Wei Cao

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Innate immune functions of plasmacytoid dendritic cells
    Wei Cao
    Department of Immunology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Curr Opin Immunol 19:24-30. 2007
  2. pmc Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production
    Wei Cao
    Department of Immunology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 203:1399-405. 2006
  3. pmc Signaling and ligand interaction of ILT7: receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells
    Wei Cao
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
    Immunol Rev 234:163-76. 2010
  4. doi request reprint Molecular characterization of human plasmacytoid dendritic cells
    Wei Cao
    Department of Immunology, Unit 901, 7455 Fannin, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Immunol 29:257-64. 2009
  5. pmc BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells
    Wei Cao
    Department of Immunology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    PLoS Biol 5:e248. 2007
  6. pmc Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction
    Wei Cao
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
    J Exp Med 206:1603-14. 2009
  7. pmc Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymus
    Shino Hanabuchi
    Department of Immunology and Center for Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030 1903, USA
    J Immunol 184:2999-3007. 2010
  8. ncbi request reprint Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL)
    Shino Hanabuchi
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, 7455 Fannin, Unit 910, Houston, 77030 1903, USA
    Blood 107:3617-23. 2006
  9. pmc CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl
    Musheng Bao
    Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 189:786-92. 2012
  10. pmc TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand
    Tomoki Ito
    Center for Cancer Immunology Research, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    J Exp Med 202:1213-23. 2005

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Innate immune functions of plasmacytoid dendritic cells
    Wei Cao
    Department of Immunology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Curr Opin Immunol 19:24-30. 2007
    ..The recent research progress provides an in-depth understanding of the biology of pDCs and a sensible basis for future therapeutic interventions...
  2. pmc Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production
    Wei Cao
    Department of Immunology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 203:1399-405. 2006
    ..Therefore, the ILT7-Fc epsilonRI gamma receptor complex negatively regulates the innate immune functions of human pDCs...
  3. pmc Signaling and ligand interaction of ILT7: receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells
    Wei Cao
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
    Immunol Rev 234:163-76. 2010
    ..Two opposing modes of receptor-mediated regulatory mechanisms work jointly to fine tune the innate immunity of pDCs...
  4. doi request reprint Molecular characterization of human plasmacytoid dendritic cells
    Wei Cao
    Department of Immunology, Unit 901, 7455 Fannin, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Immunol 29:257-64. 2009
    ..CONCLUSION: A detailed molecular description of pDCs helps us better define, understand, and track human pDCs in relation to their functions and physiological involvement...
  5. pmc BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells
    Wei Cao
    Department of Immunology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    PLoS Biol 5:e248. 2007
    ..Therefore, by associating with Fc epsilon RI gamma, BDCA2 activates a novel BCR-like signaling pathway to regulate the immune functions of pDCs...
  6. pmc Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction
    Wei Cao
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
    J Exp Med 206:1603-14. 2009
    ..Readily induced by IFN and other proinflammatory cytokines, BST2 may modulate the human pDC's IFN responses through ILT7 in a negative feedback fashion...
  7. pmc Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymus
    Shino Hanabuchi
    Department of Immunology and Center for Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030 1903, USA
    J Immunol 184:2999-3007. 2010
    ..The inability of TSLP to induce DC maturation without producing Th1- or Th2-polarizing cytokines may provide a thymic niche for T(R) development...
  8. ncbi request reprint Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL)
    Shino Hanabuchi
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, 7455 Fannin, Unit 910, Houston, 77030 1903, USA
    Blood 107:3617-23. 2006
    ..This study reveals a novel function of GITR/GITRL in pDC-mediated coactivation of NK cells...
  9. pmc CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl
    Musheng Bao
    Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 189:786-92. 2012
    ..Therefore, CD2AP positively regulates BDCA2/FcεR1γ signaling by forming a complex with SHIP1 to inhibit the E3 ubiquitin ligase Cbl...
  10. pmc TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand
    Tomoki Ito
    Center for Cancer Immunology Research, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    J Exp Med 202:1213-23. 2005
    ..We conclude that OX40L on TSLP-activated DCs triggers Th2 cell polarization in the absence of IL-12, and propose that OX40L can switch IL-10-producing regulatory Th cell responses into TNF-alpha-producing inflammatory Th cell responses...
