LAWRENCE C CHAN

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi Apobec-1 and apolipoprotein B mRNA editing
    L Chan
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Biochim Biophys Acta 1345:11-26. 1997
  2. pmc Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related protein
    Benny Hung Junn Chang
    Division of Diabetes, Endocrinology, and Metabolism, Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 26:1063-76. 2006
  3. pmc Bone marrow expression of poly(ADP-ribose) polymerase underlies diabetic neuropathy via hematopoietic-neuronal cell fusion
    Tomoya Terashima
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    FASEB J 26:295-308. 2012
  4. ncbi In vivo gene therapy for diabetes mellitus
    Lawrence Chan
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Texas Medical Center, Houston, TX 77030, USA
    Trends Mol Med 9:430-5. 2003
  5. ncbi Functional compensation for adipose differentiation-related protein (ADFP) by Tip47 in an ADFP null embryonic cell line
    Carole Sztalryd
    Geriatric Research, Education and Clinical Center, Baltimore Veterans Affairs Health Care Center, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 281:34341-8. 2006
  6. pmc Deficiency of adipose differentiation-related protein impairs foam cell formation and protects against atherosclerosis
    Antoni Paul
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Circ Res 102:1492-501. 2008
  7. ncbi Metabolic adaptations in the absence of perilipin: increased beta-oxidation and decreased hepatic glucose production associated with peripheral insulin resistance but normal glucose tolerance in perilipin-null mice
    Pradip K Saha
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Biol Chem 279:35150-8. 2004
  8. pmc Beta2 integrins modulate the initiation and progression of atherosclerosis in low-density lipoprotein receptor knockout mice
    Aksam Merched
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, R630, Houston, TX 77030, USA
    Cardiovasc Res 85:853-63. 2010
  9. ncbi Helper-dependent adenoviral vector-mediated long-term expression of human apolipoprotein A-I reduces atherosclerosis in apo E-deficient mice
    Lucio Pastore
    Department of Molecular and Human Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA
    Gene 327:153-60. 2004
  10. ncbi Recent advances in liver-directed gene therapy for dyslipidemia
    Kazuhiro Oka
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Curr Atheroscler Rep 4:199-207. 2002

Research Grants

  1. Abnormal Bone Marrow Cells and Diabetic Neuropathy
    Lawrence Chan; Fiscal Year: 2010
  2. Animal Models for Lipid Metabolism and Atherosclerosis
    Lawrence Chan; Fiscal Year: 2005
  3. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 2004
  4. LIPOPROTEIN METABOLISM AND HORMONAL REGULATION
    Lawrence Chan; Fiscal Year: 2003
  5. Molecular Medicine Scholars Training Grant
    Lawrence Chan; Fiscal Year: 2006
  6. Abnormal Bone Marrow Cells and Diabetic Neuropathy
    Lawrence Chan; Fiscal Year: 2010
  7. Animal Models for Lipid Metabolism and Atherosclerosis
    Lawrence Chan; Fiscal Year: 2009
  8. NOVEL THERAPY FOR DIABETES
    Lawrence Chan; Fiscal Year: 2007
  9. Induced islet neogenesis therapy in vivo
    Lawrence Chan; Fiscal Year: 2007
  10. Animal Models for Lipid Metabolism and Atherosclerosis
    Lawrence Chan; Fiscal Year: 2007

Collaborators

Detail Information

Publications63

  1. ncbi Apobec-1 and apolipoprotein B mRNA editing
    L Chan
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Biochim Biophys Acta 1345:11-26. 1997
    ..ApoB mRNA editing is the prototype of RNA editing in mammals. What we learn from apoB mRNA editing will be useful in our understanding of other examples of RNA editing in vertebrates which are being described with increasing frequency...
  2. pmc Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related protein
    Benny Hung Junn Chang
    Division of Diabetes, Endocrinology, and Metabolism, Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 26:1063-76. 2006
    ..In the absence of ADFP, impairment of LD formation is associated with the accumulation of microsomal TG but a reduction in TG in other subcellular compartments...
