year: 2000
    ..g., rheumatoid arthritis), without compromising host defenses. ..
  17. COLONIC CYTOKINETICS AND CELL SIGNALING--DIETARY EFFECT
    ROBERT CHAPKIN; Fiscal Year: 2000
    ..Therefore, chemopreventive dietary strategies must be developed in order to decrease the risk of colon cancer. ..
  18. SUPPRESSION OF T CELL ACTIVATION BY DIETARY FATTY ACIDS
    ROBERT CHAPKIN; Fiscal Year: 2001
    ..g., rheumatoid arthritis), without compromising host defenses. ..
  19. COLONIC CYTOKINETICS AND CELL SIGNALING--DIETARY EFFECT
    ROBERT CHAPKIN; Fiscal Year: 2001
    ..Therefore, chemopreventive dietary strategies must be developed in order to decrease the risk of colon cancer. ..
  20. COLONIC CYTOKINETICS AND CELL SIGNALING--DIETARY EFFECT
    ROBERT CHAPKIN; Fiscal Year: 2002
    ..Therefore, chemopreventive dietary strategies must be developed in order to decrease the risk of colon cancer. ..
  21. SUPPRESSION OF T CELL ACTIVATION BY DIETARY FATTY ACIDS
    ROBERT CHAPKIN; Fiscal Year: 2002
    ..g., rheumatoid arthritis), without compromising host defenses. ..
  22. Colonic Cytokinetics and Cell Signaling: Dietary Effects
    ROBERT CHAPKIN; Fiscal Year: 2003
    ..At present, the molecular basis of the n-3 PUFA effects on colonocyte apoptosis is a complete black box. The proposed experiments represent the first attempt to provide an explanation of EPA and DHA action at the molecular level. ..
  23. SUPPRESSION OF T CELL ACTIVATION BY DIETARY FATTY ACIDS
    ROBERT CHAPKIN; Fiscal Year: 2003
    ..g., rheumatoid arthritis), without compromising host defenses. ..
  24. n-3 Fatty Acids Alter T-cell Activation and Signaling
    ROBERT STEPHEN CHAPKIN; Fiscal Year: 2010
    ..Findings from the proposed studies could lead to the development of new therapeutic tools to treat T-cell-mediated inflammation and autoimmunity. ..