  11. pmc PACSIN1 regulates the TLR7/9-mediated type I interferon response in plasmacytoid dendritic cells
    Eiji Esashi
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Eur J Immunol 42:573-9. 2012
    ....
  12. pmc Nucleic acid-containing amyloid fibrils potently induce type I interferon and stimulate systemic autoimmunity
    Jérémy Di Domizio
    Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 109:14550-5. 2012
    ..Our study reveals an innate immune function of nucleic acid-containing amyloid fibrils and provides a potential link between compromised protein homeostasis and autoimmunity via a pDC-IFN axis...
  13. ncbi request reprint Specialization, kinetics, and repertoire of type 1 interferon responses by human plasmacytoid predendritic cells
    Tomoki Ito
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 1903, USA
    Blood 107:2423-31. 2006
    ..This study provides formal proof that the plasticity of DC subsets is limited and that different DC subsets evolve to perform distinct functions in linking innate and adaptive immunity...
  14. ncbi request reprint Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
    Roberto Lande
    Department of Immunology, M D Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA
    Nature 449:564-9. 2007
    ..Thus, our data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis...
  15. doi request reprint Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
    Michel Gilliet
    Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Rev Immunol 8:594-606. 2008
    ..Several pDC receptors negatively regulate type I IFN responses by pDCs during viral infection and for normal homeostasis...
  16. doi request reprint Fueling autoimmunity: type I interferon in autoimmune diseases
    Jérémy Di Domizio
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
    Expert Rev Clin Immunol 9:201-10. 2013
    ..Given the central role of type I interferon, various strategies are devised to target these cytokines or related pathways to curtail the progression of autoimmune diseases...
  17. ncbi request reprint Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus
    Norihiko Watanabe
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas, M D Anderson Cancer Center, 7455 Fannin Street, Houston, Texas 77054, USA
    Nature 436:1181-5. 2005
    ....
  18. pmc Methylated BSA mimics amyloid-related proteins and triggers inflammation
    Jérémy Di Domizio
    Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 8:e63214. 2013
    ..These findings advance our understanding on the underlying mechanism of how aberrant immune responses lead to autoimmune reactions...
  19. pmc Reduced graft-versus-host disease in C3-deficient mice is associated with decreased donor Th1/Th17 differentiation
    Qing Ma
    Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Biol Blood Marrow Transplant 18:1174-81. 2012
    ..We conclude that C3 regulates Th1/17 differentiation in bone marrow transplantation, and define a novel function of the complement system in GVHD...
  20. pmc Binding with nucleic acids or glycosaminoglycans converts soluble protein oligomers to amyloid
    Jérémy Di Domizio
    Department of Immunology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Biol Chem 287:736-47. 2012
    ..These findings concur with reports of cofactor involvement with disease-associated amyloid and shed light on potential means to interfere with the pathogenic properties of misfolded proteins...
  21. pmc Lipid accumulation and dendritic cell dysfunction in cancer
    Donna L Herber
    Department of Immunology, H Lee Moffitt Cancer Center, Tampa, Florida, USA
    Nat Med 16:880-6. 2010
    ..These findings suggest that immune responses in cancer can be improved by manipulating the lipid levels in DCs...
  22. pmc Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells
    David B Rosen
    Department of Microbiology and Immunology, Biomedical Sciences Graduate Program, and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 180:6508-17. 2008
    ..Expression of LLT1 on activated dendritic cells and B cells suggests that it might regulate the cross-talk between NK cells and APCs...
  23. doi request reprint Anti-inflammatory effects of pigment epithelium-derived factor in diabetic nephropathy
    Joshua J Wang
    Department of Medicine Endocrinology and Cell Biology, Dean A McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Am J Physiol Renal Physiol 294:F1166-73. 2008
    ..These results suggest that the renoprotective effect of PEDF against diabetic nephropathy may be partially through its anti-inflammatory activity, likely by blocking the NF-kappaB and HIF-1 pathways...
  24. ncbi request reprint TNF-alpha promotes Doxorubicin-induced cell apoptosis and anti-cancer effect through downregulation of p21 in p53-deficient tumor cells
    Wei Cao
    Laboratory of Medical Molecular Virology, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China
    Biochem Biophys Res Commun 330:1034-40. 2005
    ....