  3. pmc Bone marrow expression of poly(ADP-ribose) polymerase underlies diabetic neuropathy via hematopoietic-neuronal cell fusion
    Tomoya Terashima
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    FASEB J 26:295-308. 2012
    ..These complementary in vivo and in vitro experiments indicate that BMDC-PARP expression promotes diabetic neuropathy via BMDC-neuron fusion...
  4. ncbi In vivo gene therapy for diabetes mellitus
    Lawrence Chan
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Texas Medical Center, Houston, TX 77030, USA
    Trends Mol Med 9:430-5. 2003
    ..Much work remains to be done, however, before this regimen can be taken from the bench to the bedside...
  5. ncbi Functional compensation for adipose differentiation-related protein (ADFP) by Tip47 in an ADFP null embryonic cell line
    Carole Sztalryd
    Geriatric Research, Education and Clinical Center, Baltimore Veterans Affairs Health Care Center, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 281:34341-8. 2006
    ..Tip47 and ADFP in peripheral tissues may play a critical role in regulating the formation and turnover, and hence metabolic consequences, of ectopic fat...
  6. pmc Deficiency of adipose differentiation-related protein impairs foam cell formation and protects against atherosclerosis
    Antoni Paul
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Circ Res 102:1492-501. 2008
    ..In conclusion, Adfp inactivation in ApoE(-/-) background protects against atherosclerosis and appears to be a relatively pure model of impaired foam cell formation...
  7. ncbi Metabolic adaptations in the absence of perilipin: increased beta-oxidation and decreased hepatic glucose production associated with peripheral insulin resistance but normal glucose tolerance in perilipin-null mice
    Pradip K Saha
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Biol Chem 279:35150-8. 2004
    ..These experiments uncover the metabolic adaptations associated with the constitutional lipolysis in plin(-/-) mice that allowed the mice to continue to exhibit normal glucose tolerance in the presence of peripheral insulin resistance...
  8. pmc Beta2 integrins modulate the initiation and progression of atherosclerosis in low-density lipoprotein receptor knockout mice
    Aksam Merched
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, R630, Houston, TX 77030, USA
    Cardiovasc Res 85:853-63. 2010
    ..Here, we investigated the effect of inactivation of beta2 integrins at different stages of atherosclerosis by timed bone marrow transplantation (BMT) of CD18(-/-) cells in low-density lipoprotein receptor knockout (LDLR(-/-)) mice...
  9. ncbi Helper-dependent adenoviral vector-mediated long-term expression of human apolipoprotein A-I reduces atherosclerosis in apo E-deficient mice
    Lucio Pastore
    Department of Molecular and Human Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA
    Gene 327:153-60. 2004
    ..In conclusion, liver-directed gene transfer of human APOA-I using a HD-Ad vector resulted in a reduction of the development of atherosclerosis with the absence of significant toxicity...
  10. ncbi Recent advances in liver-directed gene therapy for dyslipidemia
    Kazuhiro Oka
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Curr Atheroscler Rep 4:199-207. 2002
    ..The evidence presented suggests that some of the approaches taken in animals may be ready for clinical trials in the near future...
  11. pmc Gene therapy for diabetes: metabolic effects of helper-dependent adenoviral exendin 4 expression in a diet-induced obesity mouse model
    Susan L Samson
    Division of Diabetes and Endocrinology, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Ther 16:1805-12. 2008
    ..These observations are important in considering the development of longer acting GLP-1R agonists for the treatment of type 2 diabetes...
  12. pmc Inhibition and regression of atherosclerotic lesions
    Kazuhiro Oka
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
    Acta Biochim Pol 52:311-9. 2005
    ..Recent results on the long-term effect of gene therapy suggest that hepatic expression of therapeutic genes suppresses inflammation and has profound effects on the nature of the atherogenic process...
  13. ncbi Absence of p21Waf1/Cip1/Sdi1 modulates macrophage differentiation and inflammatory response and protects against atherosclerosis
    Aksam J Merched
    Department of Molecular, Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Circulation 110:3830-41. 2004
    ..p21 is also involved in the maturation and differentiation of monocytes into macrophages...
