Research Topics
| ROBERT STEPHEN CHAPKINSummaryAffiliation: Texas A and M University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
A metagenomic study of diet-dependent interaction between gut microbiota and host in infants reveals differences in immune responseScott Schwartz
Training Program in Biostatistics, Bioinformatics, Nutrition and Cancer, Texas A and M University, 155 Ireland Street, College Station, TX 77843, USA
Genome Biol 13:r32. 2012..Here we report the results from a simultaneous study of the gut microbiome and host epithelial transcriptome of three-month-old exclusively breast- and formula-fed infants...- Evaluation of fecal mRNA reproducibility via a marginal transformed mixture modeling approachNysia I George
Department of Statistics, University of Michigan, Ann Arbor, MI 48109 1107, USA
BMC Bioinformatics 11:13. 2010..We used outcomes from bootstrapped goodness-of-fit tests to determine which approach is less sensitive toward potential violation of distributional assumptions... 
Dietary n-3 PUFA alter colonocyte mitochondrial membrane composition and functionRobert S Chapkin
Department of Veterinary Anatomy and Public Health, Center for Environmental and Rural Health, Texas A and M University, College Station 77843 2471, USA
Lipids 37:193-9. 2002..026) were positively correlated with caspase 3 activity. These data provide evidence in vivo indicating that dietary EPA and DHA induce compositional changes in colonic mitochondrial membrane phospholipids that facilitate apoptosis...- Use of a novel genetic mouse model to investigate the role of folate in colitis-associated colon cancerRobert S Chapkin
Faculty of Nutrition, Texas A and M University, College Station, TX 77843 2253, USA
J Nutr Biochem 20:649-55. 2009..9+/-0.3) and wild-type control mice (1.1+/-0.1). These data demonstrate that the ablation of two receptor/carrier-mediated pathways for folate transport increases the risk for developing inflammation-associated colon cancer... - Bioactive dietary long-chain fatty acids: emerging mechanisms of actionRobert S Chapkin
Faculty of Nutrition, Texas A and M University, College Station, TX, USA
Br J Nutr 100:1152-7. 2008.... - Dietary docosahexaenoic and eicosapentaenoic acid: emerging mediators of inflammationRobert S Chapkin
Department of Nutrition and Food Science, Faculty of Nutrition, Kleberg Biotechnology Center, MS 2253, Texas A and M University, College Station, TX 77843 2253, USA
Prostaglandins Leukot Essent Fatty Acids 81:187-91. 2009..We propose that lipid rafts may be targets for the development of n-3 PUFA-containing dietary bioactive agents to down-modulate inflammatory and immune responses and for the treatment of autoimmune and chronic inflammatory diseases... - Mechanisms by which docosahexaenoic acid and related fatty acids reduce colon cancer risk and inflammatory disorders of the intestineRobert S Chapkin
Center for Environmental and Rural Health, Texas A and M University, College Station, TX 77843 2553, United States
Chem Phys Lipids 153:14-23. 2008..Ultimately, this may allow organ systems such as the colon to optimally decode, respond, and adapt to the vagaries of an ever-changing extracellular environment... - Colon cancer, fatty acids and anti-inflammatory compoundsRobert S Chapkin
Faculty of Nutrition, Texas A and M University System Health Science Center, College Station, Texas 77843, USA
Curr Opin Gastroenterol 23:48-54. 2007..To outline recent findings on the efficacy of n-3 polyunsaturated fatty acids in the prevention/treatment of inflammatory bowel disease and colorectal cancer... - Docosahexaenoic acid alters the size and distribution of cell surface microdomainsRobert S Chapkin
Center for Environmental and Rural Health, Texas A and M University, College Station, Texas, USA
Biochim Biophys Acta 1778:466-71. 2008..We speculate that our findings may help define a new paradigm to better understand the complexity of n-3 PUFA modulation of signaling networks... - Noninvasive stool-based detection of infant gastrointestinal development using gene expression profiles from exfoliated epithelial cellsRobert S Chapkin
Texas A and M Univ, College Station, TX 77843 2253, USA
Am J Physiol Gastrointest Liver Physiol 298:G582-9. 2010..As larger data sets become available, this methodology can be extended to validation and, ultimately, identification of the main nutritional components that modulate intestinal maturation and function... - Immunomodulatory effects of (n-3) fatty acids: putative link to inflammation and colon cancerRobert S Chapkin
Faculty of Nutrition, Center for Environmental and Rural Health, Texas A and M University, College Station, TX 77843, USA
J Nutr 137:200S-204S. 2007..Precisely how the immunomodulatory effects of (n-3) PUFAs influence inflammation-associated colonic tumor development is the subject of an ongoing investigation... - Immunomodulatory action of dietary fish oil and targeted deletion of intestinal epithelial cell PPARĪ“ in inflammation-induced colon carcinogenesisJennifer M Monk
Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, Texas 77843 2253, USA
Am J Physiol Gastrointest Liver Physiol 302:G153-67. 2012..Moreover, we provide new evidence that dietary n-3 PUFAs attenuate intestinal inflammation in an intestinal epithelial cell PPARĪ“-independent manner... - Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesisDavid W L Ma
Molecular and Cell Biology Section, Faculty of Nutrition, Texas A and M University, Kleberg Center, College Station, TX 77843 2471, USA
Cancer Res 65:887-97. 2005..In conclusion, Folbp1 and RFC1 genetically modified mice exhibit distinct changes in colonocyte phenotype and therefore have utility as models to examine the role of folate homeostasis in colon cancer development... - Dietary eicosapentaenoic acid modulates CTLA-4 expression in murine CD4+ T-cellsLan H Ly
Department of Nutrition and Food Science, Texas A and M University System Health Science Center, College Station, TX, USA
Prostaglandins Leukot Essent Fatty Acids 74:29-37. 2006..01). Therefore, we conclude that dietary EPA may suppress CD4(+) T-cell activation by enhancing the downregulatory co-receptor CTLA-4, while not altering the levels of CD28... - Chemopreventive n-3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the ratLaurie A Davidson
Faculty of Nutrition, Texas A and M University, College Station, Texas 77843-2471, USA
Cancer Res 64:6797-804. 2004.... - n-3 Polyunsaturated fatty acids modulate carcinogen-directed non-coding microRNA signatures in rat colonLaurie A Davidson
Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, TX 77843 2253, USA
Carcinogenesis 30:2077-84. 2009..32-fold) in adenocarcinomas. These results demonstrate for the first time the utility of the rat AOM model and the novel role of fish oil in protecting the colon from carcinogen-induced miRNA dysregulation... - Dietary fish oil reduces oxidative DNA damage in rat colonocytesLaura K Bancroft
Molecular and Cell Biology Group, Faculty of Nutrition, Texas A and M University, College Station, TX 77843 2471, USA
Free Radic Biol Med 35:149-59. 2003..05) and increased apoptosis (p =.04) in the upper crypt region; however, FO had no significant effect on OGG1 mRNA. We conclude that FO protects intestinal cells against oxidative DNA damage in part via deletion mechanisms... - Identification of actively translated mRNA transcripts in a rat model of early-stage colon carcinogenesisLaurie A Davidson
Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, Texas 77843 2253, USA
Cancer Prev Res (Phila) 2:984-94. 2009..Therefore, during early stage colonic neoplasia, diet and carcinogen seem to predominantly regulate gene expression at multiple levels via unique mechanisms... - Upregulation of p21Waf1/Cip1 expression in vivo by butyrate administration can be chemoprotective or chemopromotive depending on the lipid component of the dietKristy Covert Crim
Faculty of Nutrition, Texas A and M University, College Station, TX 77843 2253, USA
Carcinogenesis 29:1415-20. 2008.... - n-3 PUFA alter caveolae lipid composition and resident protein localization in mouse colonDavid W L Ma
Faculty of Nutrition, Texas A and M University, College Station, Texas 77843-2471, USA
FASEB J 18:1040-2. 2004..These findings reveal a novel modality by which n-3 PUFA remodel membrane microdomains in vivo and thereby alter caveolae protein localization and functionality... - Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca(2+) accumulation in colonocytesSatya Sree N Kolar
Department of Nutrition and Food Science, Kleberg Biotechnology Center, MS 2253, Texas A and M University, College Station, TX 77843 2253, USA
Am J Physiol Gastrointest Liver Physiol 293:G935-43. 2007.... - Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated ratsTety Leonardi
Faculty of Nutrition, Texas A and M University, College Station, TX 77843 3143, USA
Exp Biol Med (Maywood) 235:710-7. 2010..However, these effects were not due to mitigation of iNOS and COX-2 protein levels at the ACF stage of colon cancer... - Dietary docosahexaenoic acid suppresses T cell protein kinase C theta lipid raft recruitment and IL-2 productionYang-Yi Fan
Molecular and Cell Biology Section, Faculty of Nutrition, Texas A and M University Health Science Center, College Station, TX 77843-2471, USA
J Immunol 173:6151-60. 2004..Similar results were obtained when purified DHA was fed. These data demonstrate for the first time that dietary DHA alters T cell membrane microdomain composition and suppresses the PKCtheta; signaling axis... - Testing for spatial correlation in nonstationary binary data, with application to aberrant crypt foci in colon carcinogenesisTatiyana V Apanasovich
Department of Statistics, Texas A and M University College Station, Texas, USA