  25. ncbi request reprint Identification of mouse retinal genes differentially regulated by dim and bright cyclic light rearing
    Hu Huang
    Department of Ophthalmology, University of Oklahoma Health Sciences Center, 608 Stanton L Young Boulevard, Oklahoma City, OK 73104, USA
    Exp Eye Res 80:727-39. 2005
    ..Those that directly affect cell processes such as survival, apoptosis, and transcription are likely play a pivotal role in the regulation of retinal neuroprotection against light-induced photoreceptor apoptosis...
  26. ncbi request reprint Pharmacological characterization of guinea pig chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)
    Fang Liu
    Department of Inflammation, Millennium Pharmaceutical Inc, Cambridge, MA 02139, USA
    Prostaglandins Other Lipid Mediat 76:133-47. 2005
    ..These results indicate that PGD(2) and the stable metabolite, Delta(12)-PGJ(2), play important roles in CRTH2 activation in the guinea pig...
  27. ncbi request reprint Involvement of inflammation, degradation, and apoptosis in a mouse model of glaucoma
    Xiaohong Zhou
    Department of Ophthalmology, Dean A McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 280:31240-8. 2005
    ..The possibility that altered IL-18 expression in the eye of DBA/2J mice initiates and/or amplifies the pathogenesis of pigmentary glaucoma requires further investigation...
  28. ncbi request reprint Protection against hydrogen peroxide-induced cell death in cultured human retinal pigment epithelial cells by 17beta-estradiol: a differential gene expression profile
    Xiaorui Yu
    Department of Ophthalmology, University of Oklahoma Health Science Center, Dean A McGee Eye Institute, 608 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Mech Ageing Dev 126:1135-45. 2005
    ....
  29. ncbi request reprint Optimization of culture on the overproduction of TRAIL in high-cell-density culture by recombinant Escherichia coli
    Qingping Luo
    State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, People s Republic of China
    Appl Microbiol Biotechnol 71:184-91. 2006
    ..51 g l(-1), approximately 16.1% of total cellular protein. The mechanisms behind the preinduction specific growth rate effect on the expression level may be ascribed to the leakage secretion of acetate...
  30. ncbi request reprint 17beta-estradiol (betaE2) protects human retinal Müller cell against oxidative stress in vitro: evaluation of its effects on gene expression by cDNA microarray
    Chao Li
    Department of Ophthalmology, University of Oklahoma Health Science Center, Dean A McGee Eye Institute, 608 Stanton L Young Blvd, Oklahoma City, 73104, USA
    Glia 53:392-400. 2006
    ..This protective effect may operate through regulation of genes, such as TSP1, MAP3K3, SOX11, TSP1, and PEDF, and may in turn exert an important role in protecting retinal neurons...
  31. ncbi request reprint Opn: key regulator of pDC interferon production
    Wei Cao
    Nat Immunol 7:441-3. 2006
  32. ncbi request reprint Retinal ganglion cell protection by 17-beta-estradiol in a mouse model of inherited glaucoma
    Xiaohong Zhou
    Department of Ophthalmology, Dean A McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Dev Neurobiol 67:603-16. 2007
    ..These findings suggest the possible involvement of multiple biochemical events, including estrogen receptor/Akt/CREB/thioredoxin-1, and estrogen receptor/MAPK/NF-kappaB, in estrogen-mediated retinal ganglion cell protection...
  33. ncbi request reprint RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity
    Wei Cao
    Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, National Key Laboratory of Medical Molecular Biology, Beijing 100005 China
    J Biol Chem 282:18922-8. 2007
    ....
  34. ncbi request reprint Biochemical alterations in the retinas of very low-density lipoprotein receptor knockout mice: an animal model of retinal angiomatous proliferation
    Chao Li
    Department of Ophthalmology, University of Oklahoma Health Sciences Center, Dean A McGee Eye Institute, 608 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Arch Ophthalmol 125:795-803. 2007
    ..To identify and characterize biochemical alterations in the retinas of very low-density lipoprotein receptor (VLDLr) knockout mice in an animal model of retinal angiomatous proliferation...
  35. ncbi request reprint UL16 binding proteins
    Wei Cao
    Peking Union Medical College, Dong Dan San Tiao 5, Beijing 100005, People s Republic of China
    Immunobiology 209:283-90. 2004
    ..This review summarizes the research achievements in a new ligand family (UL16 binding proteins) of NKG2D in human and shows the possible prospects of ULBP function and application...