  14. ncbi Long-term stable expression of human apolipoprotein A-I mediated by helper-dependent adenovirus gene transfer inhibits atherosclerosis progression and remodels atherosclerotic plaques in a mouse model of familial hypercholesterolemia
    L Maria Belalcazar
    Department of Medicine, University of Texas Medical Branch, Galveston, Tex, USA
    Circulation 107:2726-32. 2003
    ..We used helper-dependent adenovirus (HD-Ad) gene transfer to examine the effect of long-term hepatic apoA-I expression on atherosclerotic lesion progression and remodeling in a mouse model of familial hypercholesterolemia...
  15. ncbi NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice
    Hideto Kojima
    Section of Diabetes, Endocrinology and Metabolism, Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Nat Med 9:596-603. 2003
    ..Our data suggest that Neurod-Btc gene therapy is a promising regimen to induce islet neogenesis for the treatment of insulin-dependent diabetes...
  16. ncbi Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis
    Li Wang
    Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Mol Endocrinol 20:2671-81. 2006
    ....
  17. pmc DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice
    Tomoya Terashima
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Invest 119:2100-112. 2009
    ..The development of DRG neuron-targeted HDAd with proven efficacy in a preclinical model may have implications for the treatment of sensory neuronopathies of diverse etiologies...
  18. pmc Absence of adipose differentiation related protein upregulates hepatic VLDL secretion, relieves hepatosteatosis, and improves whole body insulin resistance in leptin-deficient mice
    Benny Hung Junn Chang
    Departmentsof Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Lipid Res 51:2132-42. 2010
    ..The alteration of LD size in the liver of Lep(ob/ob)/Adfp(-/-) mice despite the relocation of other LDPs to the LD indicates a nonredundant role for ADFP in determining the size and distribution of hepatic LDs...
  19. pmc Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease
    Atul R Chopra
    Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Science 322:1395-9. 2008
    ..In addition, SRC-2 ablation, in both a whole-body and liver-specific manner, resulted in a Von Gierke's disease phenotype in mice. Our results position SRC-2 as a critical regulator of mammalian glucose production...
  20. pmc Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes
    Vijay Yechoor
    Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Cell 16:358-73. 2009
    ..This paradigm of induced transdetermination of receptive progenitor cells in vivo may be generally applicable to therapeutic organogenesis for multiple diseases, including diabetes...
  21. ncbi T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity
    Huaizhu Wu
    Section of Atherosclerosis and Vascular Medicine, Baylor College of Medicine, 6565 Fannin, Houston, TX 77030, USA
    Circulation 115:1029-38. 2007
    ..T cells also play important roles in chronic inflammatory diseases such as atherosclerosis but have not been well studied in obesity...
  22. ncbi Endothelial lipase modulates HDL but has no effect on atherosclerosis development in apoE-/- and LDLR-/- mice
    Kerry W S Ko
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Lipid Res 46:2586-94. 2005
    ..Thus, although EL modulated lipoprotein profile in mice, there was no effect of EL inactivation on atherosclerosis development in two hyperlipidemic atherosclerosis-prone mouse models...
  23. ncbi Restoration of type VII collagen expression and function in dystrophic epidermolysis bullosa
    Mei Chen
    Department of Medicine, Division of Dermatology, University of Southern California, CRL 204, 1303 Mission Road, Los Angeles, California 90033, USA
    Nat Genet 32:670-5. 2002
    ..These studies demonstrate that it is possible to restore type VII collagen gene expression in RDEB skin in vivo...
  24. ncbi Macrophage-specific p53 expression plays a crucial role in atherosclerosis development and plaque remodeling
    Aksam J Merched
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Arterioscler Thromb Vasc Biol 23:1608-14. 2003
    ..In this study, we investigated how macrophage-specific loss of p53 function might modulate atherosclerosis development in LDL receptor-deficient mice, a model for familial hypercholesterolemia...
  25. pmc Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease
    Weiqin Chen
    Diabetes and Endocrinology Research Center, Section of Diabetes and Endocrinology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Hepatology 52:1134-42. 2010
    ..CONCLUSION: Loss of Pnpla3 does not cause fatty liver, liver enzyme elevation, or insulin resistance in mice...