Biometrics 59:752-61. 2003..When applied to our data, the methods indicate the existence of spatial correlation, and hence indicate localization of damage... - Linoleic acid and butyrate synergize to increase Bcl-2 levels in colonocytesHarmony F Turk
Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, TX, USA
Int J Cancer 128:63-71. 2011..In comparison, overexpression of bcl-2 blocked the proapoptotic effect of DHA and butyrate. These data provide new mechanistic insights into the regulation of apoptosis by dietary PUFA and fiber... - Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosisCynthia A Warren
Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA Vegetable and Fruit Improvement Center, Texas A and M University corrected
J Nutr 139:101-5. 2009..It is possible the effects on proliferation and apoptosis resulted from the tendency for quercetin to suppress the expression of proinflammatory mediators... - Dietary curcumin and limonin suppress CD4+ T-cell proliferation and interleukin-2 production in miceWooki Kim
Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, TX 77843, USA
J Nutr 139:1042-8. 2009..05) of Cur or Lim with respect to CD4(+) T-cell proliferation in response to anti-CD3/28 mAb. These results suggest that combination chemotherapy (FO+Cur or Lim) may favorably modulate CD4(+) T-cell-mediated inflammation... - Dietary polyunsaturated fatty acids modulate resistance to Mycobacterium tuberculosis in guinea pigsChristine T McFarland
Department of Microbial and Molecular Pathogenesis, Texas A and M Health Science Center, College Station, TX 77843, USA
J Nutr 138:2123-8. 2008..The loss of antigen-specific T-cell functions in addition to impaired resistance to mycobacterial disease suggests a susceptible phenotype in (n-3) fatty acid-fed guinea pigs... - n-3 polyunsaturated fatty acids suppress the localization and activation of signaling proteins at the immunological synapse in murine CD4+ T cells by affecting lipid raft formationWooki Kim
Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
J Immunol 181:6236-43. 2008..These data imply that lipid rafts may be targets for the development of dietary agents for the treatment of autoimmune and chronic inflammatory diseases... - Proapoptotic effects of dietary (n-3) fatty acids are enhanced in colonocytes of manganese-dependent superoxide dismutase knockout miceYang Yi Fan
Program in Integrative Nutrition and Complex Diseases, Center for Environmental and Rural Health, Texas A and M University, College Station, TX 77843, USA
J Nutr 139:1328-32. 2009..Thus, (n-3) PUFA appear to promote an oxidation-reduction imbalance in the intestine, which may directly or indirectly trigger apoptosis and thereby reduce colon cancer risk... - Dietary fish oil inhibits antigen-specific murine Th1 cell development by suppression of clonal expansionPing Zhang
Department of Microbial and Molecular Pathogenesis, Texas A and M University System Health Science Center, College Station, TX, USA
J Nutr 136:2391-8. 2006..05) the number of cell divisions in vivo. These studies suggest that the attenuated inflammatory response which accompanies FO feeding may be explained, at least in part, by suppression of Th1 clonal expansion... - Docosahexaenoic acid selectively inhibits plasma membrane targeting of lipidated proteinsJeongmin Seo
Department of Nutrition and Food Science, Chemistry, and Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843-2253, USA
FASEB J 20:770-2. 2006.... - The role of docosahexaenoic acid in mediating mitochondrial membrane lipid oxidation and apoptosis in colonocytesYeevoon Ng
Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
Carcinogenesis 26:1914-21. 2005..These data indicate that DHA and butyrate potentiate mitochondrial lipid oxidation and the dissipation of MP which contribute to the induction of apoptosis... - Dietary n-3 polyunsaturated fatty acids promote activation-induced cell death in Th1-polarized murine CD4+ T-cellsKirsten C Switzer
Molecular and Cell Biology Section, Faculty of Nutrition, Texas A and M University, College Station, TX, USA
J Lipid Res 45:1482-92. 2004..In conclusion, n-3 PUFAs enhance the polarization and deletion of proinflammatory Th1 cells, possibly as a result of alterations in membrane microdomain fatty acid composition... - Quantification of human intestinal gene expression profiles using exfoliated colonocytes: a pilot studyLaurie A Davidson
Faculty of Nutrition and the Center for Environmental and Rural Health, Texas A and M University, College Station, TX 77843-2471, USA
Biomarkers 8:51-61. 2003..This will allow for the development of robust classifiers that can determine critical gene sets for the diagnosis and prediction of colon cancer in animal models and humans... - Dietary (n-3) polyunsaturated fatty acids modulate murine Th1/Th2 balance toward the Th2 pole by suppression of Th1 developmentPing Zhang