  26. ncbi Coordinated upregulation of oxidative pathways and downregulation of lipid biosynthesis underlie obesity resistance in perilipin knockout mice: a microarray gene expression profile
    Fernando Castro-Chavez
    Section of Diabetes, Endocrinology and Metabolism, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Diabetes 52:2666-74. 2003
    ..The biochemical pathways involved in obesity resistance in plin(-/-) mice identified in this study may represent potential targets for the treatment of obesity...
  27. ncbi C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice
    Antoni Paul
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, Tex 77030, USA
    Circulation 109:647-55. 2004
    ..Plasma C-reactive protein (CRP) concentration is a strong predictor of atherosclerosis. However, to date, there is no in vivo evidence that CRP is proatherogenic...
  28. pmc Liver-directed gene therapy for dyslipidemia and diabetes
    Kazuhiro Oka
    Departments of Molecular and Cellular Biology and Medicine, Division of Endocrinology and Metabolism, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Curr Atheroscler Rep 6:203-9. 2004
    ..A novel strategy for gene therapy for diabetes was published recently. Gene therapy for dyslipidemia and diabetes is still in its infancy. Nonetheless, recent progress in this area is encouraging and bodes well for the future...
  29. ncbi Differential additive effects of endothelial lipase and scavenger receptor-class B type I on high-density lipoprotein metabolism in knockout mouse models
    Ke Ma
    Section of Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, and St Luke s Episcopal Hospital, Houston, Tex 77030, USA
    Arterioscler Thromb Vasc Biol 25:149-54. 2005
    ..Scavenger receptor-class B type I (SR-BI) is an HDL receptor that mediates the selective uptake of cholesteryl ester. This study investigates the role of EL and SR-BI in the regulation of HDL metabolism in gene knockout mouse models...
  30. pmc Adiponectin regulates albuminuria and podocyte function in mice
    Kumar Sharma
    Translational Research in Kidney Disease, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0711, La Jolla, California 92093 0711, USA
    J Clin Invest 118:1645-56. 2008
    ..These results suggest that adiponectin is a key regulator of albuminuria, likely acting through the AMPK pathway to modulate oxidant stress in podocytes...
  31. pmc The nuclear orphan receptor COUP-TFII plays an essential role in adipogenesis, glucose homeostasis, and energy metabolism
    Luoping Li
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell Metab 9:77-87. 2009
    ..Thus, COUP-TFII regulates adipogenesis by regulating the key molecules in adipocyte development and can serve as a target for regulating energy metabolism...
  32. pmc A neuronal VLDLR variant lacking the third complement-type repeat exhibits high capacity binding of apoE containing lipoproteins
    Keiko Sakai
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Brain Res 1276:11-21. 2009
    ..These results suggest that a VLDLR variant lacking the third complement-type repeat is generated by neuron-specific alternative splicing. Such differential splicing may result in different lipid uptake in neurons and astrocytes...
  33. pmc Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators
    Aksam J Merched
    Department of Molecular and Cellular Biology, Baylor College of Medicine and St Luke s Episcopal Hospital, Houston, TX 77030, USA
    FASEB J 22:3595-606. 2008
    ..Taken together, these findings suggest that a failure of local endogenous resolution mechanisms may underlie the unremitting inflammation that fuels atherosclerosis...
  34. pmc Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease
    Bingning Dong
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:18831-6. 2009
    ..We conclude that CAR activation improves type 2 diabetes, and that these actions of CAR suggest therapeutic approaches to the disease...
  35. pmc Extravascular inflammation does not increase atherosclerosis in apoE-deficient mice
    Kerry W S Ko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Biochem Biophys Res Commun 384:93-9. 2009
    ..We found that all three forms of chronic extravascular inflammation had no effect on the rate of atherosclerosis development...
  36. pmc The human lipodystrophy gene product Berardinelli-Seip congenital lipodystrophy 2/seipin plays a key role in adipocyte differentiation
    Weiqin Chen
    Division of Diabetes and Endocrinology, Department of Medicine, Baylor College of Medicine, Diabetes and Endocrinology Research Center, Houston, Texas 77030, USA
    Endocrinology 150:4552-61. 2009
    ..Loss of Bscl2 function thus interferes with the normal transcriptional cascade of adipogenesis during fat cell differentiation, resulting in near total loss of fat or lipodystrophy...
  37. pmc Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo
    Raogo Ouedraogo
    Division of Endocrinology, Diabetes, and Metabolic Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 6799, USA
    J Clin Invest 117:1718-26. 2007
    ..Overall, we provide evidence that loss of adiponectin induces a primary state of endothelial dysfunction with increased leukocyte-endothelium adhesiveness...
  38. ncbi Nicotine induces proinflammatory responses in macrophages and the aorta leading to acceleration of atherosclerosis in low-density lipoprotein receptor(-/-) mice
    Paul P Lau
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Arterioscler Thromb Vasc Biol 26:143-9. 2006
    ..We investigated the molecular mechanism of nicotine-accelerated atherosclerosis in a hyperlipidemic low-density lipoprotein receptor(-/-) mouse model...
  39. pmc Regulatable atrial natriuretic peptide gene therapy for hypertension
    Kurt J Schillinger
    Department of Molecular and Cellular Biology, Section of Cardiovascular Sciences and Cardiology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:13789-94. 2005
    ..Given these capabilities, this vector represents a paradigm for the gene therapy of HTN...
  40. ncbi Construction and characterization of helper-dependent adenoviral vectors for sustained in vivo gene therapy
    Kazuhiro Oka
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
    Methods Mol Med 108:329-50. 2005
    ..Vector characterization and troubleshooting are also provided at appropriate steps...
  41. pmc Farnesoid X receptor is essential for normal glucose homeostasis
    Ke Ma
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    J Clin Invest 116:1102-9. 2006
    ..Taken together, our results identify a link between lipid and glucose metabolism mediated by the FXR-SHP cascade...
  42. pmc Gene therapy with neurogenin 3 and betacellulin reverses major metabolic problems in insulin-deficient diabetic mice
    Vijay Yechoor
    Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, R614, Houston, Texas 77030, USA
    Endocrinology 150:4863-73. 2009
    ....
  43. ncbi Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance
    Dan Liao
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Circ Res 99:598-606. 2006
    ..These findings indicate that HHcy inhibits reverse cholesterol transport by reducing circulating HDL via inhibiting apoA-I protein synthesis and enhancing HDL-C clearance...
  44. ncbi Regulation of Triglyceride Metabolism. III. Emerging role of lipid droplet protein ADFP in health and disease
    Benny Hung Junn Chang
    Division of Diabetes, Endocrinology, and Metabolism, Depts of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1465-8. 2007
    ..Space limitation has precluded a complete cataloging of all publications on the topic. We instead highlight some of the salient developments in the last few years...
  45. pmc Minireview: beta-cell replacement therapy for diabetes in the 21st century: manipulation of cell fate by directed differentiation
    Vijay Yechoor
    One Baylor Plaza, R614, Baylor College of Medicine, Houston, Texas, USA
    Mol Endocrinol 24:1501-11. 2010
    ..We will examine the pros and cons of each strategy as well as the hurdles that must be overcome before these approaches to generate new beta-cells will be ready for clinical application...
  46. pmc Extrapancreatic insulin-producing cells in multiple organs in diabetes
    Hideto Kojima
    Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:2458-63. 2004
    ..These observations have implications for the regulation of insulin gene expression, modulation of self-tolerance by insulin gene expression, and strategies for the generation of insulin-producing cells for the treatment of diabetes...
  47. ncbi The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes
    Li Wang
    Department of Medicine, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Cell Metab 2:227-38. 2005
    ..The orphan nuclear receptor ERRgamma is expressed in BAT and its transactivation of the PGC-1alpha promoter is potently inhibited by SHP. We conclude that SHP functions as a negative regulator of energy production in BAT...