Faculty of Nutrition, Texas A and M University, TX, USA
J Nutr 135:1745-51. 2005.... - Oncogenic ras alters sensitivity of mouse colonocytes to butyrate and fatty acid mediated growth arrest and apoptosisNancy D Turner
Faculty of Nutrition, Texas A and M University, 2471 TAMU, College Station, TX 77843-2471, USA
Cancer Lett 186:29-35. 2002..Only non-transformed cells were sensitive to the apoptogenic effects of DHA, indicating that Ras transformation alters sensitivity to dietary chemopreventive agents... - Fish oil enhances targeted apoptosis during colon tumor initiation in part by downregulating Bcl-2Mee Young Hong
Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
Nutr Cancer 46:44-51. 2003..05) in the top third of the crypt in the distal colon. In conclusion, one pathway by which fish oil may mediate apoptosis and thus protect against colon tumorigenesis is by downregulation of anti-apoptotic bcl-2... - Noninvasive detection of candidate molecular biomarkers in subjects with a history of insulin resistance and colorectal adenomasChen Zhao
Department of Electrical Engineering, Texas A and M University, College Station, Texas 77843 2253, USA
Cancer Prev Res (Phila) 2:590-7. 2009..These results support our premise that gene products (RNA) isolated from stool have diagnostic value in terms of assessing colon cancer risk... - Incorporation of a dietary omega 3 fatty acid impairs murine macrophage responses to Mycobacterium tuberculosisDiana L Bonilla
Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, College Station, Texas, United States of America
PLoS ONE 5:e10878. 2010..We hypothesized that incorporation of n-3 PUFA suppresses activation of macrophage antimycobacterial responses and favors bacterial growth, in part, by modulating the IFNgamma-mediated signaling pathway... - n-3 polyunsaturated fatty acids--physiological relevance of doseWooki Kim
Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, TX 77843, USA
Prostaglandins Leukot Essent Fatty Acids 82:155-8. 2010.... - fat-1 transgene expression prevents cell culture-induced loss of membrane n-3 fatty acids in activated CD4+ T-cellsYang Yi Fan
Department of Nutrition and Food Science, Texas A and M University, College Station, TX 77843 2253, USA
Prostaglandins Leukot Essent Fatty Acids 79:209-14. 2008..05) number of cell divisions. We conclude that fat-1-containing CD4+ T-cells express a physiologically relevant, n-3 PUFA enriched, membrane fatty acid composition which is resistant to conventional cell culture-induced depletion... - Suppression of colon carcinogenesis by bioactive compounds in grapefruitJairam Vanamala
Department of Nutrition and Food Science, Texas A and M University, College Station, TX 77843, USA
Carcinogenesis 27:1257-65. 2006..These results suggest that consumption of grapefruit or limonin may help to suppress colon cancer development... - Effects of dietary n-3 polyunsaturated fatty acids on T-cell membrane composition and functionKirsten C Switzer
Molecular and Cell Biology Section, Faculty of Nutrition, Texas A and M University Health Science Center, College Station, Texas 77843-2471, USA
Lipids 39:1163-70. 2004.... - Docosahexaenoic acid and butyrate synergistically induce colonocyte apoptosis by enhancing mitochondrial Ca2+ accumulationSatya Sree N Kolar
Faculty of Nutrition, Texas A and M University, College Station, Texas 77843 2253, USA
Cancer Res 67:5561-8. 2007..Collectively, these data show that the combination of DHA and butyrate, compared with butyrate alone, further enhances apoptosis by additionally recruiting a Ca2+ -mediated intrinsic mitochondrial pathway... - Fish oil decreases oxidative DNA damage by enhancing apoptosis in rat colonMee Young Hong
Department of Nutrition and Food Science and the Center for Environmental and Rural Health, Texas A and M University, College Station, TX 77843, USA
Nutr Cancer 52:166-75. 2005..corn oil on these variables may account, in part, for the observed protective effect of fish oil against oxidatively induced colon cancer... - n-3 PUFA and membrane microdomains: a new frontier in bioactive lipid researchDavid W L Ma
Molecular and Cell Biology Section, Faculty of Nutrition, Texas A and M University, College Station, TX 77843-2471, USA
J Nutr Biochem 15:700-6. 2004..This review examines the role of n-3 PUFA in modulating the lipid composition and functionality of lipid microdomains and its potential significance to human health... - (n-3) Polyunsaturated fatty acids promote activation-induced cell death in murine T lymphocytesKirsten C Switzer
Molecular and Cell Biology Section, Faculty of Nutrition, Texas A and M University, College Station, TX, USA
J Nutr 133:496-503. 2003..In conclusion, we have identified a novel mechanism by which (n-3) PUFA modulate T cell-mediated immunity by selective deletion of Th1-like cells while maintaining or enhancing the Th2-mediated humoral immune response... 