  48. ncbi Reversal of obesity by targeted ablation of adipose tissue
    Mikhail G Kolonin
    The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Med 10:625-32. 2004
    ..Because prohibitin is also expressed in blood vessels of human white fat, this work may lead to the development of targeted drugs for treatment of obese patients...
  49. pmc Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism
    Ke Ma
    Section of Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine and Methodist Hospital, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:2748-53. 2003
    ..We conclude that EL is a major determinant of HDL concentration, structure, and metabolism in mice, and a major determinant of HDL concentration in humans...
  50. ncbi Increased beta -oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin
    Ke Ma
    Section of Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine and the St Luke s Episcopal Hospital, Texas Medical Center, Houston, Texas 77030, USA
    J Biol Chem 277:34658-61. 2002
    ..In conclusion, our study indicates that absence of adipo causes increased beta-oxidation but does not cause glucose intolerance or insulin resistance in mice...
  51. pmc Stem cell approaches for the treatment of type 1 diabetes mellitus
    Ryan T Wagner
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Transl Res 156:169-79. 2010
    ..We discussed the pros and cons of the different strategies that are being used to re-invent the pancreatic b cell...
  52. ncbi Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver
    Jiansheng Huang
    Department of Medicine, University of Kansas Medical Center, Kansas, KS 66160, USA
    Hepatology 46:147-57. 2007
    ..In addition, the pathways for hepatic lipid uptake and lipogenic program are also downregulated in OB(-/-)/SHP(-/-) mice, which may contribute to the decreased hepatic lipid content...
  53. ncbi Gene therapy for diabetes: reinventing the islet
    Susan L Samson
    Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Trends Endocrinol Metab 17:92-100. 2006
    ..Further research is necessary, however, to better define the most effective pro-endocrine factors and the most amenable cell types to achieve transdifferentiation for beta cell replacement...
  54. pmc Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion
    Kazuhiro Matsumura
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 27:6026-37. 2007
    ..In conclusion, we found that pancreatic beta cells express AQP7, which appears to be a key regulator of intraislet glycerol content as well as insulin production and secretion...
  55. doi Helper-dependent adenoviral vectors
    Kazuhiro Oka
    Baylor College of Medicine, Houston, Texas, USA
    Curr Protoc Mol Biol . 2005
    ..Included are protocols for Southern blot analysis to monitor vector amplification, slot blot assay to determine the infectious titer of the purified HDAd, and real-time PCR to detect helper virus contamination in the preparation...
  56. doi Helper-dependent adenoviral vectors
    Kazuhiro Oka
    Baylor College of Medicine, Houston, Texas, USA
    Curr Protoc Hum Genet . 2005
    ..Included are protocols for Southern blot analysis to monitor vector amplification, slot blot assay to determine the infectious titer of the purified HDAd, and real-time PCR to detect helper virus contamination in the preparation...
  57. pmc Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
    Masaki Kato
    Department of Molecular and Cellular Biology and Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 157:303-14. 2002
    ..Moreover, these features recapitulate human osteoporosis-pseudoglioma syndrome, caused by LRP5 inactivation...
  58. ncbi Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice
    Yuxiang Sun
    Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell Metab 3:379-86. 2006
    ..Hence, chronically, ghrelin controls glucose homeostasis by regulating pancreatic Ucp2 expression and insulin sensitivity...
  59. pmc The PAT family of lipid droplet proteins in heart and vascular cells
    Antoni Paul
    Brown Foundation Institute of Molecular Medicine, Houston, TX 77030, USA
    Curr Hypertens Rep 10:461-6. 2008
    ....
  60. pmc The Kr├╝ppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription
    Yisheng Yang
    Diabetes and Endocrinology Research Center, Division of Diabetes and Endocrinology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Nucleic Acids Res 37:2529-38. 2009
    ..This study uncovers a role of Glis3 for regulation of insulin gene expression and expands our understanding of its role in the beta cell...
  61. pmc Glucose-mediated transactivation of carbohydrate response element-binding protein requires cooperative actions from Mondo conserved regions and essential trans-acting factor 14-3-3
    Ming V Li
    Department of Medicine, Baylor College of Medicine N510, Houston, TX 77030, USA
    Mol Endocrinol 22:1658-72. 2008
    ..We conclude that individual subdomains in the GSM (MCR I through V) play diverse but crucial roles in cooperation with essential trans-acting cofactors such as 14-3-3 proteins to mediate the glucose response of ChREBP...
  62. ncbi Glucose-dependent transcriptional regulation by an evolutionarily conserved glucose-sensing module
    Ming V Li
    Program of Cardiovascular Sciences, Baylor College of Medicine N510, 1 Baylor Plaza, Houston, TX 77030, USA
    Diabetes 55:1179-89. 2006
    ..This evolutionally conserved mechanism may play an essential role in glucose-responsive gene regulation...
  63. ncbi Ubiquitin-dependent and -independent proteasomal degradation of apoB associated with endoplasmic reticulum and Golgi apparatus, respectively, in HepG2 cells
    Wei Liao
    The Section of Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 3498, USA
    J Cell Biochem 89:1019-29. 2003
    ....

Research Grants52

  1. Abnormal Bone Marrow Cells and Diabetic Neuropathy
    Lawrence Chan; Fiscal Year: 2010
    ..We will study the molecular and cellular mechanisms involved in these processes and events. ..
  2. Animal Models for Lipid Metabolism and Atherosclerosis
    Lawrence Chan; Fiscal Year: 2005
    ..We believe that the mechanistic experiments proposed will advance our understanding of lipid and carbohydrate metabolism, energy homeostasis, and atherosclerosis. ..
  3. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 2004
    ..Thus, the overall project is highly relevant to lipid nutrient absorption and homeostasis. Significantly, it also provides important information on a newly described pathway in posttranscriptional gene regulation. ..
  4. LIPOPROTEIN METABOLISM AND HORMONAL REGULATION
    Lawrence Chan; Fiscal Year: 2003
    ..In summary, this application utilizes state-of-the-art gene delivery technology plus a conditional knockout model to examine important issues in MTP biology, tissue-specific gene targeting, and intestinal gene therapy. ..
  5. Molecular Medicine Scholars Training Grant
    Lawrence Chan; Fiscal Year: 2006
    ..We are hopeful that the Program will play a significant role in reversing the national trend of increasing numbers of well-trained physicians leaving an academic research oriented career in biomedicine. ..
  6. Abnormal Bone Marrow Cells and Diabetic Neuropathy
    Lawrence Chan; Fiscal Year: 2010
    ..We will study the molecular and cellular mechanisms involved in these processes and events. ..
  7. Animal Models for Lipid Metabolism and Atherosclerosis
    Lawrence Chan; Fiscal Year: 2009
    ..Specific Aims 2 and 3 will further explore this novel therapy by mechanistic experiments in mice and testing the therapy in nonhuman primates in collaboration with SFBR. ..
  8. NOVEL THERAPY FOR DIABETES
    Lawrence Chan; Fiscal Year: 2007
    ..Finally, the best regimens identified by the experiments proposed are strong candidates for clinical trials in the future. ..
  9. Induced islet neogenesis therapy in vivo
    Lawrence Chan; Fiscal Year: 2007
    ..If the treatment strategy ameliorates diabetes in baboons without significant toxic side effects, then it will be an important proof-of-principle experiment that will pave the way for possible clinical trials in the future. ..
  10. Animal Models for Lipid Metabolism and Atherosclerosis
    Lawrence Chan; Fiscal Year: 2007
    ..Specific Aims 2 and 3 will further explore this novel therapy by mechanistic experiments in mice and testing the therapy in nonhuman primates in collaboration with SFBR. ..
  11. ANIMAL MODELS FOR ATHEROSCLEROSIS RESEARCH
    Lawrence Chan; Fiscal Year: 2001
    ..The overall project represents an in-depth study on the role of an enzyme, 15-LO, and a particular cell type, macrophages, in atherosclerosis initiation and progression in animal models in vivo. ..
  12. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 1999
    ..The project may provide important information related to lipoprotein metabolism and atherosclerosis and a novel pathway involved in the posttranscriptional regulation of gene expression. ..