Transgenic mice enriched in omega-3 fatty acids are more susceptible to pulmonary tuberculosis: impaired resistance to tuberculosis in fat-1 miceDiana L Bonilla
Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, Texas A and M University, College Station, Texas, USA
J Infect Dis 201:399-408. 2010..These data suggest that n-3 PUFA-supplemented diets might have a detrimental effect on immunity to M. tuberculosis and raise concerns regarding the safety of omega-3 dietary supplementation in humans...- Dietary (n-3) polyunsaturated fatty acids remodel mouse T-cell lipid raftsYang-Yi Fan
Faculty of Nutrition, Center for Environmental and Rural Health, Texas A and M University System, Health Science Center, College Station, TX, USA
J Nutr 133:1913-20. 2003..These data indicate for the first time that dietary (n-3) PUFA differentially modulate T-cell raft and soluble membrane phospholipid and fatty acyl composition... - Reduced colitis-associated colon cancer in Fat-1 (n-3 fatty acid desaturase) transgenic miceQian Jia
Department of Nutrition and Food Science, Intercollegiate Faculty of Nutrition, Texas A and M University, Houston, USA
Cancer Res 68:3985-91. 2008..05) CD3(+), CD4(+) T helper, and macrophage cell numbers per colon as compared with wt mice. These results suggest that the antitumorigenic effect of n-3 PUFA may be mediated, in part, via its anti-inflammatory properties... - Chemopreventive n-3 fatty acids activate RXRalpha in colonocytesYang-Yi Fan
Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
Carcinogenesis 24:1541-8. 2003..These data indicate that, RXRalpha, an obligatory component of various nuclear receptors, preferentially binds n-3 PUFA in colonocytes, and that the nuclear receptor targets for PUFA in the colon are modulated by dietary lipid exposure... - Dietary fish oil promotes colonic apoptosis and mitochondrial proton leak in oxidatively stressed miceYang Yi Fan
Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, TX, USA
Cancer Prev Res (Phila) 4:1267-74. 2011.... - Fish oil increases mitochondrial phospholipid unsaturation, upregulating reactive oxygen species and apoptosis in rat colonocytesMee Young Hong
TX A and M U, College Station
Carcinogenesis 23:1919-25. 2002.... - Understanding the relationship between carcinogen-induced DNA adduct levels in distal and proximal regions of the colonJeffrey S Morris
Department of Biostatistics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
Adv Exp Med Biol 537:105-16. 2003 - An increase in reactive oxygen species by dietary fish oil coupled with the attenuation of antioxidant defenses by dietary pectin enhances rat colonocyte apoptosisLisa M Sanders
TX A and M U, College Station
J Nutr 134:3233-8. 2004..These results suggest that the enhancement of apoptosis associated with fish oil and pectin feeding may be due to a modulation of the redox environment that promotes ROS-mediated apoptosis... - Protein kinase C betaII and TGFbetaRII in omega-3 fatty acid-mediated inhibition of colon carcinogenesisNicole R Murray
Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, TX 77555-1048, USA
J Cell Biol 157:915-20. 2002..These data indicate that dietary omega-3 fatty acids prevent colon cancer, at least in part, through inhibition of colonic PKCbetaII signaling and restoration of TGF-beta responsiveness... - A two-stage normalization method for partially degraded mRNA microarray dataLi-yu D Liu
Department of Agronomy, Biostatistic Division, National Taiwan University Taipei, Taiwan
Bioinformatics 21:4000-6. 2005..The new method favorably compared with the global median and quantile normalization methods. AVAILABILITY: The R codes implementing the two-stage method may be obtained from the corresponding author... - Tissue-specific attenuation of endogenous DNA I-compounds in rats by carcinogen azoxymethane: possible role of dietary fish oil in colon cancer preventionGuo Dong Zhou
Institute of Biosciences and Technology, Texas Medical Center, Texas A and M University System, 2121 West Holcombe Boulevard, Houston, TX 77030 3303, USA
Cancer Epidemiol Biomarkers Prev 14:1230-5. 2005.... - Aberrant crypt foci and semiparametric modeling of correlated binary dataTatiyana V Apanasovich
School of Operations Research and Industrial Engineering, Cornell University, Ithaca, New York 14853, USA
Biometrics 64:490-500. 2008..Finally, we apply the methods to the data from our experiment ACF. We discover an unexpected location for peak formation of ACF... - Differential response to DNA damage may explain different cancer susceptibility between small and large intestineMee Young Hong
TX A and M U, College Stn
Exp Biol Med (Maywood) 230:464-71. 2005..These differential responses to oxidative DNA damage may contribute to the difference in cancer susceptibility between these two anatomic sites of the intestine... - Pro-oxidant environment of the colon compared to the small intestine may contribute to greater cancer susceptibilityLisa M Sanders
TX A and M U, College Station
Cancer Lett 208:155-61. 2004..Thus the colon responds to oxidative stress less effectively than the small intestine, possibly contributing to increased cancer incidence at this site...
Research Grants
- N-3 Fatty Acids Alter T Cell Activation and SignalingROBERT CHAPKIN; Fiscal Year: 2007..Findings from the proposed studies could lead to the development of new therapeutic tools to treat T-cell-mediated inflammation and autoimmunity. ..
- Colonic Cytokinetics and Cell Signaling: Dietary EffectsROBERT CHAPKIN; Fiscal Year: 2007..At present, the molecular basis of the n-3 PUFA effects on colonocyte apoptosis is a complete black box. The proposed experiments represent the first attempt to provide an explanation of EPA and DHA action at the molecular level. ..
- Gene expression analysis of coding and non-coding RNAs in colon cancer preventionROBERT CHAPKIN; Fiscal Year: 2007..This effort will identify new molecular targets for chemotherapeutic tools to both prevent and treat colon cancer. ..
- n-3 Fatty Acids Alter T-cell Activation and SignalingROBERT CHAPKIN; Fiscal Year: 2007..Findings from the proposed studies could lead to the development of new therapeutic tools to treat T-cell-mediated inflammation and autoimmunity. ..
- n-3 Fatty Acids Alter T-cell Activation and SignalingROBERT CHAPKIN; Fiscal Year: 2009..Findings from the proposed studies could lead to the development of new therapeutic tools to treat T-cell-mediated inflammation and autoimmunity. ..
- Colonic Cytokinetics and Cell Signaling: Dietary EffectsROBERT CHAPKIN; Fiscal Year: 2009....
- n-3 Fatty Acids Alter T-cell Activation and SignalingROBERT STEPHEN CHAPKIN; Fiscal Year: 2010..Findings from the proposed studies could lead to the development of new therapeutic tools to treat T-cell-mediated inflammation and autoimmunity. ..
- Colonic Cytokinetics and Cell Signaling: Dietary EffectsROBERT STEPHEN CHAPKIN; Fiscal Year: 2010....
- Gene expression analysis of coding and non-coding RNAs in colon cancer preventionROBERT STEPHEN CHAPKIN; Fiscal Year: 2010..This effort will identify new molecular targets for chemotherapeutic tools to both prevent and treat colon cancer. ..
- COLONIC CYTOKINETICS AND CELL SIGNALING--DIETARY EFFECTROBERT CHAPKIN; Fiscal Year: 2002..Therefore, chemopreventive dietary strategies must be developed in order to decrease the risk of colon cancer. ..
- SUPPRESSION OF T CELL ACTIVATION BY DIETARY FATTY ACIDSROBERT CHAPKIN; Fiscal Year: 2003..g., rheumatoid arthritis), without compromising host defenses. ..
- n-3 Fatty Acids Alter T-cell Activation and SignalingROBERT STEPHEN CHAPKIN; Fiscal Year: 2010..Findings from the proposed studies could lead to the development of new therapeutic tools to treat T-cell-mediated inflammation and autoimmunity. ..